Hsd3b5 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5) - Rat Genome Database

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Gene: Hsd3b5 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Hsd3b5
Name: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5
RGD ID: 2838
Description: Enables 3-beta-hydroxy-delta5-steroid dehydrogenase activity and steroid binding activity. Involved in progesterone metabolic process; regulation of steroid biosynthetic process; and steroid biosynthetic process. Predicted to be located in endoplasmic reticulum membrane and mitochondrial membrane. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in hypertension and hypospadias. Orthologous to human HSD3B1 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1) and HSD3B2 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2); PARTICIPATES IN isoprenoid metabolic pathway; steroid hormone biosynthetic pathway; .
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 3 beta-HSD III; 3 beta-hydroxysteroid dehydrogenase 5; 3 beta-hydroxysteroid dehydrogenase type 3; 3 beta-hydroxysteroid dehydrogenase type 5; 3 beta-hydroxysteroid dehydrogenase type 5-like; 3 beta-hydroxysteroid dehydrogenase type III; 3 beta-hydroxysteroid dehydrogenase type V; 3-beta-HSD V; 3-beta-hydroxy-5-ene steroid dehydrogenase; dihydrotestosterone 3-ketoreductase; Hsd1; Hsd3b; Hydroxy-delta-5-steroid dehydrogenase 3 beta- and steroid delta-isomerase; hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase; LOC108348209; NADPH-dependent 3-beta-hydroxy-Delta(5)-steroid dehydrogenase; NADPH-dependent 3-keto-steroid reductase Hsd3b5; progesterone reductase; RATHSDI; steroid delta-isomerase, 3 beta
RGD Orthologs
Alliance Genes
More Info homologs ...
Candidate Gene For: Hcuc3
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82188,697,669 - 188,717,141 (-)NCBIGRCr8
mRatBN7.22186,008,944 - 186,028,417 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2186,008,943 - 186,020,393 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2193,657,598 - 193,676,873 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02191,466,848 - 191,486,172 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02186,290,168 - 186,309,440 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02200,615,910 - 200,633,317 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2200,584,986 - 200,692,335 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02220,060,508 - 220,087,584 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42193,249,949 - 193,269,979 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12193,212,702 - 193,232,733 (-)NCBI
Celera2178,496,737 - 178,516,049 (-)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. 3 Beta-hydroxysteroid dehydrogenase expression in rat spinal cord. Coirini H, etal., Neuroscience 2002;113(4):883-91.
2. Mapping of a quantitative trait locus for blood pressure on rat chromosome 2. Deng AY, etal., J Clin Invest 1994 Jul;94(1):431-6
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. The application of continuous monitoring microdensitometry to an analysis of NAD+ binding and 3 beta-hydroxy-delta 5-steroid dehydrogenase activity in the regressing corpus luteum of the pro-oestrous rat ovary. Gordon M and Robertson WR, Histochem J. 1986 Jan;18(1):41-4.
5. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
6. The roles of pregn-5-ene-3 beta, 20 alpha-diol and 20 alpha-hydroxy steroid dehydrogenase in the control of progesterone synthesis preceding parturition and lactogenesis in the rat. Kuhn NJ and Briley MS, Biochem J. 1970 Apr;117(2):193-201.
7. Direct effects of IL-15 on corticosterone secretion by rat adrenocortical cells. Lo MJ and Lee SD, Immunol Cell Biol. 2006 Feb;84(1):38-43.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Ontogeny of immunoreactive and bioactive microsomal steroidogenic enzymes during adrenocortical development in rats. Nagaya M, etal., Mol Cell Endocrinol. 1995 Oct 30;114(1-2):27-34.
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. Development of a quantitative assay method for 3 beta-hydroxy-delta 5-steroid dehydrogenase in the rat testis. Qujeq D Steroids. 2002 Dec;67(13-14):1071-7.
13. GOA pipeline RGD automated data pipeline
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Structure and sexual dimorphic expression of a liver-specific rat 3 beta-hydroxysteroid dehydrogenase/isomerase. Zhao HF, etal., Endocrinology 1990 Dec;127(6):3237-9.
Additional References at PubMed
PMID:1298957   PMID:12477932   PMID:15489334   PMID:16020475   PMID:17428656   PMID:18511507   PMID:30884106  


