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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (-)-epigallocatechin 3-gallate | multiple interactions | ISO | RGD:732984 | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ATP2B1 mRNA | CTD | PMID:22079256 | 17alpha-ethynylestradiol | affects expression | ISO | RGD:735441 | 6480464 | Ethinyl Estradiol affects the expression of ATP2B1 mRNA | CTD | PMID:17555576 | 17alpha-ethynylestradiol | decreases expression | EXP | | 6480464 | Ethinyl Estradiol results in decreased expression of ATP2B1 mRNA | CTD | PMID:15834898 PMID:17557909 | 17alpha-ethynylestradiol | decreases expression | EXP | | 6480464 | Ethinyl Estradiol results in decreased expression of ATP2B1 mRNA | CTD | PMID:17557909 PMID:15834898 | 17beta-estradiol | decreases expression | ISO | RGD:732984 | 6480464 | Estradiol results in decreased expression of ATP2B1 mRNA | CTD | PMID:21185374 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:735441 | 6480464 | [Tetrachlorodibenzodioxin binds to AHR protein] which results in decreased expression of ATP2B1 mRNA | CTD | PMID:16214954 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:732984 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of ATP2B1 mRNA | CTD | PMID:20106945 PMID:21632981 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of ATP2B1 mRNA | CTD | PMID:22298810 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:735441 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of ATP2B1 mRNA | CTD | PMID:19770486 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:732984 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of ATP2B1 mRNA | CTD | PMID:20106945 | 2,3-dimethoxynaphthalene-1,4-dione | decreases expression | ISO | RGD:732984 | 6480464 | 2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of ATP2B1 mRNA | CTD | PMID:17547211 | 2,6-dinitrotoluene | affects expression | EXP | | 6480464 | 2,6-dinitrotoluene affects the expression of ATP2B1 mRNA | CTD | PMID:21346803 | 4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid | decreases expression | ISO | RGD:732984 | 6480464 | Am 580 results in decreased expression of ATP2B1 mRNA | CTD | PMID:16982809 | aflatoxin B1 | decreases expression | ISO | RGD:735441 | 6480464 | Aflatoxin B1 results in decreased expression of ATP2B1 mRNA | CTD | PMID:19770486 | all-trans-retinoic acid | decreases expression | ISO | RGD:732984 | 6480464 | Tretinoin results in decreased expression of ATP2B1 mRNA | CTD | PMID:15498508 | aminoguanidine | decreases expression | EXP | | 6480464 | pimagedine results in decreased expression of ATP2B1 mRNA | CTD | PMID:15003327 | antimony(0) | decreases expression | ISO | RGD:732984 | 6480464 | Antimony results in decreased expression of ATP2B1 mRNA | CTD | PMID:17547211 | arsenic atom | decreases expression | ISO | RGD:735441 | 6480464 | Arsenic results in decreased expression of ATP2B1 mRNA | CTD | PMID:19654921 | arsenite(3-) | affects expression | ISO | RGD:732984 | 6480464 | arsenite affects the expression of ATP2B1 mRNA | CTD | PMID:22959463 | benzo[a]pyrene | decreases expression | EXP | | 6480464 | Benzo(a)pyrene results in decreased expression of ATP2B1 mRNA | CTD | PMID:21839799 | benzo[a]pyrene | affects expression | ISO | RGD:735441 | 6480464 | Benzo(a)pyrene affects the expression of ATP2B1 mRNA | CTD | PMID:19770486 | benzo[a]pyrene | decreases expression | ISO | RGD:732984 | 6480464 | Benzo(a)pyrene results