Sctr (secretin receptor) - Rat Genome Database

Name: Sctr
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Sctr (secretin receptor) Rattus norvegicus

Analyze

Symbol:

Sctr

Name:

secretin receptor

RGD ID:

621342

Description:

Enables peptide binding activity and secretin receptor activity. Involved in positive regulation of cAMP-mediated signaling. Predicted to be located in cytoplasmic microtubule. Predicted to be active in plasma membrane. Orthologous to human SCTR (secretin receptor); PARTICIPATES IN bile acid transport pathway; INTERACTS WITH 1,2-dimethylhydrazine; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

MGC93381; SCT-R

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SCTR (secretin receptor)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther
Mus musculus (house mouse):	Sctr (secretin receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Sctr (secretin receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SCTR (secretin receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SCTR (secretin receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Sctr (secretin receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SCTR (secretin receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SCTR (secretin receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Sctr (secretin receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	SCTR (secretin receptor)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Sctr (secretin receptor)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	seb-3	Alliance	DIOPT (InParanoid\|PANTHER\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	33,680,562 - 33,744,049 (+)	NCBI		GRCr8
mRatBN7.2	13	31,127,781 - 31,190,162 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	31,127,858 - 31,180,189 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	13	33,709,188 - 33,765,504 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	34,997,029 - 35,053,348 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	32,271,626 - 32,327,778 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	36,039,241 - 36,090,515 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	36,039,283 - 36,090,530 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	13	41,160,339 - 41,201,354 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	13	31,000,848 - 31,067,419 (+)	NCBI		Celera
Cytogenetic Map	13	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

type 2 diabetes mellitus (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (EXP)

1-naphthyl isothiocyanate (EXP)

17alpha-ethynylestradiol (EXP)

17beta-estradiol (EXP)

17beta-estradiol 3-benzoate (EXP)

2,2',4,4'-Tetrabromodiphenyl ether (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-acetamidofluorene (EXP)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

aflatoxin B1 (EXP,ISO)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

antirheumatic drug (ISO)

benzo[a]pyrene (ISO)

Benzo[ghi]perylene (ISO)

beta-naphthoflavone (EXP)

bisphenol A (EXP,ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

carbon nanotube (EXP)

CGP 52608 (ISO)

cobalt dichloride (EXP)

copper atom (EXP)

copper(0) (EXP)

cyclosporin A (ISO)

decabromodiphenyl ether (EXP)

dibutyl phthalate (EXP)

dichlorine (EXP)

endosulfan (EXP)

furan (EXP)

genistein (EXP)

gentamycin (EXP)

indole-3-methanol (EXP)

methimazole (EXP)

methoxychlor (EXP)

N-nitrosodiethylamine (EXP,ISO)

nickel atom (ISO)

nickel dichloride (EXP)

Nonylphenol (EXP)

ozone (EXP)

paracetamol (EXP,ISO)

pirinixic acid (ISO)

resveratrol (ISO)

rotenone (EXP)

testosterone (EXP)

tetrachloromethane (EXP)

thioacetamide (EXP)

trichloroethene (EXP)

triclosan (ISO)

valproic acid (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adenylate cyclase-activating G protein-coupled receptor signaling pathway (ISO)

adenylate cyclase-modulating G protein-coupled receptor signaling pathway (IBA,IEA)

cell surface receptor signaling pathway (IEA)

diet induced thermogenesis (ISO,ISS)

G protein-coupled receptor signaling pathway (IEA,ISO)

intracellular water homeostasis (ISO,ISS)

positive regulation of cAMP-mediated signaling (IDA)

positive regulation of lipid catabolic process (ISO)

regulation of appetite (ISO,ISS)

regulation of synaptic plasticity (ISO,ISS)

renal water absorption (ISO)

response to nutrient levels (ISO,ISS)

Cellular Component

cytoplasmic microtubule (IEA,ISO,ISS)

plasma membrane (IBA,IEA)

Molecular Function

G protein-coupled peptide receptor activity (IBA,IEA)

