Nucb1 (nucleobindin 1) - Rat Genome Database

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Gene: Nucb1 (nucleobindin 1) Rattus norvegicus
Analyze
Symbol: Nucb1
Name: nucleobindin 1
RGD ID: 620030
Description: Enables G-protein alpha-subunit binding activity; calcium ion binding activity; and guanyl-nucleotide exchange factor activity. Involved in regulation of protein targeting and small GTPase-mediated signal transduction. Located in Golgi apparatus; cytoplasmic vesicle; and extracellular space. Is extrinsic component of Golgi membrane. Orthologous to human NUCB1 (nucleobindin 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: bone 63 kDa calcium-binding protein; CALNUC; Nucb; nucleobindin; nucleobindin-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81105,104,793 - 105,135,730 (-)NCBIGRCr8
mRatBN7.2195,968,325 - 95,999,183 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl195,968,326 - 96,003,220 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1101,353,752 - 101,373,866 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01109,826,428 - 109,846,542 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01103,116,822 - 103,136,934 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01101,480,160 - 101,511,029 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1101,480,145 - 101,500,850 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01102,559,072 - 102,579,628 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4195,961,163 - 95,981,910 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1196,039,273 - 96,060,021 (-)NCBI
Celera190,224,246 - 90,244,279 (-)NCBICelera
Cytogenetic Map1q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. A systematic analysis of 40 random genes in cultured vascular smooth muscle subtypes reveals a heterogeneity of gene expression and identifies the tight junction gene zonula occludens 2 as a marker of epithelioid "pup" smooth muscle cells and a participant in carotid neointimal formation. Adams LD, etal., Arterioscler Thromb Vasc Biol 1999 Nov;19(11):2600-8.
2. Calnuc binds to LRP9 and affects its endosomal sorting. Brodeur J, etal., Traffic. 2009 Aug;10(8):1098-114. doi: 10.1111/j.1600-0854.2009.00933.x. Epub 2009 May 30.
3. Proteomic analysis of cisplatin-induced cochlear damage: methods and early changes in protein expression. Coling DE, etal., Hear Res. 2007 Apr;226(1-2):140-56. Epub 2007 Jan 24.
4. Nucleobindin-2/nesfatin in the endocrine pancreas: distribution and relationship to glycaemic state. Foo KS, etal., J Endocrinol. 2010 Mar;204(3):255-63. doi: 10.1677/JOE-09-0254. Epub 2009 Dec 23.
5. G Protein binding sites on Calnuc (nucleobindin 1) and NUCB2 (nucleobindin 2) define a new class of G(alpha)i-regulatory motifs. Garcia-Marcos M, etal., J Biol Chem. 2011 Aug 12;286(32):28138-49. doi: 10.1074/jbc.M110.204099. Epub 2011 Jun 8.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Calnuc, an EF-hand Ca(2+)-binding protein, is stored and processed in the Golgi and secreted by the constitutive-like pathway in AtT20 cells. Lavoie C, etal., Mol Endocrinol. 2002 Nov;16(11):2462-74.
9. The mammalian calcium-binding protein, nucleobindin (CALNUC), is a Golgi resident protein. Lin P, etal., J Cell Biol. 1998 Jun 29;141(7):1515-27.
10. Overexpression of CALNUC (nucleobindin) increases agonist and thapsigargin releasable Ca2+ storage in the Golgi. Lin P, etal., J Cell Biol. 1999 Apr 19;145(2):279-89.
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. Nucleobindin is produced by bone cells and secreted into the osteoid, with a potential role as a modulator of matrix maturation. Petersson U, etal., Bone. 2004 Jun;34(6):949-60.
13. GOA pipeline RGD automated data pipeline
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Isolation, characterization, and primary structure of a calcium-binding 63-kDa bone protein. Wendel M, etal., J Biol Chem 1995 Mar 17;270(11):6125-33.
Additional References at PubMed
PMID:10639138   PMID:12477932   PMID:15308636   PMID:16502470   PMID:16641100   PMID:19199708   PMID:19946888   PMID:20679342   PMID:23533145   PMID:23955309   PMID:25002582   PMID:25736948  
PMID:26666627  