in decreased expression of ATP2B1 mRNA | CTD | PMID:20064835 | cadmium atom | decreases expression | ISO | RGD:732984 | 6480464 | Cadmium results in decreased expression of ATP2B1 mRNA | CTD | PMID:17547211 | cadmium dichloride | decreases expression | ISO | RGD:732984 | 6480464 | Cadmium Chloride results in decreased expression of ATP2B1 mRNA | CTD | PMID:17547211 | calcitriol | increases expression | EXP | | 6480464 | Calcitriol results in increased expression of ATP2B1 mRNA | CTD | PMID:10927029 | calcitriol | increases expression | ISO | RGD:732984 | 6480464 | Calcitriol results in increased expression of ATP2B1 mRNA | CTD | PMID:21592394 | calcitriol | multiple interactions | ISO | RGD:732984 | 6480464 | [Testosterone co-treated with Calcitriol] results in increased expression of ATP2B1 mRNA | CTD | PMID:21592394 | calcium atom | multiple interactions | ISO | RGD:732984 | 6480464 | caloxin 1b1 inhibits the reaction [ATP2B1 protein results in increased export of Calcium] | CTD | PMID:16452157 | calcium atom | increases export | ISO | RGD:732984 | 6480464 | ATP2B1 protein results in increased export of Calcium | CTD | PMID:16452157 | calcium(0) | multiple interactions | ISO | RGD:732984 | 6480464 | caloxin 1b1 inhibits the reaction [ATP2B1 protein results in increased export of Calcium] | CTD | PMID:16452157 | calcium(0) | increases export | ISO | RGD:732984 | 6480464 | ATP2B1 protein results in increased export of Calcium | CTD | PMID:16452157 | chromium atom | decreases expression | ISO | RGD:732984 | 6480464 | Chromium results in decreased expression of ATP2B1 mRNA | CTD | PMID:17547211 | coumestrol | multiple interactions | ISO | RGD:732984 | 6480464 | [Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of ATP2B1 mRNA | CTD | PMID:19167446 | coumestrol | decreases expression | ISO | RGD:732984 | 6480464 | Coumestrol results in decreased expression of ATP2B1 mRNA | CTD | PMID:19167446 | cyclosporin A | increases expression | ISO | RGD:732984 | 6480464 | Cyclosporine results in increased expression of ATP2B1 mRNA | CTD | PMID:20106945 | cyclosporin A | decreases expression | EXP | | 6480464 | Cyclosporine results in decreased expression of ATP2B1 mRNA | CTD | PMID:21865292 | diarsenic trioxide | decreases expression | ISO | RGD:732984 | 6480464 | arsenic trioxide results in decreased expression of ATP2B1 mRNA | CTD | PMID:12852829 PMID:17547211 | diarsenic trioxide | decreases expression | ISO | RGD:732984 | 6480464 | arsenic trioxide results in decreased expression of ATP2B1 mRNA | CTD | PMID:17547211 PMID:12852829 | dibutyl phthalate | increases expression | EXP | | 6480464 | Dibutyl Phthalate results in increased expression of ATP2B1 mRNA | CTD | PMID:21266533 | diethylstilbestrol | decreases expression | EXP | | 6480464 | Diethylstilbestrol results in decreased expression of ATP2B1 mRNA | CTD | PMID:17011747 | diethylstilbestrol | increases expression | EXP | | 6480464 | Diethylstilbestrol results in increased expression of ATP2B1 mRNA | CTD | PMID:17011747 | dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate | decreases expression | ISO | RGD:732984 | 6480464 | Antimony Potassium Tartrate results in decreased expression of ATP2B1 mRNA | CTD | PMID:17547211 | disulfiram | decreases expression | EXP | | 6480464 | Disulfiram results in decreased expression of ATP2B1 mRNA | CTD | PMID:15003327 | ethanol | affects expression | EXP | | 6480464 | Ethanol affects the