Ibsp (integrin-binding sialoprotein)

Gene: Ibsp (integrin-binding sialoprotein) Rattus norvegicus

Analyze

Symbol:

Ibsp

Name:

integrin-binding sialoprotein

RGD ID:

2855

Description:

Predicted to enable integrin binding activity and small molecule binding activity. Involved in cell adhesion. Located in extracellular space and vesicle. Orthologous to human IBSP (integrin binding sialoprotein); PARTICIPATES IN cell-extracellular matrix signaling pathway; INTERACTS WITH (S)-nicotine; 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

bone sialoprotein 2; bone sialoprotein II; Bsp; BSP II; cell-binding sialoprotein; integrin binding sialoprotein; Integrin-binding sialoprotein (bone sialoprotein II); MGC156673

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	5,744,497 - 5,757,242 (-)	NCBI		GRCr8
mRatBN7.2	14	5,439,825 - 5,452,570 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	5,439,829 - 5,452,693 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	PNT010000191.1	7,456 - 18,326 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	6,702,628 - 6,715,531 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	5,392,008 - 5,404,941 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	6,801,200 - 6,813,987 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	6,801,204 - 6,813,945 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	6,789,269 - 6,807,502 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	6,548,541 - 6,561,165 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	14	6,548,544 - 6,561,169 (-)	NCBI
Celera	14	5,578,651 - 5,591,441 (-)	NCBI		Celera
RH 3.4 Map	14	89.7	RGD
Cytogenetic Map	14	p22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autosomal dominant polycystic kidney disease (ISO)

Breast Neoplasms (ISO)

genetic disease (ISO)

Neoplasm Metastasis (ISO)

Osteolysis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(S)-nicotine (EXP)

1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine (EXP)

17beta-estradiol (ISO)

1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

6-propyl-2-thiouracil (EXP,ISO)

Actein (ISO)

all-trans-retinoic acid (ISO)

aluminium oxide (ISO)

ammonium chloride (EXP)

anthra[1,9-cd]pyrazol-6(2H)-one (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP)

cadmium atom (ISO)

caffeine (EXP)

calcidiol (ISO)

calciol (ISO)

calcitriol (ISO)

camptothecin (ISO)

chlorpromazine (EXP)

cisplatin (EXP)

cobalt dichloride (EXP,ISO)

daidzein (ISO)

DDT (EXP)

decabromodiphenyl ether (EXP)

dexamethasone (EXP,ISO)

diiodine (ISO)

ethanol (EXP,ISO)

eugenol (ISO)

flavonoids (EXP)

furan (EXP)

genistein (ISO)

geranylgeraniol (ISO)

glycerol 2-phosphate (EXP,ISO)

herbimycin (EXP)

hydrogen peroxide (EXP)

ketoconazole (ISO)

L-ascorbic acid (EXP,ISO)

lead diacetate (ISO)

lipopolysaccharide (ISO)

lithium chloride (ISO)

magnesium atom (ISO)

nickel atom (ISO)

nicotine (EXP)

nitroprusside (ISO)

oxaliplatin (EXP)

paraquat (EXP)

phorbol 13-acetate 12-myristate (ISO)

pirinixic acid (ISO)

quercetin (EXP)

quercetin 3-O-beta-D-glucofuranoside (EXP)

quercetin 3-O-beta-D-glucopyranoside (EXP)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

simvastatin (ISO)

sirolimus (ISO)

sodium arsenite (ISO)

sodium chloride (EXP)

spermine (ISO)

tacrine (EXP)

tamoxifen (ISO)

telmisartan (EXP)

titanium dioxide (ISO)

topotecan (EXP)

Tributyltin oxide (ISO)

trichloroethene (EXP)

trichostatin A (ISO)

zinc atom (ISO)

zinc(0) (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

bone mineralization (IBA,IEA,ISO)

cell adhesion (IEA,IMP)

cellular response to growth factor stimulus (ISO,ISS)

extracellular matrix organization (IBA,IEA,ISO,ISS)

ossification (TAS)

positive regulation of cell adhesion (IEA,ISO)

