Mir208b (microRNA 208b) - Rat Genome Database

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Gene: Mir208b (microRNA 208b) Rattus norvegicus
Analyze
Symbol: Mir208b
Name: microRNA 208b
RGD ID: 4888543
Description: Predicted to enable chromatin binding activity and nucleic acid binding activity. Predicted to be involved in chromatin organization; miRNA-mediated post-transcriptional gene silencing; and negative regulation of calcium ion import across plasma membrane. Predicted to act upstream of or within several processes, including cardiac muscle hypertrophy in response to stress; cellular response to trichostatin A; and establishment of protein localization to chromatin. Predicted to be located in cytosol and nucleus. Orthologous to human MIR208B (microRNA 208b); INTERACTS WITH cadmium atom; cadmium dichloride; isoprenaline.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: microRNA mir-208b; rno-mir-208b
RGD Orthologs
Human
Mouse
Dog
Pig
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81532,421,615 - 32,421,726 (-)NCBIGRCr8
mRatBN7.21528,451,638 - 28,451,749 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1528,451,638 - 28,451,749 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1530,297,322 - 30,297,433 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01531,444,521 - 31,444,632 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01529,687,213 - 29,687,324 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01533,639,510 - 33,639,621 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1533,639,510 - 33,639,621 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01537,526,109 - 37,526,220 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1528,029,311 - 28,029,422 (-)NCBICelera
Cytogenetic Map15p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (ISO)
nucleus  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:16381832   PMID:19726871   PMID:19922871   PMID:20403161   PMID:23623871   PMID:24137001   PMID:26658785   PMID:28283792  


Genomics

Comparative Map Data
Mir208b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81532,421,615 - 32,421,726 (-)NCBIGRCr8
mRatBN7.21528,451,638 - 28,451,749 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1528,451,638 - 28,451,749 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1530,297,322 - 30,297,433 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01531,444,521 - 31,444,632 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01529,687,213 - 29,687,324 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01533,639,510 - 33,639,621 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1533,639,510 - 33,639,621 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01537,526,109 - 37,526,220 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1528,029,311 - 28,029,422 (-)NCBICelera
Cytogenetic Map15p13NCBI
MIR208B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381423,417,987 - 23,418,063 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1423,417,987 - 23,418,063 (-)EnsemblGRCh38hg38GRCh38
GRCh371423,887,196 - 23,887,272 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361422,957,035 - 22,957,111 (-)NCBINCBI36Build 36hg18NCBI36
Celera143,749,891 - 3,749,967 (-)NCBICelera
Cytogenetic Map14q11.2NCBI
HuRef144,003,632 - 4,003,708 (-)NCBIHuRef
CHM1_11423,885,868 - 23,885,944 (-)NCBICHM1_1
T2T-CHM13v2.01417,618,991 - 17,619,067 (-)NCBIT2T-CHM13v2.0
Mir208b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391455,213,157 - 55,213,233 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1455,213,157 - 55,213,233 (-)EnsemblGRCm39 Ensembl
GRCm381454,975,700 - 54,975,776 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1454,975,700 - 54,975,776 (-)EnsemblGRCm38mm10GRCm38
MGSCv371455,594,537 - 55,594,613 (-)NCBIGRCm37MGSCv37mm9NCBIm37
Celera1452,781,639 - 52,781,715 (-)NCBICelera
Cytogenetic Map14C3NCBI
cM Map1428.02NCBI
MIR208B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.183,665,163 - 3,665,236 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl83,665,163 - 3,665,236 (-)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.083,772,895 - 3,772,968 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.183,464,425 - 3,464,498 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.083,525,897 - 3,525,970 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.083,787,921 - 3,787,994 (-)NCBIUU_Cfam_GSD_1.0
MIR208B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl775,667,786 - 75,667,865 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1775,667,786 - 75,667,865 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2781,071,323 - 81,071,402 (-)NCBISscrofa10.2Sscrofa10.2susScr3

miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:7878
Count of gene targets:5261
Count of transcripts:5636
Interacting mature miRNAs:rno-miR-208b-3p, rno-miR-208b-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15129912054Rat
8552920Pigfal8Plasma insulin-like growth factor 1 level QTL 83blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)15134723002Rat
8694361Abfw6Abdominal fat weight QTL 610.20.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)15134723002Rat
9589149Insul29Insulin level QTL 299.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)15134723002Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
5685002Bss103Bone structure and strength QTL 1032.8tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)151448116528469888Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)151985656634924750Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)151985656646187442Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)152803066582262678Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)152803066582262678Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)152803066582262678Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system appendage
High
Medium 19
Low 22 8 8 1 1 7 8
Below cutoff 2 1 1 1 1 1 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000063134
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1528,451,638 - 28,451,749 (-)Ensembl
Rnor_6.0 Ensembl1533,639,510 - 33,639,621 (-)Ensembl
RefSeq Acc Id: NR_037354
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81532,421,615 - 32,421,726 (-)NCBI
mRatBN7.21528,451,638 - 28,451,749 (-)NCBI
Rnor_6.01533,639,510 - 33,639,621 (-)NCBI
Rnor_5.01537,526,109 - 37,526,220 (-)NCBI
Celera1528,029,311 - 28,029,422 (-)NCBI
Sequence:
Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:4888543 AgrOrtholog
BioCyc Gene G2FUF-13748 BioCyc
Ensembl Genes ENSRNOG00000041381 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000063134 ENTREZGENE
miRBase MI0015434 ENTREZGENE
NCBI Gene 100526635 ENTREZGENE
PhenoGen Mir208b PhenoGen
RatGTEx ENSRNOG00000041381 RatGTEx
RNAcentral URS0000759C11 RNACentral
  URS000075A6AF RNACentral
  URS000075B3EA RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-03-25 Mir208b  microRNA 208b  Mir208b  microRNA mir-208b  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-11-23 Mir208b  microRNA mir-208b      Symbol and Name status set to provisional 70820 PROVISIONAL