expression of ATP2B1 mRNA | CTD | PMID:11772933 | gold atom | multiple interactions | ISO | RGD:735441 | 6480464 | [Gold co-treated with Polyethylene Glycols] results in decreased expression of ATP2B1 mRNA | CTD | PMID:19695318 | gold(0) | multiple interactions | ISO | RGD:735441 | 6480464 | [Gold co-treated with Polyethylene Glycols] results in decreased expression of ATP2B1 mRNA | CTD | PMID:19695318 | melphalan | decreases expression | ISO | RGD:732984 | 6480464 | Melphalan results in decreased expression of ATP2B1 mRNA | CTD | PMID:22363485 | N-nitrosodimethylamine | decreases expression | ISO | RGD:732984 | 6480464 | Dimethylnitrosamine results in decreased expression of ATP2B1 mRNA | CTD | PMID:17547211 | paracetamol | affects expression | ISO | RGD:735441 | 6480464 | Acetaminophen affects the expression of ATP2B1 mRNA | CTD | PMID:17562736 | paracetamol | increases expression | ISO | RGD:732984 | 6480464 | Acetaminophen results in increased expression of ATP2B1 mRNA | CTD | PMID:21420995 | phenobarbital | affects expression | ISO | RGD:732984 | 6480464 | Phenobarbital affects the expression of ATP2B1 mRNA | CTD | PMID:19159669 | phenobarbital | decreases expression | ISO | RGD:735441 | 6480464 | Phenobarbital results in decreased expression of ATP2B1 mRNA | CTD | PMID:23091169 | potassium dichromate | decreases expression | ISO | RGD:732984 | 6480464 | Potassium Dichromate results in decreased expression of ATP2B1 mRNA | CTD | PMID:17547211 | rosiglitazone | decreases expression | ISO | RGD:732984 | 6480464 | rosiglitazone results in decreased expression of ATP2B1 mRNA | CTD | PMID:16982809 | succimer | multiple interactions | ISO | RGD:735441 | 6480464 | [Succimer binds to Magnetite Nanoparticles] which results in increased expression of ATP2B1 mRNA | CTD | PMID:21641980 | tamibarotene | affects expression | ISO | RGD:732984 | 6480464 | Am 80 affects the expression of ATP2B1 mRNA; more ... | CTD | PMID:15498508 | tamoxifen | affects expression | ISO | RGD:735441 | 6480464 | Tamoxifen affects the expression of ATP2B1 mRNA | CTD | PMID:17555576 | tert-butyl hydroperoxide | increases expression | ISO | RGD:732984 | 6480464 | tert-Butylhydroperoxide results in increased expression of ATP2B1 mRNA | CTD | PMID:15336504 | testosterone | multiple interactions | ISO | RGD:732984 | 6480464 | [Testosterone co-treated with Calcitriol] results in increased expression of ATP2B1 mRNA | CTD | PMID:21592394 | testosterone | decreases expression | ISO | RGD:735441 | 6480464 | Testosterone results in decreased expression of ATP2B1 mRNA | CTD | PMID:20090667 | testosterone | increases expression | ISO | RGD:732984 | 6480464 | Testosterone results in increased expression of ATP2B1 mRNA | CTD | PMID:21592394 | testosterone enanthate | affects expression | ISO | RGD:732984 | 6480464 | testosterone enanthate affects the expression of ATP2B1 mRNA | CTD | PMID:17440010 | vanadium atom | increases expression | ISO | RGD:732984 | 6480464 | Vanadium results in increased expression of ATP2B1 mRNA | CTD | PMID:19000753 | vanadium(0) | increases expression | ISO | RGD:732984 | 6480464 | Vanadium results in increased expression of ATP2B1 mRNA | CTD | PMID:19000753 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Calcium signaling pathway |
| Endocrine and other factor-regulated calcium reabsorption | |
| Mineral absorption | |
| Pancreatic secretion | |
| Salivary secretion | |