Genomics

Variants

.
Variants in Hsd3b5
132 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:80
Count of miRNA genes:69
Interacting mature miRNAs:71
Transcripts:ENSRNOT00000026290
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2133914684202447032Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2135552573202446871Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2136916935189599348Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2141596551202447032Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2143157029210020885Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2143657411190602963Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2143657411190602963Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2144599348189599348Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2147798556192798556Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150341585189039377Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150341684202446871Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150540301202447032Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2150540301202447032Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2157142078192625452Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2157142078211086598Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2157142209202446871Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2160564068205564068Rat
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2162765032207765032Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
1598838Bp290Blood pressure QTL 2901.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166539266211539266Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2168594495213594495Rat
61469Bp16Blood pressure QTL 165.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
70162Bp63Blood pressure QTL 635.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
2293084Iddm26Insulin dependent diabetes mellitus QTL 262.9blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2174930955213594495Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2179335906224335906Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2179946951224946951Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2182171407227171407Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2182171407227171407Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2182171407227171407Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2182171407227171407Rat
4889834Pur24Proteinuria QTL 245.80.014urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)2184114274202447032Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2184165752229165752Rat
7488929Bp366Blood pressure QTL 3660.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2184974550193094998Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2185876309219753474Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2185876309219753474Rat

Markers in Region
D2Wox25  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22186,009,113 - 186,009,259 (+)MAPPERmRatBN7.2
Rnor_6.02200,616,080 - 200,616,223NCBIRnor6.0
Rnor_6.02200,585,156 - 200,585,297NCBIRnor6.0
Rnor_5.02220,060,678 - 220,060,819UniSTSRnor5.0
Rnor_5.02220,089,124 - 220,089,267UniSTSRnor5.0
RGSC_v3.42193,250,118 - 193,250,260RGDRGSC3.4
RGSC_v3.42193,250,119 - 193,250,260UniSTSRGSC3.4
RGSC_v3.12193,212,872 - 193,213,014RGD
Celera2178,496,907 - 178,497,024UniSTS
RH 3.4 Map21257.6RGD
RH 3.4 Map21257.6UniSTS
RH 2.0 Map2951.6RGD
Cytogenetic Map2q34UniSTS
D2Arb20  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22186,009,118 - 186,009,356 (+)MAPPERmRatBN7.2
Rnor_6.02200,585,161 - 200,585,394NCBIRnor6.0
Rnor_6.02200,616,085 - 200,616,320NCBIRnor6.0
Rnor_5.02220,060,683 - 220,060,916UniSTSRnor5.0
Rnor_5.02220,089,129 - 220,089,364UniSTSRnor5.0
RGSC_v3.42193,250,123 - 193,250,357RGDRGSC3.4
RGSC_v3.42193,250,124 - 193,250,357UniSTSRGSC3.4
RGSC_v3.12193,212,877 - 193,213,111RGD
Celera2178,496,912 - 178,497,121UniSTS
RH 3.4 Map21261.2UniSTS
RH 3.4 Map21261.2RGD
RH 2.0 Map2952.9RGD
SHRSP x BN Map273.6298RGD
Cytogenetic Map2q34UniSTS
RH132844  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22186,003,657 - 186,003,855 (+)MAPPERmRatBN7.2
Rnor_6.02200,610,624 - 200,610,821NCBIRnor6.0
Rnor_6.02200,579,700 - 200,579,897NCBIRnor6.0
Rnor_5.02220,083,668 - 220,083,865UniSTSRnor5.0
Rnor_5.02220,055,222 - 220,055,419UniSTSRnor5.0
RGSC_v3.42193,244,663 - 193,244,860UniSTSRGSC3.4
Celera2178,491,451 - 178,491,648UniSTS
RH 3.4 Map21260.1UniSTS
Cytogenetic Map2q34UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 17 9 9 4 5 3
Low 2 9 18 10 18 10 8 9 5 9 13 7 8
Below cutoff 1 2 2 2 1 2 3 9

