Mpdz (multiple PDZ domain crumbs cell polarity complex component) - Rat Genome Database

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Gene: Mpdz (multiple PDZ domain crumbs cell polarity complex component) Rattus norvegicus
Analyze
Symbol: Mpdz
Name: multiple PDZ domain crumbs cell polarity complex component
RGD ID: 3105
Description: Involved in myelination. Is active in glutamatergic synapse and postsynaptic density. Human ortholog(s) of this gene implicated in hydrocephalus. Orthologous to human MPDZ (multiple PDZ domain crumbs cell polarity complex component); INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: multi-PDZ domain protein 1; multiple PDZ domain protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85100,812,121 - 100,966,566 (-)NCBIGRCr8
mRatBN7.2595,766,112 - 95,920,531 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl595,766,118 - 95,920,499 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx598,137,388 - 98,291,673 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0599,947,068 - 100,102,219 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0599,948,242 - 100,102,527 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0599,413,184 - 99,566,356 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl599,413,187 - 99,566,318 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05103,442,806 - 103,596,600 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45100,008,984 - 100,170,202 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15100,014,212 - 100,175,428 (-)NCBI
Celera594,336,315 - 94,488,569 (-)NCBICelera
Cytogenetic Map5q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
(2,4,5-trichlorophenoxy)acetic acid  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
aldrin  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
bicuculline  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
CGP 52608  (ISO)
chloroethene  (ISO)
choline  (ISO)
cisplatin  (ISO)
clofibric acid  (EXP)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (EXP,ISO)
folic acid  (ISO)
FR900359  (ISO)
glafenine  (EXP)
hexadecanoic acid  (ISO)
indometacin  (ISO)
isobutanol  (ISO)
kainic acid  (ISO)
L-methionine  (ISO)
N-nitrosodiethylamine  (EXP)
O-methyleugenol  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
pentetrazol  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (EXP)
pirinixic acid  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
quercetin  (ISO)
sodium arsenite  (ISO)
temozolomide  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
topotecan  (EXP)
trichloroethene  (EXP)
triphenyl phosphate  (EXP)
triptonide  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function
protein binding  (IPI,ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. CLIC6, a member of the intracellular chloride channel family, interacts with dopamine D(2)-like receptors. Griffon N, etal., Brain Res Mol Brain Res 2003 Sep 10;117(1):47-57.
4. SynGAP-MUPP1-CaMKII synaptic complexes regulate p38 MAP kinase activity and NMDA receptor-dependent synaptic AMPA receptor potentiation. Krapivinsky G, etal., Neuron. 2004 Aug 19;43(4):563-74. doi: 10.1016/j.neuron.2004.08.003.
5. Multi-PDZ domain protein MUPP1 is a cellular target for both adenovirus E4-ORF1 and high-risk papillomavirus type 18 E6 oncoproteins. Lee SS, etal., J Virol. 2000 Oct;74(20):9680-93.
6. Interaction of the human somatostatin receptor 3 with the multiple PDZ domain protein MUPP1 enables somatostatin to control permeability of epithelial tight junctions. Liew CW, etal., FEBS Lett. 2009 Jan 5;583(1):49-54. doi: 10.1016/j.febslet.2008.11.048. Epub 2008 Dec 9.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. Distinct claudins and associated PDZ proteins form different autotypic tight junctions in myelinating Schwann cells. Poliak S, etal., J Cell Biol 2002 Oct 28;159(2):361-72.
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
15. Cloning and characterization of MUPP1, a novel PDZ domain protein. Ullmer C, etal., FEBS Lett 1998 Mar 6;424(1-2):63-8.
