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Gene-Chemical Interaction AnnotationsGene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (-)-epigallocatechin 3-gallate | multiple interactions | ISO | RGD:69145 | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of KHK mRNA | CTD | PMID:22079256 | 17alpha-ethynylestradiol | decreases expression | EXP | | 6480464 | Ethinyl Estradiol results in decreased expression of KHK mRNA | CTD | PMID:17108234 | 17beta-estradiol | decreases expression | ISO | RGD:69145 | 6480464 | Estradiol results in decreased expression of KHK mRNA | CTD | PMID:20106945 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:10837 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of KHK mRNA | CTD | PMID:19770486 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of KHK mRNA | CTD | PMID:21215274 PMID:21724226 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:10837 | 6480464 | Tetrachlorodibenzodioxin affects the expression of KHK mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of KHK mRNA | CTD | PMID:21215274 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of KHK mRNA | CTD | PMID:22298810 | 3,3',4,4',5-pentachlorobiphenyl | decreases expression | EXP | | 6480464 | 3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of KHK mRNA | CTD | PMID:20959002 | 5-fluorouracil | affects response to substance | ISO | RGD:69145 | 6480464 | KHK protein affects the susceptibility to Fluorouracil | CTD | PMID:15352031 | 5-fluorouracil | increases expression | ISO | RGD:69145 | 6480464 | Fluorouracil results in increased expression of KHK protein | CTD | PMID:15352031 | afimoxifene | decreases response to substance | ISO | RGD:69145 | 6480464 | KHK results in decreased susceptibility to 4-hydroxytamoxifen | CTD | PMID:21233418 | aflatoxin B1 | affects expression | ISO | RGD:69145 | 6480464 | Aflatoxin B1 affects the expression of KHK protein | CTD | PMID:20106945 | aflatoxin B1 | decreases expression | ISO | RGD:69145 | 6480464 | Aflatoxin B1 results in decreased expression of KHK mRNA | CTD | PMID:22100608 | aflatoxin B1 | decreases expression | ISO | RGD:10837 | 6480464 | Aflatoxin B1 results in decreased expression of KHK mRNA | CTD | PMID:19770486 | all-trans-retinoic acid | decreases expression | ISO | RGD:10837 | 6480464 | Tretinoin results in decreased expression of KHK mRNA | CTD | PMID:16604517 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of KHK mRNA | CTD | PMID:16483693 | ATP | multiple interactions | ISO | RGD:69145 | 6480464 | KHK protein promotes the reaction [Fructose results in decreased abundance of Adenosine Triphosphate] | CTD | PMID:19158351 | benzo[a]pyrene | decreases expression | ISO | RGD:10837 | 6480464 | Benzo(a)pyrene results in decreased expression of KHK mRNA | CTD | PMID:19770486 | copper atom | decreases expression | EXP | | 6480464 | Copper results in decreased expression of KHK mRNA | CTD | PMID:22465980 | copper(0) | decreases expression | EXP | | 6480464 | Copper results in decreased expression of KHK mRNA | CTD | PMID:22465980 | copper(2+) sulfate | decreases expression | ISO | RGD:69145 | 6480464 | Copper Sulfate results in decreased expression of KHK mRNA | CTD | PMID:19549813 | cyclosporin A | decreases expression | ISO | RGD:69145 | 6480464 | Cyclosporine results in decreased expression of KHK mRNA | CTD | PMID:20106945 | dibutyl phthalate | increases expression | EXP | | 6480464 | Dibutyl Phthalate results in increased expression of KHK mRNA | CTD | PMID:17379624 | fructose | multiple interactions | ISO | RGD:69145 | 6480464 | KHK protein promotes the reaction [Fructose results in decreased abundance of Adenosine Triphosphate]; more ... | CTD | PMID:19158351 | fructose | increases expression | EXP | | 6480464 | Fructose results in increased expression of KHK protein | CTD | PMID:21122807 | fructose | multiple interactions | EXP | | 6480464 | atorvastatin inhibits the reaction [Fructose results in increased expression of KHK protein] | CTD | PMID:21122807 | fructose | increases expression | EXP | | 6480464 | Fructose results in increased expression of KHK mRNA | CTD | PMID:18346472 | fructose | increases expression | ISO | RGD:10837 | 6480464 | Fructose results in increased expression of KHK mRNA | CTD | PMID:15066988 | fructose | multiple interactions | ISO | RGD:10837 | 6480464 | Fructose results in increased expression of and results in increased activity of KHK protein | CTD | PMID:18395287 | N-nitrosodiethylamine | decreases expression | EXP | | 6480464 | Diethylnitrosamine results in decreased expression of KHK mRNA | CTD | PMID:19638242 | paracetamol | affects expression | ISO | RGD:10837 | 6480464 | Acetaminophen affects the expression of KHK mRNA | CTD | PMID:17562736 | paracetamol | decreases expression | ISO | RGD:69145 | 6480464 | Acetaminophen results in decreased expression of KHK mRNA | CTD | PMID:21420995 | perfluorooctanoic acid | decreases expression | EXP | | 6480464 | perfluorooctanoic acid results in decreased expression of KHK mRNA | CTD | PMID:19162173 | pirinixic acid | decreases expression | ISO | RGD:10837 | 6480464 | pirinixic acid results in decreased expression of KHK mRNA | CTD | PMID:20813756 | pirinixic acid | decreases expression | ISO | RGD:10837 | 6480464 | pirinixic acid results in decreased expression of KHK protein | CTD | PMID:15226431 | pirinixic acid | multiple interactions | ISO | RGD:10837 | 6480464 | [pirinixic acid co-treated with PPARA] results in decreased expression of KHK mRNA | CTD | PMID:20813756 | valproic acid | affects expression | ISO | RGD:10837 | 6480464 | Valproic Acid affects the expression of KHK mRNA | CTD | PMID:17963808 PMID:17292431 | valproic acid | affects expression | ISO | RGD:10837 | 6480464 | Valproic Acid affects the expression of KHK mRNA | CTD | PMID:17292431 PMID:17963808 | vancomycin | increases expression | ISO | RGD:10837 | 6480464 | Vancomycin results in increased expression of KHK mRNA | CTD | PMID:18930951 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology AnnotationsMolecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Fructose and mannose metabolism |
| Metabolic pathways | |
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Fructose and mannose metabolism |
| Metabolic pathways | |
References - curated| 1. |
Coyle P, etal., Biol Trace Elem Res. 2003 Apr;92(1):41-54. |
| 2. |
Donaldson IA, etal., Biochem J 1993 Apr 1;291 ( Pt 1):179-86. |
| 3. |
Fukuda H and Iritani N, Biochim Biophys Acta. 1984 Aug 15;795(1):79-84. |
| 4. |
GOA data from the GO Consortium |
| 5. |
Hayward BE and Bonthron DT, Eur J Biochem 1998 Oct 1;257(1):85-91. |
| 6. |
KEGG |
| 7. |
Koo HY, etal., Biochim Biophys Acta. 2008 May;1782(5):341-8. Epub 2008 Feb 29. |
| 8. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 9. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 10. |
RGD automated import pipeline for gene-chemical interactions |
| 11. |
RGD Automated Pipelines |
| 12. |
RGD comprehensive gene curation |
| 13. |
Shafrir E and Orevi M, Comp Biochem Physiol B. 1984;78(2):493-8. |
| 14. |
Strausberg RL, etal., Proc Natl Acad Sci U S A 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11. |
| 15. |
Szpirer C, etal., Mamm Genome 2000 Sep;11(9):729-35 |
| 16. |
Weiser MM, etal., Am J Physiol. 1971 Sep;221(3):844-9. |
References - uncuratedRGD Disease Portals| Khk has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Khk (Rattus norvegicus) |
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| KHK (Homo sapiens) |
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| Khk (Mus musculus) |
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Position Markers| RH131913 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_031855 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06042446 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHX01042335 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC078752 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473947 | (Get FASTA) | Search GEO for Microarray Profiles | |
| X63658 | (Get FASTA) | Search GEO for Microarray Profiles | |
| Y09337 | (Get FASTA) | Search GEO for Microarray Profiles | |
| Y09339 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_031855 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_114061 | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_114061 | (Get FASTA) |
| GenBank Protein | AAH78752 | (Get FASTA) |
| CAA45198 | (Get FASTA) | |
| CAA70517 | (Get FASTA) | |
| CAA70520 | (Get FASTA) | |
| EDM02964 | (Get FASTA) | |
| Q02974 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000008047 | UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000046296 | UniProtKB/TrEMBL |
| Ensembl Transcript | ENSRNOT00000043572 | UniProtKB/TrEMBL |
| Entrez Gene | 25659 | ENTREZGENE |
| Germonline | ENSRNOG00000008047 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 38187 | ENTREZGENE |
| IMAGE_CLONE | IMAGE:7109062 | IMAGE-MGC_LOAD |
| InterPro | Carb/pur_kinase | UniProtKB/Swiss-Prot |
| IPI | IPI00211989 | UniProtKB/Swiss-Prot |
| IPI00231910 | UniProtKB/Swiss-Prot | |
| IPI00960038 | UniProtKB/TrEMBL | |
| KEGG Report | rno:25659 | ENTREZGENE, UniProtKB/Swiss-Prot |
| MGC_CLONE | MGC:93239 | IMAGE-MGC_LOAD |
| Pfam | PfkB | UniProtKB/Swiss-Prot |
| PROSITE | PFKB_KINASES_1; FALSE_NEG | UniProtKB/Swiss-Prot |
| PFKB_KINASES_2; FALSE_NEG | UniProtKB/Swiss-Prot | |
| UniGene | Rn.33324 | ENTREZGENE |
| UniProt | D3ZN65_RAT | UniProtKB/TrEMBL |
| KHK_RAT | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2002-06-10 | Khk | Ketohexokinase | Symbol and Name status set to approved | 1490 | APPROVED |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_protein | 299 amino acids | 633105 |
| gene_transcript | transcript consists of two alternatively spliced forms | 633104 |
| More on Khk | |
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Entrez Gene |
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Ensembl Gene |
| Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 2966 |
| Created: | 2000-05-25 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.