Annotation (Toggle Detail/Summary View) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (+)-pilocarpine | increases expression | EXP | | 6480464 | Pilocarpine results in increased expression of POLG mRNA; more ... | CTD | PMID:20446108 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:732179 | 6480464 | [Triiodothyronine co-treated with Tetrachlorodibenzodioxin] results in decreased expression of POLG mRNA | CTD | PMID:14761676 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:732180 | 6480464 | Tetrachlorodibenzodioxin affects the expression of POLG mRNA | CTD | PMID:21570461 | 3,3',5-triiodo-L-thyronine | multiple interactions | ISO | RGD:732179 | 6480464 | [Triiodothyronine co-treated with Tetrachlorodibenzodioxin] results in decreased expression of POLG mRNA | CTD | PMID:14761676 | 4,4'-diaminodiphenylmethane | increases expression | ISO | RGD:732180 | 6480464 | 4,4'-diaminodiphenylmethane results in increased expression of POLG mRNA | CTD | PMID:18648102 | 5-fluorouracil | affects response to substance | ISO | RGD:732179 | 6480464 | POLG protein affects the susceptibility to Fluorouracil | CTD | PMID:15548681 | acetohydrazide | decreases expression | ISO | RGD:732180 | 6480464 | acetylhydrazine results in decreased expression of POLG mRNA | CTD | PMID:15282401 | aflatoxin B1 | increases expression | ISO | RGD:732180 | 6480464 | Aflatoxin B1 results in increased expression of POLG mRNA | CTD | PMID:19770486 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of POLG mRNA | CTD | PMID:16483693 | benzo[a]pyrene | increases expression | ISO | RGD:732180 | 6480464 | Benzo(a)pyrene results in increased expression of POLG mRNA | CTD | PMID:20504355 | benzo[a]pyrene | increases expression | EXP | | 6480464 | Benzo(a)pyrene results in increased expression of POLG protein | CTD | PMID:21467743 | carbon monoxide | increases expression | ISO | RGD:732180 | 6480464 | Carbon Monoxide results in increased expression of POLG mRNA; more ... | CTD | PMID:17179207 | chloramphenicol | increases expression | ISO | RGD:732179 | 6480464 | Chloramphenicol results in increased expression of POLG mRNA | CTD | PMID:22712077 | clofibric acid | multiple interactions | EXP | | 6480464 | [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of POLG mRNA | CTD | PMID:17602206 | dimethylarsinic acid | increases expression | ISO | RGD:732180 | 6480464 | Cacodylic Acid results in increased expression of POLG mRNA | CTD | PMID:17441966 | furan | increases methylation | EXP | | 6480464 | furan results in increased methylation of POLG gene | CTD | PMID:22079235 | hydrazine | decreases expression | ISO | RGD:732180 | 6480464 | hydrazine results in decreased expression of POLG mRNA | CTD | PMID:15282401 | indole-3-methanol | affects expression | EXP | | 6480464 | indole-3-carbinol affects the expression of POLG mRNA | CTD | PMID:21396975 | ketamine | decreases expression | EXP | | 6480464 | Ketamine results in decreased expression of POLG mRNA | CTD | PMID:20080153 | N-nitrosodiethylamine | multiple interactions | EXP | | 6480464 | [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of POLG mRNA | CTD | PMID:20360939 | N-nitrosodiethylamine | multiple interactions | EXP | | 6480464 | [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of POLG mRNA | CTD | PMID:17602206 | paracetamol | affects expression | ISO | RGD:732180 | 6480464 | Acetaminophen affects the expression of POLG mRNA | CTD | PMID:17562736 | paracetamol | increases expression | ISO | RGD:732179 | 6480464 | Acetaminophen results in increased expression of POLG mRNA | CTD | PMID:22230336 | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of POLG mRNA | CTD | PMID:16751229 | perfluorooctane-1-sulfonic acid | increases expression | EXP | | 6480464 | perfluorooctane sulfonic acid results in increased expression of POLG mRNA | CTD | PMID:18692542 | pirinixic acid | multiple interactions | ISO | RGD:732180 | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of POLG mRNA | CTD | PMID:19710929 | streptozocin | affects expression | ISO | RGD:732180 | 6480464 | Streptozocin affects the expression of POLG mRNA | CTD | PMID:18583417 | valproic acid | increases response to substance | ISO | RGD:732179 | 6480464 | POLG gene SNP results in increased susceptibility to Valproic Acid | CTD | PMID:18716558 | valproic acid | increases response to substance | ISO | RGD:732179 | 6480464 | POLG protein mutant form results in increased susceptibility to Valproic Acid | CTD | PMID:20138553 | valproic acid | affects expression | ISO | RGD:732180 | 6480464 | Valproic Acid affects the expression of POLG mRNA | CTD | PMID:17292431 | vincristine | increases response to substance | ISO | RGD:732179 | 6480464 | POLG gene SNP results in increased susceptibility to Vincristine | CTD | PMID:20864405 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Metabolic pathways |