G protein-coupled receptor activity (IEA)

peptide binding (IDA,IPI)

peptide hormone binding (IBA,IEA,ISO)

secretin receptor activity (IBA,IDA,IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

bile acid transport pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Interaction among four residues distributed through the secretin pharmacophore and a focused region of the secretin receptor amino terminus.	Dong M, etal., Mol Endocrinol. 2002 Nov;16(11):2490-501.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	Molecular cloning and expression of a cDNA encoding the secretin receptor.	Ishihara T, etal., EMBO J 1991 Jul;10(7):1635-41.
5.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
6.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
7.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
8.	GOA pipeline	RGD automated data pipeline
9.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
11.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
12.	Age-related and regional differences in secretin and secretin receptor mRNA levels in the rat brain.	Tay J, etal., Neurosci Lett. 2004 Aug 12;366(2):176-81.

Additional References at PubMed

PMID:7612008	PMID:15489334	PMID:15664984	PMID:15670850	PMID:15731172	PMID:17008357	PMID:17283064	PMID:17827151	PMID:18467541	PMID:20927047	PMID:21388146	PMID:21566140
PMID:22692904	PMID:23264731	PMID:24273196	PMID:27330080	PMID:30449620

Genomics

Comparative Map Data

Sctr
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	33,680,562 - 33,744,049 (+)	NCBI		GRCr8
mRatBN7.2	13	31,127,781 - 31,190,162 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	31,127,858 - 31,180,189 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	13	33,709,188 - 33,765,504 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	34,997,029 - 35,053,348 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	32,271,626 - 32,327,778 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	36,039,241 - 36,090,515 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	36,039,283 - 36,090,530 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	13	41,160,339 - 41,201,354 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	13	31,000,848 - 31,067,419 (+)	NCBI		Celera
Cytogenetic Map	13	q11	NCBI

SCTR
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	119,439,843 - 119,524,483 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	119,439,843 - 119,525,301 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	120,197,419 - 120,282,059 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	119,913,889 - 119,998,498 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	119,913,650 - 119,998,136	NCBI
Celera	2	113,523,544 - 113,607,897 (-)	NCBI		Celera
Cytogenetic Map	2	q14.2	NCBI
HuRef	2	112,522,346 - 112,606,933 (-)	NCBI		HuRef
CHM1_1	2	120,200,944 - 120,285,215 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	2	119,873,301 - 119,957,984 (-)	NCBI		T2T-CHM13v2.0

Sctr
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	119,934,710 - 119,991,269 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	119,934,624 - 119,991,266 (+)	Ensembl		GRCm39 Ensembl
GRCm38	1	120,006,879 - 120,063,539 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	120,006,894 - 120,063,536 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	121,903,557 - 121,960,111 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	1	121,834,524 - 121,891,084 (+)	NCBI		MGSCv36	mm8
Celera	1	122,666,492 - 122,721,998 (+)	NCBI		Celera
Cytogenetic Map	1	E2.3	NCBI
cM Map	1	52.57	NCBI

Sctr
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955459	10,218,210 - 10,270,212 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955459	10,192,449 - 10,270,483 (+)	NCBI	ChiLan1.0	ChiLan1.0

SCTR
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	13	21,439,472 - 21,524,924 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2B	21,454,520 - 21,539,895 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2B	6,374,400 - 6,458,595 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2B	119,952,714 - 120,036,326 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2B	119,952,714 - 120,036,326 (-)	Ensembl	panpan1.1		panPan2

SCTR
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	19	30,505,059 - 30,577,371 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	19	30,526,055 - 30,577,075 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	19	30,768,711 - 30,844,497 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	19	31,890,123 - 31,966,380 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	19	31,889,725 - 31,961,438 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	19	30,576,866 - 30,653,075 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	19	30,743,177 - 30,819,391 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	19	31,929,956 - 32,001,323 (+)	NCBI		UU_Cfam_GSD_1.0

