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Gene Ontology AnnotationsGene Ontology Annotations
Gene Ontology AnnotationsBiological Process Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | chromatin remodeling | | ISO | RGD:1316832 | 1624291 | PMID:18850004 | RGD | PMID:18850004 | chromatin remodeling | | IEA | Ensembl:ENSP00000264606 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | histone deacetylation | | ISO | RGD:1316832 | 1624291 | PMID:10869435 | RGD | PMID:10869435 | histone deacetylation | | IMP | | 7241147 | | RGD | | histone deacetylation | | ISO | RGD:1316832 | 1624291 | PMID:18850004 | RGD | PMID:18850004 | histone H3 deacetylation | | ISO | RGD:1316832 | 1624291 | PMID:12590135 | RGD | PMID:12590135 | histone H4 deacetylation | | ISO | RGD:1316832 | 1624291 | PMID:12590135 | RGD | PMID:12590135 | negative regulation of cell proliferation | | ISO | RGD:1550759 | 1624291 | MGI:MGI:3513625|PMID:15537544 | RGD | MGI:MGI:3513625 PMID:15537544 | negative regulation of cell proliferation | | IEA | Ensembl:ENSMUSP00000008995 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | negative regulation of glycolysis | | ISO | RGD:1550759 | 1624291 | MGI:MGI:4365327|PMID:19109424 | RGD | MGI:MGI:4365327 PMID:19109424 | negative regulation of glycolysis | | IEA | Ensembl:ENSMUSP00000008995 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | negative regulation of myotube differentiation | | ISO | RGD:1316832 | 1624291 | PMID:10983972 | RGD | PMID:10983972 | negative regulation of myotube differentiation | | IEA | Ensembl:ENSP00000264606 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | negative regulation of osteoblast differentiation | | ISO | RGD:1550759 | 1624291 | MGI:MGI:3584056|PMID:15990875 | RGD | MGI:MGI:3584056 PMID:15990875 | negative regulation of osteoblast differentiation | | IEA | Ensembl:ENSMUSP00000008995 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | negative regulation of sequence-specific DNA binding transcription factor activity | | ISO | RGD:1316832 | 1624291 | PMID:18850004 | RGD | PMID:18850004 | negative regulation of sequence-specific DNA binding transcription factor activity | | IEA | Ensembl:ENSP00000264606 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | negative regulation of transcription from RNA polymerase II promoter | | ISO | RGD:1550759 | 1624291 | MGI:MGI:99458 | RGD | MGI:MGI:3701381 PMID:17336904 | negative regulation of transcription from RNA polymerase II promoter | | IEA | Ensembl:ENSMUSP00000008995 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | negative regulation of transcription from RNA polymerase II promoter | | ISO | RGD:1316832 | 1624291 | PMID:19276356 | RGD | PMID:19276356 | negative regulation of transcription from RNA polymerase II promoter | | ISO | RGD:1316832 | 1624291 | PMID:18850004 | RGD | PMID:18850004 | negative regulation of transcription from RNA polymerase II promoter | | ISO | RGD:1316832 | 1624291 | PMID:16236793 | RGD | PMID:16236793 | negative regulation of transcription from RNA polymerase II promoter | | ISO | RGD:1316832 | 1624291 | PMID:10869435 | RGD | PMID:10869435 | negative regulation of transcription from RNA polymerase II promoter | | ISO | RGD:1550759 | 1624291 | MGI:MGI:98725 | RGD | MGI:MGI:3584056 PMID:15990875 | negative regulation of transcription from RNA polymerase II promoter | | ISO | RGD:1550759 | 1624291 | MGI:MGI:2137495 | RGD | MGI:MGI:3525929 PMID:15601857 | negative regulation of transcription from RNA polymerase II promoter | | ISO | RGD:1550759 | 1624291 | MGI:MGI:99829 | RGD | MGI:MGI:3513625 PMID:15537544 | negative regulation of transcription from RNA polymerase II promoter | | ISO | RGD:1550759 | 1624291 | MGI:MGI:3766846|PMID:17873280 | RGD | MGI:MGI:3766846 PMID:17873280 | negative regulation of transcription, DNA-dependent | | ISO | RGD:1550759 | 1624291 | MGI:MGI:2684511|PMID:14576337 | RGD | MGI:MGI:2684511 PMID:14576337 | negative regulation of transcription, DNA-dependent | | ISO | RGD:1316832 | 1624291 | PMID:19276356 | RGD | PMID:19276356 | negative regulation of transcription, DNA-dependent | | ISO | RGD:1316832 | 1624291 | PMID:10869435 | RGD | PMID:10869435 | negative regulation of transcription, DNA-dependent | | ISO | RGD:1550759 | 1624291 | MGI:MGI:3607445|PMID:16260608 | RGD | MGI:MGI:3607445 PMID:16260608 | osteoblast development | | ISO | RGD:1550759 | 1624291 | MGI:MGI:3584056|PMID:15990875 | RGD | MGI:MGI:3584056 PMID:15990875 | osteoblast