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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (+)-trans-(S)-allethrin | affects activity | EXP | | 6480464 | bioallethrin affects the activity of SCN10A protein | CTD | PMID:19766671 | allethrin | multiple interactions | EXP | | 6480464 | Allethrin affects the reaction [SCN10A protein results in increased transport of Sodium] | CTD | PMID:16051293 | benzo[a]pyrene | decreases expression | EXP | | 6480464 | Benzo(a)pyrene results in decreased expression of SCN10A mRNA | CTD | PMID:21839799 | benzo[a]pyrene | decreases expression | ISO | RGD:1349086 | 6480464 | Benzo(a)pyrene results in decreased expression of SCN10A mRNA | CTD | PMID:22316170 | bifenthrin | multiple interactions | EXP | | 6480464 | bifenthrin affects the reaction [SCN10A protein results in increased transport of Sodium] | CTD | PMID:16051293 | C60 fullerene | decreases expression | EXP | | 6480464 | fullerene C60 results in decreased expression of SCN10A mRNA | CTD | PMID:19167457 | capsaicin | multiple interactions | ISO | RGD:736179 | 6480464 | SCN10A protein affects the reaction [Capsaicin results in increased secretion of TAC1 protein alternative form] | CTD | PMID:18845912 | capsaicin | increases response to substance | ISO | RGD:736179 | 6480464 | SCN10A results in increased susceptibility to Capsaicin | CTD | PMID:12351708 | cocaine | affects expression | EXP | | 6480464 | Cocaine affects the expression of SCN10A mRNA | CTD | PMID:20187946 | cyfluthrin | multiple interactions | EXP | | 6480464 | cyfluthrin affects the reaction [SCN10A protein results in increased transport of Sodium] | CTD | PMID:16051293 | cyfluthrin | affects activity | EXP | | 6480464 | cyfluthrin affects the activity of SCN10A protein | CTD | PMID:19766671 | cyhalothrin | multiple interactions | EXP | | 6480464 | cyhalothrin affects the reaction [SCN10A protein results in increased transport of Sodium] | CTD | PMID:16051293 | cyhalothrin | affects activity | EXP | | 6480464 | cyhalothrin affects the activity of SCN10A protein | CTD | PMID:19766671 | cypermethrin | multiple interactions | EXP | | 6480464 | cypermethrin affects the reaction [SCN10A protein results in increased transport of Sodium] | CTD | PMID:16051293 | cypermethrin | affects activity | EXP | | 6480464 | cypermethrin affects the activity of SCN10A protein | CTD | PMID:19766671 | fenpropathrin | multiple interactions | EXP | | 6480464 | fenpropathrin affects the reaction [SCN10A protein results in increased transport of Sodium] | CTD | PMID:16051293 | fenpropathrin | affects activity | EXP | | 6480464 | fenpropathrin affects the activity of SCN10A protein | CTD | PMID:19766671 | fenvalerate | multiple interactions | EXP | | 6480464 | fenvalerate affects the reaction [SCN10A protein results in increased transport of Sodium] | CTD | PMID:16051293 | kojic acid | decreases expression | ISO | RGD:1349086 | 6480464 | kojic acid results in decreased expression of SCN10A mRNA | CTD | PMID:16595896 | mexiletine | multiple interactions | ISO | RGD:1349086 | 6480464 | Mexiletine inhibits the reaction [decamethrin results in increased activity of SCN10A protein] | CTD | PMID:16325806 | N-methyl-N-nitrosurea | decreases expression | EXP | | 6480464 | Methylnitrosourea results in decreased expression of SCN10A mRNA | CTD | PMID:16525678 | permethrin | multiple interactions | EXP | | 6480464 | Permethrin affects the reaction [SCN10A protein results in increased transport of Sodium] | CTD | PMID:16051293 | potassium chloride | multiple interactions | ISO | RGD:736179 | 6480464 | SCN10A protein affects the reaction [Potassium Chloride results in increased secretion of TAC1 protein alternative form] | CTD | PMID:18845912 | sodium atom | multiple interactions | EXP | | 6480464 | Allethrin affects the reaction [SCN10A protein results in increased transport of Sodium]; more ... | CTD | PMID:16051293 | sodium atom | increases transport | EXP | | 6480464 | SCN10A protein results in increased transport of Sodium | CTD | PMID:16051293 PMID:19026681 | sodium atom | increases transport | EXP | | 6480464 | SCN10A protein results in increased transport of Sodium | CTD | PMID:16051293 | tetracaine | multiple interactions | ISO | RGD:1349086 | 6480464 | Tetracaine inhibits the reaction [decamethrin results in increased activity of SCN10A protein] | CTD | PMID:16325806 | tetracaine | multiple interactions | EXP | | 6480464 | Tetracaine inhibits the reaction [decamethrin results in increased activity of SCN10A protein] | CTD | PMID:16325806 | valproic acid | affects expression | ISO | RGD:736179 | 6480464 | Valproic Acid affects the expression of SCN10A mRNA | CTD | PMID:17292431 | vanadium atom | increases expression | ISO | RGD:1349086 | 6480464 | Vanadium results in increased expression of SCN10A mRNA | CTD | PMID:19000753 | vanadium(0) | increases expression | ISO | RGD:1349086 | 6480464 | Vanadium results in increased expression of SCN10A mRNA | CTD | PMID:19000753 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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References - curated| 1. |
Akopian AN, etal., Nature 1996 Jan 18;379(6562):257-62. |
| 2. |
Byers MR and Westenbroek RE, Arch Oral Biol. 2011 Nov;56(11):1199-220. |
