Adam3a (ADAM metallopeptidase domain 3A) - Rat Genome Database

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Gene: Adam3a (ADAM metallopeptidase domain 3A) Rattus norvegicus
Analyze
Symbol: Adam3a
Name: ADAM metallopeptidase domain 3A
RGD ID: 621469
Description: Predicted to enable metalloendopeptidase activity. Involved in male gonad development. Predicted to be located in cell surface; membrane raft; and sperm head. Predicted to be part of protein-containing complex. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in brain glioma and conjunctival squamous cell carcinoma. Orthologous to human ADAM3A (ADAM metallopeptidase domain 3A (pseudogene)); INTERACTS WITH ammonium chloride; bisphenol A; cadmium dichloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: a disintegrin and metallopeptidase domain 3 (cyritestin); a disintegrin and metalloprotease domain 3; a disintegrin and metalloprotease domain 3 (cyritestin); ADAM metallopeptidase domain 3; ADAM metallopeptidase domain 3A (cyritestin 1); ADAM metallopeptidase domain 3A (pseudogene); Adam3; cyritestin; tMDC I; tMDCI
RGD Orthologs
Human
Mouse
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81674,002,566 - 74,052,579 (+)NCBIGRCr8
mRatBN7.21667,299,949 - 67,349,970 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1667,299,949 - 67,349,968 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1672,577,102 - 72,627,111 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01675,982,777 - 76,032,785 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01671,231,868 - 71,282,130 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01672,086,878 - 72,136,685 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1672,086,878 - 72,136,687 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01671,733,699 - 71,783,768 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41671,729,856 - 71,779,922 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11671,730,120 - 71,780,187 (+)NCBI
Celera1665,201,618 - 65,251,184 (+)NCBICelera
Cytogenetic Map16q12.4NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Identification of multiple DNA copy number alterations including frequent 8p11.22 amplification in conjunctival squamous cell carcinoma. Asnaghi L, etal., Invest Ophthalmol Vis Sci. 2014 Dec 9;55(12):8604-13. doi: 10.1167/iovs.14-14920.
2. Homozygous loss of ADAM3A revealed by genome-wide analysis of pediatric high-grade glioma and diffuse intrinsic pontine gliomas. Barrow J, etal., Neuro Oncol. 2011 Feb;13(2):212-22. doi: 10.1093/neuonc/noq158. Epub 2010 Dec 7.
3. Rat MDC family of proteins: sequence analysis, tissue distribution, and expression in prepubertal and adult rat testis. Frayne J, etal., Mol Reprod Dev 1997 Oct;48(2):159-67.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Comprehensive gene review and curation RGD comprehensive gene curation
10. Chronological gene expression of ADAMs during testicular development: prespermatogonia (gonocytes) express fertilin beta (ADAM2). Rosselot C, etal., Dev Dyn. 2003 Jul;227(3):458-67.
11. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:15194697   PMID:15514464   PMID:16330764   PMID:19129510   PMID:19339711   PMID:21339297   PMID:22357757   PMID:22621904   PMID:24501175  


Genomics

Comparative Map Data
Adam3a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81674,002,566 - 74,052,579 (+)NCBIGRCr8
mRatBN7.21667,299,949 - 67,349,970 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1667,299,949 - 67,349,968 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1672,577,102 - 72,627,111 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01675,982,777 - 76,032,785 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01671,231,868 - 71,282,130 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01672,086,878 - 72,136,685 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1672,086,878 - 72,136,687 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01671,733,699 - 71,783,768 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41671,729,856 - 71,779,922 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11671,730,120 - 71,780,187 (+)NCBI
Celera1665,201,618 - 65,251,184 (+)NCBICelera
Cytogenetic Map16q12.4NCBI
ADAM3A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38839,451,045 - 39,522,989 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl839,451,045 - 39,522,852 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p14 Ensembl839,455,339 - 39,522,810 (-)EnsemblGRCh38hg38GRCh38
GRCh37839,308,564 - 39,380,508 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36839,427,721 - 39,499,524 (-)NCBINCBI36Build 36hg18NCBI36
Build 34839,427,721 - 39,499,524NCBI
Cytogenetic Map8p11.22NCBI
HuRef837,840,707 - 37,913,729 (-)NCBIHuRef
T2T-CHM13v2.0839,728,311 - 39,800,254 (-)NCBIT2T-CHM13v2.0
Adam3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39825,167,248 - 25,216,393 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl825,167,241 - 25,215,868 (-)EnsemblGRCm39 Ensembl
GRCm38824,677,232 - 24,726,377 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl824,677,225 - 24,725,852 (-)EnsemblGRCm38mm10GRCm38
MGSCv37825,787,706 - 25,836,297 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36826,142,777 - 26,191,370 (-)NCBIMGSCv36mm8
Celera826,157,717 - 26,206,590 (-)NCBICelera
Cytogenetic Map8A2NCBI
cM Map813.09NCBI

