Slc38a5 (solute carrier family 38, member 5)

Gene: Slc38a5 (solute carrier family 38, member 5) Rattus norvegicus

Analyze

Symbol:

Slc38a5

Name:

solute carrier family 38, member 5

RGD ID:

620702

Description:

Enables L-amino acid transmembrane transporter activity and neutral amino acid, sodium:proton antiporter activity. Involved in amino acid transport. Located in plasma membrane. Orthologous to human SLC38A5 (solute carrier family 38 member 5); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

AF276870; amino acid transporter system N2; SN2; sodium-coupled neutral amino acid transporter 5; solute carrier family 38 member 5; system N transporter 2

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	16,885,701 - 16,894,470 (-)	NCBI		GRCr8
mRatBN7.2	X	14,213,727 - 14,222,498 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	14,213,729 - 14,222,498 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	19,027,241 - 19,036,002 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	21,047,080 - 21,055,839 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	17,312,273 - 17,321,032 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	14,963,919 - 14,972,675 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	14,963,921 - 14,972,675 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	15,748,231 - 15,756,314 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	26,244,421 - 26,253,596 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	X	26,297,889 - 26,307,057 (-)	NCBI
Celera	X	14,299,226 - 14,307,991 (-)	NCBI		Celera
Cytogenetic Map	X	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autistic disorder (ISO)

congenital disorder of glycosylation type IIm (ISO)

Endotoxemia (IEP)

genetic disease (ISO)

immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome (ISO)

neurodegeneration with brain iron accumulation 5 (ISO)

syndromic X-linked intellectual disability Lubs type (ISO)

X-linked epilepsy with variable learning disabilities and behavior disorders (ISO)

X-linked severe congenital neutropenia (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17beta-estradiol (EXP,ISO)

17beta-estradiol 3-benzoate (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

3,7-dihydropurine-6-thione (EXP)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

acrolein (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

allethrin (EXP)

alpha-pinene (ISO)

amitrole (EXP)

ammonium chloride (EXP)

arsenite(3-) (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

carbon nanotube (ISO)

chloroprene (ISO)

choline (ISO)

cisplatin (ISO)

Cuprizon (EXP)

cyhalothrin (EXP)

cypermethrin (EXP)

dexamethasone (ISO)

dibutyl phthalate (ISO)

dichloroacetic acid (ISO)

dioxygen (ISO)

dorsomorphin (ISO)

entinostat (ISO)

ethanol (EXP)

ethyl methanesulfonate (ISO)

fenvalerate (EXP)

flavonoids (EXP)

folic acid (ISO)

formaldehyde (ISO)

gentamycin (EXP)

indometacin (ISO)

ketamine (EXP)

L-methionine (ISO)

mercaptopurine (EXP)

methamphetamine (EXP)

methimazole (EXP)

methyl methanesulfonate (ISO)

nickel sulfate (ISO)

oxaliplatin (EXP)

ozone (ISO)

paracetamol (ISO)

paraquat (EXP)

pioglitazone (ISO)

purine-6-thiol (EXP)

pyrethrins (EXP)

quercetin (ISO)

SB 431542 (ISO)

SCH 23390 (EXP)

silicon dioxide (EXP)

sodium arsenite (ISO)

sulfadimethoxine (EXP)

tamoxifen (ISO)

testosterone (EXP,ISO)

titanium dioxide (ISO)

toluene (EXP)

topotecan (EXP)

trichloroethene (EXP)

tris(2-butoxyethyl) phosphate (ISO)

valproic acid (EXP)

XL147 (ISO)

zidovudine (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

amino acid export across plasma membrane (IDA)

amino acid import across plasma membrane (IDA)

asparagine transmembrane transport (ISO)

asparagine transport (IEA)

glutamine transport (IBA,IDA,ISO)

glycine transport (IBA,IDA,ISO)

inorganic cation transmembrane transport (IEA)

L-alanine transmembrane transport (ISO)

L-glutamine import across plasma membrane (IDA,IEA,ISO,ISS)