| 3. |
GOA data from the GO Consortium |
| 4. |
Gold MS, etal., J Neurosci 2003 Jan 1;23(1):158-66. |
| 5. |
Joshi SK, etal., J Pain. 2009 Mar;10(3):306-15. Epub 2008 Dec 13. |
| 6. |
Liu C, etal., Mol Cell Neurosci 2005 Apr;28(4):636-49. |
| 7. |
MGD data from the GO Consortium |
| 8. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 9. |
RGD automated data pipeline |
| 10. |
RGD automated import pipeline for gene-chemical interactions |
| 11. |
Ruangsri S, etal., J Biol Chem. 2011 Nov 18;286(46):39836-47. Epub 2011 Sep 30. |
| 12. |
Sangameswaran L, etal., J Biol Chem 1996 Mar 15;271(11):5953-6. |
| 13. |
Tentative Sequence Data IDs. TIGR Gene Index, Rat Data |
References - uncurated| PubMed | 11487631 |
| 12050667 | |
| 12591166 | |
| 14759526 | |
| 14960304 | |
| 15047701 | |
| 15178439 | |
| 16545521 | |
| 17108087 | |
| 17568746 | |
| 17950013 | |
| 18552876 | |
| 18782866 | |
| 19162133 | |
| 19164297 | |
| 19269275 | |
| 19320998 | |
| 19575990 | |
| 19607921 | |
| 19953341 | |
| 20028484 | |
| 20482896 | |
| 20720009 | |
| 21276017 | |
| 21562192 | |
| 22127815 | |
| 22225591 | |
| 22342308 | |
| 23139220 | |
| 9450690 |
RGD Disease Portals| Scn10a has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Scn10a (Rattus norvegicus) |
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| SCN10A (Homo sapiens) |
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| Scn10a (Mus musculus) |
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Position Markers| D8Rat4 |
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| D8Got185 |
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| BE096280 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_017247 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06057565 | (Get FASTA) | Search GEO for Microarray Profiles |
| AABR06057566 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06057567 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01057539 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01057540 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01057541 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AJ623271 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CQ891315 | (Get FASTA) | Search GEO for Microarray Profiles | |
| DQ497426 | (Get FASTA) | Search GEO for Microarray Profiles | |
| U53833 | (Get FASTA) | Search GEO for Microarray Profiles | |
| X92184 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_017247 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_058943 | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_058943 | (Get FASTA) |
| GenBank Protein | AAC52619 | (Get FASTA) |
| ABF59054 | (Get FASTA) | |
| CAA63095 | (Get FASTA) | |
| CAF25041 | (Get FASTA) | |
| CAH68676 | (Get FASTA) | |
| Q62968 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000032473 | ENTREZGENE |
| Ensembl Protein | ENSRNOP00000047944 | ENTREZGENE |
| Ensembl Transcript | ENSRNOT00000046864 | ENTREZGENE |
| Entrez Gene | 29571 | ENTREZGENE |
| Germonline | ENSRNOG00000032473 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 21300 | ENTREZGENE |
| InterPro | Ion_trans | UniProtKB/Swiss-Prot |
| Na_channel | UniProtKB/Swiss-Prot | |
| Na_trans_assoc | UniProtKB/Swiss-Prot | |
| IPI | IPI00210089 | UniProtKB/Swiss-Prot |
| IPI00515844 | UniProtKB/Swiss-Prot | |
| KEGG Report | rno:29571 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Pfam | Ion_trans | UniProtKB/Swiss-Prot |
| Na_trans_assoc | UniProtKB/Swiss-Prot | |
| PRINTS | NACHANNEL | UniProtKB/Swiss-Prot |
| PROSITE | PS50096 | UniProtKB/Swiss-Prot |
| TIGR | TC208312 | |
| UniGene | Rn.10246 | ENTREZGENE |
| UniProt | Q0Q789_RAT | UniProtKB/TrEMBL |
| SCNAA_RAT | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2010-09-16 | Scn10a | sodium channel, voltage-gated, type X, alpha subunit | Scn10a | sodium channel, voltage-gated, type X, alpha | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2009-12-15 | Scn10a | sodium channel, voltage-gated, type X, alpha | Scn10a | sodium channel, voltage-gated, type X, alpha subunit | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2008-09-18 | Scn10a | sodium channel, voltage-gated, type X, alpha subunit | Scn10a | sodium channel, voltage-gated, type X, alpha | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2008-02-13 | Scn10a | sodium channel, voltage-gated, type X, alpha | Scn10a | sodium channel, voltage-gated, type 10, alpha polypeptide | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2005-01-20 | Scn10a | sodium channel, voltage-gated, type 10, alpha polypeptide | Symbol and Name status set to approved | 10779 | APPROVED | ||
| 2002-06-10 | Scn10a | sodium channel, voltage-gated, type 10, alpha polypeptide | Name updated | 1489 | PROVISIONAL |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_expression | expressed primarily in small sensory neurons of the peripheral nervous system | 69978 |
| More on Scn10a | |
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Entrez Gene |
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Ensembl Gene |
![]() | Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 3629 |
| Created: | 2000-05-25 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-05-14 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