Additional References at PubMed
PMID:10967549   PMID:11150294   PMID:11689568   PMID:11802782   PMID:15364909   PMID:15863617   PMID:17397395   PMID:17894389   PMID:18417361   PMID:18537874   PMID:19934217   PMID:20237282  
PMID:25977097  


Genomics

Comparative Map Data
Mpdz
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85100,812,121 - 100,966,566 (-)NCBIGRCr8
mRatBN7.2595,766,112 - 95,920,531 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl595,766,118 - 95,920,499 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx598,137,388 - 98,291,673 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0599,947,068 - 100,102,219 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0599,948,242 - 100,102,527 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0599,413,184 - 99,566,356 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl599,413,187 - 99,566,318 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05103,442,806 - 103,596,600 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45100,008,984 - 100,170,202 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15100,014,212 - 100,175,428 (-)NCBI
Celera594,336,315 - 94,488,569 (-)NCBICelera
Cytogenetic Map5q31NCBI
MPDZ
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38913,105,707 - 13,279,692 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl913,105,706 - 13,279,692 (-)EnsemblGRCh38hg38GRCh38
GRCh37913,105,706 - 13,279,691 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36913,095,703 - 13,240,365 (-)NCBINCBI36Build 36hg18NCBI36
Build 34913,096,575 - 13,240,357NCBI
Celera913,038,280 - 13,183,037 (-)NCBICelera
Cytogenetic Map9p23NCBI
HuRef913,069,879 - 13,214,632 (-)NCBIHuRef
CHM1_1913,105,992 - 13,279,791 (-)NCBICHM1_1
T2T-CHM13v2.0913,115,022 - 13,289,091 (-)NCBIT2T-CHM13v2.0
Mpdz
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39481,196,736 - 81,361,112 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl481,196,742 - 81,361,052 (-)EnsemblGRCm39 Ensembl
GRCm38481,278,499 - 81,442,897 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl481,278,500 - 81,442,815 (-)EnsemblGRCm38mm10GRCm38
MGSCv37480,924,404 - 81,088,709 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36480,750,824 - 80,913,903 (-)NCBIMGSCv36mm8
Celera479,839,558 - 79,997,048 (-)NCBICelera
Cytogenetic Map4C3NCBI
cM Map438.0NCBI
Mpdz
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543416,284,123 - 16,418,092 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543416,284,123 - 16,431,853 (-)NCBIChiLan1.0ChiLan1.0
MPDZ
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v211111,253,670 - 111,430,166 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan19111,259,645 - 111,436,524 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0912,943,252 - 13,120,126 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1913,390,642 - 13,564,246 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl913,391,903 - 13,535,292 (-)Ensemblpanpan1.1panPan2
MPDZ
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11133,691,434 - 33,826,500 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1133,692,296 - 33,826,437 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1132,400,323 - 32,561,595 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01134,595,030 - 34,756,348 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1134,595,575 - 34,756,388 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11133,300,994 - 33,462,185 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01133,086,512 - 33,254,154 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01133,749,245 - 33,910,664 (-)NCBIUU_Cfam_GSD_1.0
Mpdz
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947148,481,482 - 148,631,516 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365396,932,473 - 7,084,227 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365396,934,180 - 7,084,117 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MPDZ
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1209,181,467 - 209,349,297 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11209,181,441 - 209,351,797 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21233,122,084 - 233,215,771 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MPDZ
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11266,275,725 - 66,450,398 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1266,304,514 - 66,449,110 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603854,508,794 - 54,683,624 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mpdz
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473617,397,405 - 17,533,674 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473617,392,132 - 17,555,612 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mpdz
823 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:116
Count of miRNA genes:89
Interacting mature miRNAs:108
Transcripts:ENSRNOT00000051028
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
7394712Emca13Estrogen-induced mammary cancer QTL 13mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)5982326699753708Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512789751113558310Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)531663789131345958Rat