Sctr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	90,701,781 - 90,766,441 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936469	50,865,115 - 50,915,695 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936469	50,851,569 - 50,916,183 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SCTR
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	31,707,555 - 31,785,955 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	15	31,707,755 - 31,782,193 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	35,970,285 - 36,021,782 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SCTR
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	10	10,802,156 - 10,883,884 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	10	10,833,507 - 10,883,605 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666061	11,803,913 - 11,884,184 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Sctr
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624732	25,633,149 - 25,686,128 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624732	25,611,603 - 25,687,129 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Sctr
515 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	40
Count of miRNA genes:	38
Interacting mature miRNAs:	40
Transcripts:	ENSRNOT00000072088
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2317027	Aia22	Adjuvant induced arthritis QTL 22	2.29		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	13	1	34266636	Rat
738036	Lnnr4	Liver neoplastic nodule remodeling QTL 4	3.64		liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number (CMO:0001461)	13	1	42356786	Rat
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	1	101056920	Rat
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	1	101056920	Rat
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	1	101056920	Rat
631672	Iddm12	Insulin dependent diabetes mellitus QTL 12	2.2	0.0032	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	13	5994668	34535351	Rat
61339	Bp24	Blood pressure QTL 24		0.05	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	5994668	44807491	Rat
1581554	Pur11	Proteinuria QTL 11			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	5994833	77046787	Rat
1581573	Uae36	Urinary albumin excretion QTL 36			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	5994833	77046787	Rat
1581570	Eae17	Experimental allergic encephalomyelitis QTL 17	4.1		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	13	8897350	101631289	Rat
7411662	Foco29	Food consumption QTL 29	20.8	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	13	9313465	54313465	Rat
9589141	Insul28	Insulin level QTL 28	10.82	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	13	9313465	54313465	Rat
2317040	Aia21	Adjuvant induced arthritis QTL 21	2.75		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	13	9831541	54831541	Rat
2317046	Aia8	Adjuvant induced arthritis QTL 8	3.9700000286102295		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	13	9831541	54831541	Rat
2317034	Aia9	Adjuvant induced arthritis QTL 9	4.62		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	13	11766535	32331607	Rat
2317044	Aia23	Adjuvant induced arthritis QTL 23	2.3		joint integrity trait (VT:0010548)	ankle joint diameter (CMO:0002148)	13	11766535	32331607	Rat
1300163	Cardf1	Cardiac cell morphology QTL 1	4.18		aorta morphology trait (VT:0000272)	artery lesion measurement (CMO:0000975)	13	11929449	45417941	Rat
2302275	Gluco37	Glucose level QTL 37	3.8		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	13	11929449	46193066	Rat
631645	Bp121	Blood pressure QTL 121	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	14915655	59915655	Rat
9589164	Gluco66	Glucose level QTL 66	6.67	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	13	15158722	60158722	Rat
1331784	Bp222	Blood pressure QTL 222	2.944		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	17694436	53050594	Rat
7207885	Glom27	Glomerulus QTL 27	3.9		kidney glomerulus integrity trait (VT:0010546)	kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)	13	20605871	101339738	Rat
61391	Bp5	Blood pressure QTL 5	5.6		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	22301875	67301875	Rat
70170	Eae14	Experimental allergic encephalomyelitis QTL 14		0.0024	nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	13	23203448	68203448	Rat
6893338	Cm76	Cardiac mass QTL 76	0	0.99	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	13	23692969	68692969	Rat
1558644	Cm45	Cardiac mass QTL 45	3.6	0.002	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	13	23692969	68692969	Rat
2303030	Bp327	Blood pressure QTL 327			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	30395351	41184251	Rat
1354621	Rf47	Renal function QTL 47	3.7		kidney renin amount (VT:0010559)	kidney renin level (CMO:0002166)	13	30395351	101056920	Rat

Markers in Region

RH142442

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	13	31,179,836 - 31,179,996 (+)	MAPPER	mRatBN7.2
Rnor_6.0	13	36,090,180 - 36,090,339	NCBI	Rnor6.0
Rnor_5.0	13	41,201,019 - 41,201,178	UniSTS	Rnor5.0
Celera	13	31,067,084 - 31,067,243	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium		3			3						2	1
Low	2	20	40	27	13	27			61	35	39	8
Below cutoff	1	20	17	14	3	14	7	10	13			2	7