L-histidine transmembrane transport (IBA,IDA,IEA,ISO)

L-serine import across plasma membrane (IDA)

L-serine transport (IDA)

monoatomic cation transmembrane transport (IEA)

neutral amino acid transport (IDA,ISO)

serine transport (IBA,IEA,ISO)

sodium ion transmembrane transport (IEA)

Cellular Component

membrane (IEA)

plasma membrane (IBA,IDA)

Molecular Function

alanine transmembrane transporter activity (ISO)

amino acid transmembrane transporter activity (IDA)

glycine transmembrane transporter activity (IBA,IDA,IEA,ISO)

L-asparagine transmembrane transporter activity (ISO)

L-glutamine transmembrane transporter activity (IBA,IDA,ISO)

L-glutamine, sodium:proton antiporter activity (IDA,IEA,ISO,ISS)

L-histidine transmembrane transporter activity (IDA,ISO)

L-serine transmembrane transporter activity (IDA,ISO)

neutral amino acid, sodium:proton antiporter activity (IDA,ISO,ISS)

neutral L-amino acid transmembrane transporter activity (IDA)

References

References - curated

#	Reference Title	Reference Citation
1.	Evidence for allosteric regulation of pH-sensitive System A (SNAT2) and System N (SNAT5) amino acid transporter activity involving a conserved histidine residue.	Baird FE, etal., Biochem J. 2006 Jul 15;397(2):369-75. doi: 10.1042/BJ20060026.
2.	Bidirectional substrate fluxes through the system N (SNAT5) glutamine transporter may determine net glutamine flux in rat liver.	Baird FE, etal., J Physiol. 2004 Sep 1;559(Pt 2):367-81. doi: 10.1113/jphysiol.2003.060293. Epub 2004 Jun 24.
3.	Amino acid transporter SNAT5 localizes to glial cells in the rat brain.	Cubelos B, etal., Glia. 2005 Jan 15;49(2):230-44. doi: 10.1002/glia.20106.
4.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5.	The system N transporter SN2 doubles as a transmitter precursor furnisher and a potential regulator of NMDA receptors.	Hamdani el H, etal., Glia. 2012 Nov;60(11):1671-83. doi: 10.1002/glia.22386. Epub 2012 Jul 20.
6.	Cloning and functional characterization of a new subtype of the amino acid transport system N.	Nakanishi T, etal., Am J Physiol Cell Physiol 2001 Dec;281(6):C1757-68.
7.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
8.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
10.	Expression and function of glutamine transporters SN1 (SNAT3) and SN2 (SNAT5) in retinal Müller cells.	Umapathy NS, etal., Invest Ophthalmol Vis Sci. 2005 Nov;46(11):3980-7. doi: 10.1167/iovs.05-0488.
11.	Changes of plasma glutamine concentration and hepatocyte membrane system N transporters expression in early endotoxemia.	Wang W, etal., J Surg Res. 2011 Apr;166(2):290-7. doi: 10.1016/j.jss.2009.08.027. Epub 2009 Sep 23.

Additional References at PubMed

PMID:11243884	PMID:12477932	PMID:24333324

Genomics

Comparative Map Data

Slc38a5
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	16,885,701 - 16,894,470 (-)	NCBI		GRCr8
mRatBN7.2	X	14,213,727 - 14,222,498 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	14,213,729 - 14,222,498 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	19,027,241 - 19,036,002 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	21,047,080 - 21,055,839 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	17,312,273 - 17,321,032 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	14,963,919 - 14,972,675 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	14,963,921 - 14,972,675 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	15,748,231 - 15,756,314 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	26,244,421 - 26,253,596 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	X	26,297,889 - 26,307,057 (-)	NCBI
Celera	X	14,299,226 - 14,307,991 (-)	NCBI		Celera
Cytogenetic Map	X	q12	NCBI

