Klk1c2 (kallikrein 1-related peptidase C2) - Rat Genome Database

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Pathways
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Gene: Klk1c2 (kallikrein 1-related peptidase C2) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Klk1c2
Name: kallikrein 1-related peptidase C2 (Ensembl:kallikrein 1-related peptidase C2)
RGD ID: 3888
Description: Enables serine-type peptidase activity. Predicted to be involved in regulation of systemic arterial blood pressure and zymogen activation. Predicted to be active in secretory granule. Human ortholog(s) of this gene implicated in cardiomyopathy; chronic kidney disease; end stage renal disease; hypertension; and myocardial infarction. Orthologous to human KLK1 (kallikrein 1); INTERACTS WITH ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: esterase 1; glandular kallikrein-2; kallikrein 1-related peptidase C2; kallikrein a1; KLK2; Klna1; rGK-2; RSKG-5; S2 kallikrein; Ton; tonin
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81103,628,854 - 103,633,000 (-)NCBIGRCr8
mRatBN7.2194,492,332 - 94,496,480 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl194,492,332 - 94,496,481 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx199,877,721 - 99,881,867 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01108,350,346 - 108,354,494 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01101,640,795 - 101,644,875 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0199,981,045 - 99,985,422 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl199,981,045 - 99,985,422 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01101,046,494 - 101,050,871 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4194,471,693 - 94,475,839 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1194,549,803 - 94,553,950 (-)NCBI
Celera188,759,439 - 88,763,585 (-)NCBICelera
Cytogenetic Map1q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
secretory granule  (IBA,IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Tonin expression in the rat brain and tonin-mediated central production of angiotensin II. Araujo RC, etal., Physiol Behav 2002 Jun 1;76(2):327-33.
2. Kallikrein-related mRNAs of the rat submaxillary gland: nucleotide sequences of four distinct types including tonin. Ashley PL and MacDonald RJ, Biochemistry 1985 Aug 13;24(17):4512-20.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Klk1 as one of the genes contributing to hypertension in Dahl salt-sensitive rat. Iwai N, etal., Hypertension 2005 May;45(5):947-53. Epub 2005 Apr 4.
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Characterization of genes encoding rat tonin and a kallikrein-like serine protease. Shai SY, etal., Biochemistry 1989 Jun 27;28(13):5334-43.
9. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
10. Organization and expression of the rat kallikrein gene family. Wines DR, etal., J Biol Chem 1989 May 5;264(13):7653-62.
Additional References at PubMed
PMID:1315752   PMID:2302205   PMID:2821276   PMID:3038148   PMID:6320014   PMID:12543632   PMID:15203212   PMID:17366701   PMID:20180641   PMID:26216430  


Genomics

Variants

.
Variants in Klk1c2
30 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:98
Count of miRNA genes:78
Interacting mature miRNAs:82
Transcripts:ENSRNOT00000025701
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)180592172125592172Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)number of 20 x 20 cm floor squares crossed into, out of or within a discrete space in an experimental apparatus (CMO:0001514)183547917128547917Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)194494440117601394Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)190664883143200202Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)190532338123479925Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)177876254106047988Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192184926137184926Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)185424647100358001Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)182174743118944897Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)187580395150700247Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)192948896144267916Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat

Markers in Region
D1Mit30  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2194,494,440 - 94,494,763 (+)MAPPERmRatBN7.2
mRatBN7.2194,494,579 - 94,494,763 (+)MAPPERmRatBN7.2
Rnor_6.0199,983,524 - 99,983,705NCBIRnor6.0
Rnor_6.0199,983,293 - 99,983,705NCBIRnor6.0
Rnor_5.01101,048,742 - 101,049,154UniSTSRnor5.0
Rnor_5.01101,048,973 - 101,049,154UniSTSRnor5.0
RGSC_v3.4194,473,941 - 94,474,122UniSTSRGSC3.4
RGSC_v3.4194,473,940 - 94,474,122RGDRGSC3.4
RGSC_v3.1194,552,051 - 94,552,233RGD
Celera188,761,687 - 88,761,868UniSTS
RH 3.4 Map1904.9UniSTS
RH 3.4 Map1904.9RGD
RH 2.0 Map1595.2RGD
Cytogenetic Map1q22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system hemolymphoid system renal system reproductive system
High
Medium
Low 3 3 9 1
Below cutoff 1 4 4 12 8

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000025701   ⟹   ENSRNOP00000025701
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl199,981,045 - 99,985,422 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000081095   ⟹   ENSRNOP00000070080
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl194,492,332 - 94,494,728 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000107012   ⟹   ENSRNOP00000081904
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl194,492,332 - 94,496,481 (-)Ensembl
RefSeq Acc Id: NM_012677   ⟹   NP_036809
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81103,628,854 - 103,633,000 (-)NCBI
mRatBN7.2194,492,332 - 94,496,480 (-)NCBI
Rnor_6.0199,981,045 - 99,985,422 (-)NCBI
Rnor_5.01101,046,494 - 101,050,871 (-)NCBI
RGSC_v3.4194,471,693 - 94,475,839 (-)RGD
Celera188,759,439 - 88,763,585 (-)RGD
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_036809   ⟸   NM_012677
- Peptide Label: precursor
- UniProtKB: P00759 (UniProtKB/Swiss-Prot),   A0A1R3UCJ3 (UniProtKB/TrEMBL),   A0A0G2JX00 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000025701   ⟸   ENSRNOT00000025701
RefSeq Acc Id: ENSRNOP00000081904   ⟸   ENSRNOT00000107012
RefSeq Acc Id: ENSRNOP00000070080   ⟸   ENSRNOT00000081095
Protein Domains
Peptidase S1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P00759-F1-model_v2 AlphaFold P00759 1-259 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3888 AgrOrtholog
BioCyc Gene G2FUF-59808 BioCyc
Ensembl Genes ENSRNOG00000029237 Ensembl
  ENSRNOG00000068685 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055005801 UniProtKB/Swiss-Prot
  ENSRNOG00060011050 UniProtKB/Swiss-Prot
  ENSRNOG00065029884 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000081095.2 UniProtKB/TrEMBL
  ENSRNOT00000107012 ENTREZGENE
  ENSRNOT00000107012.1 UniProtKB/Swiss-Prot
  ENSRNOT00055009379 UniProtKB/Swiss-Prot
  ENSRNOT00060018708 UniProtKB/Swiss-Prot
  ENSRNOT00065051642 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Peptidase_S1_PA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24841 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 24841 ENTREZGENE
PANTHER KALLIKREIN-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KALLIKREIN-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Trypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Klk1c2 PhenoGen
PRINTS CHYMOTRYPSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TRYPSIN_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000029237 RatGTEx
  ENSRNOG00000068685 RatGTEx
  ENSRNOG00055005801 RatGTEx
  ENSRNOG00060011050 RatGTEx
  ENSRNOG00065029884 RatGTEx
SMART Tryp_SPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50494 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC229150
UniProt A0A0G2JX00 ENTREZGENE, UniProtKB/TrEMBL
  A0A1R3UCJ3 ENTREZGENE, UniProtKB/TrEMBL
  KLK2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-06-29 Klk1c2  kallikrein 1-related peptidase C2  Ton  tonin  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Ton  Tonin      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in the submandibular gland 634504
gene_process mediates central production of angiotensin II in brain 634504