Annotation (Toggle Detail/Summary View) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (-)-epigallocatechin 3-gallate | multiple interactions | ISO | RGD:736433 | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PTPRJ mRNA | CTD | PMID:22079256 | 17alpha-ethynylestradiol | multiple interactions | ISO | RGD:736434 | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PTPRJ mRNA | CTD | PMID:17942748 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:736434 | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PTPRJ mRNA | CTD | PMID:17942748 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:736433 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of PTPRJ mRNA | CTD | PMID:21632981 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of PTPRJ mRNA | CTD | PMID:22298810 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:736434 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of PTPRJ mRNA | CTD | PMID:19933214 | 2,4-dinitrotoluene | affects expression | EXP | | 6480464 | 2,4-dinitrotoluene affects the expression of PTPRJ mRNA | CTD | PMID:21346803 | aflatoxin B1 | decreases expression | ISO | RGD:736433 | 6480464 | Aflatoxin B1 results in decreased expression of PTPRJ mRNA | CTD | PMID:22100608 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of PTPRJ mRNA | CTD | PMID:16483693 | benzo[a]pyrene | decreases expression | ISO | RGD:736433 | 6480464 | Benzo(a)pyrene results in decreased expression of PTPRJ mRNA | CTD | PMID:20064835 | benzo[a]pyrene | decreases expression | ISO | RGD:736434 | 6480464 | Benzo(a)pyrene results in decreased expression of PTPRJ mRNA | CTD | PMID:19770486 | benzo[a]pyrene | multiple interactions | ISO | RGD:736434 | 6480464 | [Benzo(a)pyrene co-treated with XPA gene mutant form co-treated with TRP53 gene mutant form] results in decreased expression of PTPRJ mRNA | CTD | PMID:21715664 | benzo[a]pyrene | increases expression | ISO | RGD:736433 | 6480464 | Benzo(a)pyrene results in increased expression of PTPRJ mRNA | CTD | PMID:20106945 | clofibrate | multiple interactions | ISO | RGD:736434 | 6480464 | PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of PTPRJ mRNA] | CTD | PMID:17585979 | clofibric acid | multiple interactions | EXP | | 6480464 | [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of PTPRJ mRNA | CTD | PMID:17602206 | cyclosporin A | increases expression | ISO | RGD:736433 | 6480464 | Cyclosporine results in increased expression of PTPRJ mRNA | CTD | PMID:20106945 | hydralazine | multiple interactions | ISO | RGD:736433 | 6480464 | [Hydralazine co-treated with Valproic Acid] results in increased expression of PTPRJ mRNA | CTD | PMID:17183730 | methotrexate | affects expression | ISO | RGD:736434 | 6480464 | Methotrexate affects the expression of PTPRJ mRNA | CTD | PMID:18502557 | N-nitrosodiethylamine | multiple interactions | EXP | | 6480464 | [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of PTPRJ mRNA | CTD | PMID:17602206 | paracetamol | multiple interactions | ISO | RGD:736434 | 6480464 | PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of PTPRJ mRNA] | CTD | PMID:17585979 | paracetamol | decreases expression | ISO | RGD:736433 | 6480464 | Acetaminophen results in decreased expression of PTPRJ mRNA | CTD | PMID:21420995 | paracetamol | affects expression | ISO | RGD:736434 | 6480464 | Acetaminophen affects the expression of PTPRJ mRNA | CTD | PMID:17562736 | pregnenolone 16alpha-carbonitrile | decreases expression | EXP | | 6480464 | Pregnenolone Carbonitrile results in decreased expression of PTPRJ mRNA | CTD | PMID:19162173 | propiconazole | decreases expression | ISO | RGD:736434 | 6480464 | propiconazole results in decreased expression of PTPRJ mRNA | CTD | PMID:21278054 | tetrachloromethane | affects expression | ISO | RGD:736434 | 6480464 | Carbon Tetrachloride affects the expression of PTPRJ mRNA | CTD | PMID:17484886 | valproic acid | multiple interactions | ISO | RGD:736433 | 6480464 | [Hydralazine co-treated with Valproic Acid] results in increased expression of PTPRJ mRNA | CTD | PMID:17183730 | valproic acid | affects expression | ISO | RGD:736434 | 6480464 | Valproic Acid affects the expression of PTPRJ mRNA | CTD | PMID:17292431 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Adherens junction |
| Pathway Interaction Database | PDGFR-beta signaling pathway (PID:200149) |
| Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) (PID:200041) | |
| Signaling events mediated by VEGFR1 and VEGFR2 (PID:200188) | |
Disease Annotations
|
|
Gene-Chemical Interaction Annotations
|
|
|
Gene Ontology Annotations
|
|
|
|
|
|
Molecular Pathway Annotations
|
|
| External Database Links | |
| KEGG Pathway | Adherens junction |
| Pathway Interaction Database | PDGFR-beta signaling pathway (PID:200149) |
| Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) (PID:200041) | |
