Imported Disease Annotations - ClinVarTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | acromesomelic dysplasia-4 | | ISO | PRKG2 (Homo sapiens) | 8554872 | ClinVar Annotator: match by term: Acromesomelic dysplasia 4 | ClinVar | PMID:25741868 more ... | genetic disease | | ISO | PRKG2 (Homo sapiens) | 8554872 | ClinVar Annotator: match by term: Inborn genetic diseases | ClinVar | | Spondylometaphyseal Dysplasia Pagnamenta Type | | ISO | PRKG2 (Homo sapiens) | 8554872 | ClinVar Annotator: match by term: Spondylometaphyseal dysplasia and pagnamenta type | ClinVar | PMID:34782440 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Imported Disease Annotations - OMIM
Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Gene Ontology Annotations Click to see Annotation Detail View
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Molecular Pathway Annotations Click to see Annotation Detail View
Imported Annotations - KEGG (archival)
Phenotype Annotations Click to see Annotation Detail View
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References
References - curated
| # | Reference Title | Reference Citation |
| 1. | Cyclic GMP-dependent protein kinase II is a molecular switch from proliferation to hypertrophic differentiation of chondrocytes. | Chikuda H, etal., Genes Dev. 2004 Oct 1;18(19):2418-29. doi: 10.1101/gad.1224204. |
| 2. | Guanylyl cyclase and protein kinase G mediate nitric oxide suppression of 5-lipoxygenase metabolism in rat alveolar macrophages. | Coffey MJ, etal., Biochim Biophys Acta. 2008 Jun-Jul;1781(6-7):299-305. doi: 10.1016/j.bbalip.2008.04.005. Epub 2008 Apr 24. |
| 3. | ICln159 folds into a pleckstrin homology domain-like structure. Interaction with kinases and the splicing factor LSm4. | Fürst J, etal., J Biol Chem. 2005 Sep 2;280(35):31276-82. Epub 2005 May 19. |
| 4. | Inhibition of cGMP-dependent protein kinase II by its own splice isoform. | Gambaryan S, etal., Biochem Biophys Res Commun 2002 May 24;293(5):1438-44. |
| 5. | cGMP-dependent protein kinase type II regulates basal level of aldosterone production by zona glomerulosa cells without increasing expression of the steroidogenic acute regulatory protein gene. | Gambaryan S, etal., J Biol Chem 2003 Aug 8;278(32):29640-8. Epub 2003 May 29. |
| 6. | Expression of type II cGMP-dependent protein kinase in rat kidney is regulated by dehydration and correlated with renin gene expression. | Gambaryan S, etal., J Clin Invest 1996 Aug 1;98(3):662-70. |
| 7. | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
| 8. | Rat ISS GO annotations from GOA human gene data--August 2006 | GOA data from the GO Consortium |
| 9. | STa and cGMP stimulate CFTR translocation to the surface of villus enterocytes in rat jejunum and is regulated by protein kinase G. | Golin-Bisello F, etal., Am J Physiol Cell Physiol. 2005 Sep;289(3):C708-16. Epub 2005 May 4. |
| 10. | Cloning, expression, and in situ localization of rat intestinal cGMP-dependent protein kinase II. | Jarchau T, etal., Proc Natl Acad Sci U S A 1994 Sep 27;91(20):9426-30. |
| 11. | Rat ISS GO annotations from MGI mouse gene data--August 2006 | MGD data from the GO Consortium |
| 12. | Electronic Transfer of LocusLink and RefSeq Data | NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 13. | Content of mRNA for NMDA glutamate receptor subunits in the frontal cortex and striatum of rats after morphine withdrawal is related to the degree of abstinence. | Peregud DI, etal., Bull Exp Biol Med. 2012 Oct;153(6):835-8. doi: 10.1007/s10517-012-1838-x. |
| 14. | KEGG Annotation Import Pipeline | Pipeline to import KEGG annotations from KEGG into RGD |
| 15. | Expression, purification, and characterization of the cGMP-dependent protein kinases I beta and II using the baculovirus system. | Pohler D, etal., FEBS Lett. 1995 Nov 6;374(3):419-25. |
| 16. | GOA pipeline | RGD automated data pipeline |
| 17. | ClinVar Automated Import and Annotation Pipeline | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
| 18. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
| 19. | Tentative Sequence Identification Numbers | Tentative Sequence Data IDs. TIGR Gene Index, Rat Data |
| 20. | Phenotypic characterization of the Komeda miniature rat Ishikawa, an animal model of dwarfism caused by a mutation in Prkg2. | Tsuchida A, etal., Comp Med. 2008 Dec;58(6):560-7. |
| 21. | Autophosphorylation of cGMP-dependent protein kinase type II. | Vaandrager AB, etal., J Biol Chem 2003 Aug 1;278(31):28651-8. Epub 2003 May 22. |
| 22. | Endogenous type II cGMP-dependent protein kinase exists as a dimer in membranes and can Be functionally distinguished from the type I isoforms. | Vaandrager AB, etal., J Biol Chem. 1997 May 2;272(18):11816-23. |
Additional References at PubMed
| PMID:12725729 | PMID:14960318 | PMID:15312652 | PMID:15582712 | PMID:15763176 | PMID:15958724 | PMID:17341596 | PMID:17626895 | PMID:18656450 | PMID:22203739 | PMID:23545413 | PMID:24966379 |
| PMID:28057484 |
Genomics
Comparative Map Data
| Prkg2 (Rattus norvegicus - Norway rat) |
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| PRKG2 (Homo sapiens - human) |
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| Prkg2 (Mus musculus - house mouse) |
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| Prkg2 (Chinchilla lanigera - long-tailed chinchilla) |
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| PRKG2 (Pan paniscus - bonobo/pygmy chimpanzee) |
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| PRKG2 (Canis lupus familiaris - dog) |
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| Prkg2 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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| PRKG2 (Sus scrofa - pig) |
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| PRKG2 (Chlorocebus sabaeus - green monkey) |
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| Prkg2 (Heterocephalus glaber - naked mole-rat) |
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Variants
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Variants in Prkg2
1697 total Variants 
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