development | | IEA | Ensembl:ENSMUSP00000008995 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | peptidyl-lysine deacetylation | | ISO | RGD:1316832 | 1624291 | PMID:18614528 | RGD | PMID:18614528 | peptidyl-lysine deacetylation | | IEA | Ensembl:ENSP00000264606 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | positive regulation of cell proliferation | | ISO | RGD:1316832 | 1624291 | PMID:18850004 | RGD | PMID:18850004 | positive regulation of cell proliferation | | IEA | Ensembl:ENSP00000264606 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | positive regulation of protein sumoylation | | ISO | RGD:1316832 | 1624291 | PMID:17696781 | RGD | PMID:17696781 | positive regulation of protein sumoylation | | IEA | Ensembl:ENSP00000264606 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | positive regulation of sequence-specific DNA binding transcription factor activity | | ISO | RGD:1316832 | 1624291 | PMID:19071119 | RGD | PMID:19071119 | positive regulation of sequence-specific DNA binding transcription factor activity | | IEA | Ensembl:ENSP00000264606 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | positive regulation of transcription from RNA polymerase II promoter | | ISO | RGD:1550759 | 1624291 | MGI:MGI:4365327|PMID:19109424 | RGD | MGI:MGI:4365327 PMID:19109424 | positive regulation of transcription from RNA polymerase II promoter | | IEA | Ensembl:ENSMUSP00000008995 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | positive regulation of transcription from RNA polymerase II promoter | | ISO | RGD:1316832 | 1624291 | PMID:19071119 | RGD | PMID:19071119 | positive regulation of transcription, DNA-dependent | | ISO | RGD:1550759 | 1624291 | MGI:MGI:4365327|PMID:19109424 | RGD | MGI:MGI:4365327 PMID:19109424 | protein deacetylation | | ISO | RGD:1550759 | 1624291 | MGI:MGI:3793386|PMID:18250163 | RGD | MGI:MGI:3793386 PMID:18250163 | regulation of cardiac muscle contraction by calcium ion signaling | | ISO | RGD:1550759 | 1624291 | MGI:MGI:3793386|PMID:18250163 | RGD | MGI:MGI:3793386 PMID:18250163 | regulation of cardiac muscle contraction by calcium ion signaling | | IEA | Ensembl:ENSMUSP00000008995 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | regulation of protein binding | | ISO | RGD:1316832 | 1624291 | PMID:19071119 | RGD | PMID:19071119 | regulation of protein binding | | IEA | Ensembl:ENSP00000264606 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | regulation of skeletal muscle fiber development | | ISO | RGD:1550759 | 1624291 | MGI:MGI:1931221|MGI:MGI:1333784 | RGD | MGI:MGI:3763703 PMID:17786239 | regulation of striated muscle cell differentiation | | ISO | RGD:1550759 | 1624291 | MGI:MGI:1931221|MGI:MGI:1333784 | RGD | MGI:MGI:3763703 PMID:17786239 | response to denervation involved in regulation of muscle adaptation | | ISO | RGD:1550759 | 1624291 | MGI:MGI:4365327|PMID:19109424 | RGD | MGI:MGI:4365327 PMID:19109424 | response to denervation involved in regulation of muscle adaptation | | IEA | Ensembl:ENSMUSP00000008995 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | response to drug | | IDA | | 2306455 | phenylephrine | RGD | | response to interleukin-1 | | ISO | RGD:1316832 | 1624291 | PMID:19281832 | RGD | PMID:19281832 | response to interleukin-1 | | IEA | Ensembl:ENSP00000264606 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | skeletal system development | | ISO | RGD:1550759 | 1624291 | MGI:MGI:3525071 | RGD | MGI:MGI:3513625 PMID:15537544 | skeletal system development | | IEA | Ensembl:ENSMUSP00000008995 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | transcription, DNA-dependent | | IEA | UniProtKB-KW:KW-0804 | 1600115 | GO_REF:0000037 | UniProtKB | GO_REF:0000037 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Molecular Pathway AnnotationsGene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Alcoholism |
| Epstein-Barr virus infection | |
| Viral carcinogenesis | |
| Pathway Interaction Database | Signaling events mediated by HDAC Class I (PID:200084) |
| Signaling events mediated by HDAC Class II (PID:200023) | |
| Signaling events mediated by HDAC Class III (PID:200025) | |
| Sumoylation by RanBP2 regulates transcriptional repression (PID:200115) | |
| Validated nuclear estrogen receptor alpha network (PID:200158) | |
References - curated| 1. |
Backs J, etal., J Clin Invest. 2006 Jul;116(7):1853-64. Epub 2006 Jun 8. |
| 2. |
Bers DM Heart Rhythm. 2011 Jul;8(7):1101-4. doi: 10.1016/j.hrthm.2011.01.030. Epub 2011 Jan 18. |