1576317Eutr2Estrogen induced uterine response QTL 20.01uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)534730116104251008Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)534944474113558310Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535189153141643988Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)543726656129132602Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)550328551141643988Rat
2303615Vencon7Ventilatory control QTL 70.001respiration trait (VT:0001943)respiration rate (CMO:0000289)55098389595983895Rat
2303574Gluco42Glucose level QTL 422blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)55349671998496719Rat
61359EaexExperimental allergic encephalomyelitis QTL x3nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)555715622100715622Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555805606132207589Rat
1358895Bp254Blood pressure QTL 2543.60.0003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)558829236128034027Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)559793399143070159Rat
2316957Pur21Proteinuria QTL 216.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)559793528113558156Rat
61386Bp49Blood pressure QTL 4916.6cerebrum integrity trait (VT:0010549)brain infarction volume (CMO:0001013)56029343498603051Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
2290005Mcs24Mammary carcinoma susceptibility QTL 24mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)564719390109719390Rat
2306971Anxrr21Anxiety related response QTL 219.47fear/anxiety-related behavior trait (VT:1000241)number of entries into a discrete space in an experimental apparatus (CMO:0000960)566174080124160948Rat
2312671Scl64Serum cholesterol level QTL 640.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)568984307104251008Rat
61380Edpm5Estrogen-dependent pituitary mass QTL 54.50.92pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)568984307104251008Rat
1357396Bw44Body weight QTL 444.19body mass (VT:0001259)body weight (CMO:0000012)568984307104251008Rat
1357402Bw46Body weight QTL 464.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)568984307104251008Rat
2302381Bw84Body weight QTL 844.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)568984307104251008Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat
1298070Scl18Serum cholesterol level QTL 183.7blood LDL cholesterol amount (VT:0000181)calculated plasma low density lipoprotein cholesterol level (CMO:0001245)579584860124584860Rat
1598846Bp293Blood pressure QTL 2933.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)579584860124584860Rat
1598859Cm66Cardiac mass QTL 662heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)579584860124584860Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1331782Rf36Renal function QTL 363.296kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)58384059897059958Rat
1298086Bp156Blood pressure QTL 156arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)584132602129132602Rat
7411601Foco12Food consumption QTL 1219.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)587468046132468046Rat
7411564Bw135Body weight QTL 1350.001body mass (VT:0001259)body weight gain (CMO:0000420)587468046132468046Rat
7411582Foco3Food consumption QTL 37.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)587468046132468046Rat
6903316Bw113Body weight QTL 11320.0103body mass (VT:0001259)body weight (CMO:0000012)587765973132765973Rat
1358889Bp261Blood pressure QTL 2612.86arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)590067849128034027Rat
1358909Kidm25Kidney mass QTL 251.87kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)590067849128034027Rat
631527Tls1T-lymphoma susceptibility QTL 100.001thymus integrity trait (VT:0010555)post-insult time to onset of T-cell lymphoma (CMO:0001907)590450144135450144Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)594858972143070159Rat

Markers in Region
D5Rat98  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2595,774,194 - 95,774,399 (+)MAPPERmRatBN7.2
Rnor_6.0599,421,434 - 99,421,638NCBIRnor6.0
Rnor_5.05103,451,053 - 103,451,257UniSTSRnor5.0
RGSC_v3.45100,017,061 - 100,017,265UniSTSRGSC3.4
RGSC_v3.45100,017,060 - 100,017,265RGDRGSC3.4
RGSC_v3.15100,022,287 - 100,022,491RGD
Celera594,344,392 - 94,344,614UniSTS
RH 3.4 Map5724.1RGD
RH 3.4 Map5724.1UniSTS
RH 2.0 Map5603.7RGD
SHRSP x BN Map553.5899RGD
Cytogenetic Map5q31UniSTS
D5Got256  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2595,860,869 - 95,861,088 (+)MAPPERmRatBN7.2
Rnor_6.0599,506,864 - 99,507,082NCBIRnor6.0
Rnor_5.05103,537,072 - 103,537,290UniSTSRnor5.0
RGSC_v3.45100,111,273 - 100,111,491UniSTSRGSC3.4
Celera594,430,290 - 94,430,492UniSTS
Cytogenetic Map5q31UniSTS
D5Got312  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2595,793,950 - 95,794,214 (+)MAPPERmRatBN7.2
Rnor_6.0599,440,546 - 99,440,809NCBIRnor6.0
Rnor_5.05103,470,165 - 103,470,428UniSTSRnor5.0
RGSC_v3.45100,037,650 - 100,037,913UniSTSRGSC3.4
Celera594,363,928 - 94,364,189UniSTS
Cytogenetic Map5q31UniSTS
RH138353  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2595,782,346 - 95,782,503 (+)MAPPERmRatBN7.2
Rnor_6.0599,429,135 - 99,429,291NCBIRnor6.0
Rnor_5.05103,458,754 - 103,458,910UniSTSRnor5.0
RGSC_v3.45100,025,212 - 100,025,368UniSTSRGSC3.4
Celera594,352,561 - 94,352,717UniSTS
RH 3.4 Map5749.3UniSTS
Cytogenetic Map5q31UniSTS
