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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:11501 | 6480464 | [Tetrachlorodibenzodioxin binds to AHR protein] which results in decreased expression of ZAP70 mRNA | CTD | PMID:16214954 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of ZAP70 mRNA | CTD | PMID:21724226 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of ZAP70 mRNA | CTD | PMID:22298810 | 3,3',4,4'-tetrachlorobiphenyl | multiple interactions | ISO | RGD:11501 | 6480464 | 3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of ZAP70 mRNA] | CTD | PMID:19467301 | aflatoxin B1 | increases expression | ISO | RGD:1349191 | 6480464 | Aflatoxin B1 results in increased expression of ZAP70 mRNA | CTD | PMID:21641981 | benzo[a]pyrene | multiple interactions | ISO | RGD:11501 | 6480464 | Benzo(a)pyrene promotes the reaction [AHR protein binds to ZAP70 promoter] | CTD | PMID:19654925 | benzo[a]pyrene | increases expression | ISO | RGD:1349191 | 6480464 | Benzo(a)pyrene results in increased expression of ZAP70 mRNA | CTD | PMID:22316170 | benzo[a]pyrene | increases expression | EXP | | 6480464 | Benzo(a)pyrene results in increased expression of ZAP70 mRNA | CTD | PMID:21839799 | benzo[a]pyrene | decreases expression | ISO | RGD:1349191 | 6480464 | Benzo(a)pyrene results in decreased expression of ZAP70 mRNA | CTD | PMID:20498004 | cadmium dichloride | increases methylation | EXP | | 6480464 | Cadmium Chloride results in increased methylation of ZAP70 promoter | CTD | PMID:22457795 | calciol | decreases expression | ISO | RGD:11501 | 6480464 | Cholecalciferol results in decreased expression of ZAP70 mRNA | CTD | PMID:16508948 | clofibrate | multiple interactions | ISO | RGD:11501 | 6480464 | PPARA protein affects the reaction [Clofibrate results in decreased expression of ZAP70 mRNA]; more ... | CTD | PMID:17585979 | clofibrate | decreases expression | ISO | RGD:11501 | 6480464 | Clofibrate results in decreased expression of ZAP70 mRNA | CTD | PMID:17585979 | copper(2+) sulfate | increases expression | ISO | RGD:1349191 | 6480464 | Copper Sulfate results in increased expression of ZAP70 mRNA | CTD | PMID:19549813 | cyclophosphamide | decreases expression | ISO | RGD:11501 | 6480464 | Cyclophosphamide results in decreased expression of ZAP70 mRNA | CTD | PMID:21041162 | dasatinib (anhydrous) | increases response to substance | ISO | RGD:1349191 | 6480464 | ZAP70 protein results in increased susceptibility to dasatinib | CTD | PMID:18550857 | dexamethasone | decreases expression | ISO | RGD:11501 | 6480464 | Dexamethasone results in decreased expression of ZAP70 mRNA | CTD | PMID:21041162 | dibutyl phthalate | increases expression | EXP | | 6480464 | Dibutyl Phthalate results in increased expression of ZAP70 mRNA | CTD | PMID:21266533 | diethylstilbestrol | decreases expression | ISO | RGD:11501 | 6480464 | Diethylstilbestrol results in decreased expression of ZAP70 mRNA | CTD | PMID:21041162 | disodium selenite | increases expression | ISO | RGD:1349191 | 6480464 | Sodium Selenite results in increased expression of ZAP70 mRNA | CTD | PMID:18175754 | fumonisin B1 | decreases expression | ISO | RGD:11501 | 6480464 | fumonisin B1 results in decreased expression of ZAP70 mRNA | CTD | PMID:16221962 | lead diacetate | decreases expression | ISO | RGD:11501 | 6480464 | lead acetate results in decreased expression of ZAP70 mRNA | CTD | PMID:20542052 | N-ethyl-N-nitrosourea | increases mutagenesis | ISO | RGD:11501 | 6480464 | Ethylnitrosourea results in increased mutagenesis of ZAP70 gene | CTD | PMID:17767948 | paracetamol | affects expression | ISO | RGD:11501 | 6480464 | Acetaminophen affects the expression of ZAP70 mRNA | CTD | PMID:17562736 | paracetamol | multiple interactions | ISO | RGD:11501 | 6480464 | PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of ZAP70 mRNA] | CTD | PMID:17585979 | phenobarbital | multiple interactions | ISO | RGD:11501 | 6480464 | NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of ZAP70 mRNA] | CTD | PMID:19482888 | phenobarbital | affects expression | ISO | RGD:11501 | 6480464 | Phenobarbital affects the expression of ZAP70 mRNA | CTD | PMID:23091169 | phenobarbital | decreases expression | ISO | RGD:11501 | 6480464 | Phenobarbital results in decreased expression of ZAP70 mRNA | CTD | PMID:19482888 | phenytoin | decreases expression | ISO | RGD:11501 | 6480464 | Phenytoin results in decreased expression of ZAP70 mRNA | CTD | PMID:15136057 | pirinixic acid | decreases expression | ISO | RGD:11501 | 6480464 | pirinixic acid results in decreased expression of ZAP70 mRNA | CTD | PMID:20059764 more ... | pirinixic acid | decreases expression | ISO | RGD:11501 | 6480464 | pirinixic acid results in decreased expression of ZAP70 mRNA | CTD | PMID:11798191 more ... | pirinixic acid | decreases expression | ISO | RGD:11501 | 6480464 | pirinixic acid results in decreased expression of ZAP70 mRNA | CTD | PMID:11798191 more ... | pirinixic acid | decreases expression | ISO | RGD:11501 | 6480464 | pirinixic acid results in decreased expression of ZAP70 mRNA | CTD | PMID:20059764 more ... | pirinixic acid | decreases expression | ISO | RGD:11501 | 6480464 | pirinixic acid results in decreased expression of ZAP70 mRNA | CTD | PMID:16221962 more ... | pirinixic acid | multiple interactions | ISO | RGD:11501 | 6480464 | PPARA protein promotes the reaction [pirinixic acid results in decreased expression of ZAP70 mRNA] | CTD | PMID:20059764 | tert-butyl hydroperoxide | increases expression | EXP | | 6480464 | tert-Butylhydroperoxide results in increased expression of ZAP70 mRNA | CTD | PMID:22659508 | vanadium atom | decreases expression | ISO | RGD:1349191 | 6480464 | Vanadium results in decreased expression of ZAP70 mRNA | CTD | PMID:19000753 | vanadium(0) | decreases expression | ISO | RGD:1349191 | 6480464 | Vanadium results in decreased expression of ZAP70 mRNA | CTD | PMID:19000753 | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Natural killer cell mediated cytotoxicity |
| NF-kappa B signaling pathway | |
| Primary immunodeficiency | |
| T cell receptor signaling pathway | |
| Pathway Interaction Database | Class I PI3K signaling events (PID:200116) |
| TCR signaling in naïve CD4+ T cells (PID:200027) | |
| TCR signaling in naïve CD8+ T cells (PID:200075) | |
Disease Annotations
Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Natural killer cell mediated cytotoxicity |
| NF-kappa B signaling pathway | |
| Primary immunodeficiency | |
| T cell receptor signaling pathway | |
| Pathway Interaction Database | Class I PI3K signaling events (PID:200116) |
| TCR signaling in naïve CD4+ T cells (PID:200027) | |
| TCR signaling in naïve CD8+ T cells (PID:200075) | |
References - curated
References - uncurated
RGD Disease Portals| Zap70 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Zap70 (Rattus norvegicus) |
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| ZAP70 (Homo sapiens) |
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| Zap70 (Mus musculus) |
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Position Markers| RH132636 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| RefSeq Acc Id: | NM_001012002 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_001012002 | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_001012002 | (Get FASTA) |
| GenBank Protein | AAH89855 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000016995 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000023036 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Transcript | ENSRNOT00000023036 | ENTREZGENE, UniProtKB/TrEMBL |
| Entrez Gene | 301348 | ENTREZGENE |
| Gene3D-CATH | G3DSA:1.10.930.10 | UniProtKB/TrEMBL |
| SH2 | UniProtKB/TrEMBL | |
