Lct (lactase) - Rat Genome Database

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Gene: Lct (lactase) Rattus norvegicus
Analyze
Symbol: Lct
Name: lactase
RGD ID: 620823
Description: Enables hydrolase activity, hydrolyzing O-glycosyl compounds and transferase activity. Involved in several processes, including disaccharide catabolic process; glycosylceramide catabolic process; and response to estrogen. Located in brush border. Used to study diarrhea. Biomarker of colitis. Human ortholog(s) of this gene implicated in congenital lactase deficiency. Orthologous to human LCT (lactase); PARTICIPATES IN galactose metabolic pathway; galactosemia pathway; lactose degradation pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetylsalicylic acid; aldehydo-D-glucose.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: lactase-glycosylceramidase; lactase-phlorizin hydrolase; lactase/phlorizin hydrolase; Lph
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81342,334,347 - 42,376,872 (-)NCBIGRCr8
mRatBN7.21339,781,929 - 39,824,456 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1339,781,929 - 39,824,456 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1342,375,821 - 42,418,341 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01343,663,926 - 43,706,446 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01340,917,951 - 40,960,284 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01344,998,414 - 45,040,593 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1344,998,414 - 45,040,593 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01350,083,769 - 50,125,203 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41340,990,315 - 41,043,388 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11341,017,068 - 41,018,494 (-)NCBI
Celera1340,155,673 - 40,198,507 (-)NCBICelera
Cytogenetic Map13q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Butyric acid modulates activities of intestinal and renal disaccharidases in experimentally induced diabetic rats. Chethankumar M, etal., Nahrung. 2002 Oct;46(5):345-8.
2. Comparative effects of osmotic and secretory diarrhoea on brush-border disaccharide hydrolases in rat. Elemo BO Afr J Med Med Sci. 2004 Dec;33(4):293-8.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Effects of long-term ethanol consumption on jejunal lipase and disaccharidase activities in male and female rats. Huang CC, etal., World J Gastroenterol. 2005 May 7;11(17):2603-8.
6. Morphological and biochemical alterations in the jejunum following iodoacetamide-induced colitis in rats. Jurjus A, etal., Can J Physiol Pharmacol. 2006 Nov;84(11):1191-203.
7. Expression of brush border enzymes in response to lead exposure in rat intestine. Kapur P, etal., J Appl Toxicol. 2005 Sep-Oct;25(5):361-4.
8. Modulatory effect of fenugreek seed mucilage and spent turmeric on intestinal and renal disaccharidases in streptozotocin induced diabetic rats. Kumar GS, etal., Plant Foods Hum Nutr. 2005 Jun;60(2):87-91.
9. Dietary sucrose enhances intestinal lactase gene expression in euthyroid rats. Kuranuki S, etal., J Nutr Sci Vitaminol (Tokyo). 2006 Oct;52(5):347-51.
10. Effects of hypoxia on the development of intestinal enzymes in neonatal and juvenile rats. Lee PC, etal., Exp Biol Med (Maywood). 2003 Jun;228(6):717-23.
11. On the identity between the small intestinal enzymes phlorizin hydrolase and glycosylceramidase. Leese HJ and Semenza G, J Biol Chem. 1973 Dec 10;248(23):8170-3.
12. Enzymatic hydrolysis of pyridoxine-5'-beta-D-glucoside is catalyzed by intestinal lactase-phlorizin hydrolase. Mackey AD, etal., J Biol Chem 2002 Jul 26;277(30):26858-64. Epub 2002 May 21.
13. Intestinal disaccharidases and some renal enzymes in streptozotocin-induced diabetic rats fed sapogenin extract from bitter yam (Dioscorea polygonoides). McAnuff-Harding MA, etal., Life Sci. 2006 Apr 25;78(22):2595-600. Epub 2006 Feb 23.
14. Effects of non steroidal anti-inflammatory drugs on the antioxidant defense system and the membrane functions in the rat intestine. Nair P, etal., Nutr Hosp. 2006 Nov-Dec;21(6):638-49.
15. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
16. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
17. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
18. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
19. Effects of oestrogen on trigeminal ganglia in culture: implications for hormonal effects on migraine. Puri V, etal., Cephalalgia. 2006 Jan;26(1):33-42.
