Ramp3 (receptor activity modifying protein 3) - Rat Genome Database

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Gene: Ramp3 (receptor activity modifying protein 3) Rattus norvegicus
Analyze
Symbol: Ramp3
Name: receptor activity modifying protein 3
RGD ID: 61873
Description: Enables coreceptor activity. Predicted to be involved in several processes, including G protein-coupled receptor signaling pathway; positive regulation of intracellular signal transduction; and positive regulation of macromolecule metabolic process. Predicted to be located in plasma membrane. Predicted to be part of adrenomedullin receptor complex and amylin receptor complex 3. Predicted to be active in cell surface. Predicted to colocalize with lysosome. Orthologous to human RAMP3 (receptor activity modifying protein 3); INTERACTS WITH (S)-nicotine; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: receptor (calcitonin) activity modifying protein 3; receptor (G protein-coupled) activity modifying protein 3; receptor activity-modifying protein 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81485,741,314 - 85,758,813 (+)NCBIGRCr8
mRatBN7.21481,527,404 - 81,544,905 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1481,527,385 - 81,544,902 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1485,928,688 - 85,946,185 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01487,168,498 - 87,186,001 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01483,618,093 - 83,635,590 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01486,922,223 - 86,939,722 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1486,922,223 - 86,939,719 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01480,555,482 - 80,572,981 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41487,417,290 - 87,434,789 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11487,436,434 - 87,453,933 (+)NCBI
Celera1480,409,008 - 80,426,508 (+)NCBICelera
Cytogenetic Map14q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (EXP,ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2-palmitoylglycerol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP)
aldehydo-D-glucose  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amphotericin B  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (ISO)
calciol  (EXP)
carbon nanotube  (ISO)
chloroprene  (ISO)
chrysene  (ISO)
D-glucose  (ISO)
dextran sulfate  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP)
dioxygen  (ISO)
ethanol  (ISO)
furan  (EXP)
glucose  (ISO)
hydralazine  (EXP)
hydrochlorothiazide  (EXP)
hydrogen cyanide  (ISO)
indole-3-methanol  (EXP)
inulin  (ISO)
isoprenaline  (EXP)
methimazole  (EXP)
methoxychlor  (EXP)
morphine  (ISO)
nicotine  (EXP,ISO)
nitric oxide  (EXP)
oxaliplatin  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenylephrine  (EXP)
pirinixic acid  (ISO)
potassium cyanide  (ISO)
progesterone  (ISO)
sulfadimethoxine  (EXP)
testosterone  (EXP)
tetrachloromethane  (EXP)
tetraphene  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (EXP)
troglitazone  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Increased myocardial expression of RAMP1 and RAMP3 in rats with chronic heart failure. Cueille C, etal., Biochem Biophys Res Commun 2002 Jun 7;294(2):340-6.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Adrenomedullin production is increased in colorectal adenocarcinomas; its relation to matrix metalloproteinase-9. Hikosaka T, etal., Peptides. 2011 Sep;32(9):1825-31. doi: 10.1016/j.peptides.2011.07.012. Epub 2011 Aug 3.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Rat receptor-activity-modifying proteins (RAMPs) for adrenomedullin/CGRP receptor: cloning and upregulation in obstructive nephropathy. Nagae T, etal., Biochem Biophys Res Commun 2000 Apr 2;270(1):89-93.
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. Novel regulation of adrenomedullin receptor by PDGF: role of receptor activity modifying protein-3. Nowak W, etal., Am J Physiol Cell Physiol 2002 Jun;282(6):C1322-31.
9. Cloning, characterization and central nervous system distribution of receptor activity modifying proteins in the rat. Oliver KR, etal., Eur J Neurosci 2001 Aug;14(4):618-28.
10. mRNA expression of novel CGRP1 receptors and their activity-modifying proteins in hypoxic rat lung. Qing X, etal., Am J Physiol Lung Cell Mol Physiol 2001 Mar;280(3):L547-54.
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Cardiac fibroblasts are major production and target cells of adrenomedullin in the heart in vitro. Tomoda Y, etal., Cardiovasc Res 2001 Mar;49(4):721-30.
15. Adrenomedullin and its receptor complexes in remnant kidneys of rats with renal mass ablation: decreased expression of calcitonin receptor-like receptor and receptor-activity modifying protein-3. Totsune K, etal., Peptides 2001 Nov;22(11):1933-7.
16. Alterations of intrarenal adrenomedullin and its receptor system in heart failure rats. Yoshihara F, etal., Hypertension 2001 Feb;37(2):216-22.