| HomoloGene Group ID | 839 | ENTREZGENE |
| IMAGE_CLONE | IMAGE:7380367 | IMAGE-MGC_LOAD |
| InterPro | Kinase-like_dom | UniProtKB/TrEMBL |
| Kinase_SYK/ZAP-70_inter-SH2 | UniProtKB/TrEMBL | |
| Prot_kinase_cat_dom | UniProtKB/TrEMBL | |
| Protein_kinase_ATP_BS | UniProtKB/TrEMBL | |
| Ser-Thr/Tyr-Pkinase | UniProtKB/TrEMBL | |
| SH2 | UniProtKB/TrEMBL | |
| Tyr_kinase_non-rcpt_SYK/ZAP70 | UniProtKB/TrEMBL | |
| Tyr_Pkinase_cat_dom | UniProtKB/TrEMBL | |
| Tyr_prot_kinase_AS | UniProtKB/TrEMBL | |
| IPI | IPI00357886 | UniProtKB/TrEMBL |
| KEGG Report | rno:301348 | ENTREZGENE, UniProtKB/TrEMBL |
| MGC_CLONE | MGC:108902 | IMAGE-MGC_LOAD |
| Pfam | Pkinase_Tyr | UniProtKB/TrEMBL |
| SH2 | UniProtKB/TrEMBL | |
| PIRSF | TyrPK_SYK | UniProtKB/TrEMBL |
| PRINTS | SH2DOMAIN | UniProtKB/TrEMBL |
| TYRKINASE | UniProtKB/TrEMBL | |
| PROSITE | PROTEIN_KINASE_ATP | UniProtKB/TrEMBL |
| PROTEIN_KINASE_DOM | UniProtKB/TrEMBL | |
| PROTEIN_KINASE_TYR | UniProtKB/TrEMBL | |
| SH2 | UniProtKB/TrEMBL | |
| SMART | SH2 | UniProtKB/TrEMBL |
| TyrKc | UniProtKB/TrEMBL | |
| Superfamily-SCOP | Kinase_like | UniProtKB/TrEMBL |
| UniGene | Rn.17862 | ENTREZGENE |
| UniProt | Q5FVN9_RAT | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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| 2012-03-06 | Zap70 | zeta-chain (TCR) associated protein kinase 70 | Zap70 | zeta-chain (TCR) associated protein kinase | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2008-06-27 | Zap70 | zeta-chain (TCR) associated protein kinase | Zap70 | zeta-chain (TCR) associated protein kinase 70 | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2007-02-20 | Zap70 | zeta-chain (TCR) associated protein kinase 70 | Zap70_mapped | zeta-chain (TCR) associated protein kinase 70 (mapped) | Symbol and Name updated to reflect Human and Mouse nomenclature | 10779 | PROVISIONAL |
| 2007-02-20 | Zap70_mapped | zeta-chain (TCR) associated protein kinase 70 (mapped) | Zap70_retired | zeta-chain (TCR) associated protein kinase 70 (mapped) | Data Merged | 9333 | PROVISIONAL |
| 2007-02-20 | Zap70_retired | Zap70 | zeta-chain (TCR) associated protein kinase 70 (mapped) | Symbol updated | 10779 | PROVISIONAL | |
| 2006-11-19 | Zap70 | zeta-chain (TCR) associated protein kinase 70 (mapped) | Symbol and Name status set to provisional | 1724 | PROVISIONAL | ||
| 2005-11-17 | Zap70_mapped | zeta-chain (TCR) associated protein kinase 70 (mapped) | Zap70 | zeta-chain (TCR) associated protein kinase 70kDa | Symbol and Name updated | 14094 | APPROVED |
| 2003-04-09 | Zap70 | zeta-chain (TCR) associated protein kinase 70kDa | Name updated | 2575 | APPROVED | ||
| 2003-03-11 | zeta-chain (TCR) associated protein kinase 70kDa | Zap70 | zeta-chain (TCR) associated protein kinase | Name updated to reflect Human and Mouse nomenclature | 101 | PROVISIONAL | |
| 2002-06-10 | Zap70 | zeta-chain (TCR) associated protein kinase | Name updated | 1488 | APPROVED | ||
| 2001-07-23 | Zap70 | zeta-chain (TCR) associated protein kinase (70kD) | Name updated to reflect Human and Mouse nomenclature | 461 | APPROVED | ||
| 2001-07-23 | Zap70 | zeta-chain (TCR) associated protein kinase (70kD) | Name withdrawn | 461 | WITHDRAWN | ||
| 2001-07-09 | Zap70 | zeta-chain (TCR) associated protein kinase (70kD) | Name updated to reflect Human and Mouse nomenclature | 461 | APPROVED | ||
| 2001-07-09 | Zap70 | Syk-related protein tyrosine kinase | Name withdrawn | 461 | WITHDRAWN |
RGD Curation Notes| Note Type | Note | Reference |
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| More on Zap70 | |
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Entrez Gene |
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Ensembl Gene |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 3983 |
| Created: | 2000-05-25 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




