Gng4 (G protein subunit gamma 4) - Rat Genome Database

Name: Gng4
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Gng4 (G protein subunit gamma 4) Rattus norvegicus

Analyze

Symbol:

Gng4

Name:

G protein subunit gamma 4

RGD ID:

620806

Description:

Predicted to enable G-protein beta-subunit binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway and negative regulation of cell growth. Predicted to be part of heterotrimeric G-protein complex. Orthologous to human GNG4 (G protein subunit gamma 4); PARTICIPATES IN chemokine mediated signaling pathway; glutamate signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; atrazine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

guanine nucleotide binding protein (G protein), gamma 4; guanine nucleotide binding protein (G protein), gamma 4 subunit; guanine nucleotide binding protein 4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4; heterotrimeric guanine nucleotide-binding protein 3c; Hg3c

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	GNG4 (G protein subunit gamma 4)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther
Mus musculus (house mouse):	Gng4 (guanine nucleotide binding protein (G protein), gamma 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Gng4 (G protein subunit gamma 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	GNG4 (G protein subunit gamma 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	GNG4 (G protein subunit gamma 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Gng4 (G protein subunit gamma 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	GNG4 (G protein subunit gamma 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	GNG4 (G protein subunit gamma 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Gng4 (G protein subunit gamma 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	GNG4 (G protein subunit gamma 4)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Gng4 (guanine nucleotide binding protein (G protein), gamma 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	gng2 (guanine nucleotide binding protein (G protein), gamma 2)	Alliance	DIOPT (InParanoid\|OrthoInspector\|SonicParanoid)
Caenorhabditis elegans (roundworm):	gpc-1	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Ggamma1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER)
Drosophila melanogaster (fruit fly):	CG43324	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	gng2	Alliance	DIOPT (InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	17	93,432,791 - 93,481,709 (+)	NCBI		GRCr8
mRatBN7.2	17	86,448,708 - 86,497,560 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	86,449,022 - 86,495,254 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	17	90,687,122 - 90,735,625 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	17	94,523,029 - 94,571,532 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	17	88,539,549 - 88,588,049 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	17	90,266,571 - 90,316,278 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	90,266,794 - 90,315,492 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	17	91,928,440 - 91,976,187 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	17	85,118,055 - 85,165,657 (-)	NCBI		Celera
Cytogenetic Map	17	q12.3	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Chediak-Higashi syndrome (ISO)

common variable immunodeficiency 14 (ISO)

gastrointestinal stromal tumor (ISO)

genetic disease (ISO)

parathyroid carcinoma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(R)-adrenaline (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

4,4'-sulfonyldiphenol (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

arsenite(3-) (ISO)

atrazine (EXP,ISO)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

bisphenol A (EXP,ISO)

butanal (ISO)

carbamazepine (ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

dextran sulfate (ISO)

diclofenac (ISO)

dorsomorphin (ISO)

ethanol (ISO)

ethyl methanesulfonate (ISO)

folic acid (ISO)

formaldehyde (ISO)

isotretinoin (ISO)

L-ascorbic acid (ISO)

lead(0) (ISO)

lipopolysaccharide (ISO)

methapyrilene (ISO)

methyl methanesulfonate (ISO)

methylmercury chloride (ISO)

mono(2-ethylhexyl) phthalate (ISO)

paracetamol (EXP,ISO)

phenobarbital (ISO)

phenylmercury acetate (ISO)

pirinixic acid (ISO)

progesterone (ISO)

quercetin (ISO)

resveratrol (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

succimer (ISO)

tamibarotene (ISO)

testosterone (ISO)

thimerosal (ISO)

titanium dioxide (ISO)

trichloroethene (EXP)

tunicamycin (ISO)

urethane (ISO)

valproic acid (ISO)

vitamin E (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

G protein-coupled receptor signaling pathway (IBA)

negative regulation of cell growth (ISO)

Cellular Component

heterotrimeric G-protein complex (IBA)

synapse (ISO)

Molecular Function

G-protein beta-subunit binding (IBA)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

chemokine mediated signaling pathway (IEA)

glutamate signaling pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Distribution of heterotrimeric G-protein beta and gamma subunits in the rat brain.	Betty M, etal., Neuroscience 1998 Jul;85(2):475-86.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
4.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
5.	GOA pipeline	RGD automated data pipeline
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:15824735	PMID:23533145

