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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (-)-anisomycin | multiple interactions | ISO | RGD:732851 | 6480464 | Anisomycin promotes the reaction [Tretinoin results in increased expression of HOXA1 mRNA] | CTD | PMID:16038797 | 17alpha-ethynylestradiol | affects expression | EXP | | 6480464 | Ethinyl Estradiol affects the expression of HOXA1 mRNA | CTD | PMID:16079270 | 2-amino-2-deoxy-D-glucopyranose | decreases expression | ISO | RGD:732851 | 6480464 | Glucosamine results in decreased expression of HOXA1 mRNA | CTD | PMID:17178593 | aldehydo-D-glucosamine | decreases expression | ISO | RGD:732851 | 6480464 | Glucosamine results in decreased expression of HOXA1 mRNA | CTD | PMID:17178593 | alendronic acid | affects expression | EXP | | 6480464 | Alendronate affects the expression of HOXA1 mRNA | CTD | PMID:16079270 | all-trans-retinoic acid | increases expression | ISO | RGD:737614 | 6480464 | Tretinoin results in increased expression of HOXA1 mRNA | CTD | PMID:17185360 PMID:17218384 | all-trans-retinoic acid | increases expression | ISO | RGD:737614 | 6480464 | Tretinoin results in increased expression of HOXA1 mRNA | CTD | PMID:17185360 more ... | all-trans-retinoic acid | increases expression | ISO | RGD:732851 | 6480464 | Tretinoin results in increased expression of HOXA1 mRNA | CTD | PMID:16038797 more ... | all-trans-retinoic acid | increases expression | EXP | | 6480464 | Tretinoin results in increased expression of HOXA1 mRNA | CTD | PMID:16989981 PMID:20488242 | all-trans-retinoic acid | increases expression | EXP | | 6480464 | Tretinoin results in increased expression of HOXA1 mRNA | CTD | PMID:20488242 PMID:16989981 | all-trans-retinoic acid | increases expression | ISO | RGD:737614 | 6480464 | Tretinoin results in increased expression of HOXA1 mRNA | CTD | PMID:17218384 more ... | all-trans-retinoic acid | increases expression | ISO | RGD:732851 | 6480464 | Tretinoin results in increased expression of HOXA1 mRNA | CTD | PMID:16604517 more ... | all-trans-retinoic acid | increases expression | ISO | RGD:732851 | 6480464 | Tretinoin results in increased expression of HOXA1 mRNA | CTD | PMID:16788091 more ... | all-trans-retinoic acid | increases expression | ISO | RGD:737614 | 6480464 | Tretinoin results in increased expression of HOXA1 mRNA | CTD | PMID:21934132 more ... | all-trans-retinoic acid | increases expression | ISO | RGD:732851 | 6480464 | Tretinoin results in increased expression of HOXA1 mRNA | CTD | PMID:19897914 more ... | all-trans-retinoic acid | increases expression | ISO | RGD:737614 | 6480464 | Tretinoin results in increased expression of HOXA1 mRNA | CTD | PMID:17218384 more ... | all-trans-retinoic acid | increases expression | ISO | RGD:732851 | 6480464 | Tretinoin results in increased expression of HOXA1 | CTD | PMID:8838863 | all-trans-retinoic acid | increases expression | EXP | | 6480464 | Tretinoin results in increased expression of HOXA1 mRNA | CTD | PMID:16989981 | all-trans-retinoic acid | increases expression | ISO | RGD:732851 | 6480464 | Tretinoin results in increased expression of HOXA1 mRNA | CTD | PMID:19897914 more ... | all-trans-retinoic acid | affects expression | ISO | RGD:732851 | 6480464 | Tretinoin affects the expression of HOXA1 | CTD | PMID:15722554 | all-trans-retinoic acid | multiple interactions | ISO | RGD:732851 | 6480464 | Anisomycin promotes the reaction [Tretinoin results in increased expression of HOXA1 mRNA] | CTD | PMID:16038797 | all-trans-retinoic acid | multiple interactions | ISO | RGD:737614 | 6480464 | Tretinoin promotes the reaction [IL8 protein results in increased expression of HOXA1 mRNA polymorphism] | CTD | PMID:17218384 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of HOXA1 mRNA | CTD | PMID:16483693 | beta-D-glucosamine | decreases expression | ISO | RGD:732851 | 6480464 | Glucosamine results in decreased expression of HOXA1 mRNA | CTD | PMID:17178593 | bis(2-chloroethyl) sulfide | increases expression | ISO | RGD:732851 | 6480464 | Mustard Gas results in increased expression of HOXA1 mRNA | CTD | PMID:15674843 | cadmium dichloride | decreases expression | ISO | RGD:737614 | 6480464 | Cadmium Chloride results in decreased expression of HOXA1 mRNA | CTD | PMID:12160620 | chloroprene | decreases expression | ISO | RGD:732851 | 6480464 | Chloroprene results in decreased expression of HOXA1 mRNA | CTD | PMID:23125180 | copper atom | multiple interactions | ISO | RGD:737614 | 6480464 | [NSC 689534 binds to Copper] which results in increased expression of HOXA1 mRNA | CTD | PMID:20971185 | copper(0) | multiple interactions | ISO | RGD:737614 | 6480464 | [NSC 689534 binds to Copper] which results in increased expression of HOXA1 mRNA | CTD | PMID:20971185 | cyclophosphamide | affects response to substance | ISO | RGD:737614 | 6480464 | HOXA1 protein affects the susceptibility to Cyclophosphamide | CTD | PMID:16217747 | D-gluconic acid | multiple interactions | EXP | | 6480464 | [gluconic acid co-treated with Deoxycholic Acid] results in increased expression of HOXA1 mRNA | CTD | PMID:16556975 | deoxycholic acid | multiple interactions | EXP | | 6480464 | [gluconic acid co-treated with Deoxycholic Acid] results in increased expression of HOXA1 mRNA | CTD | PMID:16556975 | diethylstilbestrol | decreases expression | EXP | | 6480464 | Diethylstilbestrol results in decreased expression of HOXA1 protein | CTD | PMID:22198180 | dimethylarsinic acid | decreases expression | EXP | | 6480464 | Cacodylic Acid results in decreased expression of HOXA1 mRNA | CTD | PMID:16122865 | endosulfan | increases expression | EXP | | 6480464 | Endosulfan results in increased expression of HOXA1 protein | CTD | PMID:22198180 | hydrogen peroxide | affects expression | ISO | RGD:737614 | 6480464 | Hydrogen Peroxide affects the expression of HOXA1 mRNA | CTD | PMID:20044591 | N-nitrosodiethylamine | multiple interactions | EXP | | 6480464 | [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of HOXA1 mRNA | CTD | PMID:18164116 | pirinixic acid | multiple interactions | ISO | RGD:732851 | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of HOXA1 mRNA | CTD | PMID:19710929 | raloxifene | affects expression | EXP | | 6480464 | Raloxifene affects the expression of HOXA1 mRNA | CTD | PMID:16079270 | resveratrol | decreases expression | ISO | RGD:737614 | 6480464 | resveratrol results in decreased expression of HOXA1 mRNA | CTD | PMID:20878097 | silicon dioxide | decreases expression | ISO | RGD:732851 | 6480464 | Silicon Dioxide results in decreased expression of HOXA1 mRNA | CTD | PMID:19073995 | trans-resveratrol | decreases expression | ISO | RGD:737614 | 6480464 | resveratrol results in decreased expression of HOXA1 mRNA | CTD | PMID:20878097 | valproic acid | increases expression | EXP | | 6480464 | Valproic Acid analog results in increased expression of HOXA1 mRNA; more ... | CTD | PMID:16989981 | valproic acid | affects expression | ISO | RGD:732851 | 6480464 | Valproic Acid affects the expression of HOXA1 mRNA | CTD | PMID:17292431 | valproic acid | increases expression | ISO | RGD:732851 | 6480464 | Valproic Acid results in increased expression of HOXA1 mRNA | CTD | PMID:21427059 | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Disease Annotations
Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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References - curated| 1. |