Variants

.
Variants in Adam3a
479 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:52
Count of miRNA genes:49
Interacting mature miRNAs:50
Transcripts:ENSRNOT00000023756
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)161900443575226532Rat
8694453Bw172Body weight QTL 1728.330.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)162432551369325513Rat
6903294Stl30Serum triglyceride level QTL 302.60.0013blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)162515279370152793Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163528887080288870Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)163775215682752156Rat
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)163775215682752156Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164239634584729064Rat
8694429Bw164Body weight QTL 16450.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)165272646484729064Rat
8694364Abfw7Abdominal fat weight QTL 712.220.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)165272646484729064Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165272646484729064Rat
631525Pia14Pristane induced arthritis QTL 144.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)165571108783402471Rat

Markers in Region
AU048981  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21667,301,971 - 67,302,179 (+)MAPPERmRatBN7.2
Rnor_6.01672,088,901 - 72,089,108NCBIRnor6.0
Rnor_5.01671,735,722 - 71,735,929UniSTSRnor5.0
RGSC_v3.41671,731,879 - 71,732,086UniSTSRGSC3.4
Celera1665,203,641 - 65,203,848UniSTS
Cytogenetic Map16q12.4UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 1
Medium 6
Low 11 5 8 5 2 2 5 2 3 2
Below cutoff 2 3 5 1 9 1 3 4 11 3 8 5 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000023756   ⟹   ENSRNOP00000023756
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1667,299,949 - 67,349,968 (+)Ensembl
Rnor_6.0 Ensembl1672,086,878 - 72,136,685 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000078085   ⟹   ENSRNOP00000070106
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1672,086,907 - 72,136,687 (+)Ensembl
RefSeq Acc Id: NM_020302   ⟹   NP_064698
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81674,002,566 - 74,052,577 (+)NCBI
mRatBN7.21667,299,949 - 67,349,968 (+)NCBI
Rnor_6.01672,086,878 - 72,136,685 (+)NCBI
Rnor_5.01671,733,699 - 71,783,768 (+)NCBI
RGSC_v3.41671,729,856 - 71,779,922 (+)RGD
Celera1665,201,618 - 65,251,184 (+)RGD
Sequence:
RefSeq Acc Id: XM_039094792   ⟹   XP_038950720
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81674,002,698 - 74,052,579 (+)NCBI
mRatBN7.21667,300,078 - 67,349,970 (+)NCBI
RefSeq Acc Id: XM_039094793   ⟹   XP_038950721
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81674,018,957 - 74,052,579 (+)NCBI
mRatBN7.21667,316,352 - 67,349,970 (+)NCBI
Protein Sequences
Protein RefSeqs NP_064698 (Get FASTA)   NCBI Sequence Viewer  
  XP_038950720 (Get FASTA)   NCBI Sequence Viewer  
  XP_038950721 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH78839 (Get FASTA)   NCBI Sequence Viewer  
  CAA69210 (Get FASTA)   NCBI Sequence Viewer  
  EDM09041 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000023756
  ENSRNOP00000023756.6
Reference Protein Sequences
RefSeq Acc Id: NP_064698   ⟸   NM_020302
- Peptide Label: precursor
- UniProtKB: P70534 (UniProtKB/TrEMBL),   D3ZSV4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000023756   ⟸   ENSRNOT00000023756
RefSeq Acc Id: ENSRNOP00000070106   ⟸   ENSRNOT00000078085
RefSeq Acc Id: XP_038950720   ⟸   XM_039094792
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038950721   ⟸   XM_039094793
- Peptide Label: isoform X2
- UniProtKB: A6IW31 (UniProtKB/TrEMBL)
Protein Domains
Disintegrin   EGF-like   Peptidase M12B

