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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:731545 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of PDP1 mRNA | CTD | PMID:20106945 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:1618761 | 6480464 | Tetrachlorodibenzodioxin affects the expression of PDP1 mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:731545 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of PDP1 mRNA | CTD | PMID:20106945 PMID:21632981 | 2,4-dinitrotoluene | affects expression | EXP | | 6480464 | 2,4-dinitrotoluene affects the expression of PDP1 mRNA | CTD | PMID:21346803 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of PDP1 mRNA | CTD | PMID:16483693 | benzo[a]pyrene | multiple interactions | ISO | RGD:1618761 | 6480464 | [Benzo(a)pyrene co-treated with XPA gene mutant form co-treated with TRP53 gene mutant form] results in increased expression of PDP1 mRNA; more ... | CTD | PMID:21715664 | benzo[a]pyrene | decreases expression | EXP | | 6480464 | Benzo(a)pyrene results in decreased expression of PDP1 mRNA | CTD | PMID:21839799 | calcitriol | decreases expression | ISO | RGD:731545 | 6480464 | Calcitriol results in decreased expression of PDP1 mRNA | CTD | PMID:16002434 | choline | multiple interactions | ISO | RGD:1618761 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PDP1 mRNA | CTD | PMID:20938992 | copper atom | multiple interactions | ISO | RGD:731545 | 6480464 | [NSC 689534 binds to Copper] which results in increased expression of PDP1 mRNA | CTD | PMID:20971185 | copper atom | increases expression | EXP | | 6480464 | Copper results in increased expression of PDP1 mRNA | CTD | PMID:22465980 | copper(0) | multiple interactions | ISO | RGD:731545 | 6480464 | [NSC 689534 binds to Copper] which results in increased expression of PDP1 mRNA | CTD | PMID:20971185 | copper(0) | increases expression | EXP | | 6480464 | Copper results in increased expression of PDP1 mRNA | CTD | PMID:22465980 | copper(2+) sulfate | increases expression | ISO | RGD:731545 | 6480464 | Copper Sulfate results in increased expression of PDP1 mRNA | CTD | PMID:19549813 | coumestrol | decreases expression | ISO | RGD:731545 | 6480464 | Coumestrol results in decreased expression of PDP1 mRNA | CTD | PMID:19167446 | crocidolite asbestos | increases expression | ISO | RGD:731545 | 6480464 | Asbestos, Crocidolite results in increased expression of PDP1 mRNA | CTD | PMID:18687144 | cyclosporin A | increases expression | ISO | RGD:731545 | 6480464 | Cyclosporine results in increased expression of PDP1 mRNA | CTD | PMID:20106945 | cyclosporin A | decreases expression | ISO | RGD:731545 | 6480464 | Cyclosporine results in decreased expression of PDP1 mRNA | CTD | PMID:22147139 | D-glucose | multiple interactions | EXP | | 6480464 | [Dexamethasone results in decreased oxidation of Glucose] which results in increased phosphorylation of and results in decreased activity of PDP1 protein | CTD | PMID:20181797 | dexamethasone | multiple interactions | EXP | | 6480464 | [Dexamethasone results in decreased oxidation of Glucose] which results in increased phosphorylation of and results in decreased activity of PDP1 protein; more ... | CTD | PMID:20181797 | dibutyl phthalate | increases expression | EXP | | 6480464 | Dibutyl Phthalate results in increased expression of PDP1 mRNA | CTD | PMID:21266533 | folic acid | multiple interactions | ISO | RGD:1618761 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PDP1 mRNA | CTD | PMID:20938992 | glucose | multiple interactions | EXP | | 6480464 | [Dexamethasone results in decreased oxidation of Glucose] which results in increased phosphorylation of and results in decreased activity of PDP1 protein | CTD | PMID:20181797 | hydrogen peroxide | increases expression | ISO | RGD:731545 | 6480464 | Hydrogen Peroxide results in increased expression of PDP1 mRNA | CTD | PMID:18951874 | indomethacin | decreases expression | ISO | RGD:731545 | 6480464 | Indomethacin results in decreased expression of PDP1 mRNA | CTD | PMID:16984733 | L-methionine | multiple interactions | ISO | RGD:1618761 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PDP1 mRNA | CTD | PMID:20938992 | methapyrilene | increases expression | EXP | | 6480464 | Methapyrilene results in increased expression of PDP1 mRNA | CTD | PMID:16393664 | N-ethyl-N-nitrosourea | increases expression | EXP | | 6480464 | Ethylnitrosourea results in increased expression of PDP1 mRNA | CTD | PMID:15954086 | nicotinamide | multiple interactions | EXP | | 6480464 | Niacinamide inhibits the reaction [Dexamethasone results in increased phosphorylation of PDP1 protein] | CTD | PMID:20181797 | paracetamol | affects expression | ISO | RGD:1618761 | 6480464 | Acetaminophen affects the expression of PDP1 mRNA | CTD | PMID:17562736 | perfluorooctanoic acid | increases expression | EXP | | 6480464 | perfluorooctanoic acid results in increased expression of PDP1 mRNA | CTD | PMID:19162173 | progesterone | decreases expression | ISO | RGD:731545 | 6480464 | Progesterone results in decreased expression of PDP1 mRNA | CTD | PMID:18037150 | quercetin | affects expression | ISO | RGD:731545 | 6480464 | Quercetin affects the expression of PDP1 mRNA | CTD | PMID:21632981 | raloxifene | multiple interactions | ISO | RGD:731545 | 6480464 | [Raloxifene co-treated with ESR2 protein] results in increased expression of PDP1 mRNA | CTD | PMID:19059307 | tamoxifen | multiple interactions | ISO | RGD:731545 | 6480464 | [Tamoxifen co-treated with ESR2 protein] results in increased expression of PDP1 mRNA | CTD | PMID:19059307 | tert-butyl hydroperoxide | increases expression | ISO | RGD:731545 | 6480464 | tert-Butylhydroperoxide results in increased expression of PDP1 mRNA | CTD | PMID:15336504 | testosterone enanthate | affects expression | ISO | RGD:731545 | 6480464 | testosterone enanthate affects the expression of PDP1 mRNA | CTD | PMID:17440010 | tetrachloromethane | affects expression | ISO | RGD:1618761 | 6480464 | Carbon Tetrachloride affects the expression of PDP1 mRNA | CTD | PMID:17484886 | zinc atom | increases expression | EXP | | 6480464 | Zinc results in increased expression of PDP1 mRNA | CTD | PMID:17074742 | zinc sulfate | increases expression | EXP | | 6480464 | Zinc Sulfate results in increased expression of PDP1 mRNA | CTD | PMID:17074742 | zinc(0) | increases expression | EXP | | 6480464 | Zinc results in increased expression of PDP1 mRNA | CTD | PMID:17074742 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations
Disease Annotations
Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
References - curated| 1. |
Huang B, etal., Diabetes. 2003 Jun;52(6):1371-6. |
| 2. |
Huang B, etal., J Biol Chem 1998 Jul 10;273(28):17680-8. |
| 3. |
Karpova T, etal., Biochim Biophys Acta. 2004 Jul 1;1700(1):43-51. |
| 4. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 5. |
Piccinini M, etal., Obes Res. 2005 Apr;13(4):678-86. |
| 6. |
RGD automated data pipeline |
| 7. |
RGD automated import pipeline for gene-chemical interactions |
| 8. |
RGD Automated Pipelines |
| 9. |
Roche TE and Hiromasa Y, Cell Mol Life Sci. 2007 Apr;64(7-8):830-49. |
| 10. |
Vassylyev DG and Symersky J, J Mol Biol. 2007 Jul 13;370(3):417-26. Epub 2007 May 10. |
References - uncurated
RGD Disease Portals| Pdp1 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Pdp1 (Rattus norvegicus) |
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| PDP1 (Homo sapiens) |
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| Pdp1 (Mus musculus) |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_001271108 | (Get FASTA) | Search GEO for Microarray Profiles |
| NM_019372 | (Get FASTA) | Search GEO for Microarray Profiles | |
| GenBank Nucleotide | AABR06035506 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHX01034955 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF062740 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AW520836 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC129095 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BQ193551 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473962 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FN800686 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_019372 | ||||||||||||||||||||
| RefSeq Status: | VALIDATED | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_062245 | ||||||||||||||||||||
| Peptide Label: | precursor | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_001258037 | (Get FASTA) |
| NP_062245 | (Get FASTA) | |
| GenBank Protein | AAC40167 | (Get FASTA) |
| AAI29096 | (Get FASTA) | |
| EDL98444 | (Get FASTA) | |
| EDL98445 | (Get FASTA) | |
| EDL98446 | (Get FASTA) | |
| O88483 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000016180 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000062054 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Transcript | ENSRNOT00000067823 | ENTREZGENE, UniProtKB/TrEMBL |
| Entrez Gene | 54705 | ENTREZGENE |
| Gene3D-CATH | PP2C-related | UniProtKB/Swiss-Prot |
| Germonline | ENSRNOG00000016180 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 31928 | ENTREZGENE |
| IMAGE_CLONE | IMAGE:8369880 | IMAGE-MGC_LOAD |
| InterPro | PP2C | UniProtKB/Swiss-Prot |
| PP2C-related | UniProtKB/Swiss-Prot | |
| PP2C_Mn2_Asp60_BS | UniProtKB/Swiss-Prot | |
| IPI | IPI00209752 | UniProtKB/Swiss-Prot |
| IPI00951216 | UniProtKB/TrEMBL | |
| KEGG Report | rno:54705 | ENTREZGENE, UniProtKB/TrEMBL |
| MGC_CLONE | MGC:156655 | IMAGE-MGC_LOAD |
| PANTHER | PP2C | UniProtKB/Swiss-Prot |
| Pfam | PP2C | UniProtKB/Swiss-Prot |
| PROSITE | PP2C | UniProtKB/Swiss-Prot |
| SMART | PP2C_SIG | UniProtKB/Swiss-Prot |
| PP2Cc | UniProtKB/Swiss-Prot | |
| Superfamily-SCOP | PP2C-related | UniProtKB/Swiss-Prot |
| UniGene | Rn.31799 | ENTREZGENE |
| UniProt | A1L1J4_RAT | UniProtKB/TrEMBL |
| PDP1_RAT | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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| 2010-04-23 | Pdp1 | pyruvate dehyrogenase phosphatase catalytic subunit 1 | Ppm2c | protein phosphatase 2C, magnesium dependent, catalytic subunit | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2004-09-10 | Ppm2c | protein phosphatase 2C, magnesium-dependent, catalytic subunit | PDP1 | pyruvate dehydrogenase phosphatase isoenzyme 1 | Symbol and Name updated | 10779 | APPROVED |
| 2002-08-07 | PDP1 | pyruvate dehydrogenase phosphatase isoenzyme 1 | Symbol and Name status set to provisional | 1724 | PROVISIONAL |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_expression | predominantly expressed in mitochondria from skeletal muscle | 729524 |
| gene_function | Mg2+-dependent enzyme | 729524 |
| More on Pdp1 | |
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Entrez Gene |
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Ensembl Gene |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 620393 |
| Created: | 2002-08-06 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




