Gene: Mkln1 (muskelin 1, intracellular mediator containing kelch motifs)
Rattus norvegicus |
| Symbol: |
Mkln1
|
| Name: |
muskelin 1, intracellular mediator containing kelch motifs
|
| Description: |
FOUND IN cytoplasm (inferred); INTERACTS WITH 1,2,4-trimethylbenzene; 2,4-dinitrotoluene; 2,6-dinitrotoluene |
| Type: |
protein-coding
|
| RefSeq Status: |
PROVISIONAL
|
| Also known as: |
muskelin; muskelin 1, intracellular mediator containing kelch motifs
|
| Orthologs: |
Homo sapiens : MKLN1
(muskelin 1, intracellular mediator containing kelch motifs)
HGNC
Mus musculus : Mkln1
(muskelin 1, intracellular mediator containing kelch motifs)
MGI
|
| Latest Assembly: |
RGSC Genome Assembly v3.4
|
| Position: |
| Map | Chr | Position | Strand | Source |
|---|
Rat Cytogenetic Map | 4 | q22 | | NCBI | RGSC Genome Assembly v5.0 | 4 | 58,448,153 - 58,570,396 | + | NCBI | RGSC Genome Assembly v3.4 | 4 | 58,475,702 - 58,600,770 | + | NCBI | Rat Celera Assembly | 4 | 55,092,934 - 55,213,778 | + | NCBI | Genome Assembly 3.1 | 4 | 58,751,831 - 58,876,900 | + | NCBI |
|
| Model |
|
 Gene-Chemical Interaction Annotations
| (-)-epigallocatechin 3-gallate | multiple interactions | ISO | RGD:734391 | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of MKLN1 mRNA | CTD | PMID:22079256 | | 1,2,4-trimethylbenzene | decreases expression | EXP | | 6480464 | pseudocumene results in decreased expression of MKLN1 protein | CTD | PMID:17337753 | | 17alpha-ethynylestradiol | affects expression | ISO | RGD:734392 | 6480464 | Ethinyl Estradiol affects the expression of MKLN1 mRNA | CTD | PMID:17555576 | | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:734392 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of MKLN1 mRNA | CTD | PMID:19465110 | | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:734392 | 6480464 | Tetrachlorodibenzodioxin affects the expression of MKLN1 mRNA | CTD | PMID:21570461 | | 2,4-dinitrotoluene | affects expression | EXP | | 6480464 | 2,4-dinitrotoluene affects the expression of MKLN1 mRNA | CTD | PMID:21346803 | | 2,6-dinitrotoluene | affects expression | EXP | | 6480464 | 2,6-dinitrotoluene affects the expression of MKLN1 mRNA | CTD | PMID:21346803 | | aflatoxin B1 | increases expression | ISO | RGD:734391 | 6480464 | Aflatoxin B1 results in increased expression of MKLN1 mRNA | CTD | PMID:21641981 | | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of MKLN1 mRNA | CTD | PMID:16483693 | | benzo[a]pyrene | multiple interactions | ISO | RGD:734392 | 6480464 | [Benzo(a)pyrene co-treated with XPA gene mutant form co-treated with TRP53 gene mutant form] results in decreased expression of MKLN1 mRNA | CTD | PMID:21715664 | | benzo[a]pyrene | decreases expression | ISO | RGD:734392 | 6480464 | Benzo(a)pyrene results in decreased expression of MKLN1 mRNA | CTD | PMID:19770486 | | bisphenol A | decreases expression | ISO | RGD:734391 | 6480464 | bisphenol A results in decreased expression of MKLN1 mRNA | CTD | PMID:20678512 | | calcitriol | increases expression | ISO | RGD:734391 | 6480464 | Calcitriol results in increased expression of MKLN1 mRNA | CTD | PMID:21592394 | | calcitriol | multiple interactions | ISO | RGD:734391 | 6480464 | [Testosterone co-treated with Calcitriol] results in increased expression of MKLN1 mRNA | CTD | PMID:21592394 | | copper(2+) sulfate | increases expression | ISO | RGD:734391 | 6480464 | Copper Sulfate results in increased expression of MKLN1 mRNA | CTD | PMID:19549813 | | crocidolite asbestos | increases expression | ISO | RGD:734391 | 6480464 | Asbestos, Crocidolite results in increased expression of MKLN1 mRNA | CTD | PMID:18687144 | | paracetamol | decreases expression | ISO | RGD:734391 | 6480464 | Acetaminophen results in decreased expression of MKLN1 mRNA | CTD | PMID:21420995 | | pirinixic acid | increases expression | ISO | RGD:734392 | 6480464 | pirinixic acid results in increased expression of MKLN1 mRNA | CTD | PMID:18301758 | | pirinixic acid | decreases expression | ISO | RGD:734392 | 6480464 | pirinixic acid results in decreased expression of MKLN1 mRNA | CTD | PMID:18445702 | | propiconazole | decreases expression | ISO | RGD:734392 | 6480464 | propiconazole results in decreased expression of MKLN1 mRNA | CTD | PMID:21278054 | | tamoxifen | affects expression | ISO | RGD:734392 | 6480464 | Tamoxifen affects the expression of MKLN1 mRNA | CTD | PMID:17555576 | | testosterone | multiple interactions | ISO | RGD:734391 | 6480464 | [Testosterone co-treated with Calcitriol] results in increased expression of MKLN1 mRNA | CTD | PMID:21592394 | | testosterone | decreases expression | ISO | RGD:734391 | 6480464 | Testosterone results in decreased expression of MKLN1 mRNA | CTD | PMID:21592394 | | zinc atom | multiple interactions | ISO | RGD:734391 | 6480464 | [PCI 5002 co-treated with Zinc] results in increased expression of MKLN1 mRNA | CTD | PMID:18593933 | | zinc(0) | multiple interactions | ISO | RGD:734391 | 6480464 | [PCI 5002 co-treated with Zinc] results in increased expression of MKLN1 mRNA | CTD | PMID:18593933 | |
 Gene Ontology Annotations
Cellular Component
| cytoplasm | | IEA | UniProtKB-SubCell:SL-0086 | 1600115 | GO_REF:0000039 | UniProtKB | GO_REF:0000039 | |
| 631261 | Tcas3 | Tongue tumor susceptibility QTL 3 | 6 | | Tongue tumor susceptibility | | 4 | 6179441 | 91330582 | Rat |
| 631546 | Bp86 | Blood pressure QTL 86 | 3.2 | | Blood pressure | systolic | 4 | 55369931 | 91330856 | Rat |
| 61445 | Strs3 | Sensitivity to stroke QTL 3 | 3 | | Stroke susceptibility | latency until stroke | 4 | 39146794 | 84146794 | Rat |
| 61475 | Aia2 | Adjuvant induced arthritis QTL 2 | 5.8 | | Joint/bone inflammation | adjuvant induced | 4 | 36592628 | 73972591 | Rat |
| 70200 | Alc18 | Alcohol consumption QTL 18 | 9.2 | | Consumption level | alcohol preference | 4 | 54828166 | 152570244 | Rat |
| 619616 | Bp79 | Blood pressure QTL 79 | | .0292 | Blood pressure | systolic | 4 | 456799 | 78039637 | Rat |
| 634344 | Hcar7 | Hepatocarcinoma resistance QTL 7 | 7.8 | | Liver tumor resistance | 3-methyl-4-dimethylaminoazobenzene induced | 4 | 58550170 | 93498821 | Rat |
| 634311 | Sach7 | Saccharin preference QTL 7 | | | Consumption level | saccharin preference | 4 | 55369931 | 80464927 | Rat |
| 738009 | Sach4 | Saccharine consumption QTL 4 | 4.9 | .000016 | Consumption level | saccharin preference | 4 | 58421110 | 158108528 | Rat |
| 738016 | Alc16 | Alcohol consumption QTL 16 | 3.6 | .00015 | Consumption level | alcohol preference | 4 | 58421110 | 158108528 | Rat |
