Cep19 (centrosomal protein 19) - Rat Genome Database

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Gene: Cep19 (centrosomal protein 19) Rattus norvegicus
Analyze
Symbol: Cep19
Name: centrosomal protein 19
RGD ID: 621352
Description: Predicted to be involved in microtubule anchoring at centrosome and vesicle targeting, trans-Golgi to periciliary membrane compartment. Predicted to be located in cilium and nucleoplasm. Predicted to be active in microtubule cytoskeleton. Orthologous to human CEP19 (centrosomal protein 19); INTERACTS WITH 6-propyl-2-thiouracil; amitrole; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AF146738; centrosomal protein of 19 kDa; hypothetical protein LOC192229; RGD621352; similar to RIKEN cDNA 1500031L02; testis specific protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81182,182,868 - 82,192,134 (-)NCBIGRCr8
mRatBN7.21168,677,869 - 68,687,117 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1168,677,871 - 68,687,022 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1177,514,918 - 77,524,098 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01170,177,010 - 70,186,133 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01169,204,015 - 69,213,195 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01171,921,713 - 71,938,335 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1171,921,716 - 71,938,165 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01175,004,786 - 75,013,404 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41170,500,062 - 70,508,772 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11170,557,650 - 70,566,361 (-)NCBI
Celera1168,100,332 - 68,109,479 (-)NCBICelera
Cytogenetic Map11q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
centriole  (IBA,IEA,ISO,ISS)
centrosome  (IBA,IEA,ISO)
ciliary basal body  (IBA,IEA,ISO,ISS)
cilium  (ISO)
cytoplasm  (IEA)
nucleoplasm  (IEA,ISO)
spindle pole  (IBA,IEA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:21399614   PMID:24268657   PMID:28428259   PMID:28625565   PMID:28659385  


Genomics

Comparative Map Data
Cep19
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81182,182,868 - 82,192,134 (-)NCBIGRCr8
mRatBN7.21168,677,869 - 68,687,117 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1168,677,871 - 68,687,022 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1177,514,918 - 77,524,098 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01170,177,010 - 70,186,133 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01169,204,015 - 69,213,195 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01171,921,713 - 71,938,335 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1171,921,716 - 71,938,165 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01175,004,786 - 75,013,404 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41170,500,062 - 70,508,772 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11170,557,650 - 70,566,361 (-)NCBI
Celera1168,100,332 - 68,109,479 (-)NCBICelera
Cytogenetic Map11q22NCBI
CEP19
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383196,706,277 - 196,712,250 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3196,706,277 - 196,712,250 (-)EnsemblGRCh38hg38GRCh38
GRCh373196,433,148 - 196,439,121 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363197,918,298 - 197,923,491 (-)NCBINCBI36Build 36hg18NCBI36
Cytogenetic Map3q29NCBI
HuRef3193,729,843 - 193,735,809 (-)NCBIHuRef
CHM1_13196,404,344 - 196,410,314 (-)NCBICHM1_1
T2T-CHM13v2.03199,425,670 - 199,431,642 (-)NCBIT2T-CHM13v2.0
Cep19
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391631,918,618 - 31,926,875 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1631,918,618 - 31,926,887 (+)EnsemblGRCm39 Ensembl
GRCm381632,099,789 - 32,108,068 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1632,099,800 - 32,108,069 (+)EnsemblGRCm38mm10GRCm38
MGSCv371632,099,888 - 32,108,140 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361632,019,549 - 32,027,801 (+)NCBIMGSCv36mm8
Celera1632,595,894 - 32,605,144 (+)NCBICelera
Cytogenetic Map16B2NCBI
cM Map1622.4NCBI
Cep19
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542012,823,889 - 12,825,337 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542012,823,663 - 12,829,598 (-)NCBIChiLan1.0ChiLan1.0
CEP19
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22194,576,245 - 194,582,255 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13194,580,964 - 194,586,972 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03194,050,519 - 194,056,524 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13203,990,477 - 203,996,486 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3203,988,092 - 203,996,486 (-)Ensemblpanpan1.1panPan2
CEP19
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13329,733,860 - 29,740,836 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3329,735,351 - 29,741,128 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3329,757,517 - 29,764,533 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03329,977,353 - 29,984,376 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.13329,754,593 - 29,761,609 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03329,809,508 - 29,816,537 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03330,432,110 - 30,439,130 (-)NCBIUU_Cfam_GSD_1.0
Cep19
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602124,595,931 - 124,601,054 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367841,283,886 - 1,289,965 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367841,284,215 - 1,289,362 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CEP19
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13133,420,032 - 133,428,390 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113133,420,017 - 133,428,394 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213143,068,624 - 143,074,817 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CEP19
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11590,514,147 - 90,519,580 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1590,514,438 - 90,521,380 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604164,298,556 - 64,305,151 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cep19
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473061,783,903 - 61,790,001 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473061,783,665 - 61,789,980 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cep19
51 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:73
Count of miRNA genes:58
Interacting mature miRNAs:65
Transcripts:ENSRNOT00000037795
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113123913478851519Rat
70180BpQTLcluster10Blood pressure QTL cluster 103.19arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)113491804179918041Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114094618882566702Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)114428575982566702Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)114545932375190161Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115445753486241447Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)115513672982993457Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)115635142486241447Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)115980279482566545Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)115980279482566553Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116034659086241447Rat
1549848Bvd6Brain ventricular dilatation QTL 63.10.0001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116611332182169223Rat
634339Niddm50Non-insulin dependent diabetes mellitus QTL 503.32blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)116642214886241447Rat
1354593Stl12Serum triglyceride level QTL 123.36blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)116642214886241447Rat