Additional References at PubMed
PMID:1299115   PMID:9620797   PMID:10854696   PMID:10882736   PMID:11804624   PMID:12538603   PMID:12801991   PMID:14715154   PMID:14722252   PMID:15613468   PMID:15623431   PMID:15680493  
PMID:16040721   PMID:16376586   PMID:16713642   PMID:18434369   PMID:21034462   PMID:22500019   PMID:23674134   PMID:26927337  


Genomics

Comparative Map Data
Ramp3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81485,741,314 - 85,758,813 (+)NCBIGRCr8
mRatBN7.21481,527,404 - 81,544,905 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1481,527,385 - 81,544,902 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1485,928,688 - 85,946,185 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01487,168,498 - 87,186,001 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01483,618,093 - 83,635,590 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01486,922,223 - 86,939,722 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1486,922,223 - 86,939,719 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01480,555,482 - 80,572,981 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41487,417,290 - 87,434,789 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11487,436,434 - 87,453,933 (+)NCBI
Celera1480,409,008 - 80,426,508 (+)NCBICelera
Cytogenetic Map14q21NCBI
RAMP3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38745,157,791 - 45,184,250 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl745,157,791 - 45,186,302 (+)EnsemblGRCh38hg38GRCh38
GRCh37745,197,390 - 45,223,849 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36745,163,892 - 45,190,374 (+)NCBINCBI36Build 36hg18NCBI36
Build 34744,970,638 - 44,997,087NCBI
Celera745,296,201 - 45,322,683 (+)NCBICelera
Cytogenetic Map7p13NCBI
HuRef745,081,154 - 45,107,455 (+)NCBIHuRef
CHM1_1745,201,027 - 45,227,508 (+)NCBICHM1_1
T2T-CHM13v2.0745,318,568 - 45,345,028 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2745,236,530 - 45,263,012 (+)NCBI
Ramp3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39116,608,507 - 6,627,478 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl116,608,521 - 6,627,475 (+)EnsemblGRCm39 Ensembl
GRCm38116,658,506 - 6,677,478 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl116,658,521 - 6,677,475 (+)EnsemblGRCm38mm10GRCm38
MGSCv37116,558,536 - 6,577,478 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36116,558,536 - 6,577,478 (+)NCBIMGSCv36mm8
Celera1118,979,836 - 18,982,575 (-)NCBICelera
Cytogenetic Map11A1NCBI
cM Map114.61NCBI
Ramp3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554567,159,845 - 7,168,792 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554567,159,845 - 7,168,718 (-)NCBIChiLan1.0ChiLan1.0
RAMP3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2650,070,783 - 50,097,555 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1798,395,524 - 98,422,292 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0745,871,687 - 45,898,159 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1745,937,607 - 45,964,088 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl745,937,607 - 45,966,041 (+)Ensemblpanpan1.1panPan2
RAMP3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha162,664,601 - 2,679,402 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01614,181,470 - 14,196,274 (-)NCBIROS_Cfam_1.0
UNSW_CanFamBas_1.01613,814,391 - 13,829,193 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01613,793,847 - 13,808,648 (-)NCBIUU_Cfam_GSD_1.0
Ramp3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118100,765,846 - 100,789,731 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647819,977,539 - 20,004,838 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647819,977,618 - 20,001,366 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RAMP3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1850,319,797 - 50,366,739 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11850,319,795 - 50,366,757 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21855,155,083 - 55,174,055 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RAMP3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12113,494,981 - 13,521,141 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660629,009,778 - 9,035,756 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ramp3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247407,241,296 - 7,249,410 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247407,240,841 - 7,249,313 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ramp3
140 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:642
Count of miRNA genes:292
Interacting mature miRNAs:353
Transcripts:ENSRNOT00000010866
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
2313048Bss84Bone structure and strength QTL 843.10.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143766971982669719Rat
2313084Bss83Bone structure and strength QTL 832.90.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143766971982669719Rat
2313089Bss81Bone structure and strength QTL 813.40.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)143766971982669719Rat
2313100Bss82Bone structure and strength QTL 8230.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143766971982669719Rat
738037Hcas6Hepatocarcinoma susceptibility QTL 62.93liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)143905723783368335Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)144079346098037301Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)144226252995023211Rat
1549834Scl45Serum cholesterol level QTL 455.8blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)145002321195023211Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1455147478100147478Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1455624247100624247Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1455624247100624247Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1456631369101631369Rat