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_031115	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039091115	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039091116	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039091118	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039091119	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039091120	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC081781	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474028	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X59132	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000072088 ⟹ ENSRNOP00000064579

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	13	31,143,940 - 31,180,189 (+)	Ensembl
Rnor_6.0 Ensembl	13	36,039,283 - 36,090,530 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000119589 ⟹ ENSRNOP00000092013

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	13	31,127,858 - 31,180,172 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000119961 ⟹ ENSRNOP00000077594

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	13	31,127,858 - 31,180,172 (+)	Ensembl

RefSeq Acc Id:

NM_031115 ⟹ NP_112377

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	33,680,627 - 33,732,942 (+)	NCBI
mRatBN7.2	13	31,127,858 - 31,180,172 (+)	NCBI
Rnor_6.0	13	36,039,241 - 36,090,515 (+)	NCBI
Rnor_5.0	13	41,160,339 - 41,201,354 (+)	NCBI
Celera	13	31,000,848 - 31,067,419 (+)	RGD

Sequence:

show sequence

TTTGTTAACAGTCTTGCCACCTCCTTCAGGGAGCAGCAGCCTCAAGCCTGGCTGTGGATCTGAT
CGGACTGGGTAGGTCCAGCCATGGTCTCTCTGGGCTTGGAGGTCGCCCAGGGTCCTGGACCACG
TGCAGGTCGCTGAGCTGGACGCAGAACCGGCCACCAAGCTCCTGAAGGGGCCAGAACGCAAAGG
GGAGCAACAGTGGGCGGAGCATGCTCAGCACCATGAGACCCCGGCTGTCCCTGCTTCTGCTGAG
GCTGTTGCTGCTCACCAAAGCAGCGCACACCGTTGGAGTTCCGCCCCGACTGTGTGACGTGCGG
CGTGTGCTGCTTGAGGAACGGGCCCACTGCCTACAGCAACTCTCCAAAGAGAAGAAAGGAGCAC
TGGGCCCGGAGACAGCATCAGGCTGTGAGGGGCTTTGGGACAACATGAGCTGCTGGCCCTCCTC
TGCACCAGCACGGACAGTGGAAGTGCAGTGTCCGAAGTTCCTCCTGATGCTCTCAAACAAAAAT
GGGTCTCTGTTCCGGAACTGCACACAAGATGGATGGTCAGAAACCTTCCCCAGGCCTGACCTGG
CCTGTGGGGTCAACATAAACAACTCCTTTAATGAGAGACGGCATGCGTACCTGCTGAAACTCAA
GGTCATGTACACTGTAGGCTACAGTTCCTCCTTGGCCATGCTCCTGGTCGCCCTCAGCATCCTG
TGCTCTTTCCGGAGGCTGCACTGCACTCGCAACTACATCCACATGCACCTGTTCGTGTCCTTCA
TCCTGCGCGCCCTGTCCAACTTCATCAAGGACGCCGTACTCTTCTCCTCGGACGACGTCACCTA
CTGTGATGCCCATAAGGTGGGCTGCAAGCTGGTCATGATCTTCTTCCAGTACTGCATCATGGCC
AACTACGCATGGCTGCTGGTGGAGGGCCTCTACCTTCACACACTCCTTGCCATCTCCTTCTTCT
CAGAAAGGAAGTACCTGCAGGCCTTTGTGCTCCTCGGATGGGGTTCTCCAGCCATTTTTGTTGC
TTTGTGGGCTATCACCAGGCACTTTCTAGAAAATACTGGATGCTGGGACATCAACGCCAATGCT
TCCGTCTGGTGGGTCATTCGAGGGCCTGTGATTCTGTCCATCCTGATCAATTTCATCTTCTTCA
TAAACATTCTAAGAATCCTGATGAGGAAACTTAGAACACAAGAAACAAGAGGAAGTGAAACAAA
CCATTATAAGCGCCTGGCCAAGTCCACCCTCCTGCTGATCCCGCTCTTTGGCATCCACTACATT
GTCTTCGCCTTCTCCCCAGAGGACGCCATGGAGGTCCAGCTGTTCTTCGAACTGGCCCTGGGCT
CCTTCCAGGGTCTGGTGGTAGCTGTCCTTTACTGCTTCCTCAATGGTGAGGTGCAGTTGGAAGT
TCAGAAAAAATGGCGCCAGTGGCACCTTCAAGAGTTCCCGCTGCGCCCTGTGGCCTTCAATAAC
TCCTTCAGCAACGCCACCAACGGCCCCACCCACAGCACCAAGGCTAGCACTGAGCAAAGCCGGA
GCATCCCCAGGGCCAGTATCATCTGAGGCTGCAGCAAGGCGCCAGCGGACGAAGGGTTGGATAT
TCGGTAGGACGGACATCTGTCTGATAGCCATCTCGTGCTCGACTGGCTGAACAGGCTTGTCTCT
CGGGTCCGAGCTTCCTCGGAGATCAAGCAAGAGGAGACTACTAGGTCATCGCGGAGCAGGAAAC
GGACCCATGACTTGGTTTTTCTTGTTCTTCTAAGAAGAGCAATTCAGCAACTCCAGAAGGGGCA
GGGG