Markers in Region
AI112486  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21168,677,884 - 68,678,098 (+)MAPPERmRatBN7.2
Rnor_6.01171,921,730 - 71,921,944NCBIRnor6.0
Celera1168,100,348 - 68,100,561UniSTS
RH 3.4 Map11406.71UniSTS
Cytogenetic Map11q22UniSTS
RH125315  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21168,678,683 - 68,678,872 (+)MAPPERmRatBN7.2
Rnor_6.01171,922,530 - 71,922,718NCBIRnor6.0
Rnor_5.01175,005,510 - 75,005,698UniSTSRnor5.0
RGSC_v3.41170,500,851 - 70,501,039UniSTSRGSC3.4
Celera1168,101,147 - 68,101,335UniSTS
Cytogenetic Map11q22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 56 41 19 41 8 11 74 35 41 11 8
Low 1
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000037795   ⟹   ENSRNOP00000038182
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1168,677,871 - 68,687,022 (-)Ensembl
Rnor_6.0 Ensembl1171,921,716 - 71,938,165 (-)Ensembl
RefSeq Acc Id: NM_138865   ⟹   NP_620220
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81182,182,868 - 82,192,032 (-)NCBI
mRatBN7.21168,677,869 - 68,687,033 (-)NCBI
Rnor_6.01171,921,714 - 71,938,295 (-)NCBI
Rnor_5.01175,004,786 - 75,013,404 (-)NCBI
RGSC_v3.41170,500,062 - 70,508,772 (-)RGD
Celera1168,100,332 - 68,109,479 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008768696   ⟹   XP_008766918
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81182,182,868 - 82,192,134 (-)NCBI
mRatBN7.21168,677,869 - 68,687,117 (-)NCBI
Rnor_6.01171,921,713 - 71,938,335 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008768697   ⟹   XP_008766919
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81182,182,868 - 82,192,134 (-)NCBI
mRatBN7.21168,677,869 - 68,687,117 (-)NCBI
Rnor_6.01171,921,713 - 71,938,335 (-)NCBI
Sequence:
RefSeq Acc Id: NP_620220   ⟸   NM_138865
- UniProtKB: G3V974 (UniProtKB/TrEMBL),   A6IRT5 (UniProtKB/TrEMBL),   A6IRT6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008766919   ⟸   XM_008768697
- Peptide Label: isoform X1
- UniProtKB: G3V974 (UniProtKB/TrEMBL),   A6IRT5 (UniProtKB/TrEMBL),   A6IRT6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008766918   ⟸   XM_008768696
- Peptide Label: isoform X1
- UniProtKB: G3V974 (UniProtKB/TrEMBL),   A6IRT5 (UniProtKB/TrEMBL),   A6IRT6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000038182   ⟸   ENSRNOT00000037795

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9QZX9-F1-model_v2 AlphaFold Q9QZX9 1-163 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698215
Promoter ID:EPDNEW_R8740
Type:initiation region
Name:Cep19_1
Description:centrosomal protein 19
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01171,938,171 - 71,938,231EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621352 AgrOrtholog
BioCyc Gene G2FUF-21081 BioCyc
Ensembl Genes ENSRNOG00000024924 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000037795.4 UniProtKB/TrEMBL
InterPro CEP19 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:192229 UniProtKB/TrEMBL
NCBI Gene 192229 ENTREZGENE
PANTHER CENTROSOMAL PROTEIN OF 19 KDA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR31539 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam CEP19 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cep19 PhenoGen
RatGTEx ENSRNOG00000024924 RatGTEx
UniProt A6IRT5 ENTREZGENE, UniProtKB/TrEMBL
  A6IRT6 ENTREZGENE, UniProtKB/TrEMBL
  CEP19_RAT UniProtKB/Swiss-Prot
  G3V974 ENTREZGENE, UniProtKB/TrEMBL
  Q9QZX9 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-05-13 Cep19  centrosomal protein 19  RGD621352  similar to RIKEN cDNA 1500031L02  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 RGD621352  similar to RIKEN cDNA 1500031L02  AF146738  testis specific protein  Symbol and Name updated 1299863 APPROVED
2002-08-07 AF146738  testis specific protein      Symbol and Name status set to provisional 70820 PROVISIONAL