20. Effects of early nutrition intervention on IGF1, IGFBP3, intestinal development, and catch-up growth of intrauterine growth retardation rats. Qiu XS, etal., Chin Med Sci J. 2004 Sep;19(3):189-92.
21. GOA pipeline RGD automated data pipeline
22. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. Alterations in the expression of intestinal enzymes in rats exposed to nickel. Singla A, etal., J Appl Toxicol. 2006 Sep-Oct;26(5):397-401.
25. Decreased sucrase and lactase activity in iron deficiency is accompanied by reduced gene expression and upregulation of the transcriptional repressor PDX-1. West AR and Oates PS, Am J Physiol Gastrointest Liver Physiol. 2005 Dec;289(6):G1108-14. Epub 2005 Aug 4.
Additional References at PubMed
PMID:1299293   PMID:1339333   PMID:1691182   PMID:1909681   PMID:11812796   PMID:12663055   PMID:18064521   PMID:18273561   PMID:18712286  


Genomics

Comparative Map Data
Lct
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81342,334,347 - 42,376,872 (-)NCBIGRCr8
mRatBN7.21339,781,929 - 39,824,456 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1339,781,929 - 39,824,456 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1342,375,821 - 42,418,341 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01343,663,926 - 43,706,446 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01340,917,951 - 40,960,284 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01344,998,414 - 45,040,593 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1344,998,414 - 45,040,593 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01350,083,769 - 50,125,203 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41340,990,315 - 41,043,388 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11341,017,068 - 41,018,494 (-)NCBI
Celera1340,155,673 - 40,198,507 (-)NCBICelera
Cytogenetic Map13q13NCBI
LCT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382135,787,850 - 135,837,184 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2135,787,850 - 135,837,184 (-)EnsemblGRCh38hg38GRCh38
GRCh372136,545,420 - 136,594,754 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362136,261,885 - 136,311,220 (-)NCBINCBI36Build 36hg18NCBI36
Build 342136,379,146 - 136,428,482NCBI
Celera2130,256,175 - 130,305,504 (-)NCBICelera
Cytogenetic Map2q21.3NCBI
HuRef2128,538,586 - 128,587,979 (-)NCBIHuRef
CHM1_12136,550,605 - 136,600,149 (-)NCBICHM1_1
T2T-CHM13v2.02136,228,325 - 136,281,636 (-)NCBIT2T-CHM13v2.0
Lct
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391128,212,493 - 128,256,055 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1128,212,493 - 128,256,055 (-)EnsemblGRCm39 Ensembl
GRCm381128,284,756 - 128,328,318 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1128,284,756 - 128,328,318 (-)EnsemblGRCm38mm10GRCm38
MGSCv371130,181,341 - 130,224,895 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361130,112,310 - 130,155,864 (-)NCBIMGSCv36mm8
Celera1130,912,375 - 130,955,221 (-)NCBICelera
Cytogenetic Map1E3NCBI
cM Map155.8NCBI
Lct
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554403,148,730 - 3,197,110 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554403,148,730 - 3,197,110 (-)NCBIChiLan1.0ChiLan1.0
LCT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21339,093,531 - 39,150,819 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B39,108,500 - 39,162,817 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B24,025,383 - 24,079,779 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B139,855,600 - 139,908,764 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B139,855,605 - 139,908,764 (-)Ensemblpanpan1.1panPan2
LCT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11938,571,539 - 38,620,567 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1938,572,058 - 38,620,567 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1938,812,141 - 38,863,510 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01940,014,481 - 40,065,894 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1940,017,274 - 40,065,921 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11938,656,504 - 38,707,872 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01938,815,944 - 38,867,284 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01940,048,815 - 40,100,194 (-)NCBIUU_Cfam_GSD_1.0
Lct
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303101,510,063 - 101,552,920 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646940,064,822 - 40,107,447 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493646940,064,822 - 40,108,423 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC100625897
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11516,094,277 - 16,154,467 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21518,486,673 - 18,544,563 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LCT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11019,994,398 - 20,049,325 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1019,994,384 - 20,049,097 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660612,414,641 - 2,469,654 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lct
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473235,125,287 - 35,175,062 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473235,125,995 - 35,177,055 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Lct
404 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:152
Count of miRNA genes:109
Interacting mature miRNAs:121
Transcripts:ENSRNOT00000004908
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738036Lnnr4Liver neoplastic nodule remodeling QTL 43.64liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)13142356786Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