| Signaling events mediated by VEGFR1 and VEGFR2 (PID:200188) | |
References - curated| 1. |
Arena S, etal., Mol Endocrinol. 2007 Jan;21(1):229-46. Epub 2006 Oct 4. |
| 2. |
Borges LG, etal., Circ Res 1996 Sep;79(3):570-80. |
| 3. |
Citri A and Yarden Y, Nat Rev Mol Cell Biol. 2006 Jul;7(7):505-16. |
| 4. |
GOA data from the GO Consortium |
| 5. |
Hinojos CA, etal., Hypertension 2005 Apr;45(4):698-704. Epub 2005 Feb 14. |
| 6. |
MGD data from the GO Consortium |
| 7. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 8. |
Pipeline to import Pathway Interaction Database annotations from NCI into RGD |
| 9. |
RGD automated data pipeline |
| 10. |
RGD automated import pipeline for gene-chemical interactions |
| 11. |
RGD Automated Pipelines |
References - uncurated
RGD Disease Portals| Ptprj has been annotated in the following RGD Disease Portals. |
|||||||
![]() |
| ||||||
![]() |
| ||||||
![]() |
| ||||||
![]() |
| ||||||
![]() |
| ||||||
![]() |
| ||||||
![]() |
| ||||||
Comparative Map Data| Ptprj (Rattus norvegicus) |
|
|||||||||||||||||||||||||||||||||||
| PTPRJ (Homo sapiens) |
|
|||||||||||||||||||||||||||||||||||
| Ptprj (Mus musculus) |
|
Position Markers| D3Rat226 |
|
||||||||||||||||||||||||||||||||||||||||||||||||||
| D3Wox33 |
|
||||||||||||||||||||||||||||||||||||||||||||||||||
| BE101606 |
|
||||||||||||||||||||||||||||||||||||||||||||||||||
| AU046820 |
|
||||||||||||||||||||||||||||||||||||||||||||||||||
| RH135437 |
|
||||||||||||||||||||||||||||||||||||||||||||||||||
| AI407676 |
|
||||||||||||||||||||||||||||||||||||||||||||||||||
| PMC151692P1 |
|
QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_017269 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06024685 | (Get FASTA) | Search GEO for Microarray Profiles |
| AABR06024686 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06024687 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06024688 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06024689 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06024690 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06024691 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06024692 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06024693 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01023435 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01023436 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01023437 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01023438 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01023439 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01023440 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01023441 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473949 | (Get FASTA) | Search GEO for Microarray Profiles | |
| U40790 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_017269 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_058965 | ||||||||||||||||||||
| Position: |
|
Protein Sequences| Protein RefSeqs | NP_058965 | (Get FASTA) |
| GenBank Protein | AAB53195 | (Get FASTA) |
| EDL79464 | (Get FASTA) | |
| EDL79465 | (Get FASTA) |
Strain Sequence Variants
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
External Database Links| Database | Acc Id | Source(s) |
| Entrez Gene | 29645 | ENTREZGENE |
| Gene3D-CATH | Ig-like_fold | UniProtKB/TrEMBL |
| HomoloGene Group ID | 2130 | ENTREZGENE |
| InterPro | FN_III | UniProtKB/TrEMBL |
| Ig-like_fold | UniProtKB/TrEMBL | |
| Tyr/Dual-specificity_Pase | UniProtKB/TrEMBL | |
| Tyr_Pase_AS | UniProtKB/TrEMBL | |
| Tyr_Pase_rcpt/non-rcpt | UniProtKB/TrEMBL | |
| IPI | IPI00209300 | UniProtKB/TrEMBL |
| KEGG Report | rno:29645 | ENTREZGENE |
| Pfam | fn3 | UniProtKB/TrEMBL |
| Y_phosphatase | UniProtKB/TrEMBL | |
| PRINTS | PRTYPHPHTASE | UniProtKB/TrEMBL |
| PROSITE | FN3 | UniProtKB/TrEMBL |
| TYR_PHOSPHATASE_1 | UniProtKB/TrEMBL | |
| TYR_PHOSPHATASE_2 | UniProtKB/TrEMBL | |
| TYR_PHOSPHATASE_PTP | UniProtKB/TrEMBL | |
| SMART | FN3 | UniProtKB/TrEMBL |
| PTPc | UniProtKB/TrEMBL | |
| Superfamily-SCOP | FN_III-like | UniProtKB/TrEMBL |
| UniGene | Rn.10278 | ENTREZGENE |
| UniProt | Q62884_RAT | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2002-06-10 | Ptprj | Protein tyrosine phosphatase, receptor type, J | Symbol and Name status set to approved | 1490 | APPROVED |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_domains | contains a transmembrane domain, phosphatase catalytic domain, and eight fibronectin type III repeats | 633836 |
| gene_expression | expression is decreased 3.5 fold in SHR compared with WKY rats | 1357414 |
| More on Ptprj | |
![]() |
Entrez Gene |
![]() |
Ensembl Gene |
![]() | Genome Browser |
![]() |
NCBI Map Viewer |
![]() |
Vista |
![]() |
Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 3454 |
| Created: | 2000-05-25 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