Genomics

Comparative Map Data

Gng4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	17	93,432,791 - 93,481,709 (+)	NCBI		GRCr8
mRatBN7.2	17	86,448,708 - 86,497,560 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	86,449,022 - 86,495,254 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	17	90,687,122 - 90,735,625 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	17	94,523,029 - 94,571,532 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	17	88,539,549 - 88,588,049 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	17	90,266,571 - 90,316,278 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	90,266,794 - 90,315,492 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	17	91,928,440 - 91,976,187 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	17	85,118,055 - 85,165,657 (-)	NCBI		Celera
Cytogenetic Map	17	q12.3	NCBI

GNG4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	235,547,685 - 235,650,608 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	235,547,685 - 235,650,754 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	235,710,985 - 235,813,908 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	233,777,608 - 233,880,677 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	232,040,173 - 232,140,095	NCBI
Celera	1	208,954,277 - 209,057,391 (-)	NCBI		Celera
Cytogenetic Map	1	q42.3	NCBI
HuRef	1	206,162,071 - 206,265,794 (-)	NCBI		HuRef
CHM1_1	1	236,983,524 - 237,086,799 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	234,943,567 - 235,047,271 (-)	NCBI		T2T-CHM13v2.0

Gng4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	13,958,644 - 14,002,480 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	13	13,958,644 - 14,002,481 (+)	Ensembl		GRCm39 Ensembl
GRCm38	13	13,784,059 - 13,827,895 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	13,784,059 - 13,827,896 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	13	13,876,806 - 13,920,162 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	13	13,576,665 - 13,620,021 (+)	NCBI		MGSCv36	mm8
Celera	13	14,090,226 - 14,133,654 (+)	NCBI		Celera
Cytogenetic Map	13	A1	NCBI
cM Map	13	5.29	NCBI

Gng4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955492	4,406,154 - 4,432,600 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955492	4,380,198 - 4,432,551 (+)	NCBI	ChiLan1.0	ChiLan1.0

GNG4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	13,527,011 - 13,630,496 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	13,738,842 - 13,842,571 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	211,109,952 - 211,218,547 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	216,121,864 - 216,221,681 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	216,121,864 - 216,154,657 (-)	Ensembl	panpan1.1		panPan2

GNG4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	4	4,308,892 - 4,389,812 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	4	4,354,050 - 4,387,191 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	4	4,355,567 - 4,436,458 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	4	4,330,254 - 4,411,421 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	4	4,330,185 - 4,411,408 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	4	4,342,090 - 4,422,944 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	4	4,459,681 - 4,540,292 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	4	4,680,965 - 4,761,849 (+)	NCBI		UU_Cfam_GSD_1.0

Gng4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	40,783,499 - 40,803,403 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936484	16,951,967 - 16,968,537 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936484	16,950,628 - 16,968,622 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GNG4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	55,653,034 - 55,726,373 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	55,652,743 - 55,725,085 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	59,779,582 - 59,799,741 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GNG4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	25	72,723,600 - 72,817,255 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666055	74,760,288 - 74,860,095 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Gng4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624775	14,916,063 - 14,962,667 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624775	14,916,047 - 14,962,661 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Gng4
95 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	69
Count of miRNA genes:	58
Interacting mature miRNAs:	60
Transcripts:	ENSRNOT00000070807
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
7411575	Bw140	Body weight QTL 140	30.2	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	17	48560935	86533673	Rat
8694181	Bw151	Body weight QTL 151	4.36	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	17	48560935	86533673	Rat
2317038	Ginf3	Gastrointestinal inflammation QTL 3	2.89	0.005	liver integrity trait (VT:0010547)	liver granuloma severity score (CMO:0002157)	17	49920154	86533673	Rat
2303580	Gluco49	Glucose level QTL 49	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	17	50040271	86533673	Rat
2317045	Aia11	Adjuvant induced arthritis QTL 11	4.06		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	17	60781426	86533673	Rat
7411577	Bw141	Body weight QTL 141		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	17	62619516	86533673	Rat