Cellular Component

extracellular region (IEA,TAS)

extracellular space (IDA)

vesicle (IDA)

Molecular Function

integrin binding (IEA,ISO)

protein binding (ISO)

small molecule binding (IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

cell-extracellular matrix signaling pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Telmisartan Prevents Alveolar Bone Loss by Decreasing the Expression of Osteoclasts Markers in Hypertensive Rats With Periodontal Disease.	Brito VGB, etal., Front Pharmacol. 2020 Nov 11;11:579926. doi: 10.3389/fphar.2020.579926. eCollection 2020.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence.	Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
4.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
5.	Matrix vesicles are carriers of bone morphogenetic proteins (BMPs), vascular endothelial growth factor (VEGF), and noncollagenous matrix proteins.	Nahar NN, etal., J Bone Miner Metab. 2008;26(5):514-9. Epub 2008 Aug 30.
6.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
7.	The primary structure of a cell-binding bone sialoprotein.	Oldberg A, etal., J Biol Chem 1988 Dec 25;263(36):19430-2.
8.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
9.	GOA pipeline	RGD automated data pipeline
10.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
11.	Activation of bone sialoprotein gene transcription by flavonoids is mediated through an inverted CCAAT box in ROS 17/2.8 cells.	Shimizu E and Ogata Y, J Cell Biochem 2002;86(1):35-44.
12.	Identification of a novel response element in the rat bone sialoprotein (BSP) gene promoter that mediates constitutive and fibroblast growth factor 2-induced expression of BSP.	Shimizu-Sasaki E, etal., J Biol Chem 2001 Feb 23;276(8):5459-66.
13.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data

Additional References at PubMed

PMID:7848824	PMID:8889548	PMID:12477932	PMID:12493752	PMID:12952182	PMID:15703183	PMID:16000302	PMID:16087680	PMID:16210410	PMID:16294319	PMID:16495225	PMID:17372929
PMID:17572166	PMID:18041732	PMID:18226471	PMID:18620053	PMID:18757743	PMID:20060443	PMID:20587945	PMID:23266625	PMID:24103036	PMID:24495337	PMID:25464126	PMID:25895664

Genomics

Comparative Map Data

Ibsp
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	5,744,497 - 5,757,242 (-)	NCBI		GRCr8
mRatBN7.2	14	5,439,825 - 5,452,570 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	5,439,829 - 5,452,693 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	PNT010000191.1	7,456 - 18,326 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	6,702,628 - 6,715,531 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	5,392,008 - 5,404,941 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	6,801,200 - 6,813,987 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	6,801,204 - 6,813,945 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	6,789,269 - 6,807,502 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	6,548,541 - 6,561,165 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	14	6,548,544 - 6,561,169 (-)	NCBI
Celera	14	5,578,651 - 5,591,441 (-)	NCBI		Celera
RH 3.4 Map	14	89.7	RGD
Cytogenetic Map	14	p22	NCBI

IBSP
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	87,799,554 - 87,812,435 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	4	87,799,554 - 87,812,435 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	4	88,720,706 - 88,733,587 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	88,939,726 - 88,952,098 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	4	89,077,880 - 89,090,253	NCBI
Celera	4	86,008,963 - 86,021,864 (+)	NCBI		Celera
Cytogenetic Map	4	q22.1	NCBI
HuRef	4	84,466,298 - 84,479,240 (+)	NCBI		HuRef
CHM1_1	4	88,697,498 - 88,710,400 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	4	91,125,985 - 91,138,857 (+)	NCBI		T2T-CHM13v2.0

Ibsp
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	104,447,153 - 104,459,338 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	104,447,037 - 104,459,335 (+)	Ensembl		GRCm39 Ensembl
GRCm38	5	104,299,287 - 104,311,472 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	104,299,171 - 104,311,469 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	104,728,306 - 104,740,491 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	104,539,600 - 104,551,767 (+)	NCBI		MGSCv36	mm8
Celera	5	101,608,398 - 101,620,486 (+)	NCBI		Celera
Cytogenetic Map	5	E5	NCBI
cM Map	5	50.68	NCBI