| 1298082 | Stresp4 | Stress response QTL 4 | | | Hormone level | corticosterone | 4 | 47889730 | 149560340 | Rat |
| 738031 | Alc14 | Alcohol consumption QTL 14 | 7.6 | .00003 | Consumption level | alcohol preference | 4 | 58421110 | 158108528 | Rat |
| 61336 | Bp21 | Blood pressure QTL 21 | 4.6 | | Blood pressure | salt-loaded systolic | 4 | 55370202 | 78038013 | Rat |
| 1300139 | Hrtrt6 | Heart rate QTL 6 | 2.85 | | Heart rate | salt-loaded | 4 | 36611842 | 117887968 | Rat |
| 1331807 | Rf31 | Renal function QTL 31 | 2.988 | | Renal function | urine potassium concentration | 4 | 36611842 | 73752590 | Rat |
| 1354612 | Foco1 | Food consumption QTL 1 | 8.87 | | Consumption level | food intake | 4 | 41729771 | 151158666 | Rat |
| 1358203 | Stl19 | Serum triglyceride level QTL 19 | 2.8 | .002 | Lipid level | triglyceride | 4 | 460493 | 64750077 | Rat |
| 1354660 | Salc1 | Saline consumption QTL 1 | 11.26 | | Consumption level | saline intake | 4 | 41729771 | 151158666 | Rat |
| 2312567 | Glom19 | Glomerulus QTL 19 | 1.9 | .006 | Renal pathology | | 4 | 43686352 | 149560340 | Rat |
| 1558651 | Swd3 | Spike wave discharge measurement QTL 3 | 4.62 | .000024 | Spike wave discharge measurement | frequency | 4 | 56704868 | 91916048 | Rat |
| 1358352 | Srcrt3 | Stress Responsive Cort QTL 3 | 2.29 | | Hypothalamic-pituitary-adrenal axis | corticosterone post-stress | 4 | 8819982 | 149560340 | Rat |
| 1641833 | Alc21 | Alcohol consumption QTL 21 | 8.6 | .0001 | Consumption level | alcohol preference | 4 | 54879077 | 127941994 | Rat |
| 1358363 | Sradr3 | Stress Responsive Adrenal Weight QTL 3 | 6.19 | | Hypothalamic-pituitary-adrenal axis | adrenal gland weight | 4 | 56690161 | 101690161 | Rat |
| 2303168 | Bp330 | Blood pressure QTL 330 | 4.25 | .017 | Blood pressure | | 4 | 456799 | 149181446 | Rat |
| 2313401 | Anxrr27 | Anxiety related response QTL 27 | | | Anxiety response | domestication | 4 | 32648616 | 61646915 | Rat |
| 2316958 | Gluco58 | Glucose level QTL 58 | 10 | | Glucose level | postprandial | 4 | 6690606 | 185398530 | Rat |
| 4889969 | Bss96 | Bone structure and strength QTL 96 | 4.9 | | Bone structure | | 4 | 54828069 | 78039637 | Rat |
| 4889972 | Bss97 | Bone structure and strength QTL 97 | 5.6 | | Bone structure | | 4 | 54828069 | 78039637 | Rat |
| 5685012 | Bmd87 | Bone mineral density QTL 87 | 5.1 | | Bone mineral density | bone mineral content | 4 | 54828069 | 78039637 | Rat |
| 5685009 | Bmd86 | Bone mineral density QTL 86 | 3.7 | | Bone mineral density | areal bone mineral density | 4 | 54828069 | 78039637 | Rat |
| 6893678 | Bw108 | Body weight QTL 108 | 2.6 | .006 | Body weight | salt-loaded | 4 | 42249950 | 87249950 | Rat |
| 631671 | Iddm11 | Insulin dependent diabetes mellitus QTL 11 | 3.6 | .0012 | Glucose level | | 4 | 56920444 | 78042833 | Rat |
| 1576305 | Emca6 | Estrogen-induced mammary cancer QTL 6 | 5.8 | | Mammary tumor susceptibility | estradiol-induced | 4 | 41729583 | 159115617 | Rat |
| 6909122 | Insul22 | Insulin level QTL 22 | 4.63 | | Insulin level | fasting | 4 | 23537363 | 74625985 | Rat |
| 6909128 | Pancm4 | Pancreatic morphology QTL 4 | 11.35 | | Pancreas weight | | 4 | 23537363 | 74625985 | Rat |
| 61412 | Pia2 | Pristane induced arthritis QTL 2 | 3.9 | | Joint/bone inflammation | day of onset | 4 | 17617956 | 60974511 | Rat |