Imported Disease Annotations - CTDTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Colonic Neoplasms | | ISO | MEP1A (Homo sapiens) | 11554173 | CTD Direct Evidence: marker/mechanism | CTD | PMID:15059925 | |
|
Imported Disease Annotations - CTDTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Colonic Neoplasms | | ISO | MEP1A (Homo sapiens) | 11554173 | CTD Direct Evidence: marker/mechanism | CTD | PMID:15059925 | |
|
|
|
|
|
|
|
|
|
|
# | Reference Title | Reference Citation |
1. | Probing the active sites and mechanisms of rat metalloproteases meprin A and B. | Bertenshaw GP, etal., Biol Chem 2002 Jul-Aug;383(7-8):1175-83. |
2. | Molecular cloning of the alpha-subunit of rat endopeptidase-24.18 (endopeptidase-2) and co-localization with endopeptidase-24.11 in rat kidney by in situ hybridization. | Corbeil D, etal., FEBS Lett 1992 Sep 7;309(2):203-8. |
3. | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
4. | Rat ISS GO annotations from GOA human gene data--August 2006 | GOA data from the GO Consortium |
5. | Cloning a rat meprin cDNA reveals the enzyme is a heterodimer. | Johnson GD and Hersh LB, J Biol Chem 1992 Jul 5;267(19):13505-12. |
6. | Rat ISS GO annotations from MGI mouse gene data--August 2006 | MGD data from the GO Consortium |
7. | Electronic Transfer of LocusLink and RefSeq Data | NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
8. | GOA pipeline | RGD automated data pipeline |
9. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
10. | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. | Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11. |
PMID:7683677 | PMID:8407940 | PMID:8760356 | PMID:9288916 | PMID:11487543 | PMID:12399461 |
Mep1a (Rattus norvegicus - Norway rat) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
MEP1A (Homo sapiens - human) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mep1a (Mus musculus - house mouse) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mep1a (Chinchilla lanigera - long-tailed chinchilla) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
MEP1A (Pan paniscus - bonobo/pygmy chimpanzee) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
MEP1A (Canis lupus familiaris - dog) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mep1a (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
MEP1A (Sus scrofa - pig) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
MEP1A (Chlorocebus sabaeus - green monkey) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mep1a (Heterocephalus glaber - naked mole-rat) |
|
.
Variants in Mep1a
183 total Variants |
The detailed report is available here: | Full Report | CSV | TAB | Printer | ||||
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
The following QTLs overlap with this region. | Full Report | CSV | TAB | Printer | Gviewer |
alimentary part of gastrointestinal system | circulatory system | endocrine system | exocrine system | hemolymphoid system | hepatobiliary system | integumental system | musculoskeletal system | nervous system | renal system | reproductive system | respiratory system | appendage | |
High | |||||||||||||
Medium | 3 | 29 | 1 | ||||||||||
Low | 4 | 1 | 3 | 1 | 2 | 12 | 5 | ||||||
Below cutoff | 34 | 19 | 7 | 12 | 7 | 6 | 6 | 31 | 4 | 19 | 6 | 6 |
RefSeq Acc Id: | ENSRNOT00000014791 ⟹ ENSRNOP00000014791 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
|
RefSeq Acc Id: | ENSRNOT00000105548 ⟹ ENSRNOP00000077952 | ||||||||
Type: | CODING | ||||||||
Position: |
|
RefSeq Acc Id: | NM_013143 ⟹ NP_037275 | ||||||||||||||||||||||||||||
RefSeq Status: | PROVISIONAL | ||||||||||||||||||||||||||||
Type: | CODING | ||||||||||||||||||||||||||||
Position: |
|
||||||||||||||||||||||||||||
Sequence: |
Protein RefSeqs | NP_037275 | (Get FASTA) | NCBI Sequence Viewer |
GenBank Protein | AAB23030 | (Get FASTA) | NCBI Sequence Viewer |
AAH81834 | (Get FASTA) | NCBI Sequence Viewer | |
EDM18694 | (Get FASTA) | NCBI Sequence Viewer | |
Ensembl Protein | ENSRNOP00000014791 | ||
ENSRNOP00000014791.5 | |||
ENSRNOP00000077952.1 | |||
GenBank Protein | Q64230 | (Get FASTA) | NCBI Sequence Viewer |
RefSeq Acc Id: | NP_037275 ⟸ NM_013143 |
- Peptide Label: | precursor |
- UniProtKB: | Q642C9 (UniProtKB/Swiss-Prot), Q64230 (UniProtKB/Swiss-Prot) |
- Sequence: |
RefSeq Acc Id: | ENSRNOP00000014791 ⟸ ENSRNOT00000014791 |
RefSeq Acc Id: | ENSRNOP00000077952 ⟸ ENSRNOT00000105548 |
Name | Modeler | Protein Id | AA Range | Protein Structure |
AF-Q64230-F1-model_v2 | AlphaFold | Q64230 | 1-748 | view protein structure |