RH134440  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2595,766,308 - 95,766,513 (+)MAPPERmRatBN7.2
Rnor_6.0599,413,381 - 99,413,585NCBIRnor6.0
Rnor_5.05103,443,000 - 103,443,204UniSTSRnor5.0
RGSC_v3.45100,009,178 - 100,009,382UniSTSRGSC3.4
Celera594,336,509 - 94,336,713UniSTS
RH 3.4 Map5749.5UniSTS
Cytogenetic Map5q31UniSTS
AU046394  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2595,793,950 - 95,794,188 (+)MAPPERmRatBN7.2
Rnor_6.0599,440,546 - 99,440,783NCBIRnor6.0
Rnor_5.05103,470,165 - 103,470,402UniSTSRnor5.0
RGSC_v3.45100,037,650 - 100,037,887UniSTSRGSC3.4
Celera594,363,928 - 94,364,163UniSTS
Cytogenetic Map5q31UniSTS
Mpdz  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2595,874,646 - 95,875,800 (+)MAPPERmRatBN7.2
Rnor_6.0599,520,641 - 99,521,794NCBIRnor6.0
Rnor_5.05103,550,849 - 103,552,002UniSTSRnor5.0
RGSC_v3.45100,125,050 - 100,126,203UniSTSRGSC3.4
Celera594,444,045 - 94,445,198UniSTS
Cytogenetic Map5q31UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 41 19 11 1 11 8 10 74 28 34 11 8
Low 3 2 38 30 18 30 1 7 6
Below cutoff 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_019196 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006238340 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006238341 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006238342 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006238343 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006238344 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593204 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039109363 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039109364 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039109365 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039109366 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063287255 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063287256 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AJ001320 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473978 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000051028   ⟹   ENSRNOP00000051321
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl595,766,118 - 95,920,499 (-)Ensembl
Rnor_6.0 Ensembl599,413,190 - 99,566,317 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000089235   ⟹   ENSRNOP00000072433
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl595,766,118 - 95,920,499 (-)Ensembl
Rnor_6.0 Ensembl599,413,187 - 99,566,318 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000099740   ⟹   ENSRNOP00000081232
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl595,766,118 - 95,896,820 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000105796   ⟹   ENSRNOP00000088952
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl595,766,118 - 95,920,499 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000108047   ⟹   ENSRNOP00000095980
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl595,766,118 - 95,920,499 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000112827   ⟹   ENSRNOP00000092356
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl595,766,118 - 95,896,820 (-)Ensembl
RefSeq Acc Id: NM_019196   ⟹   NP_062069
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85100,812,121 - 100,966,504 (-)NCBI
mRatBN7.2595,766,115 - 95,920,499 (-)NCBI
Rnor_6.0599,413,187 - 99,566,317 (-)NCBI
Rnor_5.05103,442,806 - 103,596,600 (-)NCBI
RGSC_v3.45100,008,984 - 100,170,202 (-)RGD
Celera594,336,315 - 94,488,569 (-)RGD
Sequence:
RefSeq Acc Id: XM_006238340   ⟹   XP_006238402
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85100,812,121 - 100,966,566 (-)NCBI
mRatBN7.2595,766,112 - 95,920,527 (-)NCBI
Rnor_6.0599,413,184 - 99,566,356 (-)NCBI
Rnor_5.05103,442,806 - 103,596,600 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006238341   ⟹   XP_006238403
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85100,812,121 - 100,966,566 (-)NCBI
mRatBN7.2595,766,973 - 95,920,526 (-)NCBI
Rnor_6.0599,414,045 - 99,566,356 (-)NCBI
Rnor_5.05103,442,806 - 103,596,600 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006238342   ⟹   XP_006238404
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85100,812,121 - 100,966,566 (-)NCBI
mRatBN7.2595,766,973 - 95,920,527 (-)NCBI
Rnor_6.0599,414,045 - 99,566,356 (-)NCBI
Rnor_5.05103,442,806 - 103,596,600 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006238343   ⟹   XP_006238405
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85100,812,121 - 100,966,566 (-)NCBI
mRatBN7.2595,766,973 - 95,920,525 (-)NCBI
Rnor_6.0599,414,045 - 99,566,355 (-)NCBI
Rnor_5.05103,442,806 - 103,596,600 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006238344   ⟹   XP_006238406
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85100,812,121 - 100,966,566 (-)NCBI
mRatBN7.2595,766,973 - 95,920,526 (-)NCBI
Rnor_6.0599,414,045 - 99,566,355 (-)NCBI
Rnor_5.05103,442,806 - 103,596,600 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039109363   ⟹   XP_038965291
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85100,812,121 - 100,966,566 (-)NCBI
mRatBN7.2595,766,973 - 95,920,528 (-)NCBI
RefSeq Acc Id: XM_039109364   ⟹   XP_038965292
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85100,812,121 - 100,966,566 (-)NCBI
mRatBN7.2595,766,973 - 95,920,527 (-)NCBI
RefSeq Acc Id: XM_039109365   ⟹   XP_038965293
