Sry (sex determining region Y) - Rat Genome Database

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Gene: Sry (sex determining region Y) Rattus norvegicus
Analyze
Symbol: Sry
Name: sex determining region Y
RGD ID: 3759
Description: Enables enzyme binding activity and sequence-specific DNA binding activity. Involved in male sex determination and positive regulation of transcription by RNA polymerase II. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in 46,XX sex reversal 1; 46,XY sex reversal; and 46,XY sex reversal 1. Orthologous to human SRY (sex determining region Y); INTERACTS WITH ammonium chloride; bisphenol A; copper atom.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: HMG box transcription factor Sry1; HMG box transcription factor Sry3; HMG box transcription factor Sry3B; HMG box transcription factor Sry3BI; HMG box transcription factor Sry3C; sex determining region of Chr Y; sex determining region on Y; sex-determining region Y protein; sex-determining region Y protein 3B; Sry1; Sry3; Sry3B; Sry3BI; Sry3C; SRYGENE; Tdf; Tdy; testis determining locus; testis-determining factor
RGD Orthologs
Human
Mouse
Bonobo
Dog
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8Y465,260 - 465,772 (+)NCBIGRCr8
mRatBN7.2Y441,525 - 442,037 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_UtxY1,408,967 - 1,409,476 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0Y1,568,514 - 1,569,023 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0Y780,432 - 780,941 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0Y327,176 - 327,685 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblY327,166 - 329,299 (+)EnsemblRnor6.0rn6Rnor6.0
Cytogenetic MapYq11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Use of a rat cDNA probe specific for the Y chromosome to detect male-derived cells. An J, etal., J Androl 1997 May-Jun;18(3):289-93.
2. Direct regulation of adult brain function by the male-specific factor SRY. Dewing P, etal., Curr Biol. 2006 Feb 21;16(4):415-20.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. SRY recognizes conserved DNA sites in sex-specific promoters. Haqq CM, etal., Proc Natl Acad Sci U S A. 1993 Feb 1;90(3):1097-101.
5. Mutational analysis of SRY in XY females. Hawkins JR Hum Mutat. 1993;2(5):347-50.
6. A human XY female with a frame shift mutation in the candidate testis-determining gene SRY. Jager RJ, etal., Nature. 1990 Nov 29;348(6300):452-4.
7. The poly(ADP-ribose) polymerase 1 interacts with Sry and modulates its biological functions. Li Y, etal., Mol Cell Endocrinol. 2006 Sep 26;257-258:35-46. Epub 2006 Aug 9.
8. Regulation of tyrosine hydroxylase gene transcription by Sry. Milsted A, etal., Neurosci Lett. 2004 Oct 21;369(3):203-7.
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:1425584   PMID:7774816   PMID:8162230   PMID:8265659   PMID:8625802   PMID:9486644   PMID:9571157   PMID:11869290   PMID:15469996   PMID:15879091   PMID:16185683   PMID:16414182  
PMID:16582099   PMID:16700629   PMID:16996051   PMID:17408480   PMID:19075093   PMID:19457926   PMID:19809364   PMID:19850934   PMID:21412441   PMID:21508350   PMID:21637323   PMID:22344693  
PMID:22514746   PMID:22984422   PMID:23034159   PMID:23893245   PMID:24228692   PMID:24681825   PMID:25759379   PMID:27576690   PMID:28030592   PMID:31371505   PMID:32398044  