Ibsp
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955474	2,074,659 - 2,086,289 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955474	2,074,659 - 2,086,289 (-)	NCBI	ChiLan1.0	ChiLan1.0

IBSP
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	3	85,806,206 - 85,819,449 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	4	86,068,641 - 86,081,881 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	4	80,061,960 - 80,105,560 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	4	90,817,072 - 90,830,021 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	90,817,072 - 90,830,021 (+)	Ensembl	panpan1.1		panPan2

IBSP
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	32	11,187,188 - 11,200,860 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	32	11,187,160 - 11,200,846 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	32	30,753,404 - 30,767,085 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	32	11,240,790 - 11,254,453 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	32	11,240,716 - 11,254,466 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	32	11,323,638 - 11,337,299 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	32	11,149,296 - 11,162,980 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	32	28,790,260 - 28,803,929 (-)	NCBI		UU_Cfam_GSD_1.0

Ibsp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405285	1,896,163 - 1,905,843 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936905	316,459 - 323,446 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936905	316,459 - 323,446 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

IBSP
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	131,208,282 - 131,241,266 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	8	131,208,281 - 131,222,048 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	140,438,439 - 140,452,241 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

IBSP
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	7	36,170,411 - 36,185,099 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	7	36,174,903 - 36,184,278 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	14,894,526 - 14,905,166 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ibsp
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624872	4,322,330 - 4,333,080 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624872	4,324,812 - 4,333,080 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Ibsp
303 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	662
Count of miRNA genes:	280
Interacting mature miRNAs:	351
Transcripts:	ENSRNOT00000002938
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2300159	Bmd61	Bone mineral density QTL 61	5.3	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	14	1	26541967	Rat
2300183	Bmd60	Bone mineral density QTL 60	5.7	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	14	1	26541967	Rat
619619	Rf4	Renal disease susceptibility QTL 4	4.1	0.002	urine total protein amount (VT:0000032)	urine protein excretion rate to body weight ratio (CMO:0001099)	14	1	32754612	Rat
634352	Apr6	Acute phase response QTL 6	3.7		blood interleukin-6 amount (VT:0008595)	plasma interleukin-6 level (CMO:0001927)	14	1	41131407	Rat
71115	Niddm15	Non-insulin dependent diabetes mellitus QTL 15	4.8		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	14	1217606	11030812	Rat
70204	Niddm20	Non-insulin dependent diabetes mellitus QTL 20	5.1	0.000008	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	14	1217606	16960180	Rat
724541	Niddm53	Non-insulin dependent diabetes mellitus QTL 53		0.001	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	14	3813074	9088978	Rat
2293089	Iddm31	Insulin dependent diabetes mellitus QTL 31	4.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	14	3813074	18274691	Rat
2293089	Iddm31	Insulin dependent diabetes mellitus QTL 31	4.7		blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	14	3813074	18274691	Rat
1300114	Srn2	Serum renin concentration QTL 2	3.27		blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	14	3813074	21217635	Rat
70195	Mcs8	Mammary carcinoma susceptibility QTL 8	4.28		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	14	3813074	24531477	Rat
1331740	Bw26	Body weight QTL 26	3.028		body mass (VT:0001259)	body weight (CMO:0000012)	14	3813074	30767156	Rat

Markers in Region

D14Arb1

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	14	5,440,438 - 5,440,710 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	6,801,814 - 6,802,085	NCBI	Rnor6.0
Rnor_5.0	14	6,789,883 - 6,790,154	UniSTS	Rnor5.0
RGSC_v3.4	14	6,549,154 - 6,549,426	RGD	RGSC3.4
RGSC_v3.4	14	6,549,155 - 6,549,426	UniSTS	RGSC3.4
RGSC_v3.1	14	6,549,154 - 6,549,426	RGD
Celera	14	5,579,265 - 5,579,536	UniSTS
RH 3.4 Map	14	91.2	UniSTS
RH 3.4 Map	14	91.2	RGD
SHRSP x BN Map	14	2.29	UniSTS
SHRSP x BN Map	14	2.29	RGD
Cytogenetic Map	14	p22	UniSTS