hide sequence

RefSeq Acc Id:

XM_039091115 ⟹ XP_038947043

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	33,680,564 - 33,732,964 (+)	NCBI
mRatBN7.2	13	31,127,782 - 31,180,194 (+)	NCBI

RefSeq Acc Id:

XM_039091116 ⟹ XP_038947044

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	33,680,562 - 33,732,964 (+)	NCBI
mRatBN7.2	13	31,127,781 - 31,180,194 (+)	NCBI

RefSeq Acc Id:

XM_039091118 ⟹ XP_038947046

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	33,680,564 - 33,732,964 (+)	NCBI
mRatBN7.2	13	31,127,782 - 31,180,194 (+)	NCBI

RefSeq Acc Id:

XM_039091119 ⟹ XP_038947047

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	33,680,562 - 33,744,049 (+)	NCBI
mRatBN7.2	13	31,127,782 - 31,190,162 (+)	NCBI

RefSeq Acc Id:

XM_039091120 ⟹ XP_038947048

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	33,680,565 - 33,732,964 (+)	NCBI
mRatBN7.2	13	31,127,782 - 31,180,194 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_112377	(Get FASTA)	NCBI Sequence Viewer
	XP_038947043	(Get FASTA)	NCBI Sequence Viewer
	XP_038947044	(Get FASTA)	NCBI Sequence Viewer
	XP_038947046	(Get FASTA)	NCBI Sequence Viewer
	XP_038947047	(Get FASTA)	NCBI Sequence Viewer
	XP_038947048	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH81781	(Get FASTA)	NCBI Sequence Viewer
	CAA41849	(Get FASTA)	NCBI Sequence Viewer
	EDL87929	(Get FASTA)	NCBI Sequence Viewer
	EDL87930	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000064579.3
	ENSRNOP00000077594
	ENSRNOP00000077594.1
	ENSRNOP00000092013
	ENSRNOP00000092013.1
	ENSRNOP00055017922
	ENSRNOP00060007027
	ENSRNOP00065011446
GenBank Protein	P23811	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_112377 ⟸ NM_031115
- Peptide Label:	precursor
- UniProtKB:	P23811 (UniProtKB/Swiss-Prot), M0R5B5 (UniProtKB/TrEMBL)
- Sequence:	show sequence MLSTMRPRLSLLLLRLLLLTKAAHTVGVPPRLCDVRRVLLEERAHCLQQLSKEKKGALGPETAS GCEGLWDNMSCWPSSAPARTVEVQCPKFLLMLSNKNGSLFRNCTQDGWSETFPRPDLACGVNIN NSFNERRHAYLLKLKVMYTVGYSSSLAMLLVALSILCSFRRLHCTRNYIHMHLFVSFILRALSN FIKDAVLFSSDDVTYCDAHKVGCKLVMIFFQYCIMANYAWLLVEGLYLHTLLAISFFSERKYLQ AFVLLGWGSPAIFVALWAITRHFLENTGCWDINANASVWWVIRGPVILSILINFIFFINILRIL MRKLRTQETRGSETNHYKRLAKSTLLLIPLFGIHYIVFAFSPEDAMEVQLFFELALGSFQGLVV AVLYCFLNGEVQLEVQKKWRQWHLQEFPLRPVAFNNSFSNATNGPTHSTKASTEQSRSIPRASI I hide sequence

