Gene: Gjb5 (gap junction protein, beta 5)
Rattus norvegicus
Symbol:
Gjb5
Name:
gap junction protein, beta 5
Description:
INVOLVED IN labyrinthine layer morphogenesis (ortholog); spongiotrophoblast differentiation (ortholog); FOUND IN connexon complex (inferred); integral to membrane (inferred); INTERACTS WITH 1,2,4-trimethylbenzene; 17alpha-ethynylestradiol; ammonium chloride
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
connexin 31.1; connexin-31.1; Cx31.1; gap junction beta-5 protein; gap junction membrane channel protein beta 5; gap junction protein, beta 5
Orthologs:
Homo sapiens : GJB5
(gap junction protein, beta 5, 31.1kDa)
HGNC
Gjb5
(gap junction protein, beta 5)
MGI
Latest Assembly:
RGSC Genome Assembly v3.4
Position:
Map Chr Position Strand Source Rat Cytogenetic Map 5 q36 NCBI RGSC Genome Assembly v5.0 5 149,190,332 - 149,191,313 - NCBI RGSC Genome Assembly v3.4 5 146,802,849 - 146,803,664 - NCBI Rat Celera Assembly 5 138,175,690 - 138,176,505 - NCBI Genome Assembly 3.1 5 146,812,887 - 146,813,703 - NCBI
Model
Gene-Chemical Interaction Annotations
1,2,4-trimethylbenzene decreases expression EXP 6480464 pseudocumene results in decreased expression of GJB5 protein CTD PMID:17337753 17alpha-ethynylestradiol affects expression ISO RGD:736420 6480464 Ethinyl Estradiol affects the expression of GJB5 mRNA CTD PMID:17555576 17alpha-ethynylestradiol multiple interactions ISO RGD:736420 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GJB5 mRNA CTD PMID:17942748 17alpha-ethynylestradiol increases expression EXP 6480464 Ethinyl Estradiol results in increased expression of GJB5 mRNA CTD PMID:15212814 17alpha-ethynylestradiol increases expression ISO RGD:736420 6480464 Ethinyl Estradiol results in increased expression of GJB5 mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:736420 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GJB5 mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:736420 6480464 Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to GJB5 promoter] CTD PMID:19654925 7,12-dimethyltetraphene multiple interactions ISO RGD:736420 6480464 [9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of GJB5 mRNA CTD PMID:7586191 all-trans-retinoic acid decreases expression ISO RGD:736420 6480464 Tretinoin results in decreased expression of GJB5 mRNA CTD PMID:16604517 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of GJB5 mRNA CTD PMID:16483693 C60 fullerene decreases expression EXP 6480464 fullerene C60 results in decreased expression of GJB5 mRNA CTD PMID:19167457 methylmercury chloride affects expression ISO RGD:736420 6480464 methylmercuric chloride affects the expression of GJB5 mRNA CTD PMID:21613230 naphthalene increases expression ISO RGD:736420 6480464 naphthalene results in increased expression of GJB5 mRNA CTD PMID:18978301 okadaic acid decreases expression ISO RGD:736420 6480464 Okadaic Acid results in decreased expression of GJB5 mRNA CTD PMID:8597533 paracetamol affects expression ISO RGD:736420 6480464 Acetaminophen affects the expression of GJB5 mRNA CTD PMID:17562736 phenobarbital affects expression ISO RGD:736420 6480464 Phenobarbital affects the expression of GJB5 mRNA CTD PMID:19136022 phorbol 13-acetate 12-myristate multiple interactions ISO RGD:736420 6480464 [9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of GJB5 mRNA CTD PMID:7586191 phorbol 13-acetate 12-myristate decreases expression ISO RGD:736420 6480464 Tetradecanoylphorbol Acetate results in decreased expression of GJB5 mRNA CTD PMID:8597533 PMID:7586191 phorbol 13-acetate 12-myristate decreases expression ISO RGD:736420 6480464 Tetradecanoylphorbol Acetate results in decreased expression of GJB5 protein CTD PMID:7586191 phorbol 13-acetate 12-myristate decreases expression ISO RGD:736420 6480464 Tetradecanoylphorbol Acetate results in decreased expression of GJB5 mRNA CTD PMID:7586191 PMID:8597533 pirinixic acid multiple interactions ISO RGD:736420 6480464 NCF1 protein inhibits the reaction [pirinixic acid results in decreased expression of GJB5 mRNA] CTD PMID:17950772 pirinixic acid decreases expression ISO RGD:736420 6480464 pirinixic acid results in decreased expression of GJB5 mRNA CTD PMID:17950772 pirinixic acid affects expression ISO RGD:736420 6480464 pirinixic acid affects the expression of GJB5 mRNA CTD PMID:19136022 tamoxifen affects expression ISO RGD:736420 6480464 Tamoxifen affects the expression of GJB5 mRNA CTD PMID:17555576 undecane decreases expression EXP 6480464 undecane results in decreased expression of GJB5 protein CTD PMID:17337753