Genomics

Comparative Map Data
Nucb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81105,104,793 - 105,135,730 (-)NCBIGRCr8
mRatBN7.2195,968,325 - 95,999,183 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl195,968,326 - 96,003,220 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1101,353,752 - 101,373,866 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01109,826,428 - 109,846,542 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01103,116,822 - 103,136,934 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01101,480,160 - 101,511,029 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1101,480,145 - 101,500,850 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01102,559,072 - 102,579,628 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4195,961,163 - 95,981,910 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1196,039,273 - 96,060,021 (-)NCBI
Celera190,224,246 - 90,244,279 (-)NCBICelera
Cytogenetic Map1q22NCBI
NUCB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381948,900,312 - 48,923,372 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1948,900,050 - 48,923,473 (+)EnsemblGRCh38hg38GRCh38
GRCh371949,403,569 - 49,426,629 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361954,091,637 - 54,118,340 (+)NCBINCBI36Build 36hg18NCBI36
Build 341954,095,852 - 54,118,337NCBI
Celera1946,270,663 - 46,293,902 (+)NCBICelera
Cytogenetic Map19q13.33NCBI
HuRef1945,779,769 - 45,802,972 (+)NCBIHuRef
CHM1_11949,405,174 - 49,428,729 (+)NCBICHM1_1
T2T-CHM13v2.01951,895,140 - 51,918,232 (+)NCBIT2T-CHM13v2.0
Nucb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39745,142,300 - 45,159,813 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl745,139,882 - 45,159,830 (-)EnsemblGRCm39 Ensembl
GRCm38745,492,674 - 45,510,408 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl745,490,458 - 45,510,406 (-)EnsemblGRCm38mm10GRCm38
MGSCv37752,748,044 - 52,765,778 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36745,361,150 - 45,378,372 (-)NCBIMGSCv36mm8
Celera740,949,201 - 40,966,928 (-)NCBICelera
Cytogenetic Map7B3NCBI
cM Map729.33NCBI
Nucb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555591,722,411 - 1,740,596 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555591,723,986 - 1,739,776 (-)NCBIChiLan1.0ChiLan1.0
NUCB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22055,003,893 - 55,026,955 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11956,930,112 - 56,953,069 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01945,900,098 - 45,923,056 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11954,831,582 - 54,856,711 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1954,832,426 - 54,855,962 (-)Ensemblpanpan1.1panPan2
NUCB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11107,453,965 - 107,476,458 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1107,454,636 - 107,476,375 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1106,976,497 - 106,999,075 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01107,978,613 - 108,001,223 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1107,978,615 - 108,001,085 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11107,646,057 - 107,668,201 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01107,292,476 - 107,315,053 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01108,128,088 - 108,150,670 (-)NCBIUU_Cfam_GSD_1.0
Nucb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934921,305,942 - 21,327,980 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366642,924,719 - 2,945,178 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366642,924,186 - 2,946,035 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NUCB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl654,180,038 - 54,209,930 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1654,186,610 - 54,209,457 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2650,119,224 - 50,141,964 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NUCB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1642,133,505 - 42,154,461 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607322,017,037 - 22,040,686 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nucb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248325,071,869 - 5,085,623 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248325,073,022 - 5,085,493 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nucb1
96 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:148
Count of miRNA genes:100
Interacting mature miRNAs:119
Transcripts:ENSRNOT00000028390
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)177876254106047988Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)180592172125592172Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)182174743118944897Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)number of 20 x 20 cm floor squares crossed into, out of or within a discrete space in an experimental apparatus (CMO:0001514)183547917128547917Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)185424647100358001Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)187580395150700247Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)190532338123479925Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)190664883143200202Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192184926137184926Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)192948896144267916Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)194494440117601394Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat

Markers in Region
RH127506  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2195,968,419 - 95,968,600 (+)MAPPERmRatBN7.2
Rnor_6.01101,480,255 - 101,480,435NCBIRnor6.0
Rnor_5.01102,559,167 - 102,559,347UniSTSRnor5.0
RGSC_v3.4195,961,257 - 95,961,437UniSTSRGSC3.4
Celera190,224,340 - 90,224,520UniSTS
RH 3.4 Map1909.6UniSTS
Cytogenetic Map1q22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000028390   ⟹   ENSRNOP00000028390
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl195,968,327 - 95,988,963 (-)Ensembl
Rnor_6.0 Ensembl1101,480,145 - 101,500,850 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000079633   ⟹   ENSRNOP00000075192
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl195,968,326 - 96,003,220 (-)Ensembl
RefSeq Acc Id: NM_053463   ⟹   NP_445915
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81105,104,793 - 105,125,430 (-)NCBI
mRatBN7.2195,968,325 - 95,988,962 (-)NCBI
Rnor_6.01101,480,161 - 101,500,284 (-)NCBI
Rnor_5.01102,559,072 - 102,579,628 (-)NCBI
RGSC_v3.4195,961,163 - 95,981,910 (-)RGD
Celera190,224,246 - 90,244,279 (-)RGD
Sequence:
RefSeq Acc Id: XM_006229164   ⟹   XP_006229226
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81105,104,793 - 105,125,395 (-)NCBI
mRatBN7.2195,968,325 - 95,988,958 (-)NCBI
Rnor_6.01101,480,160 - 101,500,731 (-)NCBI
Rnor_5.01102,559,072 - 102,579,628 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017589801   ⟹   XP_017445290
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81105,104,793 - 105,135,725 (-)NCBI
mRatBN7.2195,968,325 - 95,999,183 (-)NCBI
Rnor_6.01101,480,160 - 101,511,029 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017589802   ⟹   XP_017445291
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81105,104,793 - 105,135,730 (-)NCBI
mRatBN7.2195,968,325 - 95,999,182 (-)NCBI
Rnor_6.01101,480,160 - 101,511,029 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_445915   ⟸   NM_053463
- Peptide Label: precursor
- UniProtKB: P97623 (UniProtKB/Swiss-Prot),   Q497A4 (UniProtKB/Swiss-Prot),   Q63083 (UniProtKB/Swiss-Prot),   A6JB42 (UniProtKB/TrEMBL),   A0A8L2UKK1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229226   ⟸   XM_006229164
- Peptide Label: isoform X3
- UniProtKB: A0A8L2UKK1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017445291   ⟸   XM_017589802
- Peptide Label: isoform X2
- UniProtKB: A0A0G2K9Z3 (UniProtKB/TrEMBL),   A0A8L2UKK1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017445290   ⟸   XM_017589801
- Peptide Label: isoform X1
- UniProtKB: A0A8L2UKK1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000028390   ⟸   ENSRNOT00000028390
RefSeq Acc Id: ENSRNOP00000075192   ⟸   ENSRNOT00000079633
Protein Domains
EF-hand

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63083-F1-model_v2 AlphaFold Q63083 1-459 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690042
Promoter ID:EPDNEW_R567
Type:initiation region
Name:Nucb1_1
Description:nucleobindin 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01101,500,796 - 101,500,856EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620030 AgrOrtholog
BioCyc Gene G2FUF-59679 BioCyc
Ensembl Genes ENSRNOG00000020889 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000028390.6 UniProtKB/TrEMBL
  ENSRNOT00000079633.2 UniProtKB/TrEMBL
Gene3D-CATH EF-hand UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7930904 IMAGE-MGC_LOAD
InterPro EF-hand-dom_pair UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nucleobindin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:84595 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:124586 IMAGE-MGC_LOAD
NCBI Gene 84595 ENTREZGENE
PANTHER PTHR19237 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR19237:SF21 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nucb1 PhenoGen
PROSITE EF_HAND_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000020889 RatGTEx
Superfamily-SCOP SSF47473 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K9Z3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2UKK1 ENTREZGENE, UniProtKB/TrEMBL
  A6JB39_RAT UniProtKB/TrEMBL
  A6JB42 ENTREZGENE, UniProtKB/TrEMBL
  A6JB44_RAT UniProtKB/TrEMBL
  NUCB1_RAT UniProtKB/Swiss-Prot
  P97623 ENTREZGENE
  Q497A4 ENTREZGENE
  Q63083 ENTREZGENE
  Q6P6Q3_RAT UniProtKB/TrEMBL
UniProt Secondary P97623 UniProtKB/Swiss-Prot
  Q497A4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Nucb1  nucleobindin 1  Nucb  nucleobindin  Symbol and Name updated 1299863 APPROVED
2002-08-07 Nucb  nucleobindin      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in calvaria of bone 633377