Genomics

Comparative Map Data
Sry
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8Y465,260 - 465,772 (+)NCBIGRCr8
mRatBN7.2Y441,525 - 442,037 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_UtxY1,408,967 - 1,409,476 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0Y1,568,514 - 1,569,023 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0Y780,432 - 780,941 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0Y327,176 - 327,685 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblY327,166 - 329,299 (+)EnsemblRnor6.0rn6Rnor6.0
Cytogenetic MapYq11NCBI
SRY
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38Y2,786,855 - 2,787,682 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblY2,786,855 - 2,787,682 (-)EnsemblGRCh38hg38GRCh38
GRCh37Y2,654,896 - 2,655,723 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36Y2,714,896 - 2,715,792 (-)NCBINCBI36Build 36hg18NCBI36
Build 34Y2,698,256 - 2,699,153NCBI
CeleraX88,844,082 - 88,844,978 (-)NCBICelera
Cytogenetic MapYp11.2NCBI
HuRefY7,900 - 8,786 (-)NCBIHuRef
T2T-CHM13v2.0Y2,463,695 - 2,464,522 (-)NCBIT2T-CHM13v2.0
Sry
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39Y2,662,471 - 2,663,658 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblY2,662,471 - 2,663,658 (-)EnsemblGRCm39 Ensembl
GRCm38Y2,662,471 - 2,663,658 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblY2,662,471 - 2,663,658 (-)EnsemblGRCm38mm10GRCm38
MGSCv37Y1,918,381 - 1,919,568 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36Y1,947,341 - 1,948,528 (-)NCBIMGSCv36mm8
CeleraY5,570,827 - 5,572,014 (+)NCBICelera
Cytogenetic MapYpterNCBI
SRY
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2Y44,391,717 - 44,406,267 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1Y2,531,737 - 2,532,564 (-)NCBINHGRI_mPanPan1
SRY
(Canis lupus familiaris - dog)		 No map positions available.
SRY
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblY40,484,990 - 40,485,700 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1Y40,484,990 - 40,485,700 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2Y279,587 - 280,297 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig CytomapYp12-p13NCBI
SRY
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X927,143 - 928,924 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX927,692 - 928,303 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system nervous system reproductive system
High
Medium
Low 2
Below cutoff 4 4 7

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000092902   ⟹   ENSRNOP00000076001
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblY327,166 - 329,299 (+)Ensembl
RefSeq Acc Id: NM_001416740   ⟹   NP_001403669
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8Y465,260 - 465,772 (+)NCBI
mRatBN7.2Y441,525 - 442,037 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000076001   ⟸   ENSRNOT00000092902
RefSeq Acc Id: NP_001403669   ⟸   NM_001416740
- UniProtKB: Q811V5 (UniProtKB/TrEMBL),   Q811V4 (UniProtKB/TrEMBL)
Protein Domains
HMG box

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P36394-F1-model_v2 AlphaFold P36394 1-169 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3759 AgrOrtholog
BioCyc Gene G2FUF-418 BioCyc
Ensembl Genes ENSRNOG00000062090 Ensembl
Gene3D-CATH 1.10.30.10 UniProtKB/TrEMBL
InterPro HMG_box_dom UniProtKB/TrEMBL
  HMG_box_dom_sf UniProtKB/TrEMBL
KEGG Report rno:103694545 UniProtKB/TrEMBL
  rno:103694550 UniProtKB/TrEMBL
NCBI Gene 25221 ENTREZGENE
PANTHER SEX-DETERMINING REGION Y PROTEIN UniProtKB/TrEMBL
  SOX TRANSCRIPTION FACTOR UniProtKB/TrEMBL
Pfam HMG_box UniProtKB/TrEMBL
PhenoGen Sry PhenoGen
PROSITE HMG_BOX_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000062090 RatGTEx
SMART HMG UniProtKB/TrEMBL
Superfamily-SCOP SSF47095 UniProtKB/TrEMBL
TIGR TC233014
UniProt Q811V4 ENTREZGENE, UniProtKB/TrEMBL
  Q811V5 ENTREZGENE, UniProtKB/TrEMBL
  W8BZ20_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-23 Sry  sex determining region Y  Sry  sex determining region of Chr Y  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-15 Sry  sex determining region of Chr Y  Sry  sex determining region on Y  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Sry  sex determining region on Y      Symbol and Name status set to approved 70586 APPROVED
2001-03-05 Tdf  Testis determining locus      Symbol withdrawn, duplicate entry of Sry (RGD:3759) 61033 WITHDRAWN
2001-03-05 Tdy  Testis determining locus      Symbol withdrawn, duplicate entry of Sry (RGD:3759) 61033 WITHDRAWN

RGD Curation Notes
Note Type Note Reference
gene_process may be involved in fetal male sexual development or spermiogenesis 730036