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Gene Ontology Annotations
Gene Ontology AnnotationsBiological Process Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | brain renin-angiotensin system | | ISO | RGD:1550581 | 1624291 | MGI:MGI:3710915|PMID:16585392 | RGD | MGI:MGI:3710915 PMID:16585392 | cardiac muscle cell apoptotic process | | ISO | RGD:1550581 | 1624291 | MGI:MGI:3710915|PMID:16585392 | RGD | MGI:MGI:3710915 PMID:16585392 | cellular response to carbohydrate stimulus | | ISO | RGD:1550581 | 1624291 | MGI:MGI:3710915|PMID:16585392 | RGD | MGI:MGI:3710915 PMID:16585392 | heart contraction | | ISO | RGD:1550581 | 1624291 | MGI:MGI:3710915|PMID:16585392 | RGD | MGI:MGI:3710915 PMID:16585392 | heart development | | ISO | RGD:1550581 | 1624291 | MGI:MGI:3710915|PMID:16585392 | RGD | MGI:MGI:3710915 PMID:16585392 | intracellular protein kinase cascade | | IEA | InterPro:IPR016239 | 1600115 | GO_REF:0000002 | InterPro | GO_REF:0000002 | negative regulation of cell cycle | | ISO | RGD:1348784 | 1624291 | PMID:16878154 | RGD | PMID:16878154 | negative regulation of cell proliferation | | ISO | RGD:1348784 | 1624291 | PMID:16878154 | RGD | PMID:16878154 | negative regulation of meiosis | | ISO | RGD:1550581 | 1624291 | MGI:MGI:3521521|PMID:15526037 | RGD | MGI:MGI:3521521 PMID:15526037 | oocyte maturation | | ISO | RGD:1550581 | 1624291 | MGI:MGI:3521521|PMID:15526037 | RGD | MGI:MGI:3521521 PMID:15526037 | peptidyl-serine phosphorylation | | ISO | RGD:1550581 | 1624291 | MGI:MGI:64808|PMID:7508917 | RGD | MGI:MGI:64808 PMID:7508917 | positive regulation of apoptotic process | | ISO | RGD:1348784 | 1624291 | PMID:16878154 | RGD | PMID:16878154 | positive regulation of gene expression | | ISO | RGD:1550581 | 1624291 | MGI:MGI:3710915|PMID:16585392 | RGD | MGI:MGI:3710915 PMID:16585392 | protein phosphorylation | | ISO | RGD:1550581 | 1624291 | MGI:MGI:3521521|PMID:15526037 | RGD | MGI:MGI:3521521 PMID:15526037 | regulation of protein processing | | ISO | RGD:1550581 | 1624291 | MGI:MGI:3710915|PMID:16585392 | RGD | MGI:MGI:3710915 PMID:16585392 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Long-term potentiation |
| MAPK signaling pathway | |
| mTOR signaling pathway | |
| Neurotrophin signaling pathway | |
| Oocyte meiosis | |
| Progesterone-mediated oocyte maturation | |
Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Long-term potentiation |
| MAPK signaling pathway | |
| mTOR signaling pathway | |
| Neurotrophin signaling pathway | |
| Oocyte meiosis | |
| Progesterone-mediated oocyte maturation | |
References - curated| 1. |
Fingar DC, etal., Genes Dev 2002 Jun 15;16(12):1472-87. |
| 2. |
Gaestel M Nat Rev Mol Cell Biol. 2006 Feb;7(2):120-30. |
| 3. |
GOA data from the GO Consortium |
| 4. |
Kim YB, etal., Biochem Biophys Res Commun 1999 Jan 27;254(3):720-7. |
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MGD data from the GO Consortium |
| 6. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 7. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 8. |
RGD automated data pipeline |
| 9. |
RGD automated import pipeline for gene-chemical interactions |
References - uncurated
RGD Disease Portals| Rps6ka2 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Rps6ka2 (Rattus norvegicus) |
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| RPS6KA2 (Homo sapiens) |
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| Rps6ka2 (Mus musculus) |
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Position Markers| D1Rat489 |
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| RH127829 |
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| BF386574 |
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| BE096506 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_057128 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06002403 | (Get FASTA) | Search GEO for Microarray Profiles |
| AABR06002404 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06002405 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01003112 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01003113 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01003114 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01003115 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01003116 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01003117 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH474059 | (Get FASTA) | Search GEO for Microarray Profiles | |
| D83013 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_057128 | ||||||||||||||||||||
| RefSeq Status: | VALIDATED | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_476469 | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_476469 | (Get FASTA) |
| GenBank Protein | BAA74948 | (Get FASTA) |
| EDL83134 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000013194 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000017809 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Transcript | ENSRNOT00000017809 | ENTREZGENE, UniProtKB/TrEMBL |
| Entrez Gene | 117269 | ENTREZGENE |
| HomoloGene Group ID | 100680 | ENTREZGENE |
| InterPro | AGC-kinase_C | UniProtKB/TrEMBL |
| Kinase-like_dom | UniProtKB/TrEMBL | |
| Pkinase_C | UniProtKB/TrEMBL | |
| Prot_kinase_cat_dom | UniProtKB/TrEMBL | |
| Protein_kinase_ATP_BS | UniProtKB/TrEMBL | |
| Ribosomal_S6_kinase_II | UniProtKB/TrEMBL | |
| Ser/Thr_dual-sp_kinase_dom | UniProtKB/TrEMBL | |
| Ser/Thr_kinase_AS | UniProtKB/TrEMBL | |
| Tyr_kinase_AS | UniProtKB/TrEMBL | |
| KEGG Report | rno:117269 | ENTREZGENE |
| Pfam | Pkinase | UniProtKB/TrEMBL |
| Pkinase_C | UniProtKB/TrEMBL | |
| PIRSF | Ribsml_S6_kin_2 | UniProtKB/TrEMBL |
| PROSITE | AGC_KINASE_CTER | UniProtKB/TrEMBL |
| PROTEIN_KINASE_ATP | UniProtKB/TrEMBL | |
| PROTEIN_KINASE_DOM | UniProtKB/TrEMBL | |
| PROTEIN_KINASE_ST | UniProtKB/TrEMBL | |
| PROTEIN_KINASE_TYR | UniProtKB/TrEMBL | |
| SMART | S_TK_X | UniProtKB/TrEMBL |
| S_TKc | UniProtKB/TrEMBL | |
| Superfamily-SCOP | Kinase_like | UniProtKB/TrEMBL |
| UniGene | Rn.2356 | ENTREZGENE |
| UniProt | F1M7N7_RAT | UniProtKB/TrEMBL |
| Q9Z1I2_RAT | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2005-01-20 | Rps6ka2 | ribosomal protein S6 kinase, polypeptide 2 | ribosomal protein S6 kinase, 90kD, polypeptide 2 | Name updated | 10779 | APPROVED | |
| 2002-08-07 | Rps6ka2 | ribosomal protein S6 kinase, 90kD, polypeptide 2 | Symbol and Name status set to provisional | 1724 | PROVISIONAL |
| More on Rps6ka2 | |
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Entrez Gene |
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Ensembl Gene |
![]() | Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 620676 |
| Created: | 2002-08-06 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-05-28 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