RH94679

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	14	5,440,136 - 5,440,324 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	6,801,512 - 6,801,699	NCBI	Rnor6.0
Rnor_5.0	14	6,789,581 - 6,789,768	UniSTS	Rnor5.0
RGSC_v3.4	14	6,548,853 - 6,549,040	UniSTS	RGSC3.4
Celera	14	5,578,963 - 5,579,150	UniSTS
RH 3.4 Map	14	89.7	UniSTS
Cytogenetic Map	14	p22	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium			2		2
Low	2		10	4	6	4	1	1	62	12	23	10	1
Below cutoff	1	28	11	4	6	4	7	8	12	14	18	1	7

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_012587	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017599075	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017599076	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB001383	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC136829	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC127506	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CB324054	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474022	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DQ213013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DY313346	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DY314698	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	J04215	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000014	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000002938 ⟹ ENSRNOP00000002938

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	14	5,439,829 - 5,452,693 (-)	Ensembl
Rnor_6.0 Ensembl	14	6,801,204 - 6,813,945 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000105753 ⟹ ENSRNOP00000076389

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	14	5,439,829 - 5,452,693 (-)	Ensembl

RefSeq Acc Id:

NM_012587 ⟹ NP_036719

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	5,744,497 - 5,757,242 (-)	NCBI
mRatBN7.2	14	5,439,825 - 5,452,570 (-)	NCBI
Rnor_6.0	14	6,801,200 - 6,813,945 (-)	NCBI
Rnor_5.0	14	6,789,269 - 6,807,502 (-)	NCBI
RGSC_v3.4	14	6,548,541 - 6,561,165 (-)	RGD
Celera	14	5,578,651 - 5,591,441 (-)	RGD

Sequence:

show sequence

GCCGGGAGAACAATCCGTGCCACTCACTCACTTGCTCTCTCCAGCCAGGACTGCCGAAGGAAGA
AATTGCAAAATGAAGACTGCTTTAATCTTGCTCTGCATTTTGGGGATGGCGAGTGCTTTCTCGA
TGAAAAATTTCCATAGAAGAATCAAAGCAGAGGATTCTGAAGAAAACGGGGTCTTTAAGTACCG
GCCACGCTACTTTCTTTATAAGCATGCCTACTTTTATCCTCCTCTGAAACGGTTTCCAGTCCAG
GGAGGCAGCGACTCTTCGGAAGAAAATGGAGATGGCGATAGTTCGGAGGAGGAGGGGGAGGAAG
AGGAGACTTCAAATGAAGAGGAAAACAACGAAGACTCTGAGGGGAATGAAGACCAGGAGGCGGA
GGCAGAGAACGCCACACTCTCAGGGGTAACCGCTAGCTACGGGGTAGAGACCACAGCTGACGCT
GGAAAGTTGGAGTTAGCTGCGCTCCAGCTACCCAAGAAGGCTGGAGATGCAGAGGGCAAGGCTC
CAAAAATGAAGGAAAGCGACGAGGAAGAGGAAGAGGAAGAGGAGGAAGAAAACGAGAACGAAGA
AGCAGAAGTGGATGAAAATGAGCAGGTCGTCAACGGCACCAGCACCAACTCCACGGAGGTGGAC
GGGGGGAATGGCCCCAGCGGAGGAGACAACGGAGAAGAAGCCGAGGAGGCAAGCGTCACTGAAG
CAGGTGCAGAAGGAACAACAGCAGGGGCCAGGGAGCTGACCAGTTATGGCACCACGACAGCTGT
CCTTCTGAACGGGTTTCAGCAGACGACCCCGCCACCCGAAGCCTATGGGACCACCTCCCCACCA
GCCAGAAAGAGCAGCACGGTTGAGTATGGGGAAGAATACGAACAAATAGGCAACGAGTACAACA
CTGCGTATGAAACCTATGACGAGAACAACGGGGAGCCTCGCGGGGACACTTACCGAGCTTATGA
GGACGAATACAGCTACTACAAGGGGCATGGCTATGAAGGCTACGAGGGTCAGGATTATTACTAC
CACCAGTGAAGGCCCCTCCGGGGAGGACTCCCCATTCTGTCTTTGCATCTGGATACCATTTTCA
AAGCTCAACTCAGGAAGGTGCAATATATATATATAACAGATGTGCATTTTATAGTGTGGAATGG
TGCTACGGTCTCAGAGTGATTTCCACAAATGCTTCCGTTTGTAGCGGCCTTTTTTTTTTTTTTT
TTAATTTTTCCAGGTGCGTCATTGAAGGGTCATCGTAAATCAGGGCTGTTGATCAAGTAGCACA
CAGATCTATGAGCTGGGACCAGGTGGAATGCTTCGAGGTTGTTTTTCTATAGTGTTTGTGCTGT
GTACACCATTGCTAACCACCCTAACATACCCTGTACAAGAAGACTCCTAACGAGAGATTTATTA
ACAACACTGTATACGATGTGTGTAGTTCCTTTATCACACCCCCTACCTAATACTGTATTAGGTT
TGATTTTCATCCTCATGTATTTTACGTGACTTGTGCACATGCGTTTTTATCATAAATAAATATG
CAATCATTCACGTGTGTTATAATTAAAAAGAAAGGGAGAGTGTTGGAATGAGTGTGGGTCTAAG
GAGCAGGGAACAATTTGGCTAAAAAGAAACGCTTATCTCCATCAGGGTTTAAAACTCAGAGGAT
CCGGAAACACTCTTTATTCAGTACATCTGAACGGCTAAGGTTCGACTACGGAGGGCAGAATCAT
CTGTATACAGGAGGGAGTAAATGACCCCTTTTAGAGTTGCCAGATTTACCAAACATGAATACAC
GGTGTGAGACGCCCACCTCAGCTTGAATTCCAGATGAACAATGGCTGGTTTTTAATACAACCCC
TCCCCTACAGATAATTTGTCTCTGTGAAACATTTGGAACAAACTTATGCTAAATAAATGACTTA
TTCTTTATCTAATAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_017599076 ⟹ XP_017454565

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	5,744,499 - 5,757,233 (-)	NCBI
mRatBN7.2	14	5,439,825 - 5,452,561 (-)	NCBI
Rnor_6.0	14	6,801,200 - 6,813,967 (-)	NCBI

Sequence:

show sequence

GCGAGTGAATGGGTGAGAGGCAGCCGGGAGAACAATCCGTGCCACTCACTCACTTGCTCTCTCC
AGCCAGGACTGCCGAAGGGTAAGAAGAAATTGCAAAATGAAGACTGCTTTAATCTTGCTCTGCA
TTTTGGGGATGGCGAGTGCTTTCTCGATGAAAAATTTCCATAGAAGAATCAAAGCAGAGGATTC
TGAAGAAAACGGGGTCTTTAAGTACCGGCCACGCTACTTTCTTTATAAGCATGCCTACTTTTAT
CCTCCTCTGAAACGGTTTCCAGTCCAGGGAGGCAGCGACTCTTCGGAAGAAAATGGAGATGGCG
ATAGTTCGGAGGAGGAGGGGGAGGAAGAGGAGACTTCAAATGAAGAGGAAAACAACGAAGACTC
TGAGGGGAATGAAGACCAGGAGGCGGAGGCAGAGAACGCCACACTCTCAGGGGTAACCGCTAGC
TACGGGGTAGAGACCACAGCTGACGCTGGAAAGTTGGAGTTAGCTGCGCTCCAGCTACCCAAGA
AGGCTGGAGATGCAGAGGGCAAGGCTCCAAAAATGAAGGAAAGCGACGAGGAAGAGGAAGAGGA
AGAGGAGGAAGAAAACGAGAACGAAGAAGCAGAAGTGGATGAAAATGAGCAGGTCGTCAACGGC
ACCAGCACCAACTCCACGGAGGTGGACGGGGGGAATGGCCCCAGCGGAGGAGACAACGGAGAAG
AAGCCGAGGAGGCAAGCGTCACTGAAGCAGGTGCAGAAGGAACAACAGCAGGGGCCAGGGAGCT
GACCAGTTATGGCACCACGACAGCTGTCCTTCTGAACGGGTTTCAGCAGACGACCCCGCCACCC
GAAGCCTATGGGACCACCTCCCCACCAGCCAGAAAGAGCAGCACGGTTGAGTATGGGGAAGAAT
ACGAACAAATAGGCAACGAGTACAACACTGCGTATGAAACCTATGACGAGAACAACGGGGAGCC
TCGCGGGGACACTTACCGAGCTTATGAGGACGAATACAGCTACTACAAGGGGCATGGCTATGAA
GGCTACGAGGGTCAGGATTATTACTACCACCAGTGAAGGCCCCTCCGGGGAGGACTCCCCATTC
TGTCTTTGCATCTGGATACCATTTTCAAAGCTCAACTCAGGAAGGTGCAATATATATATATAAC
AGATGTGCATTTTATAGTGTGGAATGGTGCTACGGTCTCAGAGTGATTTCCACAAATGCTTCCG
TTTGTAGCGGCCTTTTTTTTTTTTTTTTTAATTTTTCCAGGTGCGTCATTGAAGGGTCATCGTA
AATCAGGGCTGTTGATCAAGTAGCACACAGATCTATGAGCTGGGACCAGGTGGAATGCTTCGAG
GTTGTTTTTCTATAGTGTTTGTGCTGTGTACACCATTGCTAACCACCCTAACATACCCTGTACA
AGAAGACTCCTAACGAGAGATTTATTAACAACACTGTATACGATGTGTGTAGTTCCTTTATCAC
ACCCCCTACCTAATACTGTATTAGGTTTGATTTTCATCCTCATGTATTTTACGTGACTTGTGCA
CATGCGTTTTTATCATAAATAAATATGCAATCATTCACGTGTGTTATAATTAAAAAGAAAGGGA
GAGTGTTGGAATGAGTGTGGGTCTAAGGAGCAGGGAACAATTTGGCTAAAAAGAAACGCTTATC
TCCATCAGGGTTTAAAACTCAGAGGATCCGGAAACACTCTTTATTCAGTACATCTGAACGGCTA
AGGTTCGACTACGGAGGGCAGAATCATCTGTATACAGGAGGGAGTAAATGACCCCTTTTAGAGT
TGCCAGATTTACCAAACATGAATACACGGTGTGAGACGCCCACCTCAGCTTGAATTCCAGATGA
ACAATGGCTGGTTTTTAATACAACCCCTCCCCTACAGATAATTTGTCTCTGTGAAACATTTGGA
ACAAACTTATGCTAAATAAATGACTTATTCTTTATCTAATA

hide sequence

Protein Sequences


Protein RefSeqs	NP_036719	(Get FASTA)	NCBI Sequence Viewer
	XP_017454565	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA41763	(Get FASTA)	NCBI Sequence Viewer
	AAI27507	(Get FASTA)	NCBI Sequence Viewer
	ABA42178	(Get FASTA)	NCBI Sequence Viewer
	BAA19248	(Get FASTA)	NCBI Sequence Viewer
	EDL99496	(Get FASTA)	NCBI Sequence Viewer
	EDL99497	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000002938
	ENSRNOP00000002938.2
	ENSRNOP00000076389.1
GenBank Protein	P13839	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_036719 ⟸ NM_012587
- Peptide Label:	precursor
- UniProtKB:	A0JPM6 (UniProtKB/TrEMBL), Q3HLN4 (UniProtKB/TrEMBL)
- Sequence:	show sequence MKTALILLCILGMASAFSMKNFHRRIKAEDSEENGVFKYRPRYFLYKHAYFYPPLKRFPVQGGS DSSEENGDGDSSEEEGEEEETSNEEENNEDSEGNEDQEAEAENATLSGVTASYGVETTADAGKL ELAALQLPKKAGDAEGKAPKMKESDEEEEEEEEEENENEEAEVDENEQVVNGTSTNSTEVDGGN GPSGGDNGEEAEEASVTEAGAEGTTAGARELTSYGTTTAVLLNGFQQTTPPPEAYGTTSPPARK SSTVEYGEEYEQIGNEYNTAYETYDENNGEPRGDTYRAYEDEYSYYKGHGYEGYEGQDYYYHQ hide sequence