Markers in Region

D13Sfk17

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	17	86,494,931 - 86,495,004 (-)	MAPPER	mRatBN7.2
Rnor_6.0	17	90,269,358 - 90,269,430	NCBI	Rnor6.0
Rnor_5.0	17	91,930,801 - 91,930,873	UniSTS	Rnor5.0
Celera	17	85,120,842 - 85,120,914	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium									52
Low	3		14	2	11	2			22	23	20	7
Below cutoff		39	31	27	8	27	8	9		12	20	4	8

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001400370	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_001053747	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008771924	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008774051	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF022089	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474120	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000017	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	OU667105	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000070807 ⟹ ENSRNOP00000065598

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	17	90,266,794 - 90,315,492 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000108987 ⟹ ENSRNOP00000091415

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	17	86,449,022 - 86,495,254 (+)	Ensembl

RefSeq Acc Id:

NM_001400370 ⟹ NP_001387299

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	93,433,195 - 93,481,709 (+)	NCBI
mRatBN7.2	17	86,449,040 - 86,497,560 (+)	NCBI

RefSeq Acc Id:

XM_008771924 ⟹ XP_008770146

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	93,432,791 - 93,481,709 (+)	NCBI
mRatBN7.2	17	86,448,708 - 86,497,560 (+)	NCBI
Rnor_6.0	17	90,266,571 - 90,316,278 (-)	NCBI

Sequence:

show sequence

TACAGCGAGACACACAAAACACAGTTCCATTAGGACAAGGCTTGGCAGGCCACTGGGAGTCGCC
AGGATTCCCTGCAGCAGCAGCTCCTTGCTGTTCACTTGCACTCTTGGTGACTGGCTGGGAGGCA
GTTGCTCTGCCAAGCCAGGTCGGGTGGCGGTCTTGCCCGCGTTGCTTAGCGACGTCTGCGTAAG
ATTGGTGCGCATTTCCAGATGTTCAGCATCTGCACTAACTGTGCCCACCTTCCTCCGTGTGAGG
CACCCTAGGTGTCCCCAGGGGGCTCCACAGCAGGACCCTGAGTCAGCCTCTCTTCTAACTGCCA
AATTCTGCTGCTGCAGTGTCCCCTGCCTGGACCTGTCCCTGTACCACCTCTCAGCAGGGAGCGC
AGGAATGAAGGAAGGCATGTCTAATAACAGCACCACCAGCATCTCCCAGGCCAGGAAAGCTGTA
GAGCAGCTGAAGATGGAAGCCTGCATGGACAGGGTGAAGGTCTCCCAGGCTGCCTCGGACCTCC
TGGCCTACTGTGAAGCCCACGTGCGGGAGGATCCTCTCATCATCCCTGTGCCTGCCTCAGAAAA
CCCCTTCCGGGAGAAGAAGTTCTTCTGCACCATTCTTTAACACCCATGGCCATGAAGCAGGCCC
TGTCCTGCCATAAAAGTTTGAGTAGAGACCATGCATGCTCCCATGTAGAGGCATGCCTCCCACA
ACACCCCGTCTCTGCCCAACCAGTCATGATCTGGGCTCATCTCCTTTCATCATATTTCCTTCTT
AACATTGTTTCCTCTTCCTTTTTTGTTTCACTTTTCTTATCTCCATAGAGAAAACAGACACTTT
TATACCCAAATAACAAATGTGCCATACAAAAGTGTAGATTTAAAGGTCTGCAATTTTTAAACAT
TCCCAGCCATAAATATAACCAGTTAATAAATTTTAGTGGGTAATTCATTGAAGTCAAAACCATG
CACAAGTGTCTCCCATGCACAGTAATTCAGTAGCAGATGAGAGCATGTCAGTCAGACACATGTG
ATGGTGGGGTCTTTCTCCTCTGGCATCTCTATCATAGAAGCCTTCAGGGCCCATGTGGCTAGGT
CCTGTAAATGACTAATATCTCTACCTGTTTATCACTGAGCATTCCAAAGCTGATGCGTCTGAGA
ATACATTTGTAGTGTAGACACTGAAGCAGCCTTGACTGTAGATACTCACCAGACAGCCCCACTG
GGCCATCTTCTCAATCCAAATGCCCCGCCCTCCTTGCTTGCTCCCTACTTGGTGTTTCTGGTAA
GGCAAGGAGTCTGACAACATGAACGTGTTGTTGAACTGTAGTCTGGCACAGTTATCCCTGAAAA
TGATGTCACCAGGCCACTCACTGATCTGAGAAGTTATGGGCATCAACATATTTAACCTGGCAAT
AAATACTCCAAGTATAGGTCTGTTTTTAGAGAGGGAATATCCCAGGCATAGAGAAATGACATTT
GCTGAAAGCTGTAGACAGAAAGTAGGCACACCAAGTCTTCACATGTGGGTAGTCCATCCTTAAA
GCCCTCACTGAAGCCCTGAACTGTGGCCACCTGTTGCAAGTGTGCAGATTCACAAACAGTCCTA
ACTACACGTTAGGAATGAAACAAACACATGTTCACACTAACTGGATGTACACCCCTCTCCCACC
TTCTCAAGAGAAGAGTCCCAAGCCTAGATTATGGCAGTCTGTGATAGATGATATATAGGTGCCC
CAAGACCAGATAGCAGTAAGCCTTGAGATTTTCCAAGACAAGGTTGTTGTCCTTATCTAAGGCA
CCCCCATACTCTCCTGATGGAGGCAGTAACCACAGTTGCTGAGGGCTCGGTGAGGACATTTGTT
GTGTAGATATTTGGAAACTGCTTCTCCTATGTTCTCCTCTGGATCTCAAAGAGGCTTGCTGTGT
GCTGCTGACAAGCCATTGTGTGCCAAGCTGTTCAAACCAGCAAATTGCAGCCAGTTAATTACCC
CTCTTGCTCTTCTGCCAGGGAAGAAAGCAAATAAAGCTCTGATTATCCTTGAAAGCCAATATGT
GCTGGATGATAACCTGTAATGTTGTGGAGAGTGTATGACCTCATAGACATCACGGTTCTGAGAT
GAGTGTAAAATGGCCTCCGAGTGACTCTCATTTTTAGATTGGTTTGTGCCTTGCTACCTTCTCT
TGCAGCTTTTGTGCAAACTGTCCTTAGTTTCACTACTGGACATTAGAGGAGAGGCAAATCCTCT
GGTTTTGTTGGGCTGTAACAAGATCTCTTTATTCTGTGGCTCATGTTGGCATTATTAATCCATA
GAGTAGAACATAGTCCCCAAAAGCCAAGGAAGTGTGGCAACACCTGCAGTGCAAAATCAGGTCA
AGAGAACAGTGTGCTTTAATAGCCTACCCGACTGTCTCTGCTTTCCTGCCTCCATTTCCAACCA
TCTTTCTTACATTCTCCTGTGGATGGCGTGTCCACCAGTAACTGTCCTGGGATGATTCCCCCTC
TGCCCCGCCACTCTGCTCCTTAGACCCATTAGGCTTTCTGACCCCCAACATCTTTCTACTTATT
CCTAGATTTTTGTTAATTCTTGGAGTCTTGTGATCAACACTGTAAACTCATTATTCCACAAAAT
ATCCTCATTTGGATGTAAATATTTCGTGAGAAGACAACTCCACCCCTGAGTATGTACTCAACAG
AAATGTGTACATATTGTCAGAAGAAATGTACTAGAATGTCCACAGAAGTATTGTTCACTGTAAC
CCTAACCAGAAGGAGCCCCTTATGCCCATGTTGAAGGGATAAGCAGATAAGAGTCATTAATGAA
GCAGTGGATTCTCAGCTTCACCCACAGCTTGGTTCGAATCTTGCTGTCCTGAGGGACTGAGAGC
AGGGACGTCCAAGCTACAGATCCATTTCCATACAGAACAGGCCTGGCAGGCCAACCCATGCTGA
TTGAATGAGGGGCAGTAGCTGTTCTCAAAGGAGCAACAGAGATGGAACACAAAAGACTTCTGGG
GGCTGGGGATTTAGCTCAGTGGTAGAGCGCTTGCCTAGGAAGCGCAAGGCCCTGGGTTCGGTCC
CCAGCTCCGAAAAAAAAAAAAAATGAAGTGAAGACTTCTGGAATCTTCTGTCTCTGGATCTAAC
TGTGAGTCACACTGAGATGTTTAGTTTGTGGAAGTTCTCCAACTGTCCATTTTTGGGTGCTTTT
CTGTATGTGTGTTATACTTCAATAAAACACTGGACTTTGTGACTACCAACTGTGGGTCCCTCTG
CTATTGCTCCCCCCCCTTGGTACTTTGTTCAATGTTTGACTCTTCCTTAAATGTTCTTAACATA
ACATTACTAACTCCCATTTTTAGTGGGGCACTTTAAGAGTGCACAAAGTACTTGCAATCACCAG
CTGGAGAACAAGTTTCTGTCATGCACAGGTATTTCCCCACACAAACACTATGATCTGGGATTTG
TGAGTAAACAGCAAGCACACCATG

