Ltb4r2 (leukotriene B4 receptor 2) - Rat Genome Database

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Gene: Ltb4r2 (leukotriene B4 receptor 2) Rattus norvegicus
Analyze
Symbol: Ltb4r2
Name: leukotriene B4 receptor 2
RGD ID: 621029
Description: Predicted to enable G protein-coupled peptide receptor activity and leukotriene B4 receptor activity. Predicted to be involved in neuropeptide signaling pathway. Predicted to act upstream of or within keratinocyte migration and signal transduction. Predicted to be located in membrane and nucleoplasm. Predicted to be active in plasma membrane. Orthologous to human LTB4R2 (leukotriene B4 receptor 2); PARTICIPATES IN calcium/calcium-mediated signaling pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LTB4 receptor JULF2; LTB4-R 2; LTB4-R2
RGD Orthologs
Human
Mouse
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81533,228,634 - 33,230,453 (+)NCBIGRCr8
mRatBN7.21529,258,712 - 29,260,531 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1529,259,240 - 29,260,316 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1531,104,925 - 31,106,001 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01532,252,131 - 32,253,207 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01530,494,484 - 30,495,560 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01534,446,478 - 34,448,220 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1534,446,878 - 34,447,954 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01538,335,390 - 38,336,466 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41533,923,472 - 33,924,548 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11533,939,171 - 33,940,248 (+)NCBI
Celera1528,833,900 - 28,834,976 (+)NCBICelera
Cytogenetic Map15p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
membrane  (ISO)
nucleoplasm  (IEA,ISO)
plasma membrane  (IBA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10889186   PMID:15866883   PMID:19946888   PMID:21189570  


Genomics

Comparative Map Data
Ltb4r2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81533,228,634 - 33,230,453 (+)NCBIGRCr8
mRatBN7.21529,258,712 - 29,260,531 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1529,259,240 - 29,260,316 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1531,104,925 - 31,106,001 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01532,252,131 - 32,253,207 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01530,494,484 - 30,495,560 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01534,446,478 - 34,448,220 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1534,446,878 - 34,447,954 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01538,335,390 - 38,336,466 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41533,923,472 - 33,924,548 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11533,939,171 - 33,940,248 (+)NCBI
Celera1528,833,900 - 28,834,976 (+)NCBICelera
Cytogenetic Map15p13NCBI
LTB4R2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381424,310,140 - 24,312,038 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1424,305,734 - 24,312,053 (+)EnsemblGRCh38hg38GRCh38
GRCh371424,779,346 - 24,781,244 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361423,848,001 - 23,850,798 (+)NCBINCBI36Build 36hg18NCBI36
Build 341423,848,000 - 23,850,798NCBI
Celera144,643,986 - 4,645,888 (+)NCBICelera
Cytogenetic Map14q12NCBI
HuRef144,894,524 - 4,896,426 (+)NCBIHuRef
CHM1_11424,777,957 - 24,779,859 (+)NCBICHM1_1
T2T-CHM13v2.01418,508,483 - 18,510,381 (+)NCBIT2T-CHM13v2.0
Ltb4r2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391455,995,379 - 56,001,523 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1455,998,885 - 56,002,595 (+)EnsemblGRCm39 Ensembl
GRCm381455,757,922 - 55,764,066 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1455,761,428 - 55,765,138 (+)EnsemblGRCm38mm10GRCm38
MGSCv371456,380,761 - 56,381,843 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361454,715,995 - 54,717,077 (+)NCBIMGSCv36mm8
Celera1453,566,960 - 53,568,042 (+)NCBICelera
Cytogenetic Map14C3NCBI
cM Map1428.19NCBI
Ltb4r2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540935,989,425 - 35,991,492 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540935,989,425 - 35,991,492 (-)NCBIChiLan1.0ChiLan1.0
LTB4R2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.184,278,047 - 4,282,326 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl84,280,869 - 4,281,948 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha84,199,538 - 4,206,302 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.084,388,676 - 4,392,789 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl84,391,671 - 4,392,750 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.184,079,024 - 4,083,137 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.084,140,847 - 4,144,961 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.084,403,431 - 4,407,545 (+)NCBIUU_Cfam_GSD_1.0
Ltb4r2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864036,146,927 - 36,149,192 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936722239,811 - 242,050 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LTB4R2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl774,978,876 - 74,983,768 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1774,978,871 - 74,983,811 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2780,249,814 - 80,254,577 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LTB4R2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1241,292,283 - 1,298,723 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl241,293,587 - 1,294,756 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603612,976,846 - 12,979,595 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ltb4r2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248208,192,441 - 8,196,375 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248208,192,441 - 8,196,472 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ltb4r2
1 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:170
Count of miRNA genes:127
Interacting mature miRNAs:137
Transcripts:ENSRNOT00000027619
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
10755503Bp391Blood pressure QTL 3912.37arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)152024860037896129Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)152803066582262678Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
9589149Insul29Insulin level QTL 299.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)15134723002Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
8552920Pigfal8Plasma insulin-like growth factor 1 level QTL 83blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)15134723002Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
8694361Abfw6Abdominal fat weight QTL 610.20.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)15134723002Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)152803066582262678Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
152025253Hrtrt24Heart rate QTL 243.82heart pumping trait (VT:2000009)152788577486257085Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)151985656646187442Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15129912054Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)151985656634924750Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)152803066582262678Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
5 4 12 53 32 35 9 17 9 6 77 44 36 16 26 26

Sequence


Ensembl Acc Id: ENSRNOT00000027619   ⟹   ENSRNOP00000027619
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1529,259,240 - 29,260,316 (+)Ensembl
Rnor_6.0 Ensembl1534,446,878 - 34,447,954 (+)Ensembl
RefSeq Acc Id: NM_053640   ⟹   NP_446092
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81533,228,634 - 33,230,453 (+)NCBI
mRatBN7.21529,258,712 - 29,260,531 (+)NCBI
Rnor_6.01534,446,878 - 34,447,954 (+)NCBI
Rnor_5.01538,335,390 - 38,336,466 (+)NCBI
RGSC_v3.41533,923,472 - 33,924,548 (+)RGD
Celera1528,833,900 - 28,834,976 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_446092 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAB60815 (Get FASTA)   NCBI Sequence Viewer  
  EDM14280 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000027619.1
GenBank Protein Q924U0 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_446092   ⟸   NM_053640
- UniProtKB: Q924U0 (UniProtKB/Swiss-Prot),   A6KH51 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000027619   ⟸   ENSRNOT00000027619
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q924U0-F1-model_v2 AlphaFold Q924U0 1-358 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621029 AgrOrtholog
BioCyc Gene G2FUF-13690 BioCyc
Ensembl Genes ENSRNOG00000020382 Ensembl, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000027619.3 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Leukotriene_B4_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Leukotriene_B4_typ-2_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:114098 UniProtKB/Swiss-Prot
NCBI Gene 114098 ENTREZGENE
PANTHER G-PROTEIN COUPLED RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LEUKOTRIENE B4 RECEPTOR 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ltb4r2 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LTB2RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LTBRECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000020382 RatGTEx
  ENSRNOG00055011899 RatGTEx
  ENSRNOG00060025043 RatGTEx
  ENSRNOG00065031116 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6KH51 ENTREZGENE, UniProtKB/TrEMBL
  LT4R2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Ltb4r2  leukotriene B4 receptor 2      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Ltb4r2  leukotriene B4 receptor 2      Symbol and Name status set to provisional 70820 PROVISIONAL