SLC38A5
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	48,458,544 - 48,470,260 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	X	48,458,537 - 48,470,260 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	X	48,316,927 - 48,328,648 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	48,201,871 - 48,213,509 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	X	48,073,181 - 48,084,819	NCBI
Celera	X	53,337,091 - 53,348,808 (+)	NCBI		Celera
Cytogenetic Map	X	p11.23	NCBI
HuRef	X	45,981,068 - 45,992,834 (-)	NCBI		HuRef
CHM1_1	X	48,348,162 - 48,359,900 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	X	47,867,546 - 47,879,266 (-)	NCBI		T2T-CHM13v2.0

Slc38a5
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	8,137,620 - 8,146,418 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	8,137,372 - 8,146,418 (+)	Ensembl		GRCm39 Ensembl
GRCm38	X	8,271,381 - 8,280,179 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	8,271,133 - 8,280,179 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	X	7,848,518 - 7,857,305 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	X	7,428,353 - 7,437,133 (+)	NCBI		MGSCv36	mm8
Celera	X	3,190,181 - 3,198,970 (-)	NCBI		Celera
Cytogenetic Map	X	A1.1	NCBI
cM Map	X	3.74	NCBI

Slc38a5
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955543	16,089 - 24,668 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955543	15,968 - 24,644 (-)	NCBI	ChiLan1.0	ChiLan1.0

SLC38A5
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	X	49,947,016 - 49,958,940 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	X	49,950,398 - 49,962,310 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	X	40,756,423 - 40,768,327 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	X	48,621,018 - 48,632,682 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	X	48,621,018 - 48,632,682 (-)	Ensembl	panpan1.1		panPan2

SLC38A5
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	41,709,441 - 41,718,702 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	X	41,709,467 - 41,717,080 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	X	16,085,681 - 16,094,898 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	X	41,845,558 - 41,854,816 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	X	41,845,558 - 41,854,758 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	X	41,832,556 - 41,841,772 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	X	41,820,836 - 41,830,050 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	X	41,914,395 - 41,923,619 (-)	NCBI		UU_Cfam_GSD_1.0

Slc38a5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	34,178,875 - 34,200,906 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936721	419,268 - 441,350 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936721	419,286 - 441,224 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SLC38A5
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	X	42,590,607 - 42,601,502 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	X	42,590,608 - 42,601,537 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	X	47,547,735 - 47,558,567 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SLC38A5
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	X	45,588,992 - 45,598,771 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666076	11,040,195 - 11,052,121 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Slc38a5
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624893	275,820 - 284,696 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624893	275,906 - 284,883 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Slc38a5
19 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	63
Count of miRNA genes:	49
Interacting mature miRNAs:	55
Transcripts:	ENSRNOT00000038068
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
731181	Uae27	Urinary albumin excretion QTL 27	2.7	0.0059	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	X	1	43491017	Rat
634325	Bw13	Body weight QTL 13	0		body mass (VT:0001259)	body weight (CMO:0000012)	X	1447972	20991088	Rat
70165	Bp64	Blood pressure QTL 64	5.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	X	1448129	31706553	Rat
631204	Gluco15	Glucose level QTL 15		0.001	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	X	1623715	22646544	Rat
1298071	Edpm12	Estrogen-dependent pituitary mass QTL 12	3.2		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	X	2927898	47927898	Rat
10755455	Coatc13	Coat color QTL 13		0	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	7	4406000	49406000	Rat
631666	Iddm5	Insulin dependent diabetes mellitus QTL 5			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	X	4494549	49494549	Rat

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium		2	20	20	10	20			49		5	9
Low	2	34	8	7	2	7			25	21	29	2
Below cutoff	1	7	19	9	5	9	6	9		11	7		6

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_138854	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008773068	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039099444	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF276870	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC128725	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474078	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000021	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000038068 ⟹ ENSRNOP00000038781

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	X	14,213,729 - 14,222,204 (-)	Ensembl
Rnor_6.0 Ensembl	X	14,963,921 - 14,972,389 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000079664 ⟹ ENSRNOP00000073818

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	X	14,213,729 - 14,222,498 (-)	Ensembl
Rnor_6.0 Ensembl	X	14,963,921 - 14,972,675 (-)	Ensembl

RefSeq Acc Id:

NM_138854 ⟹ NP_620209

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	16,885,701 - 16,894,470 (-)	NCBI
mRatBN7.2	X	14,213,727 - 14,222,498 (-)	NCBI
Rnor_6.0	X	14,963,919 - 14,972,675 (-)	NCBI
Rnor_5.0	X	15,748,231 - 15,756,314 (-)	NCBI
RGSC_v3.4	X	26,244,421 - 26,253,596 (-)	RGD
Celera	X	14,299,226 - 14,307,991 (-)	RGD

Sequence:

show sequence

CCCACGCGTCCGCACCTAGTTGCACTCGCATACTGGTCAGTTCTGTCCCAGGAAGAGGGACGCT
TCAATTTGCTTCGGTCTCTGCTGAAGAAAGTCAGAACCGGAATAAAAGCGGATGGAAATGCAGG
AACCAAAGATGAACGGAACCCTCTCTACGGGTGCTGCTGCGGGCTACAGACAGGAACGCGAAGG
CTTCCTGCCCACCACCCATGGCCCTGCTCCAGGGAGGAAACCTGTCCAATTCTTGGATTTCGAG
GGGAAGACATCATTCGGAATGTCAGTGTTCAACCTTAGCAATGCCATCATGGGGAGTGGCATCC
TGGGGCTCGCCTACGCCATGGCCCACACTGGAGTCATCTTCTTCTTGGCCCTCTTGCTGTGCAT
TGCCCTCCTGTCTTCTTACTCTATCCACCTCCTGCTGACCTGCGCCAGTGTTGTAGGAATCCGC
GCCTATGAGCAGCTGGGACAGAGGGCATTTGGACCTGCCGGGAAAGTAGTGGTGGCCATTATCA
TCTGTCTGCACAATGTTGGCGCTATGTCCAGTTACCTGTTCATCATCAAATCTGAACTGCCCCT
GGTTATTGGCACCTTCCTGCACATGGACCCTGAGGGGGACTGGTTCTTGAAGGGAAACCTCCTC
ATCATCCTGGTTAGCTTGTTAATCATCTTGCCTCTGGCTCTCATGAAACATCTGGGCTACTTGG
GGTATACAAGCAGCCTCTCTCTGACCTGCATGCTGTTTTTCCTTATTTCAGTCATCTATAAGAA
GTTCCAGCTTGGCTGTGTTGTGAGCCACAATGACACAGTAGTGGAGAGTGAACCAGCTCCCTTG
CAGGCGTTTAATAGCAGCTGTGAGGCCAAGCTCTTCACAGTTGACTCACAGATGTCTTACACAG
TGCCTATTATGGCTTTTGCCTTTGTCTGCCACCCTGAGGTGCTGCCCATTTACACGGAACTTTG
CTGCCCTACTCAGCGCAGGATGCAAGCTGTGGCCAACATGTCCATCGGGGCTATGTTCATCATG
TACGGACTCACAGCTACCTTTGGATACCTTACCTTCTACAGCACTGTGAAGGCAGAGATGCTGG
AGATGTACACCCAGGAGGACCTGCTTATTCTTTGTGTGCGCCTGGCCGTACTGCTTGCAGTAAC
CCTCACTGTGCCTGTTGTCCTTTTCCCTATCCGCCGAGCCCTCCAGCAGCTGCTCTTCCCAAGT
AAGGCCTTCAGCTGGCCACGACATGTGGCAATTGCCCTGATTCTGCTTAATTTGGTCAATATCC
TTGTCATTTGTGTGCCAACCATCCGGGATATCTTTGGGTTTATTGGCTCCACTTCAGCCCCTAG
CCTCATCTTCATCCTTCCCAGTGTCTTCTACCTCCGCATTGTACCTGCTGACATGGAACCCTTG
TTTTCCTGGCCCAAGATCCAGGCCCTGTGTTTTGGCGTCCTGGGAGTCCTCTTCATGGCCATCA
GTCTGGGCTTTATGTTTGCTAATTGGGCTACAGGCCAGAGCCGTATGTCTGGCCATTGAGCTGG
CCTGTCCTGCCTCACTCAGTCCCTGTGCTCACATGTGTGTATATTAGGGAATCCAAGTCACTTT
CCTGAGTCCCTTCTGCCTGGGACATGGAGGTGGCTGGTCTCTAGTAACACTGCTGTGGGAAATG
GGGACAGTCGAGGAGGCATAGTAAGTAGTCCATTTCCTTTTCCCCAGAGCTGCCTCACTGCCGA
CCCCATGAGAGGAGGAAGGGAGGCCAGCTCCTTAGAAGAGTTCTTACCCAACATAGTTCTCACT
TCCTAGATGAAGCTGTTAGGCTTACCCTGGCGCTAAAAGGGAAGAATAAAGATGCTGAATGGCA
AAAAAAAAAAAAAAAGAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_008773068 ⟹ XP_008771290

