Tpsb2 (tryptase beta 2) - Rat Genome Database

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Gene: Tpsb2 (tryptase beta 2) Rattus norvegicus
Analyze
Symbol: Tpsb2
Name: tryptase beta 2
RGD ID: 3065
Description: Predicted to enable heparin binding activity and serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular region. Orthologous to several human genes including TPSB2 (tryptase beta 2); INTERACTS WITH 6-propyl-2-thiouracil; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: mast cell protease 6; Mcpt6; rMCP-6; tryptase beta-2; tryptase-2
RGD Orthologs
Human
Mouse
Bonobo
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81014,886,310 - 14,888,102 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1014,886,360 - 14,888,100 (+)EnsemblGRCr8
mRatBN7.21014,381,779 - 14,383,571 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1014,382,013 - 14,383,569 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1019,122,492 - 19,124,284 (+)NCBIUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01018,611,363 - 18,613,155 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01014,110,546 - 14,112,338 (+)NCBIUTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1017,810,016 - 17,811,808 (+)NCBI
Lyon_Normotensive1018,471,661 - 18,473,453 (+)NCBI
Lyon_Hypertensive1020,163,335 - 20,165,127 (+)NCBI
F344_StmMcwi1020,150,053 - 20,151,845 (+)NCBI
Rnor_6.01014,722,672 - 14,724,464 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1014,722,756 - 14,724,600 (+)EnsemblRnor_6.0 Ensemblrn6Rnor6.0
Rnor_5.01014,539,018 - 14,540,810 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41014,613,118 - 14,614,917 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1014,053,492 - 14,055,284 (+)NCBICelera
RGSC_v3.11014,613,117 - 14,614,917 (+)NCBI
Cytogenetic Map10q12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
proteolysis  (IBA,IEA,ISO)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. cDNA sequencing and expression of rat mast cell tryptase. Ide H, etal., J Biochem (Tokyo) 1995 Jul;118(1):210-5.
3. Secretory granule proteases in rat mast cells. Cloning of 10 different serine proteases and a carboxypeptidase A from various rat mast cell populations. Lutzelschwab C, etal., J Exp Med 1997 Jan 6;185(1):13-29.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:11533057   PMID:23624557   PMID:27559042  


Genomics

Comparative Map Data
Tpsb2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81014,886,310 - 14,888,102 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1014,886,360 - 14,888,100 (+)EnsemblGRCr8
mRatBN7.21014,381,779 - 14,383,571 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1014,382,013 - 14,383,569 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1019,122,492 - 19,124,284 (+)NCBIUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01018,611,363 - 18,613,155 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01014,110,546 - 14,112,338 (+)NCBIUTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1017,810,016 - 17,811,808 (+)NCBI
Lyon_Normotensive1018,471,661 - 18,473,453 (+)NCBI
Lyon_Hypertensive1020,163,335 - 20,165,127 (+)NCBI
F344_StmMcwi1020,150,053 - 20,151,845 (+)NCBI
Rnor_6.01014,722,672 - 14,724,464 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1014,722,756 - 14,724,600 (+)EnsemblRnor_6.0 Ensemblrn6Rnor6.0
Rnor_5.01014,539,018 - 14,540,810 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41014,613,118 - 14,614,917 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1014,053,492 - 14,055,284 (+)NCBICelera
RGSC_v3.11014,613,117 - 14,614,917 (+)NCBI
Cytogenetic Map10q12NCBI
TPSB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38161,228,336 - 1,230,184 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl161,227,272 - 1,233,725 (-)EnsemblGRCh38.p14 Ensemblhg38GRCh38
GRCh37161,278,336 - 1,280,185 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36161,218,337 - 1,220,186 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34161,230,940 - 1,232,555NCBI
Celera161,494,229 - 1,494,587 (-)NCBICelera
Cytogenetic Map16p13.3NCBI
HuRef161,211,394 - 1,224,892 (-)NCBIHuRef
CHM1_1161,278,009 - 1,279,872 (-)NCBICHM1_1
T2T-CHM13v2.0161,243,646 - 1,245,495 (-)NCBIT2T-CHM13v2.0
Tpsb2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391725,585,282 - 25,587,070 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1725,585,170 - 25,588,079 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381725,366,308 - 25,368,096 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1725,366,305 - 25,369,098 (+)EnsemblGRCm38.p6 Ensemblmm10GRCm38
MGSCv371725,503,278 - 25,505,037 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361725,093,933 - 25,095,692 (+)NCBIMGSCv36mm8
Celera1725,894,349 - 25,896,108 (+)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1712.53NCBI
LOC100978423
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2181,484,128 - 1,485,978 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1165,264,473 - 5,266,322 (-)NCBINHGRI_mPanPan1
PanPan1.1161,234,218 - 1,236,068 (-)NCBIPanPan1.1PanPan1.1panPan2
MCT7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1340,616,642 - 40,619,148 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1