Baron A, etal., EMBO J 1987 Oct;6(10):2977-86. |
| 2. |
Conciatori M, etal., Biol Psychiatry 2004 Feb 15;55(4):413-9. |
| 3. |
GOA data from the GO Consortium |
| 4. |
Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7 |
| 5. |
MGD data from the GO Consortium |
| 6. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 7. |
RGD automated data pipeline |
| 8. |
RGD automated import pipeline for gene-chemical interactions |
| 9. |
RGD Automated Pipelines |
References - uncurated
RGD Disease Portals| Hoxa1 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Hoxa1 (Rattus norvegicus) |
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| HOXA1 (Homo sapiens) |
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| Hoxa1 (Mus musculus) |
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Position Markers| RH94642 |
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| UniSTS:143360 |
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| REN100302 |
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| Hoxa1 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_013075 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06031005 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHX01030190 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AC122669 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH474011 | (Get FASTA) | Search GEO for Microarray Profiles | |
| U93092 | (Get FASTA) | Search GEO for Microarray Profiles | |
| U93093 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_013075 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_037207 | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_037207 | (Get FASTA) |
| GenBank Protein | AAB51399 | (Get FASTA) |
| AAB51400 | (Get FASTA) | |
| EDL88168 | (Get FASTA) | |
| O08656 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000005628 | ENTREZGENE, UniProtKB/TrEMBL |
| ENSRNOG00000046750 | UniProtKB/TrEMBL | |
| Ensembl Protein | ENSRNOP00000007807 | ENTREZGENE, UniProtKB/TrEMBL |
| ENSRNOP00000065040 | UniProtKB/TrEMBL | |
| Ensembl Transcript | ENSRNOT00000007807 | ENTREZGENE, UniProtKB/TrEMBL |
| ENSRNOT00000072867 | UniProtKB/TrEMBL | |
| Entrez Gene | 25607 | ENTREZGENE |
| Gene3D-CATH | Homeodomain-rel | UniProtKB/Swiss-Prot |
| Germonline | ENSRNOG00000005628 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 4032 | ENTREZGENE |
| InterPro | Homeobox | UniProtKB/Swiss-Prot |
| Homeobox_CS | UniProtKB/Swiss-Prot | |
| Homeobox_metazoa | UniProtKB/TrEMBL | |
| Homeodomain-like | UniProtKB/Swiss-Prot | |
| IPI | IPI00324676 | UniProtKB/Swiss-Prot |
| IPI00324677 | UniProtKB/TrEMBL | |
| KEGG Report | rno:100911406 | UniProtKB/TrEMBL |
| rno:25607 | ENTREZGENE, UniProtKB/Swiss-Prot | |
| Pfam | Homeobox | UniProtKB/Swiss-Prot |
| PRINTS | HOMEOBOX | UniProtKB/TrEMBL |
| PROSITE | ANTENNAPEDIA; FALSE_NEG | UniProtKB/Swiss-Prot |
| HOMEOBOX_1 | UniProtKB/Swiss-Prot | |
| HOMEOBOX_2 | UniProtKB/Swiss-Prot | |
| SMART | HOX | UniProtKB/Swiss-Prot |
| Superfamily-SCOP | Homeodomain_like | UniProtKB/Swiss-Prot |
| UniGene | Rn.228589 | ENTREZGENE |
| Rn.9780 | ENTREZGENE | |
| UniProt | G3V6R3_RAT | UniProtKB/TrEMBL |
| HXA1_RAT | UniProtKB/Swiss-Prot | |
| O08657_RAT | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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| 2002-06-10 | Hoxa1 | Homeo box A1 | Symbol and Name status set to approved | 1490 | APPROVED |
| More on Hoxa1 | |
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Entrez Gene |
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Ensembl Gene |
![]() | Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 2812 |
| Created: | 2000-05-25 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