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	16,885,701 - 16,894,268 (-)	NCBI
mRatBN7.2	X	14,213,727 - 14,222,291 (-)	NCBI
Rnor_6.0	X	14,963,919 - 14,972,382 (-)	NCBI

Sequence:

show sequence

CTATTTCCGCACTTAAATGGCCATTTCAGGCGCTGTGGGGATGGAAATGCAGGAACCAAAGATG
AACGGAACCCTCTCTACGGGTGCTGCTGCGGGCTACAGACAGGAACGCGAAGGCTTCCTGCCCA
CCACCCATGGCCCTGCTCCAGGGAGGAAACCTGTCCAATTCTTGGATTTCGAGGGGAAGACATC
ATTCGGAATGTCAGTGTTCAACCTTAGCAATGCCATCATGGGGAGTGGCATCCTGGGGCTCGCC
TACGCCATGGCCCACACTGGAGTCATCTTCTTCTTGGCCCTCTTGCTGTGCATTGCCCTCCTGT
CTTCTTACTCTATCCACCTCCTGCTGACCTGCGCCAGTGTTGTAGGAATCCGCGCCTATGAGCA
GCTGGGACAGAGGGCATTTGGACCTGCCGGGAAAGTAGTGGTGGCCATTATCATCTGTCTGCAC
AATGTTGGCGCTATGTCCAGTTACCTGTTCATCATCAAATCTGAACTGCCCCTGGTTATTGGCA
CCTTCCTGCACATGGACCCTGAGGGGGACTGGTTCTTGAAGGGAAACCTCCTCATCATCCTGGT
TAGCTTGTTAATCATCTTGCCTCTGGCTCTCATGAAACATCTGGGCTACTTGGGGTATACAAGC
AGCCTCTCTCTGACCTGCATGCTGTTTTTCCTTATTTCAGTCATCTATAAGAAGTTCCAGCTTG
GCTGTGTTGTGAGCCACAATGACACAGTAGTGGAGAGTGAACCAGCTCCCTTGCAGGCGTTTAA
TAGCAGCTGTGAGGCCAAGCTCTTCACAGTTGACTCACAGATGTCTTACACAGTGCCTATTATG
GCTTTTGCCTTTGTCTGCCACCCTGAGGTGCTGCCCATTTACACGGAACTTTGCTGCCCTACTC
AGCGCAGGATGCAAGCTGTGGCCAACATGTCCATCGGGGCTATGTTCATCATGTACGGACTCAC
AGCTACCTTTGGATACCTTACCTTCTACAGCACTGTGAAGGCAGAGATGCTGGAGATGTACACC
CAGGAGGACCTGCTTATTCTTTGTGTGCGCCTGGCCGTACTGCTTGCAGTAACCCTCACTGTGC
CTGTTGTCCTTTTCCCTATCCGCCGAGCCCTCCAGCAGCTGCTCTTCCCAAGTAAGGCCTTCAG
CTGGCCACGACATGTGGCCATTGCCCTGATCCTGCTTATTTTGGTCAATATCCTTGTCATTTGT
GTGCCAACCATCCGGGATATCTTTGGGTTTATTGGCTCCACTTCAGCCCCTAGCCTCATCTTCA
TCCTTCCCAGTGTCTTCTACCTCCGCATTGTACCTGCTGACATGGAACCCTTGTTTTCCTGGCC
CAAGATCCAGGCCCTGTGTTTTGGCGTCCTGGGAGTCCTCTTCATGGCCATCAGTCTGGGCTTT
ATGTTTGCTAATTGGGCTACAGGCCAGAGCCGTATGTCTGGCCATTGAGCTGGCCTGTCCTGCC
TCACTCAGTCCCTGTGCTCACATGTGTGTATATTAGGGAATCCAAGTCACTTTCCTGAGTCCCT
TCTGCCTGGGACATGGAGGTGGCTGGTCTCTAGTAACACTGCTGTGGGAAATGGGGACAGTCGA
GGAGGCATAGTAAGTAGTCCATTTCCTTTTCCCCAGAGCTGCCTCACTGCCGACCCCATGAGAG
GAGGAAGGGAGGCCAGCTCCTTAGAAGGGTTCTTACCCAACATAGTTCTCACTTCCTAGATGAA
GCTGTTAGGCTTACCCTGGCGCTAAAAGGGAAGAATAAAGATGCTGAATGGCAA