| Pathway Interaction Database | C-MYB transcription factor network (PID:200153) |
Disease Annotations
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Gene-Chemical Interaction Annotations
Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Calcium signaling pathway |
| Endocrine and other factor-regulated calcium reabsorption | |
| Mineral absorption | |
| Pancreatic secretion | |
| Salivary secretion | |
| Pathway Interaction Database | C-MYB transcription factor network (PID:200153) |
References - curated| 1. |
Armbrecht HJ, etal., Biochim Biophys Acta. 1994 Oct 12;1195(1):110-4. |
| 2. |
Bhargava A, etal., J Neurosci. 2000 May 1;20(9):3129-38. |
| 3. |
Brandt P and Neve RL, J Neurochem. 1992 Oct;59(4):1566-9. |
| 4. |
Brini M and Carafoli E, Physiol Rev. 2009 Oct;89(4):1341-78. doi: 10.1152/physrev.00032.2008. |
| 5. |
Glendenning P, etal., J Bone Miner Res. 2001 Mar;16(3):525-34. |
| 6. |
GOA data from the GO Consortium |
| 7. |
Grati M, etal., J Cell Sci. 2006 Jul 15;119(Pt 14):2995-3007. Epub 2006 Jun 27. |
| 8. |
Husain M, etal., Am J Physiol. 1997 Jun;272(6 Pt 1):C1947-59. |
| 9. |
Jiang L, etal., J Neurochem. 2007 Jul;102(2):378-88. |
| 10. |
Kenyon KA, etal., J Comp Neurol. 2010 Aug 15;518(16):3169-83. doi: 10.1002/cne.22409. |
| 11. |
MGD data from the GO Consortium |
| 12. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 13. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 14. |
Post H, etal., Prostate. 2008 Jul 1;68(10):1076-85. |
| 15. |
Renteria RC, etal., Vis Neurosci. 2005 May-Jun;22(3):263-74. |
| 16. |
RGD automated import pipeline for gene-chemical interactions |
| 17. |
Sgambato-Faure V, etal., Biochem Biophys Res Commun. 2006 May 5;343(2):630-7. Epub 2006 Mar 15. |
| 18. |
Shull GE and Greeb J, J Biol Chem 1988 Jun 25;263(18):8646-57. |
| 19. |
Zhang GH, etal., Zhonghua Yi Xue Za Zhi. 2009 Nov 3;89(40):2862-6. |
References - uncurated
RGD Disease Portals| Atp2b1 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Atp2b1 (Rattus norvegicus) |
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| ATP2B1 (Homo sapiens) |
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| Atp2b1 (Mus musculus) |
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Position Markers| RH144662 |
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| BF387281 |
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| RH140668 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_053311 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06049095 | (Get FASTA) | Search GEO for Microarray Profiles |
| AABR06049096 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06049097 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01048643 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01048644 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01048645 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF076783 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473960 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ212562 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ227803 | (Get FASTA) | Search GEO for Microarray Profiles | |
| J03753 | (Get FASTA) | Search GEO for Microarray Profiles | |
| L04739 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_053311 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_445763 | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_445763 | (Get FASTA) |
| GenBank Protein | AAA50878 | (Get FASTA) |
| AAA73898 | (Get FASTA) | |