Variants

.
Variants in Tpsb2
11 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:53
Count of miRNA genes:47
Interacting mature miRNAs:52
Transcripts:ENSRNOT00000025220
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
631660Hcar1Hepatocarcinoma resistance QTL 13.40.0001liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)10666111835509383Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10589381150893811Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10589381150893811Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)101465354159653541Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10687714251877142Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135730538Rat
7387235Uae41Urinary albumin excretion QTL 415.260.1874urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)10130004247Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1092219745922197Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)10210370847103708Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10589381150893811Rat
631828Alc5Alcohol consumption QTL 52.4consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10117749933Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138832698Rat

Markers in Region
D17Mit46  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21014,381,466 - 14,381,633 (+)MAPPERmRatBN7.2
Rnor_6.01014,722,360 - 14,722,526NCBIRnor6.0
Rnor_5.01014,538,706 - 14,538,872UniSTSRnor5.0
RGSC_v3.41014,612,815 - 14,612,981UniSTSRGSC3.4
Celera1014,053,180 - 14,053,346UniSTS
Cytogenetic Map10q12UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
269 81 688 1461 1165 792 1495 7 664 205 647 144 3848 2092 428 1080 26 606 455 873 97 95

Sequence


Ensembl Acc Id: ENSRNOT00000025220   ⟹   ENSRNOP00000025220
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1014,886,360 - 14,888,100 (+)Ensembl
mRatBN7.2 Ensembl1014,382,013 - 14,383,569 (+)Ensembl
Rnor_6.0 Ensembl1014,722,756 - 14,724,600 (+)Ensembl
RefSeq Acc Id: NM_019180   ⟹   NP_062053
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,886,310 - 14,888,102 (+)NCBI
mRatBN7.21014,381,779 - 14,383,571 (+)NCBI
Dahl_SR_JrHsd1017,810,016 - 17,811,808 (+)NCBI
Lyon_Normotensive1018,471,661 - 18,473,453 (+)NCBI
Lyon_Hypertensive1020,163,335 - 20,165,127 (+)NCBI
F344_StmMcwi1020,150,053 - 20,151,845 (+)NCBI
Rnor_6.01014,722,672 - 14,724,464 (+)NCBI
Rnor_5.01014,539,018 - 14,540,810 (+)NCBI
RGSC_v3.41014,613,118 - 14,614,917 (+)RGD
Celera1014,053,492 - 14,055,284 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_062053 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB48262 (Get FASTA)   NCBI Sequence Viewer  
  BAA07486 (Get FASTA)   NCBI Sequence Viewer  
  EDM03927 (Get FASTA)   NCBI Sequence Viewer  
  EDM03928 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000025220
GenBank Protein P50343 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_062053   ⟸   NM_019180
- Peptide Label: precursor
- UniProtKB: P97593 (UniProtKB/Swiss-Prot),   P50343 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000025220   ⟸   ENSRNOT00000025220
Protein Domains
Peptidase S1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P50343-F1-model_v2 AlphaFold P50343 1-274 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697050
Promoter ID:EPDNEW_R7574
Type:single initiation site
Name:Tpsb2_1
Description:tryptase beta 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01014,722,663 - 14,722,723EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3065 AgrOrtholog
BioCyc Gene G2FUF-25783 BioCyc
Ensembl Genes ENSRNOG00000018611 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000025220 ENTREZGENE
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot
InterPro Peptidase_S1_PA UniProtKB/Swiss-Prot
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot
  Peptidase_S1A UniProtKB/Swiss-Prot
  Trypsin_dom UniProtKB/Swiss-Prot
  TRYPSIN_HIS UniProtKB/Swiss-Prot
  TRYPSIN_SER UniProtKB/Swiss-Prot
KEGG Report rno:29268 UniProtKB/Swiss-Prot
NCBI Gene 29268 ENTREZGENE
PANTHER CHYMOTRYPSIN-LIKE PROTEASE CTRL-1-RELATED UniProtKB/Swiss-Prot
  TRANSMEMBRANE PROTEASE SERINE UniProtKB/Swiss-Prot
Pfam Trypsin UniProtKB/Swiss-Prot
PhenoGen Tpsb2 PhenoGen
PRINTS CHYMOTRYPSIN UniProtKB/Swiss-Prot
PROSITE TRYPSIN_DOM UniProtKB/Swiss-Prot
  TRYPSIN_HIS UniProtKB/Swiss-Prot
  TRYPSIN_SER UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000018611 RatGTEx
SMART Tryp_SPc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50494 UniProtKB/Swiss-Prot
TIGR TC224143
UniProt G3V8F2_RAT UniProtKB/TrEMBL
  P50343 ENTREZGENE
  P97593 ENTREZGENE
  TRYB2_RAT UniProtKB/Swiss-Prot
UniProt Secondary P97593 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-15 Tpsb2  tryptase beta 2  Mcpt6  mast cell protease 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Mcpt6  mast cell protease 6      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_regulation expression is up-regulated in the lung during the inflammatory process of a parasitic infection 69886