hide sequence

RefSeq Acc Id:

XM_039099444 ⟹ XP_038955372

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	16,885,701 - 16,894,231 (-)	NCBI
mRatBN7.2	X	14,213,727 - 14,222,260 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_620209	(Get FASTA)	NCBI Sequence Viewer
	XP_008771290	(Get FASTA)	NCBI Sequence Viewer
	XP_038955372	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	A2VCW5	(Get FASTA)	NCBI Sequence Viewer
	AAI28726	(Get FASTA)	NCBI Sequence Viewer
	AAK69075	(Get FASTA)	NCBI Sequence Viewer
	EDL83782	(Get FASTA)	NCBI Sequence Viewer
	EDL83783	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000038781
	ENSRNOP00000038781.5
	ENSRNOP00000073818
	ENSRNOP00000073818.1
	ENSRNOP00055031259
	ENSRNOP00060031833
	ENSRNOP00065014643

RefSeq Acc Id:

NP_620209 ⟸ NM_138854

- UniProtKB:

A6KP35 (UniProtKB/TrEMBL), A0A0H2UHW1 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MEMQEPKMNGTLSTGAAAGYRQEREGFLPTTHGPAPGRKPVQFLDFEGKTSFGMSVFNLSNAIM
GSGILGLAYAMAHTGVIFFLALLLCIALLSSYSIHLLLTCASVVGIRAYEQLGQRAFGPAGKVV
VAIIICLHNVGAMSSYLFIIKSELPLVIGTFLHMDPEGDWFLKGNLLIILVSLLIILPLALMKH
LGYLGYTSSLSLTCMLFFLISVIYKKFQLGCVVSHNDTVVESEPAPLQAFNSSCEAKLFTVDSQ
MSYTVPIMAFAFVCHPEVLPIYTELCCPTQRRMQAVANMSIGAMFIMYGLTATFGYLTFYSTVK
AEMLEMYTQEDLLILCVRLAVLLAVTLTVPVVLFPIRRALQQLLFPSKAFSWPRHVAIALILLN
LVNILVICVPTIRDIFGFIGSTSAPSLIFILPSVFYLRIVPADMEPLFSWPKIQALCFGVLGVL
FMAISLGFMFANWATGQSRMSGH