| AAD46085 | (Get FASTA) | |
| EDM16820 | (Get FASTA) | |
| EDM16821 | (Get FASTA) | |
| EDM16822 | (Get FASTA) | |
| EDM16823 | (Get FASTA) | |
| EDM16824 | (Get FASTA) | |
| P11505 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000004026 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Protein | ENSRNOP00000005450 | UniProtKB/TrEMBL |
| ENSRNOP00000005491 | UniProtKB/TrEMBL | |
| ENSRNOP00000040092 | ENTREZGENE, UniProtKB/Swiss-Prot | |
| ENSRNOP00000059397 | UniProtKB/TrEMBL | |
| Ensembl Transcript | ENSRNOT00000005450 | UniProtKB/TrEMBL |
| ENSRNOT00000005491 | UniProtKB/TrEMBL | |
| ENSRNOT00000041354 | ENTREZGENE, UniProtKB/Swiss-Prot | |
| ENSRNOT00000066174 | UniProtKB/TrEMBL | |
| Entrez Gene | 29598 | ENTREZGENE |
| Gene3D-CATH | ATPase_P-typ_cyto_domA | UniProtKB/Swiss-Prot |
| ATPase_P-typ_cyto_domN | UniProtKB/Swiss-Prot | |
| Germonline | ENSRNOG00000004026 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 55597 | ENTREZGENE |
| InterPro | ATP_Ca_trans_C | UniProtKB/Swiss-Prot |
| ATPase_P-typ_ATPase-assoc-dom | UniProtKB/Swiss-Prot | |
| ATPase_P-typ_Ca-transp_PMCA | UniProtKB/Swiss-Prot | |
| ATPase_P-typ_cation-transptr_C | UniProtKB/Swiss-Prot | |
| ATPase_P-typ_cation-transptr_N | UniProtKB/Swiss-Prot | |
| ATPase_P-typ_cyto_domN | UniProtKB/Swiss-Prot | |
| ATPase_P-typ_ion-transptr | UniProtKB/Swiss-Prot | |
| ATPase_P-typ_P_site | UniProtKB/Swiss-Prot | |
| ATPase_P-typ_TM_dom | UniProtKB/Swiss-Prot | |
| HAD-like_dom | UniProtKB/Swiss-Prot | |
| IPI | IPI00194873 | UniProtKB/Swiss-Prot |
| IPI00231267 | UniProtKB/Swiss-Prot | |
| IPI00231268 | UniProtKB/Swiss-Prot | |
| IPI00231269 | UniProtKB/Swiss-Prot | |
| IPI00231270 | UniProtKB/Swiss-Prot | |
| IPI00231271 | UniProtKB/Swiss-Prot | |
| IPI00959266 | UniProtKB/TrEMBL | |
| IPI00960106 | UniProtKB/TrEMBL | |
| IPI01016570 | UniProtKB/TrEMBL | |
| KEGG Report | rno:29598 | ENTREZGENE, UniProtKB/Swiss-Prot |
| PANTHER | PTHR24093 | UniProtKB/Swiss-Prot |
| Pfam | ATP_Ca_trans_C | UniProtKB/Swiss-Prot |
| Cation_ATPase_C | UniProtKB/Swiss-Prot | |
| Cation_ATPase_N | UniProtKB/Swiss-Prot | |
| E1-E2_ATPase | UniProtKB/Swiss-Prot | |
| Hydrolase | UniProtKB/Swiss-Prot | |
| PRINTS | CATATPASE | UniProtKB/Swiss-Prot |
| PROSITE | ATPASE_E1_E2 | UniProtKB/Swiss-Prot |
| SMART | Cation_ATPase_N | UniProtKB/Swiss-Prot |
| Superfamily-SCOP | ATPase_cation_domN | UniProtKB/Swiss-Prot |
| HAD-like_dom | UniProtKB/Swiss-Prot | |
| TIGRFAMs | ATPase-IIB_Ca | UniProtKB/Swiss-Prot |
| ATPase_P-type | UniProtKB/Swiss-Prot | |
| UniGene | Rn.7208 | ENTREZGENE |
| UniProt | AT2B1_RAT | UniProtKB/Swiss-Prot |
| D3ZAE5_RAT | UniProtKB/TrEMBL | |
| D3ZAX3_RAT | UniProtKB/TrEMBL | |
| F1LRW6_RAT | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2004-02-26 | Atp2b1 | ATPase, Ca++ transporting, plasma membrane 1 | Symbol and Name status set to approved | 2225 | APPROVED | ||
| 2002-08-07 | Atp2b1 | ATPase, Ca++ transporting, plasma membrane 1 | Symbol and Name status set to provisional | 1724 | PROVISIONAL |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_protein | 1,176 amino acids; 129.5 kDa | 631720 |
| More on Atp2b1 | |
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Entrez Gene |
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Ensembl Gene |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 621303 |
| Created: | 2002-08-06 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