hide sequence

Protein Sequences


Protein RefSeqs	NP_001387299	(Get FASTA)	NCBI Sequence Viewer
	XP_008770146	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAB82556	(Get FASTA)	NCBI Sequence Viewer
	CAG9553623	(Get FASTA)	NCBI Sequence Viewer
	EDL83171	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000091415.1

RefSeq Acc Id:	XP_008770146 ⟸ XM_008771924
- Peptide Label:	isoform X1
- UniProtKB:	A6KTD1 (UniProtKB/TrEMBL)
- Sequence:	show sequence MKEGMSNNSTTSISQARKAVEQLKMEACMDRVKVSQAASDLLAYCEAHVREDPLIIPVPASENP FREKKFFCTIL hide sequence

RefSeq Acc Id:

ENSRNOP00000065598 ⟸ ENSRNOT00000070807

RefSeq Acc Id:

ENSRNOP00000091415 ⟸ ENSRNOT00000108987

RefSeq Acc Id:	NP_001387299 ⟸ NM_001400370
- UniProtKB:	A6KTD1 (UniProtKB/TrEMBL)

Protein Domains

G protein gamma

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-M0R809-F1-model_v2	AlphaFold	M0R809	1-75	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620806	AgrOrtholog
BioCyc Gene	G2FUF-8450	BioCyc
Ensembl Genes	ENSRNOG00000047080	Ensembl
	ENSRNOG00000068923	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000108987.1	UniProtKB/TrEMBL
Gene3D-CATH	4.10.260.10	UniProtKB/TrEMBL
InterPro	G-protein_gamma-like_dom	UniProtKB/TrEMBL
	GGL_sf	UniProtKB/TrEMBL
	Gprotein-gamma	UniProtKB/TrEMBL
KEGG Report	rno:114118	UniProtKB/TrEMBL
NCBI Gene	114118	ENTREZGENE
PANTHER	GUANINE NUCLEOTIDE-BINDING PROTEIN G(I)/G(S)/G(O) SUBUNIT GAMMA-4	UniProtKB/TrEMBL
	PTHR13809	UniProtKB/TrEMBL
Pfam	G-gamma	UniProtKB/TrEMBL
PhenoGen	Gng4	PhenoGen
PRINTS	GPROTEING	UniProtKB/TrEMBL
PROSITE	G_PROTEIN_GAMMA	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000047080	RatGTEx
	ENSRNOG00000068923	RatGTEx
SMART	G_gamma	UniProtKB/TrEMBL
	GGL	UniProtKB/TrEMBL
Superfamily-SCOP	SSF48670	UniProtKB/TrEMBL
UniProt	A0A8I6AF64_RAT	UniProtKB/TrEMBL
	A6KTD1	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2022-06-02	Gng4	G protein subunit gamma 4	Gng4	G protein subunit gamma 4	Data merged from RGD:149736400	737654	PROVISIONAL
2021-08-09	Gng4	G protein subunit gamma 4			Symbol and Name status set to provisional	45752	PROVISIONAL
2016-03-15	Gng4	G protein subunit gamma 4	Gng4	guanine nucleotide binding protein (G protein), gamma 4	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2013-08-01	Gng4	guanine nucleotide binding protein (G protein), gamma 4	Gng4	guanine nucleotide binding protein (G protein), gamma 4 subunit	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-01-20	Gng4	guanine nucleotide binding protein (G protein), gamma 4 subunit		guanine nucleotide binding protein 4	Name updated	1299863	APPROVED
2002-08-07	Gng4	guanine nucleotide binding protein 4			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_expression	highly expressed in dorsal raphe nucleus	632972
gene_process	may function in serotonergic transmission	632972

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Annotations - KEGG (archival)