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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 17alpha-ethynylestradiol | increases expression | ISO | RGD:732448 | 6480464 | Ethinyl Estradiol results in increased expression of LBR mRNA | CTD | PMID:17942748 | 17alpha-ethynylestradiol | multiple interactions | ISO | RGD:732448 | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LBR mRNA | CTD | PMID:17942748 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:736984 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of LBR mRNA | CTD | PMID:11007951 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:732448 | 6480464 | Tetrachlorodibenzodioxin affects the expression of LBR mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:732448 | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LBR mRNA | CTD | PMID:17942748 | aflatoxin B1 | increases expression | ISO | RGD:732448 | 6480464 | Aflatoxin B1 results in increased expression of LBR mRNA | CTD | PMID:19770486 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of LBR mRNA | CTD | PMID:16483693 | benzo[a]pyrene | decreases expression | ISO | RGD:736984 | 6480464 | Benzo(a)pyrene results in decreased expression of LBR mRNA | CTD | PMID:20064835 | benzo[a]pyrene | multiple interactions | ISO | RGD:732448 | 6480464 | [Benzo(a)pyrene co-treated with XPA gene mutant form co-treated with TRP53 gene mutant form] results in decreased expression of LBR mRNA | CTD | PMID:21715664 | cadmium dichloride | increases methylation | EXP | | 6480464 | Cadmium Chloride results in increased methylation of LBR promoter | CTD | PMID:22457795 | calcitriol | multiple interactions | ISO | RGD:736984 | 6480464 | [Testosterone co-treated with Calcitriol] results in decreased expression of LBR mRNA | CTD | PMID:21592394 | calcitriol | decreases expression | ISO | RGD:736984 | 6480464 | Calcitriol results in decreased expression of LBR mRNA | CTD | PMID:21592394 | cisplatin | multiple interactions | ISO | RGD:736984 | 6480464 | Cisplatin affects the reaction [Piroxicam results in increased expression of LBR mRNA] | CTD | PMID:21858171 | clofibrate | multiple interactions | ISO | RGD:732448 | 6480464 | [Clofibrate co-treated with Acetaminophen] affects the expression of LBR mRNA; more ... | CTD | PMID:17585979 | copper(2+) sulfate | decreases expression | ISO | RGD:736984 | 6480464 | Copper Sulfate results in decreased expression of LBR mRNA | CTD | PMID:19549813 | coumestrol | multiple interactions | ISO | RGD:736984 | 6480464 | [Coumestrol co-treated with resveratrol] results in increased expression of LBR mRNA | CTD | PMID:19167446 | coumestrol | increases expression | ISO | RGD:736984 | 6480464 | Coumestrol results in increased expression of LBR mRNA | CTD | PMID:19167446 | hydrogen peroxide | affects expression | ISO | RGD:736984 | 6480464 | Hydrogen Peroxide affects the expression of LBR mRNA | CTD | PMID:20044591 | hydrogen peroxide | decreases expression | ISO | RGD:736984 | 6480464 | Hydrogen Peroxide results in decreased expression of LBR mRNA | CTD | PMID:12414654 | menadione | decreases expression | ISO | RGD:736984 | 6480464 | Vitamin K 3 results in decreased expression of LBR mRNA | CTD | PMID:12414654 | paracetamol | multiple interactions | ISO | RGD:732448 | 6480464 | [Clofibrate co-treated with Acetaminophen] affects the expression of LBR mRNA; more ... | CTD | PMID:17585979 | paracetamol | affects expression | ISO | RGD:732448 | 6480464 | Acetaminophen affects the expression of LBR mRNA | CTD | PMID:17562736 | piroxicam | multiple interactions | ISO | RGD:736984 | 6480464 | Cisplatin affects the reaction [Piroxicam results in increased expression of LBR mRNA] | CTD | PMID:21858171 | piroxicam | increases expression | ISO | RGD:736984 | 6480464 | Piroxicam results in increased expression of LBR mRNA | CTD | PMID:21858171 | quercetin | decreases expression | ISO | RGD:736984 | 6480464 | Quercetin results in decreased expression of LBR mRNA | CTD | PMID:21632981 | resveratrol | multiple interactions | ISO | RGD:736984 | 6480464 | [Coumestrol co-treated with resveratrol] results in increased expression of LBR mRNA | CTD | PMID:19167446 | tert-butyl hydroperoxide | decreases expression | ISO | RGD:736984 | 6480464 | tert-Butylhydroperoxide results in decreased expression of LBR mRNA | CTD | PMID:12414654 | testosterone | decreases expression | ISO | RGD:736984 | 6480464 | Testosterone results in decreased expression of LBR mRNA | CTD | PMID:21592394 | testosterone | multiple interactions | ISO | RGD:736984 | 6480464 | [Testosterone co-treated with Calcitriol] results in decreased expression of LBR mRNA | CTD | PMID:21592394 | trans-resveratrol | multiple interactions | ISO | RGD:736984 | 6480464 | [Coumestrol co-treated with resveratrol] results in increased expression of LBR mRNA | CTD | PMID:19167446 | valproic acid | affects expression | ISO | RGD:732448 | 6480464 | Valproic Acid affects the expression of LBR mRNA | CTD | PMID:17963808 PMID:17292431 | valproic acid | affects expression | ISO | RGD:732448 | 6480464 | Valproic Acid affects the expression of LBR mRNA | CTD | PMID:17292431 PMID:17963808 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
References - curated
RGD Disease Portals| Lbr has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Lbr (Rattus norvegicus) |
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| LBR (Homo sapiens) |
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| Lbr (Mus musculus) |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| RefSeq Acc Id: | NM_134453 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_604448 | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_604448 | (Get FASTA) |
| GenBank Protein | BAA20471 | (Get FASTA) |
| O08984 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000003103 | UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000031360 | UniProtKB/TrEMBL |
| Ensembl Transcript | ENSRNOT00000029841 | UniProtKB/TrEMBL |
| Entrez Gene | 89789 | ENTREZGENE |
| Germonline | ENSRNOG00000003103 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 2455 | ENTREZGENE |
| InterPro | Ergosterol_biosynth_ERG4_ERG24 | UniProtKB/Swiss-Prot |
| Lamin-B_rcpt_of_tudor | UniProtKB/Swiss-Prot | |
| Sterol_reductase_CS | UniProtKB/Swiss-Prot | |
| Tudor | UniProtKB/Swiss-Prot | |
| IPI | IPI00324991 | UniProtKB/Swiss-Prot |
| KEGG Report | rno:89789 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Pfam | ERG4_ERG24 | UniProtKB/Swiss-Prot |
| LBR_tudor | UniProtKB/Swiss-Prot | |
| PROSITE | STEROL_REDUCT_1 | UniProtKB/Swiss-Prot |
| STEROL_REDUCT_2 | UniProtKB/Swiss-Prot | |
| TUDOR; FALSE_NEG | UniProtKB/Swiss-Prot | |
| SMART | TUDOR | UniProtKB/Swiss-Prot |
| UniGene | Rn.6499 | ENTREZGENE |
| UniProt | F1LPY9_RAT | UniProtKB/TrEMBL |
| LBR_RAT | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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| 2004-02-26 | Lbr | lamin B receptor | Symbol and Name status set to approved | 2225 | APPROVED | ||
| 2002-08-07 | Lbr | lamin B receptor | Symbol and Name status set to provisional | 1724 | PROVISIONAL |
RGD Curation Notes| Note Type | Note | Reference |
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| gene_domains | amino terminal domain has an NLS-binding site | 633039 |
| gene_expression | present in the nuclear envelope of the liver cells | 633039 |
| gene_homology | amino acids 79 and 63% identical to human and chicken LBR respectively | 633039 |
| gene_protein | encodes a protein of 620 amino acids | 633039 |
| More on Lbr | |
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Entrez Gene |
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Ensembl Gene |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 620813 |
| Created: | 2002-08-06 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