Disease Annotations
Gene-Chemical Interaction Annotations
|
|
|
Gene Ontology Annotations
|
|
|
|
|
|
Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Metabolic pathways |
References - curated| 1. |
Chan SS, etal., DNA Repair (Amst). 2005 Dec 8;4(12):1381-9. Epub 2005 Sep 21. |
| 2. |
GOA data from the GO Consortium |
| 3. |
Lestienne P Biochem Biophys Res Commun 1987 Aug 14;146(3):1146-53. |
| 4. |
MGD data from the GO Consortium |
| 5. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 6. |
Ogihara M, etal., Exp Mol Pathol 2002 Dec;73(3):234-41. |
| 7. |
RGD automated data pipeline |
| 8. |
RGD automated import pipeline for gene-chemical interactions |
| 9. |
RGD Automated Pipelines |
| 10. |
Ropp PA and Copeland WC, Genomics 1996 Sep 15;36(3):449-58. |
| 11. |
Van Goethem G, etal., Nat Genet 2001 Jul;28(3):211-2. |
References - uncurated| PubMed | 20808729 |
RGD Disease Portals| Polg has been annotated in the following RGD Disease Portals. |
|||
![]() |
| ||
![]() |
| ||
![]() |
| ||
![]() |
| ||
Comparative Map Data| Polg (Rattus norvegicus) |
|
|||||||||||||||||||||||||||||||||||
| POLG (Homo sapiens) |
|
|||||||||||||||||||||||||||||||||||
| Polg (Mus musculus) |
|
Position Markers| MARC_7859-7860:996688105:3 |
|
QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_053528 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06006572 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHX01006477 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AJ245646 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AJ245647 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473980 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_053528 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_445980 | ||||||||||||||||||||
| Position: |
|
Protein Sequences| Protein RefSeqs | NP_445980 | (Get FASTA) |
| GenBank Protein | CAB56206 | (Get FASTA) |
| CAB56207 | (Get FASTA) | |
| EDM08579 | (Get FASTA) | |
| EDM08580 | (Get FASTA) | |
| EDM08581 | (Get FASTA) | |
| Q9QYV8 | (Get FASTA) |
Strain Sequence Variants
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000032293 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Protein | ENSRNOP00000047900 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Transcript | ENSRNOT00000044567 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Entrez Gene | 85472 | ENTREZGENE |
| Germonline | ENSRNOG00000032293 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 2016 | ENTREZGENE |
| InterPro | DNA-dir_DNA_pol_A_CS | UniProtKB/Swiss-Prot |
| DNA-dir_DNA_pol_A_mt | UniProtKB/Swiss-Prot | |
| DNA-dir_DNA_pol_A_mt_sub | UniProtKB/Swiss-Prot | |
| DNA-dir_DNA_pol_A_palm_dom | UniProtKB/Swiss-Prot | |
| PolynucTfrase_RNaseH_fold | UniProtKB/Swiss-Prot | |
| KEGG Report | rno:85472 | ENTREZGENE, UniProtKB/Swiss-Prot |
| PANTHER | DNA_polG | UniProtKB/Swiss-Prot |
| Pfam | DNA_pol_A | UniProtKB/Swiss-Prot |
| PIRSF | DNA_pol_mt | UniProtKB/Swiss-Prot |
| PRINTS | DNAPOLG | UniProtKB/Swiss-Prot |
| PROSITE | DNA_POLYMERASE_A | UniProtKB/Swiss-Prot |
| SMART | POLAc | UniProtKB/Swiss-Prot |
| Superfamily-SCOP | RNaseH_fold | UniProtKB/Swiss-Prot |
| UniGene | Rn.19327 | ENTREZGENE |
| UniProt | DPOG1_RAT | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2004-09-10 | Polg | polymerase (DNA directed), gamma | DNA polymerase gamma | Name updated | 10779 | APPROVED | |
| 2002-08-07 | Polg | DNA polymerase gamma | Symbol and Name status set to provisional | 1724 | PROVISIONAL |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_expression | activity present in heart | 724601 |
| gene_regulation | activity induced by adriamycin treatment | 724601 |
| More on Polg | |
![]() |
Entrez Gene |
![]() |
Ensembl Gene |
![]() | Genome Browser |
![]() |
NCBI Map Viewer |
![]() |
Vista |
![]() |
Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 620057 |
| Created: | 2002-08-06 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-05-28 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