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JX23-F1-model_v2 AlphaFold A0A0G2JX23 1-769 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700178
Promoter ID:EPDNEW_R10700
Type:initiation region
Name:Adam3a_1
Description:ADAM metallopeptidase domain 3A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01672,086,959 - 72,087,019EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621469 AgrOrtholog
BioCyc Gene G2FUF-10946 BioCyc
Ensembl Genes ENSRNOG00000017554 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000023756 ENTREZGENE
  ENSRNOT00000023756.7 UniProtKB/TrEMBL
Gene3D-CATH 3.40.390.10 UniProtKB/TrEMBL
  4.10.70.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7114315 IMAGE-MGC_LOAD
InterPro ADAM_Cys-rich UniProtKB/TrEMBL
  Blood-coag_inhib_Disintegrin UniProtKB/TrEMBL
  Disintegrin_dom_sf UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  EGF_extracell UniProtKB/TrEMBL
  MetalloPept_cat_dom UniProtKB/TrEMBL
  Peptidase_M12B UniProtKB/TrEMBL
  Peptidase_M12B_N UniProtKB/TrEMBL
  Reprolysin_adamalysin UniProtKB/TrEMBL
KEGG Report rno:57021 UniProtKB/TrEMBL
MGC_CLONE MGC:93469 IMAGE-MGC_LOAD
NCBI Gene 57021 ENTREZGENE
PANTHER A DISINTEGRIN AND METALLOPEPTIDASE DOMAIN 3 UniProtKB/TrEMBL
  ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN UniProtKB/TrEMBL
Pfam ADAM_CR UniProtKB/TrEMBL
  Disintegrin UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  Pep_M12B_propep UniProtKB/TrEMBL
  Reprolysin UniProtKB/TrEMBL
PhenoGen Adam3a PhenoGen
PROSITE ADAM_MEPRO UniProtKB/TrEMBL
  DISINTEGRIN_2 UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000017554 RatGTEx
SMART ACR UniProtKB/TrEMBL
  DISIN UniProtKB/TrEMBL
Superfamily-SCOP Disintegrin UniProtKB/TrEMBL
  Metalloproteases ('zincins'), catalytic domain UniProtKB/TrEMBL
UniProt A6IW31 ENTREZGENE, UniProtKB/TrEMBL
  D3ZSV4 ENTREZGENE
  P70534 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary D3ZSV4 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-03-05 Adam3a  ADAM metallopeptidase domain 3A  Adam3a  ADAM metallopeptidase domain 3A (pseudogene)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-13 Adam3a  ADAM metallopeptidase domain 3A (pseudogene)  Adam3a  ADAM metallopeptidase domain 3A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-07-28 Adam3a  ADAM metallopeptidase domain 3A  Adam3a  ADAM metallopeptidase domain 3A (cyritestin 1)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-24 Adam3a  ADAM metallopeptidase domain 3A (cyritestin 1)  Adam3  ADAM metallopeptidase domain 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-18 Adam3  ADAM metallopeptidase domain 3  Adam3  a disintegrin and metallopeptidase domain 3 (cyritestin)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-22 Adam3  a disintegrin and metallopeptidase domain 3 (cyritestin)  Adam3  a disintegrin and metalloprotease domain 3 (cyritestin)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Adam3  a disintegrin and metalloprotease domain 3 (cyritestin)      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Adam3  a disintegrin and metalloprotease domain 3 (cyritestin)      Symbol and Name status set to provisional 70820 PROVISIONAL