| 3. |
Ellis JJ, etal., Mol Cell Biochem 2003 Jan;242(1-2):153-61. |
| 4. |
Ginnan R, etal., Biochem J. 2012 May 15;444(1):105-14. doi: 10.1042/BJ20120152. |
| 5. |
Gupta MP, etal., J Biol Chem. 2008 Apr 11;283(15):10135-46. Epub 2008 Feb 4. |
| 6. |
Kao GD, etal., J Cell Biol 2003 Mar 31;160(7):1017-27. |
| 7. |
Matsuda KI, etal., Endocrinology. 2011 Jul;152(7):2760-7. doi: 10.1210/en.2011-0193. Epub 2011 May 17. |
| 8. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 9. |
RGD automated data pipeline |
| 10. |
RGD automated import pipeline for gene-chemical interactions |
| 11. |
RGD comprehensive gene curation |
| 12. |
Zhang CL, etal., Mol Cell Biol 2002 Oct;22(20):7302-12. |
References - uncuratedRGD Disease Portals| Hdac4 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Hdac4 (Rattus norvegicus) |
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| HDAC4 (Homo sapiens) |
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| Hdac4 (Mus musculus) |
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Position Markers| BG377748 |
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| UniSTS:234174 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_053449 | (Get FASTA) | Search GEO for Microarray Profiles |
| XM_001067733 | (Get FASTA) | Search GEO for Microarray Profiles | |
| XM_343629 | (Get FASTA) | Search GEO for Microarray Profiles | |
| GenBank Nucleotide | AABR06061588 | (Get FASTA) | Search GEO for Microarray Profiles |
| AABR06061589 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01061501 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01061502 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01061503 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF321132 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC158868 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473997 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | XM_001067733 | ||||||||||
| RefSeq Status: | |||||||||||
| Type: | CODING | ||||||||||
| Protein Acc Id: | XP_001067733 | ||||||||||
| Position: |
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| RefSeq Acc Id: | XM_343629 | |||||||||||||||
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| Type: | CODING | |||||||||||||||
| Protein Acc Id: | XP_343630 | |||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_445901 | (Get FASTA) |
| XP_001067733 | (Get FASTA) | |
| XP_343630 | (Get FASTA) | |
| GenBank Protein | AAI58869 | (Get FASTA) |
| AAK11185 | (Get FASTA) | |
| EDL91998 | (Get FASTA) | |
| EDL91999 | (Get FASTA) | |
| EDL92000 | (Get FASTA) | |
| Q99P99 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000020372 | UniProtKB/Swiss-Prot |
| Ensembl Protein | ENSRNOP00000027622 | UniProtKB/Swiss-Prot |
| Ensembl Transcript | ENSRNOT00000027622 | UniProtKB/Swiss-Prot |
| Entrez Gene | 363287 | ENTREZGENE |
| Gene3D-CATH | His_deacetylse | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 55946 | ENTREZGENE |
| IMAGE_CLONE | IMAGE:7929963 | IMAGE-MGC_LOAD |
| InterPro | His_deacetylse | UniProtKB/Swiss-Prot |
| His_deacetylse_dom | UniProtKB/Swiss-Prot | |
| Hist_deacetylase_Gln_rich_N | UniProtKB/Swiss-Prot | |
| Histone_deAcase_II_euk | UniProtKB/Swiss-Prot | |
| IPI | IPI00367142 | UniProtKB/Swiss-Prot |
| KEGG Report | rno:363287 | ENTREZGENE, UniProtKB/Swiss-Prot |
| MGC_CLONE | MGC:188501 | IMAGE-MGC_LOAD |
| PANTHER | His_deacetylse | UniProtKB/Swiss-Prot |
| Pfam | HDAC4_Gln | UniProtKB/Swiss-Prot |
| Hist_deacetyl | UniProtKB/Swiss-Prot | |
| PIRSF | HDAC_II_euk | UniProtKB/Swiss-Prot |
| PRINTS | HDASUPER | UniProtKB/Swiss-Prot |
| UniGene | Rn.23483 | ENTREZGENE |
| UniProt | B0BNL3_RAT | UniProtKB/TrEMBL |
| HDAC4_RAT | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2007-10-22 | Hdac4 | histone deacetylase 4 | Hdac4_predicted | histone deacetylase 4 (predicted) | Data Merged | 9333 | APPROVED |
| 2005-01-12 | Hdac4_predicted | histone deacetylase 4 (predicted) | Symbol and Name status set to approved | 1724 | APPROVED | ||
| 2002-08-07 | Hdac4 | histone deacetylase 4 | Symbol and Name status set to provisional | 1724 | PROVISIONAL |
| More on Hdac4 | |
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Entrez Gene |
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Ensembl Gene |
| Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 619979 |
| Created: | 2002-08-06 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-23 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.