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Gene-Chemical Interaction AnnotationsGene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of SLC8A2 mRNA | CTD | PMID:16483693 | benzo[a]pyrene | multiple interactions | ISO | RGD:736037 | 6480464 | [Benzo(a)pyrene co-treated with XPA gene mutant form co-treated with TRP53 gene mutant form] affects the expression of SLC8A2 mRNA | CTD | PMID:21715664 | calcium atom | increases uptake | EXP | | 6480464 | SLC8A2 protein results in increased uptake of Calcium | CTD | PMID:14660663 | calcium(0) | increases uptake | EXP | | 6480464 | SLC8A2 protein results in increased uptake of Calcium | CTD | PMID:14660663 | paracetamol | decreases expression | ISO | RGD:731774 | 6480464 | Acetaminophen results in decreased expression of SLC8A2 mRNA | CTD | PMID:22230336 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology AnnotationsMolecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Calcium signaling pathway |
| Protein digestion and absorption | |
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Calcium signaling pathway |
| Protein digestion and absorption | |
References - curated| 1. |
Bojarski C, etal., Brain Res. 2008 Jan 16;1189:198-202. Epub 2007 Nov 1. |
| 2. |
Boscia F, etal., J Cereb Blood Flow Metab. 2006 Apr;26(4):502-17. |
| 3. |
Brini M, etal., Ann N Y Acad Sci 2002 Nov;976:376-81. |
| 4. |
Ketelaars SO, etal., Epilepsia. 2004 Oct;45(10):1189-201. |
| 5. |
Li Z, etal., J Biol Chem 1994 Jul 1;269(26):17434-9. |
| 6. |
Linck B, etal., Am J Physiol. 1998 Feb;274(2 Pt 1):C415-23. |
| 7. |
Lu J, etal., Neurosci Lett 2002 Oct 25;332(1):21-4. |
| 8. |
Lytton J Biochem J. 2007 Sep 15;406(3):365-82. |
| 9. |
MGD data from the GO Consortium |
| 10. |
Minelli A, etal., Cell Calcium. 2007 Mar;41(3):221-34. Epub 2006 Aug 17. |
| 11. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 12. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 13. |
Polumuri SK, etal., Ann N Y Acad Sci. 2002 Nov;976:60-3. |
| 14. |
Pulina MV, etal., J Biol Chem. 2006 Jul 14;281(28):19645-54. Epub 2006 May 5. |
| 15. |
RGD automated data pipeline |
| 16. |
RGD automated import pipeline for gene-chemical interactions |
| 17. |
Secondo A, etal., Cell Calcium. 2007 Dec;42(6):521-35. Epub 2007 Mar 6. |
| 18. |
Thurneysen T, etal., Ann N Y Acad Sci 2002 Nov;976:367-75. |
| 19. |
Yamauchi D, etal., BMC Physiol. 2010 Jan 29;10:1. |
References - uncuratedRGD Disease Portals| Slc8a2 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Slc8a2 (Rattus norvegicus) |
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| SLC8A2 (Homo sapiens) |
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| Slc8a2 (Mus musculus) |
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Position Markers| D1Got72 |
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| BE106527 |
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| RH137848 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_078619 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06003773 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHX01004072 | (Get FASTA) | Search GEO for Microarray Profiles | |
| U08141 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_078619 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_511174 | ||||||||||||||||||||
| Peptide Label: | precursor | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_511174 | (Get FASTA) |
| GenBank Protein | AAA19920 | (Get FASTA) |
| P48768 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000001492 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000042012 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Transcript | ENSRNOT00000047289 | ENTREZGENE, UniProtKB/TrEMBL |
| Entrez Gene | 140447 | ENTREZGENE |
| Germonline | ENSRNOG00000001492 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 27358 | ENTREZGENE |
| InterPro | Calx_beta | UniProtKB/Swiss-Prot |
| Na_Ca_Ex | UniProtKB/Swiss-Prot | |
| NaCa_Exmemb | UniProtKB/Swiss-Prot | |
| IPI | IPI00777757 | UniProtKB/Swiss-Prot |
| KEGG Report | rno:140447 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Pfam | Calx-beta | UniProtKB/Swiss-Prot |
| Na_Ca_ex | UniProtKB/Swiss-Prot | |
| PharmGKB | SLC8A2 | RGD |
| PRINTS | NACAEXCHNGR | UniProtKB/Swiss-Prot |
| SMART | Calx_beta | UniProtKB/Swiss-Prot |
| TIGRFAMs | caca | UniProtKB/Swiss-Prot |
| UniGene | Rn.10305 | ENTREZGENE |
| UniProt | F1M9A2_RAT | UniProtKB/TrEMBL |
| NAC2_RAT | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2004-02-26 | Slc8a2 | solute carrier family 8 (sodium/calcium exchanger), member 2 | Symbol and Name status set to approved | 2225 | APPROVED | ||
| 2002-08-07 | Slc8a2 | solute carrier family 8 (sodium/calcium exchanger), member 2 | Symbol and Name status set to provisional | 1724 | PROVISIONAL |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_expression | mRNA expressed in cerebral cortex and hippocampus | 727449 |
| gene_protein | protein contains 921 aa residues | 730182 |
| More on Slc8a2 | |
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Entrez Gene |
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Ensembl Gene |
| Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 620194 |
| Created: | 2002-08-06 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.