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000026290   ⟹   ENSRNOP00000026290
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2200,584,986 - 200,692,335 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000079754   ⟹   ENSRNOP00000072555
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2186,008,943 - 186,020,393 (-)Ensembl
Rnor_6.0 Ensembl2200,615,909 - 200,625,434 (-)Ensembl
RefSeq Acc Id: NM_012584   ⟹   NP_036716
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82188,697,671 - 188,717,018 (-)NCBI
mRatBN7.22186,008,944 - 186,028,294 (-)NCBI
Rnor_6.02200,615,910 - 200,633,317 (-)NCBI
Rnor_5.02220,060,508 - 220,087,584 (-)NCBI
RGSC_v3.42193,249,949 - 193,269,979 (-)RGD
Celera2178,496,737 - 178,516,049 (-)RGD
Sequence:
RefSeq Acc Id: XM_039101717   ⟹   XP_038957645
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82188,697,669 - 188,717,141 (-)NCBI
mRatBN7.22186,009,622 - 186,028,417 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_036716   ⟸   NM_012584
- UniProtKB: Q569C6 (UniProtKB/Swiss-Prot),   P27364 (UniProtKB/Swiss-Prot),   A0A0G2JSR3 (UniProtKB/TrEMBL),   A6K3D9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000072555   ⟸   ENSRNOT00000079754
RefSeq Acc Id: ENSRNOP00000026290   ⟸   ENSRNOT00000026290
RefSeq Acc Id: XP_038957645   ⟸   XM_039101717
- Peptide Label: isoform X1
- UniProtKB: Q569C6 (UniProtKB/Swiss-Prot),   P27364 (UniProtKB/Swiss-Prot)
Protein Domains
3-beta hydroxysteroid dehydrogenase/isomerase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P27364-F1-model_v2 AlphaFold P27364 1-373 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2838 AgrOrtholog
BioCyc Gene G2FUF-51911 BioCyc
Ensembl Genes ENSRNOG00000019417 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00055032797 UniProtKB/Swiss-Prot
  ENSRNOG00060013782 UniProtKB/Swiss-Prot
  ENSRNOG00065030863 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000079754 ENTREZGENE
  ENSRNOT00000079754.2 UniProtKB/TrEMBL
  ENSRNOT00055056713 UniProtKB/Swiss-Prot
  ENSRNOT00060023537 UniProtKB/Swiss-Prot
  ENSRNOT00065053181 UniProtKB/Swiss-Prot
Gene3D-CATH NAD(P)-binding Rossmann-like Domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7369915 IMAGE-MGC_LOAD
InterPro 3Beta_OHSteriod_DH/Estase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24470 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108750 IMAGE-MGC_LOAD
NCBI Gene 24470 ENTREZGENE
PANTHER BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 3Beta_HSD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hsd3b5 PhenoGen
RatGTEx ENSRNOG00000019417 RatGTEx
  ENSRNOG00055032797 RatGTEx
  ENSRNOG00060013782 RatGTEx
  ENSRNOG00065030863 RatGTEx
Superfamily-SCOP SSF51735 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt 3BHS5_RAT UniProtKB/Swiss-Prot
  A0A0G2JSR3 ENTREZGENE, UniProtKB/TrEMBL
  A6K3D9 ENTREZGENE, UniProtKB/TrEMBL
  P27364 ENTREZGENE
  Q569C6 ENTREZGENE
UniProt Secondary Q569C6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Hsd3b5  hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5  LOC108348209  3 beta-hydroxysteroid dehydrogenase type 5-like  Data merged from RGD:11516134 737654 PROVISIONAL
2016-08-02 LOC108348209  3 beta-hydroxysteroid dehydrogenase type 5-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-12-18 Hsd3b5  hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5  Hsd3b  steroid delta-isomerase, 3 beta  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2005-01-20 Hsd3b  steroid delta-isomerase, 3 beta    hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase  Name updated 1299863 APPROVED
2002-06-10 Hsd3b  hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase      Name updated 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_function bifunctional enzyme that catalyzes the oxidative conversion of delta(5)-ene-3-beta-hydroxy steroid and of ketosteroids 61038
gene_process plays a role in hormonal steroid biosynthesis 61038