RefSeq Acc Id:

ENSRNOP00000064579 ⟸ ENSRNOT00000072088

RefSeq Acc Id:	XP_038947044 ⟸ XM_039091116
- Peptide Label:	isoform X2
- UniProtKB:	M0R5B5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038947047 ⟸ XM_039091119
- Peptide Label:	isoform X4
- UniProtKB:	M0R5B5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038947043 ⟸ XM_039091115
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I5YBX3 (UniProtKB/TrEMBL), M0R5B5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038947046 ⟸ XM_039091118
- Peptide Label:	isoform X3
- UniProtKB:	M0R5B5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038947048 ⟸ XM_039091120
- Peptide Label:	isoform X5
- UniProtKB:	M0R5B5 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSRNOP00000092013 ⟸ ENSRNOT00000119589

RefSeq Acc Id:

ENSRNOP00000077594 ⟸ ENSRNOT00000119961

Protein Domains

G-protein coupled receptors family 2 profile

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P23811-F1-model_v2	AlphaFold	P23811	1-449	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13698766

Promoter ID:

EPDNEW_R9290

Type:

single initiation site

Name:

Sctr_1

Description:

secretin receptor

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	13	36,039,250 - 36,039,310	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:621342	AgrOrtholog
BioCyc Gene	G2FUF-18510	BioCyc
Ensembl Genes	ENSRNOG00000049766	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ENSRNOG00055012884	UniProtKB/Swiss-Prot
	ENSRNOG00060005612	UniProtKB/Swiss-Prot
	ENSRNOG00065009515	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000072088.3	UniProtKB/TrEMBL
	ENSRNOT00000119589	ENTREZGENE
	ENSRNOT00000119589.1	UniProtKB/Swiss-Prot
	ENSRNOT00000119961.1	UniProtKB/TrEMBL
	ENSRNOT00055022080	UniProtKB/Swiss-Prot
	ENSRNOT00060009352	UniProtKB/Swiss-Prot
	ENSRNOT00065015246	UniProtKB/Swiss-Prot
Gene3D-CATH	4.10.1240.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Rhodopsin 7-helix transmembrane proteins	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7189388	IMAGE-MGC_LOAD
InterPro	7tmB1_secretin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GPCR_2-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GPCR_2_extracell_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GPCR_2_extracellular_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GPCR_2_secretin-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GPCR_2_secretin-like_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GPCR_2_secretin_rcpt	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:81779	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:93381	IMAGE-MGC_LOAD
NCBI Gene	81779	ENTREZGENE
PANTHER	PDF RECEPTOR-LIKE PROTEIN-RELATED	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR45620:SF13	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	7tm_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	HRM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Sctr	PhenoGen
PRINTS	GPCRSECRETIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SECRETINR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	G_PROTEIN_RECEP_F2_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	G_PROTEIN_RECEP_F2_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	G_PROTEIN_RECEP_F2_3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	G_PROTEIN_RECEP_F2_4	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000049766	RatGTEx
	ENSRNOG00055012884	RatGTEx
	ENSRNOG00060005612	RatGTEx
	ENSRNOG00065009515	RatGTEx
SMART	HormR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	Family A G protein-coupled receptor-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF111418	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8I5YBX3	ENTREZGENE, UniProtKB/TrEMBL
	A6K7Y4_RAT	UniProtKB/TrEMBL
	A6K7Y5_RAT	UniProtKB/TrEMBL
	M0R5B5	ENTREZGENE, UniProtKB/TrEMBL
	P23811	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2004-02-26	Sctr	secretin receptor			Symbol and Name status set to approved	625702	APPROVED
2002-08-07	Sctr	secretin receptor			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)