Gene Ontology Annotations
Biological Process cell communication IEA InterPro:IPR000500|InterPro:IPR002270|InterPro:IPR017990 1600115 GO_REF:0000002 InterPro GO_REF:0000002 labyrinthine layer morphogenesis ISO RGD:736420 1624291 MGI:MGI:3769388 RGD MGI:MGI:3768289 PMID:17961533 labyrinthine layer morphogenesis IEA Ensembl:ENSMUSP00000045325 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 spongiotrophoblast differentiation ISO RGD:736420 1624291 MGI:MGI:3769388 RGD MGI:MGI:3768289 PMID:17961533 spongiotrophoblast differentiation IEA Ensembl:ENSMUSP00000045325 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019
631505 Bp103 Blood pressure QTL 103 3.2 Blood pressure systolic 5 139690801 171801867 Rat 61452 Ciaa5 CIA Autoantibody QTL 5 3.5 Anti-type II collagen autoantibody titer 5 99080786 149757440 Rat 61426 Scl2 Serum cholesterol level QTL 2 7.3 .001 Lipid level cholesterol 5 62098646 149757440 Rat 61444 Strs2 Sensitivity to stroke QTL 2 4.7 Stroke susceptibility latency until stroke 5 142575172 173096209 Rat 634349 Bp139 Blood pressure QTL 139 .001 Blood pressure systolic 5 135877124 173096209 Rat 724525 Bp147 Blood pressure QTL 147 4.3 .0001 Blood pressure systolic 5 132950669 173096209 Rat 631562 Apr2 Acute phase response QTL 2 3.7 Alpha1 acid glycoprotein level pristane induced 5 142573432 173096209 Rat 738018 Anxrr4 Anxiety related response QTL 4 5.1 Anxiety response open field inner locomotion 5 136765530 173096209 Rat 1298089 Scl14 Serum cholesterol level QTL 14 5.8 .0004 Lipid level cholesterol 5 115772027 160772027 Rat 70156 Niddm30 Non-insulin dependent diabetes mellitus QTL 30 3.98 Glucose level postprandial 5 135910738 157584492 Rat 1331803 Rf32 Renal function QTL 32 2.798 Renal function renal vascular resistance 5 135900621 149757440 Rat 61393 Bp7 Blood pressure QTL 7 4.5 .0001 Blood pressure salt-loaded systolic 5 62555131 168174140 Rat 1300122 Wbc1 White blood cell count QTL 1 2.75 White blood cell count salt-loaded 5 89261341 147065912 Rat 1331796 Thshl2 Thyroid stimulating hormone level QTL 2 2.3 Thyroid stimulating hormone level 5 101506332 154014139 Rat 1354598 Srn6 Serum renin concentration QTL 6 3.8 Renin concentration serum 5 71971592 157597184 Rat 1358187 Emca1 Estrogen-induced mammary cancer QTL 1 4.4 Mammary tumor susceptibility estradiol-induced 5 103677659 155120876 Rat 1549845 Scl44 Serum cholesterol level QTL 44 6 Lipid level serum cholesterol, post dietary 5 41498818 155121024 Rat 1598819 Bp292 Blood pressure QTL 292 4.3 Blood pressure systolic 5 134356746 173096209 Rat 1578766 Tcas11 Tongue tumor susceptibility QTL 11 4.12 Tongue tumor susceptibility tongue tumor number 5 17517235 168005953 Rat 1578673 Bmd13 Bone mineral density QTL 13 4.9 Bone mineral density femoral neck trabecular vBMD 5 108589975 153589975 Rat 1581510 Cm54 Cardiac mass QTL 54 3.4 .05 Cardiac mass left ventricle 5 126963761 150236260 Rat 1641912 Alcrsp18 Alcohol response QTL 18 Alcohol response loss of righting reflex 5 36386126 148460381 Rat 1598861 Cm64 Cardiac mass QTL 64 2.9 Cardiac mass 5 134356746 173096209 Rat 1598847 Cm62 Cardiac mass QTL 62 3.4 Cardiac mass 5 115772027 160772027 Rat 2293642 Bss37 Bone structure and strength QTL 37 4.64 .0001 Bone strength 5 126963761 157597184 Rat 2317056 Wbc3 White blood cell count QTL 3 2.51 .01 White blood cell count 5 112840801 157840801 Rat 1302790 Scl20 Serum cholesterol QTL 20 6.4 .0001 Lipid level cholesterol level 5 86116638 172913795 Rat 1549838 Bss4 Bone structure and strength QTL 4 9.2 Bone structure and strength Femoral midshaft moment of inertia 5 113689301 158689301 Rat 7207481 Bss106 Bone structure and strength QTL 106 7.9 Bone strength Femoral ultimate force 5 113689301 158689301 Rat 7207491 Bss112 Bone structure and strength QTL 112 7 Bone structure Femoral midshaft cortical area 5 113689301 158689301 Rat 7207486 Bss109 Bone structure and strength QTL 109 Bone strength Femoral energy to break 5 113689301 158689301 Rat 7207488 Bss110 Bone structure and strength QTL 1 8.4 Bone strength Femoral stiffness 5 113689301 158689301 Rat 1576312 Emca8 Estrogen-induced mammary cancer QTL 8 4.1 Mammary tumor susceptibility estradiol-induced 5 52434178 148460381 Rat
Gene Ontology Annotations
