Rps26 (ribosomal protein S26) - Rat Genome Database

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Gene: Rps26 (ribosomal protein S26) Rattus norvegicus
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Symbol: Rps26
Name: ribosomal protein S26
RGD ID: 621044
Description: Predicted to enable mRNA binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in cytoplasmic translation and negative regulation of RNA splicing. Part of cytosolic small ribosomal subunit. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 10. Orthologous to human RPS26 (ribosomal protein S26); PARTICIPATES IN ribosome biogenesis pathway; translation pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 40S ribosomal protein S26; small ribosomal subunit protein eS26
RGD Orthologs
Human
Mouse
Alliance Genes
More Info more info ...
Related Pseudogenes: LOC108349054   Rps26-ps11   Rps26l5  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr871,641,846 - 1,643,404 (-)NCBIGRCr8
mRatBN7.271,057,332 - 1,058,882 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx73,820,252 - 3,821,824 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.075,696,245 - 5,697,817 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.075,992,952 - 5,994,529 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.073,052,112 - 3,053,662 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.073,025,307 - 3,070,860 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.471,919,153 - 1,920,703 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.171,919,152 - 1,920,703 (-)NCBI
Celera7927,684 - 929,234 (-)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Structures of the human and Drosophila 80S ribosome. Anger AM, etal., Nature. 2013 May 2;497(7447):80-5. doi: 10.1038/nature12104.
2. Isolation of eukaryotic ribosomal proteins. Purification and characterization of the 40 S ribosomal subunit proteins Sa, Sc, S3a, S3b, S5', S9, S10, S11, S12, S14, S15, S15', S16, S17, S18, S19, S20, S21, S26, S27', and S29. Collatz E, etal., J Biol Chem. 1977 Dec 25;252(24):9071-80.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Molecular cloning and nucleotide sequence of DNA complementary to rat ribosomal protein S26 messenger RNA. Kuwano Y, etal., J Biochem (Tokyo) 1985 Apr;97(4):983-92.
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. Functional dichotomy of ribosomal proteins during the synthesis of mammalian 40S ribosomal subunits. O'Donohue MF, etal., J Cell Biol. 2010 Sep 6;190(5):853-66. doi: 10.1083/jcb.201005117.
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Comprehensive gene review and curation RGD comprehensive gene curation
12. Affinity labelling of rat liver ribosomal protein S26 by heptauridylate containing a 5'-terminal alkylating group. Stahl J and Kobetz ND, Mol Biol Rep. 1984 Jan;9(4):219-22.
13. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:15489334   PMID:25002582   PMID:25763846   PMID:29476059  


Genomics

Comparative Map Data
Rps26
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr871,641,846 - 1,643,404 (-)NCBIGRCr8
mRatBN7.271,057,332 - 1,058,882 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx73,820,252 - 3,821,824 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.075,696,245 - 5,697,817 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.075,992,952 - 5,994,529 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.073,052,112 - 3,053,662 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.073,025,307 - 3,070,860 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.471,919,153 - 1,920,703 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.171,919,152 - 1,920,703 (-)NCBI
Celera7927,684 - 929,234 (-)NCBICelera
Cytogenetic Map7q11NCBI
RPS26
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381256,041,918 - 56,044,697 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1256,041,351 - 56,044,697 (+)EnsemblGRCh38hg38GRCh38
GRCh371256,435,702 - 56,438,481 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361254,721,953 - 54,724,274 (+)NCBINCBI36Build 36hg18NCBI36
Build 341254,722,192 - 54,724,272NCBI
Celera1256,088,373 - 56,090,694 (+)NCBICelera
Cytogenetic Map12q13.2NCBI
HuRef1253,474,591 - 53,476,912 (+)NCBIHuRef
CHM1_11256,402,791 - 56,405,112 (+)NCBICHM1_1
T2T-CHM13v2.01256,008,421 - 56,011,764 (+)NCBIT2T-CHM13v2.0
Rps26
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910128,460,398 - 128,462,375 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10128,460,403 - 128,462,616 (-)EnsemblGRCm39 Ensembl
GRCm3810128,624,529 - 128,626,506 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10128,624,534 - 128,626,747 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710128,061,585 - 128,063,562 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610128,027,485 - 128,029,432 (-)NCBIMGSCv36mm8
Celera10131,016,529 - 131,018,506 (-)NCBICelera
Cytogenetic Map10D3NCBI
cM Map1077.11NCBI

Variants

.
Variants in Rps26
14 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:104
Count of miRNA genes:78
Interacting mature miRNAs:79
Transcripts:ENSRNOT00000007304, ENSRNOT00000051134
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7127829089Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)766427026029351Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_013224 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263070 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC128207 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC061561 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474104 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210888 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211456 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216976 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217039 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217630 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220214 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220682 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220803 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221742 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221917 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222170 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222423 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222638 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223096 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223202 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223253 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223633 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224810 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229027 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233862 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234974 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ235169 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ235253 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X02414 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: NM_013224   ⟹   NP_037356
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,641,854 - 1,643,404 (-)NCBI
mRatBN7.271,057,332 - 1,058,882 (-)NCBI
Rnor_6.073,052,112 - 3,053,662 (-)NCBI
Rnor_5.073,025,307 - 3,070,860 (-)NCBI
RGSC_v3.471,919,153 - 1,920,703 (-)RGD
Celera7927,684 - 929,234 (-)RGD
Sequence:
RefSeq Acc Id: XM_063263070   ⟹   XP_063119140
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,641,846 - 1,643,194 (-)NCBI
Protein Sequences
Protein RefSeqs NP_037356 (Get FASTA)   NCBI Sequence Viewer  
  XP_063119140 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH61561 (Get FASTA)   NCBI Sequence Viewer  
  CAA26264 (Get FASTA)   NCBI Sequence Viewer  
  EDL84832 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000048116.1
GenBank Protein P62856 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_037356   ⟸   NM_013224
- UniProtKB: P62856 (UniProtKB/Swiss-Prot),   A6KSG0 (UniProtKB/TrEMBL),   D3Z8D7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_063119140   ⟸   XM_063263070
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P62856-F1-model_v2 AlphaFold P62856 1-115 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621044 AgrOrtholog
BioCyc Gene G2FUF-35347 BioCyc
Ensembl Genes ENSRNOG00000029512 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000051134.2 UniProtKB/TrEMBL
Gene3D-CATH 3.30.1740.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:6921494 IMAGE-MGC_LOAD
InterPro Ribosomal_eS26_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ribosomal_S26e UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ribosomal_S26e_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:100360508 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  rno:100361854 UniProtKB/TrEMBL
  rno:27139 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:72903 IMAGE-MGC_LOAD
NCBI Gene 27139 ENTREZGENE
PANTHER 40S RIBOSOMAL PROTEIN S26 UniProtKB/TrEMBL
  40S RIBOSOMAL PROTEIN S26-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR12538 UniProtKB/Swiss-Prot
Pfam Ribosomal_S26e UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Rps26 PhenoGen
PROSITE RIBOSOMAL_S26E UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000029512 RatGTEx
UniProt A6KSG0 ENTREZGENE, UniProtKB/TrEMBL
  D3Z8D7 ENTREZGENE, UniProtKB/TrEMBL
  P62856 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary P02383 UniProtKB/Swiss-Prot
  P70394 UniProtKB/Swiss-Prot
  Q06722 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Rps26  ribosomal protein S26      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Rps26  ribosomal protein S26      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_protein 115 amino acids with a molecular weight of 13,015 634033