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85100,812,121 - 100,966,566 (-)NCBI
mRatBN7.2595,766,973 - 95,920,531 (-)NCBI
RefSeq Acc Id: XM_039109366   ⟹   XP_038965294
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85100,812,121 - 100,892,791 (-)NCBI
mRatBN7.2595,766,973 - 95,846,788 (-)NCBI
RefSeq Acc Id: XM_063287255   ⟹   XP_063143325
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85100,812,121 - 100,966,566 (-)NCBI
RefSeq Acc Id: XM_063287256   ⟹   XP_063143326
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85100,812,121 - 100,966,566 (-)NCBI
RefSeq Acc Id: NP_062069   ⟸   NM_019196
- UniProtKB: O55164 (UniProtKB/Swiss-Prot),   A6J832 (UniProtKB/TrEMBL),   A0A8I6AGX6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006238404   ⟸   XM_006238342
- Peptide Label: isoform X5
- UniProtKB: A0A8I6GLE5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006238405   ⟸   XM_006238343
- Peptide Label: isoform X6
- UniProtKB: A0A8L2QPJ0 (UniProtKB/TrEMBL),   A0A8I6GLE5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006238406   ⟸   XM_006238344
- Peptide Label: isoform X8
- UniProtKB: A0A8I6GLE5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006238403   ⟸   XM_006238341
- Peptide Label: isoform X4
- UniProtKB: A0A8I6GLE5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006238402   ⟸   XM_006238340
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K2Y8 (UniProtKB/TrEMBL),   A0A8I6AGX6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000072433   ⟸   ENSRNOT00000089235
RefSeq Acc Id: ENSRNOP00000051321   ⟸   ENSRNOT00000051028
RefSeq Acc Id: XP_038965293   ⟸   XM_039109365
- Peptide Label: isoform X9
- UniProtKB: A0A8I6AAR0 (UniProtKB/TrEMBL),   A0A8I6GLE5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038965291   ⟸   XM_039109363
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AGX6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038965292   ⟸   XM_039109364
- Peptide Label: isoform X3
- UniProtKB: A0A8I6AGX6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038965294   ⟸   XM_039109366
- Peptide Label: isoform X11
RefSeq Acc Id: ENSRNOP00000095980   ⟸   ENSRNOT00000108047
RefSeq Acc Id: ENSRNOP00000092356   ⟸   ENSRNOT00000112827
RefSeq Acc Id: ENSRNOP00000081232   ⟸   ENSRNOT00000099740
RefSeq Acc Id: ENSRNOP00000088952   ⟸   ENSRNOT00000105796
RefSeq Acc Id: XP_063143326   ⟸   XM_063287256
- Peptide Label: isoform X10
RefSeq Acc Id: XP_063143325   ⟸   XM_063287255
- Peptide Label: isoform X7
Protein Domains
L27   PDZ

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O55164-F1-model_v2 AlphaFold O55164 1-2054 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693818
Promoter ID:EPDNEW_R4340
Type:initiation region
Name:Mpdz_1
Description:multiple PDZ domain crumbs cell polarity complex component
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0599,566,344 - 99,566,404EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3105 AgrOrtholog
BioCyc Gene G2FUF-40910 BioCyc
Ensembl Genes ENSRNOG00000007894 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000051028.4 UniProtKB/TrEMBL
  ENSRNOT00000089235.2 UniProtKB/TrEMBL
  ENSRNOT00000099740.1 UniProtKB/TrEMBL
  ENSRNOT00000105796.1 UniProtKB/TrEMBL
  ENSRNOT00000108047 ENTREZGENE
  ENSRNOT00000108047.1 UniProtKB/TrEMBL
  ENSRNOT00000112827.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.42.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  L27 domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro L27_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  L27_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  L27_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MPDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29365 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 29365 ENTREZGENE
PANTHER MULTIPLE PDZ DOMAIN PROTEIN UniProtKB/Swiss-Prot
  MULTIPLE PDZ DOMAIN PROTEIN UniProtKB/Swiss-Prot
  MULTIPLE PDZ DOMAIN PROTEIN UniProtKB/TrEMBL
  MULTIPLE PDZ DOMAIN PROTEIN UniProtKB/TrEMBL
Pfam L27_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MPDZ_u10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mpdz PhenoGen
PROSITE L27 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000007894 RatGTEx
SMART L27 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF101288 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50156 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC231731
UniProt A0A0G2K2Y8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AAR0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AGX6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6G7P8_RAT UniProtKB/TrEMBL
  A0A8I6GLE5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QPJ0 ENTREZGENE, UniProtKB/TrEMBL
  A6J832 ENTREZGENE, UniProtKB/TrEMBL
  MPDZ_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-01 Mpdz  multiple PDZ domain crumbs cell polarity complex component  Mpdz  multiple PDZ domain protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Mpdz  multiple PDZ domain protein      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains thirteen PDZ domains and no obvious catalytic domain 69894
gene_expression abundant in the brain 69894
gene_physical_interaction interacts with the C-terminal domain of the 5-HT2C receptor 69894