hide sequence

RefSeq Acc Id:	XP_008771290 ⟸ XM_008773068
- Peptide Label:	isoform X1
- UniProtKB:	A2VCW5 (UniProtKB/Swiss-Prot), Q91XR7 (UniProtKB/Swiss-Prot), A6KP34 (UniProtKB/TrEMBL), A0A0H2UHW1 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAISGAVGMEMQEPKMNGTLSTGAAAGYRQEREGFLPTTHGPAPGRKPVQFLDFEGKTSFGMSV FNLSNAIMGSGILGLAYAMAHTGVIFFLALLLCIALLSSYSIHLLLTCASVVGIRAYEQLGQRA FGPAGKVVVAIIICLHNVGAMSSYLFIIKSELPLVIGTFLHMDPEGDWFLKGNLLIILVSLLII LPLALMKHLGYLGYTSSLSLTCMLFFLISVIYKKFQLGCVVSHNDTVVESEPAPLQAFNSSCEA KLFTVDSQMSYTVPIMAFAFVCHPEVLPIYTELCCPTQRRMQAVANMSIGAMFIMYGLTATFGY LTFYSTVKAEMLEMYTQEDLLILCVRLAVLLAVTLTVPVVLFPIRRALQQLLFPSKAFSWPRHV AIALILLILVNILVICVPTIRDIFGFIGSTSAPSLIFILPSVFYLRIVPADMEPLFSWPKIQAL CFGVLGVLFMAISLGFMFANWATGQSRMSGH hide sequence

RefSeq Acc Id:

ENSRNOP00000073818 ⟸ ENSRNOT00000079664

RefSeq Acc Id:

ENSRNOP00000038781 ⟸ ENSRNOT00000038068

RefSeq Acc Id:	XP_038955372 ⟸ XM_039099444
- Peptide Label:	isoform X2
- UniProtKB:	A0A0H2UHW1 (UniProtKB/TrEMBL)

Protein Domains

Amino acid transporter transmembrane

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-A2VCW5-F1-model_v2	AlphaFold	A2VCW5	1-479	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620702	AgrOrtholog
BioCyc Gene	G2FUF-2956	BioCyc
Ensembl Genes	ENSRNOG00000027767	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ENSRNOG00055022355	UniProtKB/Swiss-Prot
	ENSRNOG00060022262	UniProtKB/Swiss-Prot
	ENSRNOG00065011778	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000038068	UniProtKB/TrEMBL
	ENSRNOT00000038068.6	UniProtKB/Swiss-Prot
	ENSRNOT00000079664	ENTREZGENE
	ENSRNOT00000079664.2	UniProtKB/Swiss-Prot
	ENSRNOT00055038402	UniProtKB/Swiss-Prot
	ENSRNOT00060038574	UniProtKB/Swiss-Prot
	ENSRNOT00065019140	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:8362014	IMAGE-MGC_LOAD
InterPro	AA_transpt_TM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:192208	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:156591	IMAGE-MGC_LOAD
NCBI Gene	192208	ENTREZGENE
PANTHER	AMINO ACID TRANSPORTER	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 5	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Aa_trans	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Slc38a5	PhenoGen
RatGTEx	ENSRNOG00000027767	RatGTEx
	ENSRNOG00055022355	RatGTEx
	ENSRNOG00060022262	RatGTEx
	ENSRNOG00065011778	RatGTEx
UniProt	A0A0H2UHW1	ENTREZGENE, UniProtKB/TrEMBL
	A2VCW5	ENTREZGENE
	A6KP34	ENTREZGENE, UniProtKB/TrEMBL
	A6KP35	ENTREZGENE, UniProtKB/TrEMBL
	Q91XR7	ENTREZGENE
	S38A5_RAT	UniProtKB/Swiss-Prot
UniProt Secondary	Q91XR7	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2005-01-20	Slc38a5	solute carrier family 38, member 5	AF276870	amino acid transporter system N2	Symbol and Name updated	1299863	APPROVED
2002-08-07	AF276870	amino acid transporter system N2			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_expression	abundant in the liver, also expressed in brain, lung, stomach, kidney, testis, and spleen	628449
gene_homology	amino acid sequence identity between rat and human is 86%	628449
gene_process	mediates H+ movement across the membrane, and Na+-dependent transport of neutral amino into cells, leading to intracellular alkalization	628449
gene_protein	contains 471 amino acids	628449
gene_regulation	transport mechanism involves the influx of Na+ and amino acids coupled to the efflux of H+ and is electrogenic, Li+ tolerant, and pH sensitive	628449
gene_transcript	cDNA is 1,891 bp in length	628449

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar