Cetn2 (centrin 2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Cetn2 (centrin 2) Rattus norvegicus
Analyze
Symbol: Cetn2
Name: centrin 2
RGD ID: 620247
Description: Predicted to enable several functions, including G-protein beta/gamma-subunit complex binding activity; calcium ion binding activity; and heterotrimeric G-protein binding activity. Predicted to be involved in several processes, including centriole replication; nucleotide-excision repair; and regulation of cytokinesis. Located in centrosome. Orthologous to human CETN2 (centrin 2); PARTICIPATES IN nucleotide excision repair pathway; INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Calt; Caltractin; centrin, EF-hand protein, 2; centrin-2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X155,812,212 - 155,817,186 (-)NCBIGRCr8
mRatBN7.2X150,769,944 - 150,774,833 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX150,769,953 - 150,774,919 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX152,961,970 - 152,966,859 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X156,494,314 - 156,499,203 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X154,037,424 - 154,042,313 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X152,927,852 - 152,933,095 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX152,927,718 - 152,932,953 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01148,656,625 - 148,661,864 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X158,917,650 - 158,923,210 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X158,991,770 - 158,994,109 (-)NCBI
Celera1131,733,984 - 131,739,094 (-)NCBICelera
Cytogenetic MapXq37NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. TFIIH: when transcription met DNA repair. Compe E and Egly JM, Nat Rev Mol Cell Biol. 2012 May 10;13(6):343-54. doi: 10.1038/nrm3350.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Expression of centrin isoforms in the mammalian retina. Wolfrum U and Salisbury JL, Exp Cell Res 1998 Jul 10;242(1):10-7.
Additional References at PubMed
PMID:11250075   PMID:11279143   PMID:12176356   PMID:12802058   PMID:12840069   PMID:14581517   PMID:15347651   PMID:15964821   PMID:16760425   PMID:17920017   PMID:18207742   PMID:18239929  
PMID:18269917   PMID:18762898   PMID:20081859   PMID:21399614   PMID:22349705   PMID:23591820   PMID:24421332   PMID:25088364   PMID:29891944  


Genomics

Comparative Map Data
Cetn2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X155,812,212 - 155,817,186 (-)NCBIGRCr8
mRatBN7.2X150,769,944 - 150,774,833 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX150,769,953 - 150,774,919 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX152,961,970 - 152,966,859 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X156,494,314 - 156,499,203 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X154,037,424 - 154,042,313 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X152,927,852 - 152,933,095 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX152,927,718 - 152,932,953 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01148,656,625 - 148,661,864 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X158,917,650 - 158,923,210 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X158,991,770 - 158,994,109 (-)NCBI
Celera1131,733,984 - 131,739,094 (-)NCBICelera
Cytogenetic MapXq37NCBI
CETN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X152,826,994 - 152,830,757 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX152,826,994 - 152,830,757 (-)EnsemblGRCh38hg38GRCh38
GRCh37X151,995,538 - 151,999,301 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X151,746,527 - 151,749,957 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X151,666,440 - 151,669,869NCBI
CeleraX152,330,255 - 152,333,685 (-)NCBICelera
Cytogenetic MapXq28NCBI
CHM1_1X151,870,461 - 151,873,892 (-)NCBICHM1_1
T2T-CHM13v2.0X151,093,478 - 151,097,241 (-)NCBIT2T-CHM13v2.0
Cetn2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X71,957,137 - 71,961,967 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX71,957,138 - 71,962,017 (-)EnsemblGRCm39 Ensembl
GRCm38X72,913,565 - 72,918,344 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX72,913,532 - 72,918,411 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X70,158,904 - 70,163,683 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X69,166,285 - 69,171,064 (-)NCBIMGSCv36mm8
CeleraX63,848,732 - 63,853,510 (-)NCBICelera
Cytogenetic MapXA7.3NCBI
cM MapX37.29NCBI
Cetn2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554988,131,295 - 8,135,751 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554988,131,356 - 8,135,751 (-)NCBIChiLan1.0ChiLan1.0
CETN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X152,891,513 - 152,895,020 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X152,895,116 - 152,898,630 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X142,401,679 - 142,405,206 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X152,320,893 - 152,324,362 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX152,320,893 - 152,324,362 (-)Ensemblpanpan1.1panPan2
CETN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X120,714,676 - 120,720,012 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX106,083,242 - 106,088,561 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X122,939,332 - 122,944,667 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX122,939,337 - 122,944,584 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X119,655,565 - 119,660,884 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X122,146,252 - 122,151,579 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X122,021,281 - 122,026,614 (-)NCBIUU_Cfam_GSD_1.0
Cetn2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X117,977,261 - 117,982,406 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936714274,036 - 279,381 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936714274,098 - 279,177 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CETN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX123,902,241 - 123,906,230 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X123,902,240 - 123,906,046 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X141,372,858 - 141,376,715 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CETN2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X127,339,163 - 127,342,626 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX127,338,862 - 127,341,575 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606565,172,423 - 65,175,920 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cetn2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248834,035,647 - 4,039,732 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248834,035,647 - 4,039,758 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:61
Count of miRNA genes:54
Interacting mature miRNAs:55
Transcripts:ENSRNOT00000065164
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10059603Bw174Body weight QTL 1743.40.025body mass (VT:0001259)body weight (CMO:0000012)X113937816152453651Rat
634346Insul4Insulin level QTL 40blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)X126975089152453651Rat

Markers in Region
RH139236  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X150,770,013 - 150,770,170 (+)MAPPERmRatBN7.2
Rnor_6.0X152,927,915 - 152,928,071NCBIRnor6.0
Rnor_5.01148,656,688 - 148,656,844UniSTSRnor5.0
RGSC_v3.4X158,917,879 - 158,918,035UniSTSRGSC3.4
Celera1131,734,047 - 131,734,203UniSTS
Cytogenetic MapXq37.1-q37.2UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 10 74 35 34 11 8
Low 1 7
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000078929   ⟹   ENSRNOP00000073318
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX150,769,953 - 150,774,919 (-)Ensembl
Rnor_6.0 EnsemblX152,927,718 - 152,932,953 (-)Ensembl
RefSeq Acc Id: NM_001400933   ⟹   NP_001387862
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X155,812,212 - 155,817,101 (-)NCBI
mRatBN7.2X150,769,944 - 150,774,833 (-)NCBI
RefSeq Acc Id: NM_001400934   ⟹   NP_001387863
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X155,812,212 - 155,817,101 (-)NCBI
mRatBN7.2X150,769,944 - 150,774,833 (-)NCBI
RefSeq Acc Id: XM_063280344   ⟹   XP_063136414
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X155,812,219 - 155,817,186 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000073318   ⟸   ENSRNOT00000078929
RefSeq Acc Id: NP_001387863   ⟸   NM_001400934
- Peptide Label: isoform 2
- UniProtKB: A6KSY4 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001387862   ⟸   NM_001400933
- Peptide Label: isoform 1
- UniProtKB: G3V9W0 (UniProtKB/TrEMBL),   A6KSY5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063136414   ⟸   XM_063280344
- Peptide Label: isoform X1
Protein Domains
EF-hand

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V9W0-F1-model_v2 AlphaFold G3V9W0 1-172 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13702033
Promoter ID:EPDNEW_R12552
Type:initiation region
Name:Cetn2_1
Description:centrin 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X152,932,867 - 152,932,927EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620247 AgrOrtholog
BioCyc Gene G2FUF-693 BioCyc
Ensembl Genes ENSRNOG00000059593 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000078929 ENTREZGENE
  ENSRNOT00000078929.2 UniProtKB/TrEMBL
Gene3D-CATH EF-hand UniProtKB/TrEMBL
InterPro EF-hand-like_dom UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/TrEMBL
  EF_hand_Ca-bd UniProtKB/TrEMBL
  RNA-helicase_DEAD-box_CS UniProtKB/TrEMBL
KEGG Report rno:84593 UniProtKB/TrEMBL
NCBI Gene 84593 ENTREZGENE
PANTHER CALCIUM BINDING PROTEIN UniProtKB/TrEMBL
  PTHR23050:SF305 UniProtKB/TrEMBL
Pfam EF_hand_5 UniProtKB/TrEMBL
PhenoGen Cetn2 PhenoGen
PROSITE DEAD_ATP_HELICASE UniProtKB/TrEMBL
  EF_HAND_1 UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000059593 RatGTEx
SMART EFh UniProtKB/TrEMBL
Superfamily-SCOP SSF47473 UniProtKB/TrEMBL
UniProt A6KSY4 ENTREZGENE, UniProtKB/TrEMBL
  A6KSY5 ENTREZGENE, UniProtKB/TrEMBL
  G3V9W0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-09 Cetn2  centrin 2  Cetn2  centrin, EF-hand protein, 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-12-14 Cetn2  centrin 2      Symbol and Name status set to approved 1299863 APPROVED
2003-04-14 Cetn2  centrin 2  Calt  Caltractin  Data merged from RGD:2260 628472 PENDING
2002-08-07 Cetn2  centrin 2      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Calt  Caltractin      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA may be ubiquitously expressed 1303363