Gdf10 (growth differentiation factor 10) - Rat Genome Database

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Gene: Gdf10 (growth differentiation factor 10) Rattus norvegicus
Analyze
Symbol: Gdf10
Name: growth differentiation factor 10
RGD ID: 621512
Description: Predicted to enable cytokine activity. Involved in several processes, including positive regulation of osteoblast differentiation; response to kainic acid; and response to transforming growth factor beta. Located in extracellular space. Orthologous to human GDF10 (growth differentiation factor 10); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: BIP; BMP-3b; bone morphogenetic protein 3B; bone-inducing protein; GDF-10; growth/differentiation factor 10; prepro bone inducing protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8169,243,434 - 9,256,788 (+)NCBIGRCr8
mRatBN7.2169,237,182 - 9,250,537 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl169,237,261 - 9,249,343 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx169,256,689 - 9,268,770 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01610,401,395 - 10,413,477 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0169,251,785 - 9,263,853 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01610,250,508 - 10,262,383 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1610,250,404 - 10,263,150 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0168,571,370 - 8,583,245 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4169,558,781 - 9,570,656 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1169,558,727 - 9,570,654 (+)NCBI
Celera165,961,266 - 5,973,147 (-)NCBICelera
Cytogenetic Map16p16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
astemizole  (EXP)
benzo[a]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
caffeine  (EXP)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
clofibrate  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
dexamethasone  (ISO)
dibutyl phthalate  (EXP)
diethylstilbestrol  (EXP)
diuron  (EXP)
dorsomorphin  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
fenvalerate  (EXP)
folic acid  (ISO)
genistein  (EXP,ISO)
glycerol 2-phosphate  (EXP)
inulin  (ISO)
L-ascorbic acid  (EXP)
L-methionine  (ISO)
levonorgestrel  (ISO)
lipopolysaccharide  (ISO)
medroxyprogesterone acetate  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
methoxyacetic acid  (EXP)
methylmercury chloride  (EXP)
Monobutylphthalate  (EXP)
N-nitrosodiethylamine  (ISO)
nickel atom  (ISO)
oxaliplatin  (EXP)
panobinostat  (ISO)
paracetamol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sulfadimethoxine  (EXP)
tamoxifen  (ISO)
testosterone undecanoate  (ISO)
tetrachloromethane  (ISO)
tetraphene  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
XL147  (ISO)
zaragozic acid A  (EXP,ISO)
zearalenone  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
extracellular space  (IBA,IDA,IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Assessment of gene expression profiles in peripheral occlusive arterial disease. Bubenek S, etal., Can J Cardiol. 2012 Nov-Dec;28(6):712-20. doi: 10.1016/j.cjca.2012.03.013. Epub 2012 Jun 19.
2. Relationship of bone morphogenetic protein expression during osteoblast differentiation to wild type p53. Chandar N, etal., J Orthop Res. 2005 Nov;23(6):1345-53. Epub 2005 Jul 1.
3. The spatiotemporal expression pattern of the bone morphogenetic protein family in rat ovary cell types during the estrous cycle. Erickson GF and Shimasaki S, Reprod Biol Endocrinol. 2003 Feb 5;1:9.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Bone morphogenetic protein-3b (BMP-3b) gene expression is correlated with differentiation in rat calvarial osteoblasts. Hino J, etal., Biochem Biophys Res Commun. 1999 Mar 16;256(2):419-24.
7. Over expression of bone morphogenetic protein-3b (BMP-3b) using an adenoviral vector promote the osteoblastic differentiation in C2C12 cells and augment the bone formation induced by bone morphogenetic protein-2 (BMP-2) in rats. Kaihara S, etal., Life Sci. 2003 Feb 28;72(15):1683-93.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Antisense oligonucleotide for tissue factor inhibits hepatic ischemic reperfusion injury. Nakamura K, etal., Biochem Biophys Res Commun 2002 Sep 27;297(3):433-41.
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Endoplasmic reticulum stress inhibition protects against excitotoxic neuronal injury in the rat brain. Sokka AL, etal., J Neurosci. 2007 Jan 24;27(4):901-8.
15. Identification of rat bone morphogenetic protein-3b (BMP-3b), a new member of BMP-3. Takao M, etal., Biochem Biophys Res Commun 1996 Feb 15;219(2):656-62.
Additional References at PubMed
PMID:20096814   PMID:21712809   PMID:26811051   PMID:27068509   PMID:28394782   PMID:36714584  


Genomics

Comparative Map Data
Gdf10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8169,243,434 - 9,256,788 (+)NCBIGRCr8
mRatBN7.2169,237,182 - 9,250,537 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl169,237,261 - 9,249,343 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx169,256,689 - 9,268,770 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01610,401,395 - 10,413,477 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0169,251,785 - 9,263,853 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01610,250,508 - 10,262,383 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1610,250,404 - 10,263,150 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0168,571,370 - 8,583,245 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4169,558,781 - 9,570,656 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1169,558,727 - 9,570,654 (+)NCBI
Celera165,961,266 - 5,973,147 (-)NCBICelera
Cytogenetic Map16p16NCBI
GDF10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381047,300,197 - 47,313,577 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1047,300,197 - 47,313,577 (+)EnsemblGRCh38hg38GRCh38
GRCh371048,425,785 - 48,439,165 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361048,045,795 - 48,059,172 (-)NCBINCBI36Build 36hg18NCBI36
Build 341048,045,794 - 48,059,172NCBI
Celera1044,850,007 - 44,863,384 (-)NCBICelera
Cytogenetic Map10q11.22NCBI
HuRef1043,178,553 - 43,191,903 (-)NCBIHuRef
CHM1_11048,590,851 - 48,604,204 (-)NCBICHM1_1
T2T-CHM13v2.01048,191,293 - 48,204,673 (+)NCBIT2T-CHM13v2.0
Gdf10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391433,645,544 - 33,658,471 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1433,645,544 - 33,659,940 (+)EnsemblGRCm39 Ensembl
GRCm381433,923,587 - 33,936,514 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1433,923,587 - 33,937,983 (+)EnsemblGRCm38mm10GRCm38
MGSCv371434,736,773 - 34,748,471 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361432,752,679 - 32,764,377 (+)NCBIMGSCv36mm8
Celera1430,189,682 - 30,201,380 (+)NCBICelera
Cytogenetic Map14BNCBI
cM Map1420.8NCBI
Gdf10
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555562,185,121 - 2,196,502 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555562,185,121 - 2,195,150 (+)NCBIChiLan1.0ChiLan1.0
GDF10
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2859,997,778 - 60,011,111 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11060,003,095 - 60,016,428 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01046,498,600 - 46,511,933 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
GDF10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1435,008,204 - 35,017,476 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl435,008,983 - 35,018,166 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha434,972,559 - 34,981,749 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0435,368,659 - 35,377,901 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl435,368,660 - 35,378,771 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1435,200,361 - 35,209,442 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0435,381,596 - 35,390,831 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0435,889,219 - 35,898,460 (-)NCBIUU_Cfam_GSD_1.0
Gdf10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721381,283,121 - 81,297,318 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365547,292,767 - 7,307,009 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365547,292,805 - 7,307,001 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GDF10
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1488,522,948 - 88,534,709 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11488,522,956 - 88,534,719 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21496,148,673 - 96,160,426 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GDF10
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1944,066,979 - 44,080,319 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl944,067,469 - 44,079,522 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660483,837,123 - 3,850,490 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Gdf10
63 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357403Slep4Serum leptin concentration QTL 43.91blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1619639137Rat
1600369Hcas8Hepatocarcinoma susceptibility QTL 8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)16122477621Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126727669Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16126727669Rat
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16126727669Rat
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16130836262Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16132139025Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133418960Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139533930Rat
631561Hcuc2Hepatic copper content QTL 22.8liver copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16143534949Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16144588133Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683223646053497Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat
2301406Kidm39Kidney mass QTL 390.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)16285170915884239Rat
1300133Rf24Renal function QTL 243.64blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)16338015021361552Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338015043025077Rat
737825Alc13Alcohol consumption QTL 134.5consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760916039848Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16422760943025077Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16422760948972724Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
61372Bp40Blood pressure QTL 402.2blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)16422773017696785Rat

Markers in Region
RH128730  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2169,249,015 - 9,249,196 (+)MAPPERmRatBN7.2
Rnor_6.01610,262,056 - 10,262,236NCBIRnor6.0
Rnor_5.0168,582,918 - 8,583,098UniSTSRnor5.0
RGSC_v3.4169,570,329 - 9,570,509UniSTSRGSC3.4
Celera165,961,413 - 5,961,593UniSTS
RH 3.4 Map1692.8UniSTS
Cytogenetic Map16p16UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 4 4 4 21 14
Low 24 40 27 7 27 3 6 53 27 20 9 3
Below cutoff 3 18 13 10 10 10 5 5 8 7 2 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000081183   ⟹   ENSRNOP00000069581
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl169,237,261 - 9,249,343 (+)Ensembl
Rnor_6.0 Ensembl1610,250,461 - 10,263,150 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000087037   ⟹   ENSRNOP00000075201
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1610,250,404 - 10,262,383 (+)Ensembl
RefSeq Acc Id: NM_024375   ⟹   NP_077351
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8169,243,512 - 9,255,594 (+)NCBI
mRatBN7.2169,237,261 - 9,249,343 (+)NCBI
Rnor_6.01610,250,508 - 10,262,383 (+)NCBI
Rnor_5.0168,571,370 - 8,583,245 (+)NCBI
RGSC_v3.4169,558,781 - 9,570,656 (+)RGD
Celera165,961,266 - 5,973,147 (-)RGD
Sequence:
RefSeq Acc Id: XM_039094852   ⟹   XP_038950780
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8169,243,434 - 9,256,788 (+)NCBI
mRatBN7.2169,237,182 - 9,250,537 (+)NCBI
Protein Sequences
Protein RefSeqs NP_077351 (Get FASTA)   NCBI Sequence Viewer  
  XP_038950780 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAA08454 (Get FASTA)   NCBI Sequence Viewer  
  EDL88894 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000069581
  ENSRNOP00000069581.2
  ENSRNOP00055013488
  ENSRNOP00060017732
  ENSRNOP00065019296
GenBank Protein P55108 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_077351   ⟸   NM_024375
- Peptide Label: precursor
- UniProtKB: P55108 (UniProtKB/Swiss-Prot),   A6KFT7 (UniProtKB/TrEMBL),   A0A0G2JVQ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000075201   ⟸   ENSRNOT00000087037
RefSeq Acc Id: ENSRNOP00000069581   ⟸   ENSRNOT00000081183
RefSeq Acc Id: XP_038950780   ⟸   XM_039094852
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JVQ8 (UniProtKB/TrEMBL)
Protein Domains
TGF-beta family profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P55108-F1-model_v2 AlphaFold P55108 1-476 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621512 AgrOrtholog
BioCyc Gene G2FUF-12084 BioCyc
Ensembl Genes ENSRNOG00000051993 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055009884 UniProtKB/Swiss-Prot
  ENSRNOG00060013108 UniProtKB/Swiss-Prot
  ENSRNOG00065014943 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000081183 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000081183.2 UniProtKB/Swiss-Prot
  ENSRNOT00055016726 UniProtKB/Swiss-Prot
  ENSRNOT00060022349 UniProtKB/Swiss-Prot
  ENSRNOT00065024710 UniProtKB/Swiss-Prot
Gene3D-CATH 2.10.90.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro BMP3/BMP3B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cystine-knot_cytokine UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF-b_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF-beta-rel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGFb_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:79216 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 79216 ENTREZGENE
PANTHER GROWTH/DIFFERENTIATION FACTOR 10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11848 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam TGF_beta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB GDF10 RGD
PhenoGen Gdf10 PhenoGen
PIRSF BMP3/GDF10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TGF_BETA_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF_BETA_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000051993 RatGTEx
  ENSRNOG00055009884 RatGTEx
  ENSRNOG00060013108 RatGTEx
  ENSRNOG00065014943 RatGTEx
SMART TGFB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57501 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JVQ8 ENTREZGENE, UniProtKB/TrEMBL
  A6KFT7 ENTREZGENE, UniProtKB/TrEMBL
  GDF10_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Gdf10  growth differentiation factor 10    prepro bone inducing protein  Name updated 1299863 APPROVED
2002-08-07 Gdf10  prepro bone inducing protein      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in costa, costicartilage, femur, calvaria, trachea, aorta and brain 631791
gene_product member of bone morphogenetic protein-3 (BMP-3) 631791