RefSeq Acc Id:	XP_017454565 ⟸ XM_017599076
- Peptide Label:	isoform X1
- UniProtKB:	A0JPM6 (UniProtKB/TrEMBL), Q3HLN4 (UniProtKB/TrEMBL)
- Sequence:	show sequence MKTALILLCILGMASAFSMKNFHRRIKAEDSEENGVFKYRPRYFLYKHAYFYPPLKRFPVQGGS DSSEENGDGDSSEEEGEEEETSNEEENNEDSEGNEDQEAEAENATLSGVTASYGVETTADAGKL ELAALQLPKKAGDAEGKAPKMKESDEEEEEEEEEENENEEAEVDENEQVVNGTSTNSTEVDGGN GPSGGDNGEEAEEASVTEAGAEGTTAGARELTSYGTTTAVLLNGFQQTTPPPEAYGTTSPPARK SSTVEYGEEYEQIGNEYNTAYETYDENNGEPRGDTYRAYEDEYSYYKGHGYEGYEGQDYYYHQ hide sequence

RefSeq Acc Id:

ENSRNOP00000002938 ⟸ ENSRNOT00000002938

RefSeq Acc Id:

ENSRNOP00000076389 ⟸ ENSRNOT00000105753

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P13839-F1-model_v2	AlphaFold	P13839	1-320	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13699173

Promoter ID:

EPDNEW_R9698

Type:

single initiation site

Name:

Ibsp_1

Description:

integrin-binding sialoprotein

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	14	6,813,953 - 6,814,013	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:2855	AgrOrtholog
BioCyc Gene	G2FUF-16506	BioCyc
Ensembl Genes	ENSRNOG00000002158	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000002938	ENTREZGENE
	ENSRNOT00000002938.4	UniProtKB/TrEMBL
	ENSRNOT00000105753.1	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:8369751	IMAGE-MGC_LOAD
InterPro	BSP_II	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:24477	UniProtKB/TrEMBL
MGC_CLONE	MGC:156673	IMAGE-MGC_LOAD
NCBI Gene	24477	ENTREZGENE
PANTHER	BONE SIALOPROTEIN 2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR10345	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	BSP_II	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Ibsp	PhenoGen
RatGTEx	ENSRNOG00000002158	RatGTEx
TIGR	TC230187
UniProt	A0A8I5Y053_RAT	UniProtKB/TrEMBL
	A0JPM6	ENTREZGENE, UniProtKB/TrEMBL
	A6K5S7_RAT	UniProtKB/TrEMBL
	F7FLE6_RAT	UniProtKB/TrEMBL
	P13839	ENTREZGENE
	Q3HLN4	ENTREZGENE, UniProtKB/TrEMBL
	SIAL_RAT	UniProtKB/Swiss-Prot
UniProt Secondary	P97828	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2010-02-09	Ibsp	integrin-binding sialoprotein	Ibsp	integrin binding sialoprotein	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-02-26	Ibsp	integrin binding sialoprotein			Symbol and Name status set to approved	625702	APPROVED
2002-06-10	Ibsp	integrin binding sialoprotein			Name updated	70585	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_function	binds to hydroxyapatite through polyglutamic acid sequences and mediates cell attachment through an RGD sequence	62418
gene_process	may function in hydroxyapatite crystal nucleation	62418
gene_regulation	transcription is enhanced by NF-YA, a CCAAT box-binding transcription factor	727390

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)