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1458184885103184885Rat
70153Bp59Blood pressure QTL 593.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)146875779683368335Rat
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1470053989104886043Rat
1641900Alcrsp11Alcohol response QTL 11alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)1470053989104886043Rat
1582197Gluco27Glucose level QTL 273.40.0006blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)147341532392554092Rat
1582209Gluco20Glucose level QTL 203.80.0005blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532392554092Rat
1582236Gluco22Glucose level QTL 223.30.0164blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532392554092Rat
1582255Gluco29Glucose level QTL 293.10.0025blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)147341532392554092Rat
1582250Gluco26Glucose level QTL 263.30.0009blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532395876975Rat
631213Bw60Body weight QTL604.51retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)147995092195876975Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 10 2 2 29 29 14 5
Low 3 38 28 20 19 20 4 4 45 6 27 6 4
Below cutoff 5 18 18 18 4 7 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000086468   ⟹   ENSRNOP00000074204
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1481,527,385 - 81,544,902 (+)Ensembl
Rnor_6.0 Ensembl1486,922,223 - 86,939,719 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000094133   ⟹   ENSRNOP00000093875
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1481,541,303 - 81,544,902 (+)Ensembl
RefSeq Acc Id: NM_020100   ⟹   NP_064485
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81485,741,314 - 85,758,813 (+)NCBI
mRatBN7.21481,527,404 - 81,544,905 (+)NCBI
Rnor_6.01486,922,223 - 86,939,722 (+)NCBI
Rnor_5.01480,555,482 - 80,572,981 (+)NCBI
RGSC_v3.41487,417,290 - 87,434,789 (+)RGD
Celera1480,409,008 - 80,426,508 (+)RGD
Sequence:
RefSeq Acc Id: XM_063273515   ⟹   XP_063129585
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81485,746,698 - 85,758,813 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_064485   ⟸   NM_020100
- Peptide Label: precursor
- UniProtKB: Q9JJ73 (UniProtKB/Swiss-Prot),   A6IKW0 (UniProtKB/TrEMBL),   Q9JMD8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000074204   ⟸   ENSRNOT00000086468
RefSeq Acc Id: ENSRNOP00000093875   ⟸   ENSRNOT00000094133
RefSeq Acc Id: XP_063129585   ⟸   XM_063273515
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JJ73-F1-model_v2 AlphaFold Q9JJ73 1-147 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699482
Promoter ID:EPDNEW_R10005
Type:initiation region
Name:Ramp3_1
Description:receptor activity modifying protein 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01486,922,244 - 86,922,304EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61873 AgrOrtholog
BioCyc Gene G2FUF-15064 BioCyc
Ensembl Genes ENSRNOG00000053766 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000086468 ENTREZGENE
  ENSRNOT00000086468.2 UniProtKB/Swiss-Prot
  ENSRNOT00000094133.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.150.510 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro RAMP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RAMP_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:56820 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 56820 ENTREZGENE
PANTHER PTHR14076 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RECEPTOR ACTIVITY-MODIFYING PROTEIN 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam RAMP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ramp3 PhenoGen
RatGTEx ENSRNOG00000053766 RatGTEx
UniProt A0A8I6AKX1_RAT UniProtKB/TrEMBL
  A6IKW0 ENTREZGENE, UniProtKB/TrEMBL
  A6IKW1_RAT UniProtKB/TrEMBL
  Q9JJ73 ENTREZGENE
  Q9JMD8 ENTREZGENE, UniProtKB/TrEMBL
  Q9WVQ2_RAT UniProtKB/TrEMBL
  RAMP3_RAT UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-23 Ramp3  receptor activity modifying protein 3  Ramp3  receptor (G protein-coupled) activity modifying protein 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-24 Ramp3  receptor (G protein-coupled) activity modifying protein 3  Ramp3  receptor (calcitonin) activity modifying protein 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Ramp3  receptor (calcitonin) activity modifying protein 3      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease may play a role in chronic heart failure 625420
gene_expression expressed in renal cortex and medulla 68718
gene_expression mRNA and protein is expressed in both atria and ventricles with a 10 fold increase in expression observed in chronic heart failure models 625420
gene_expression expressed in quiescent mesangial cells 631307
gene_function transports calcitonin receptor-like receptor (Calcr) to the cell membrane and determines its glycosylation state 61729
gene_function transports calcitonin receptor-like receptor (Calcr) to the cell membrane and determines its glycosylation state 68718
gene_function transports calcitonin receptor-like receptor (Calcr) to the cell membrane and determines its glycosylation state 68902
gene_physical_interaction forms a complex with calcitonin receptor-like receptor (CRLR) which responds to adrenomedullin (ADM) and to a lesser extend to calcitonin gene-related peptide (CGRP) 625420
gene_process involved in potentiating adrenomedullin-mediated adenylate cyclase activity and inhibition of DNA synthesis 631307
gene_regulation expression and mRNA stability is increased by Pdgfb in a concentration-dependent manner 631307
gene_regulation mRNA expression is increased by Mek1 631307