Gene: Pcsk2 (proprotein convertase subtilisin/kexin type 2) Rattus norvegicus
Symbol: Pcsk2
Name: proprotein convertase subtilisin/kexin type 2
Description: ENCODES a protein that exhibits protein complex binding; serine-type endopeptidase activity; endopeptidase activity (ortholog); INVOLVED IN islet amyloid polypeptide processing; peptide hormone processing; proteolysis; PARTICIPATES IN melanocortin system pathway; ASSOCIATED WITH Diabetes Mellitus, Experimental; Endotoxemia; Inflammation; FOUND IN dendrite; neuronal cell body; perikaryon; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil
Type: protein-coding
Also known as: KEX2-like endoprotease 2; NEC 2; neuroendocrine convertase 2; PC2; prohormone convertase 2; proprotein convertase 2
Latest Assembly: RGSC Genome Assembly v5.0
RGSC Genome Assembly v6.03137,618,891 - 137,923,385+NCBI
Rat Cytogenetic Map3q42 NCBI
RGSC Genome Assembly v5.03144,059,121 - 144,362,761+NCBI
RGSC Genome Assembly v3.43131,925,648 - 132,256,178+NCBI
Rat Celera Assembly3129,792,699 - 130,080,973+NCBI
Genome Assembly 3.13131,831,220 - 132,161,751+NCBI
RH 3.431176.7 RGD

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Disease Annotations
Gene-Chemical Interaction Annotations
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Molecular Pathway Annotations
References - curated
References - uncurated
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Comparative Map Data
Position Markers
QTLs in Region (RGSC Genome Assembly v5.0)


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Pcsk2
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Vista + UCSC

RGD Object Information
RGD ID: 3273
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2015-05-12
Status: ACTIVE