eQTL | View at Phenogen | |
WGCNA | View at Phenogen | |
Tissue/Strain Expression | View at Phenogen |
RGD ID: | 13696557 | ||||||||
Promoter ID: | EPDNEW_R7081 | ||||||||
Type: | multiple initiation site | ||||||||
Name: | Mep1a_1 | ||||||||
Description: | meprin A subunit alpha | ||||||||
SO ACC ID: | SO:0000170 | ||||||||
Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | ||||||||
Experiment Methods: | Single-end sequencing. | ||||||||
Position: |
|
Database | Acc Id | Source(s) |
AGR Gene | RGD:3080 | AgrOrtholog |
BioCyc Gene | G2FUF-28105 | BioCyc |
Ensembl Genes | ENSRNOG00000011022 | Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
Ensembl Transcript | ENSRNOT00000014791 | ENTREZGENE |
ENSRNOT00000014791.8 | UniProtKB/Swiss-Prot | |
ENSRNOT00000105548.1 | UniProtKB/TrEMBL | |
Gene3D-CATH | 2.60.120.200 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
3.40.390.10 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Laminin | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
IMAGE_CLONE | IMAGE:7128404 | IMAGE-MGC_LOAD |
InterPro | ConA-like_dom_sf | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
EGF-like_dom | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
MAM_dom | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
MATH/TRAF_dom | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Meprin | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
MetalloPept_cat_dom_sf | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Peptidase_M12A | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Peptidase_Metallo | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
TRAF-like | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
TRAF_MEP1_MATH_dom | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
KEGG Report | rno:25684 | UniProtKB/Swiss-Prot |
MGC_CLONE | MGC:93579 | IMAGE-MGC_LOAD |
NCBI Gene | 25684 | ENTREZGENE |
PANTHER | DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
PTHR10127:SF824 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Pfam | Astacin | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
EGF | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
MAM | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
TRAF-mep_MATH | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
PhenoGen | Mep1a | PhenoGen |
PIRSF | Meprin | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
PRINTS | ASTACIN | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
MAMDOMAIN | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
PROSITE | ASTACIN | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
EGF_3 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
MAM_1 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
MAM_2 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
MATH | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
ZINC_PROTEASE | UniProtKB/Swiss-Prot | |
RatGTEx | ENSRNOG00000011022 | RatGTEx |
SMART | MAM | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
MATH | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
ZnMc | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Superfamily-SCOP | EGF/Laminin | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
Metalloproteases ('zincins'), catalytic domain | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
SSF49899 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
TRAF domain-like | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
UniProt | A0A8I5Y808_RAT | UniProtKB/TrEMBL |
A6JJ38_RAT | UniProtKB/TrEMBL | |
MEP1A_RAT | UniProtKB/Swiss-Prot, ENTREZGENE | |
Q642C9 | ENTREZGENE | |
UniProt Secondary | Q642C9 | UniProtKB/Swiss-Prot |
Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
---|---|---|---|---|---|---|---|
2017-03-29 | Mep1a | meprin A subunit alpha | Mep1a | meprin 1 subunit alpha | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
2016-03-04 | Mep1a | meprin 1 subunit alpha | Mep1a | meprin 1 alpha | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
2013-04-12 | Mep1a | meprin 1 alpha | LOC688307 | similar to Meprin A alpha-subunit precursor (Endopeptidase-2) (MEP-1) (Endopeptidase-24.18 alpha-subunit) (E-24.18) | Data merged from RGD:1590063 | 737654 | PROVISIONAL |
2006-11-20 | LOC688307 | similar to Meprin A alpha-subunit precursor (Endopeptidase-2) (MEP-1) (Endopeptidase-24.18 alpha-subunit) (E-24.18) | Symbol and Name status set to provisional | 70820 | PROVISIONAL | ||
2002-06-10 | Mep1a | Meprin 1 alpha | Symbol and Name status set to approved | 70586 | APPROVED |