61339Bp24Blood pressure QTL 240.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13599466844807491Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
7411662Foco29Food consumption QTL 2920.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)13931346554313465Rat
9589141Insul28Insulin level QTL 2810.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)13931346554313465Rat
2317040Aia21Adjuvant induced arthritis QTL 212.75joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
2317046Aia8Adjuvant induced arthritis QTL 83.9700000286102295joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
1300163Cardf1Cardiac cell morphology QTL 14.18aorta morphology trait (VT:0000272)artery lesion measurement (CMO:0000975)131192944945417941Rat
2302275Gluco37Glucose level QTL 373.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)131192944946193066Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131491565559915655Rat
9589164Gluco66Glucose level QTL 666.670.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)131515872260158722Rat
1331784Bp222Blood pressure QTL 2222.944arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131769443653050594Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132230187567301875Rat
70170Eae14Experimental allergic encephalomyelitis QTL 140.0024nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)132320344868203448Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132369296968692969Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132369296968692969Rat
2303030Bp327Blood pressure QTL 327arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133039535141184251Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
2301962Cm72Cardiac mass QTL 724.12heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)133124133158363171Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133228447177284471Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133453521879535218Rat
2292232Pur16Proteinuria QTL 1617.2urine total protein amount (VT:0000032)urine protein level (CMO:0000591)133615572341961389Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133726209282262092Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133741558480753406Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133741558482415584Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)133843340883433408Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133975454484754544Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system nervous system renal system reproductive system respiratory system
High
Medium
Low 2 2 2 13
Below cutoff 1 8 28 19 16 19 55 23 27 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000004908   ⟹   ENSRNOP00000004908
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1339,781,929 - 39,824,456 (-)Ensembl
Rnor_6.0 Ensembl1344,998,414 - 45,040,593 (-)Ensembl
RefSeq Acc Id: NM_053841   ⟹   NP_446293
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81342,334,347 - 42,376,872 (-)NCBI
mRatBN7.21339,781,929 - 39,824,456 (-)NCBI
Rnor_6.01344,998,414 - 45,040,593 (-)NCBI
Rnor_5.01350,083,769 - 50,125,203 (-)NCBI
RGSC_v3.41340,990,315 - 41,043,388 (-)RGD
Celera1340,155,673 - 40,198,507 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_446293 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41507 (Get FASTA)   NCBI Sequence Viewer  
  BAF94233 (Get FASTA)   NCBI Sequence Viewer  
  BAF94253 (Get FASTA)   NCBI Sequence Viewer  
  EDM09876 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000004908
  ENSRNOP00000004908.4
GenBank Protein Q02401 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_446293   ⟸   NM_053841
- Peptide Label: preproprotein
- UniProtKB: A9CMC8 (UniProtKB/TrEMBL),   A9CMB6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000004908   ⟸   ENSRNOT00000004908

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q02401-F1-model_v2 AlphaFold Q02401 1-1928 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698779
Promoter ID:EPDNEW_R9304
Type:multiple initiation site
Name:Lct_1
Description:lactase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01345,040,607 - 45,040,667EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620823 AgrOrtholog
BioCyc Gene G2FUF-18410 BioCyc
Ensembl Genes ENSRNOG00000003681 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000004908 ENTREZGENE
  ENSRNOT00000004908.7 UniProtKB/TrEMBL
Gene3D-CATH Glycosidases UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Glyco_hydro_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glyco_hydro_1_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glyco_hydro_1_N_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glycoside_hydrolase_SF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:116569 UniProtKB/TrEMBL
NCBI Gene 116569 ENTREZGENE
PANTHER LACTASE-LIKE PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LACTASE-PHLORIZIN HYDROLASE UniProtKB/TrEMBL
  PTHR10353 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Glyco_hydro_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Lct PhenoGen
PRINTS GLHYDRLASE1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE GLYCOSYL_HYDROL_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLYCOSYL_HYDROL_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003681 RatGTEx
Superfamily-SCOP SSF51445 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6IBX1_RAT UniProtKB/TrEMBL
  A9CMB6 ENTREZGENE, UniProtKB/TrEMBL
  A9CMC8 ENTREZGENE, UniProtKB/TrEMBL
  LPH_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q63712 UniProtKB/Swiss-Prot
  Q63719 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Lct  lactase      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Lct  lactase      Symbol and Name status set to provisional 70820 PROVISIONAL