Mycs (myc-like oncogene, s-myc protein) - Rat Genome Database

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Gene: Mycs (myc-like oncogene, s-myc protein) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Mycs
Name: myc-like oncogene, s-myc protein
RGD ID: 3133
Description: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in Feingold syndrome. Orthologous to human MYCN (MYCN proto-oncogene, bHLH transcription factor).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: protein S-myc
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X19,745,887 - 19,747,179 (+)NCBIGRCr8
mRatBN7.2X17,038,263 - 17,039,555 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX17,038,263 - 17,039,555 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX21,867,545 - 21,868,837 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X18,214,443 - 18,215,735 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X14,485,782 - 14,487,074 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X17,823,554 - 17,824,846 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX17,823,554 - 17,824,846 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X18,605,539 - 18,606,831 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X28,062,010 - 28,063,302 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X28,115,478 - 28,116,771 (-)NCBI
CeleraX17,108,281 - 17,109,573 (+)NCBICelera
Cytogenetic MapXq12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleus  (IEA)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Isolation and characterization of s-myc, a member of the rat myc gene family. Sugiyama A, etal., Proc Natl Acad Sci U S A 1989 Dec;86(23):9144-8.
6. Gene-based anchoring of the rat genetic linkage and cytogenetic maps: new regional localizations, orientation of the linkage groups, and insights into mammalian chromosome evolution. Szpirer C, etal., Mamm Genome 1998 Sep;9(9):721-34
7. Identifying genes regulated in a Myc-dependent manner. Watson JD, etal., J Biol Chem 2002 Oct 4;277(40):36921-30.

Genomics

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:39
Count of miRNA genes:38
Interacting mature miRNAs:38
Transcripts:ENSRNOT00000004118
Prediction methods:Miranda, Pita, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X143491017Rat
634325Bw13Body weight QTL 130body mass (VT:0001259)body weight (CMO:0000012)X144797220991088Rat
70165Bp64Blood pressure QTL 645.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X144812931706553Rat
631204Gluco15Glucose level QTL 150.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X162371522646544Rat
1298071Edpm12Estrogen-dependent pituitary mass QTL 123.2pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)X292789847927898Rat
10755455Coatc13Coat color QTL 130coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7440600049406000Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X449454949494549Rat
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
71116Niddm16Non-insulin dependent diabetes mellitus QTL 167.81blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X1529780260297802Rat

Markers in Region
DXMit2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X17,041,175 - 17,041,452 (+)MAPPERmRatBN7.2
Rnor_6.0X17,826,467 - 17,826,743NCBIRnor6.0
Rnor_5.0X18,608,452 - 18,608,728UniSTSRnor5.0
RGSC_v3.4X28,060,113 - 28,060,389UniSTSRGSC3.4
RGSC_v3.4X28,060,112 - 28,060,389RGDRGSC3.4
RGSC_v3.1X28,113,581 - 28,113,858RGD
CeleraX17,111,194 - 17,111,470UniSTS
RH 3.4 MapX177.2UniSTS
RH 2.0 Map21128.1RGD
Cytogenetic MapXq13-q14UniSTS
Cytogenetic MapXq13UniSTS
DXWox5  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X17,041,245 - 17,041,356 (+)MAPPERmRatBN7.2
Rnor_6.0X17,826,537 - 17,826,647NCBIRnor6.0
Rnor_5.0X18,608,522 - 18,608,632UniSTSRnor5.0
RGSC_v3.4X28,060,209 - 28,060,319UniSTSRGSC3.4
RGSC_v3.4X28,059,408 - 28,067,436RGDRGSC3.4
RGSC_v3.1X28,113,677 - 28,113,788RGD
CeleraX17,111,264 - 17,111,374UniSTS
RH 3.4 MapX177.2UniSTS
RH 3.4 MapX177.2RGD
RH 2.0 Map21136.2RGD
Cytogenetic MapXq13-q14UniSTS
Cytogenetic MapXq13UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system exocrine system hemolymphoid system hepatobiliary system nervous system reproductive system
High
Medium
Low 3
Below cutoff 3 2 1 2 11 16

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000004118   ⟹   ENSRNOP00000004118
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX17,038,263 - 17,039,555 (+)Ensembl
Rnor_6.0 EnsemblX17,823,554 - 17,824,846 (+)Ensembl
RefSeq Acc Id: NM_021837   ⟹   NP_068609
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X19,745,887 - 19,747,179 (+)NCBI
mRatBN7.2X17,038,263 - 17,039,555 (+)NCBI
Rnor_6.0X17,823,554 - 17,824,846 (+)NCBI
Rnor_5.0X18,605,539 - 18,606,831 (+)NCBI
RGSC_v3.4X28,062,010 - 28,063,302 (-)RGD
CeleraX17,108,281 - 17,109,573 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_068609 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41645 (Get FASTA)   NCBI Sequence Viewer  
  EDL83875 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000004118
  ENSRNOP00000004118.1
GenBank Protein P23999 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_068609   ⟸   NM_021837
- UniProtKB: P23999 (UniProtKB/Swiss-Prot),   G3V6D6 (UniProtKB/TrEMBL),   A6KPC7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000004118   ⟸   ENSRNOT00000004118
Protein Domains
bHLH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P23999-F1-model_v2 AlphaFold P23999 1-429 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3133 AgrOrtholog
BioCyc Gene G2FUF-2852 BioCyc
Ensembl Genes ENSRNOG00000003085 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000004118 ENTREZGENE
  ENSRNOT00000004118.3 UniProtKB/TrEMBL
Gene3D-CATH 4.10.280.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro bHLH_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HLH_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tscrpt_reg_Myc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tscrpt_reg_Myc_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24581 UniProtKB/Swiss-Prot
NCBI Gene 24581 ENTREZGENE
PANTHER MYC PROTO-ONCOGENE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN S-MYC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam HLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Myc_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mycs PhenoGen
PIRSF Myc_protein UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS LEUZIPPRMYC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE BHLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003085 RatGTEx
SMART HLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47459 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6KPC7 ENTREZGENE, UniProtKB/TrEMBL
  G3V6D6 ENTREZGENE, UniProtKB/TrEMBL
  MYCS_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Mycs  myc-like oncogene, s-myc protein      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_protein 50 kDa in size 729341
gene_transcript consists of an open reading frame consisting of 1287 base pairs without introns 729341