Prl8a2 (prolactin family 8, subfamily A, member 2) - Rat Genome Database

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Gene: Prl8a2 (prolactin family 8, subfamily A, member 2) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Prl8a2
Name: prolactin family 8, subfamily A, member 2
RGD ID: 2516
Description: Predicted to enable hormone activity and prolactin receptor binding activity. Involved in female pregnancy. Predicted to be active in extracellular space.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: d/tPRP; decidual prolactin-related protein; decidual/trophoblast prolactin-related protein; Dprp; Dtprp; Ghd12; growth hormone d12
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81737,821,651 - 37,830,676 (-)NCBIGRCr8
mRatBN7.21737,613,263 - 37,622,288 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1737,613,267 - 37,622,288 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1737,483,038 - 37,491,995 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01739,087,058 - 39,096,015 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01737,430,784 - 37,439,736 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01739,563,383 - 39,575,777 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1739,563,387 - 39,575,720 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01741,481,072 - 41,490,310 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41744,202,721 - 44,212,845 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11744,205,565 - 44,215,686 (-)NCBI
Celera1737,117,051 - 37,126,000 (-)NCBICelera
Cytogenetic Map17p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Decidual prolactin-related protein. Identification, molecular cloning, and characterization. Roby KF, etal., J Biol Chem 1993 Feb 15;268(5):3136-42.
7. Gene-based anchoring of the rat genetic linkage and cytogenetic maps: new regional localizations, orientation of the linkage groups, and insights into mammalian chromosome evolution. Szpirer C, etal., Mamm Genome 1998 Sep;9(9):721-34
Additional References at PubMed
PMID:12477932   PMID:26697363   PMID:26862561  


Genomics

Variants

.
Variants in Prl8a2
23 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:96
Count of miRNA genes:84
Interacting mature miRNAs:89
Transcripts:ENSRNOT00000022923
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2324621Coatc5Coat color QTL 5coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)173136839173951021Rat
4889955Bss93Bone structure and strength QTL 934.4tibia size trait (VT:0100001)tibia cortical bone volume to tibia total bone volume ratio (CMO:0001727)172702794960463643Rat
7394837Memor18Memory QTL 18exploratory behavior trait (VT:0010471)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)171864018263640182Rat
8552928Pigfal9Plasma insulin-like growth factor 1 level QTL 99blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)172840914773409147Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)172840914773409147Rat
7488966Bp370Blood pressure QTL 3700.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172365318457246843Rat
1300148Bp192Blood pressure QTL 1923.47arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)173455084373951021Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17452803849528038Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
1354619Bp242Blood pressure QTL 2426.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172459934069599340Rat
1354628Stl13Serum triglyceride level QTL 133.8blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)172129303960781592Rat
1354630Cm34Cardiac mass QTL 348.7heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)17429913069599340Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)17429913069599340Rat
1354640Scl32Serum cholesterol level QTL 325.4blood HDL cholesterol amount (VT:0000184)blood high density lipoprotein cholesterol level (CMO:0000052)171578159260781592Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17160781592Rat
1354659Scl68Serum cholesterol level QTL 683.9blood VLDL cholesterol amount (VT:0005144)blood very low density lipoprotein cholesterol level (CMO:0000648)171578159260781592Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat
1354663Bvd5Brain ventricular dilatation QTL 53.510.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)173199078481292925Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172365318468653184Rat
1581512Cm55Cardiac mass QTL 552.80.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172702794956836890Rat
61394Bp8Blood pressure QTL 82.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172308056759555013Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17137830672Rat
70157Niddm32Non-insulin dependent diabetes mellitus QTL 324.34blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)172245492450909196Rat
724528Uae4Urinary albumin excretion QTL 44.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)173583708569599340Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)172738994653481766Rat
2300002Iddm36Insulin dependent diabetes mellitus QTL 361.98blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)17999128640540197Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17452803849528038Rat
724549Niddm56Non-insulin dependent diabetes mellitus QTL 560.03blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)173199078476990784Rat
12903978Cm118Cardiac mass QTL 1180.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)172365318468653184Rat
2301412Kidm40Kidney mass QTL 400.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)173747984782479847Rat
12903980Cm120Cardiac mass QTL 1200.002heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)172365318468653184Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172365318470974005Rat
1331765Hrtrt15Heart rate QTL 154.094heart pumping trait (VT:2000009)heart rate (CMO:0000002)171533061355836425Rat
1354596Bw32Body weight QTL 324.5body mass (VT:0001259)body weight (CMO:0000012)17429913060781592Rat
10450503Bp386Blood pressure QTL 3860.28arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)173136839162109574Rat
2303561Bw91Body weight QTL 912body mass (VT:0001259)body weight (CMO:0000012)17886846253868462Rat
12903979Cm119Cardiac mass QTL 1190.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172365318468653184Rat
2313854Bp343Blood pressure QTL 3433.9life span trait (VT:0005372)age at time of death (CMO:0001193)173199078450909196Rat
12903981Am17Aortic mass QTL 170.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)172365318468653184Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system nervous system renal system reproductive system respiratory system
High
Medium 2 2 2 4 2
Low 4 6 6 6 23 16
Below cutoff 2 5 3 3 3 4 2 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001418512 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_022846 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC097316 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473977 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219955 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220067 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220110 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220414 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220685 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222092 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222442 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222955 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223310 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228468 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229664 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229702 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229765 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229882 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230140 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L06441 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LM644205 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U44438 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000022923   ⟹   ENSRNOP00000022923
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1737,613,267 - 37,622,288 (-)Ensembl
Rnor_6.0 Ensembl1739,563,387 - 39,575,720 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000099321   ⟹   ENSRNOP00000085551
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1737,613,267 - 37,619,668 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000106963   ⟹   ENSRNOP00000079151
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1737,613,267 - 37,619,997 (-)Ensembl
RefSeq Acc Id: NM_001418512   ⟹   NP_001405441
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81737,821,651 - 37,830,676 (-)NCBI
mRatBN7.21737,613,263 - 37,622,288 (-)NCBI
RefSeq Acc Id: NM_022846   ⟹   NP_074037
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81737,821,651 - 37,830,676 (-)NCBI
mRatBN7.21737,613,263 - 37,622,288 (-)NCBI
Rnor_6.01739,563,383 - 39,575,720 (-)NCBI
Rnor_5.01741,481,072 - 41,490,310 (-)NCBI
RGSC_v3.41744,202,721 - 44,212,845 (-)RGD
Celera1737,117,051 - 37,126,000 (-)RGD
Sequence:
RefSeq Acc Id: NP_074037   ⟸   NM_022846
- Peptide Label: isoform 2 precursor
- UniProtKB: Q63545 (UniProtKB/TrEMBL),   Q62903 (UniProtKB/TrEMBL),   A0A8I5ZMH5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000022923   ⟸   ENSRNOT00000022923
RefSeq Acc Id: ENSRNOP00000079151   ⟸   ENSRNOT00000106963
RefSeq Acc Id: ENSRNOP00000085551   ⟸   ENSRNOT00000099321
RefSeq Acc Id: NP_001405441   ⟸   NM_001418512
- Peptide Label: isoform 1 precursor
- UniProtKB: Q4QRA1 (UniProtKB/TrEMBL),   A0A0M6L0N8 (UniProtKB/TrEMBL),   A0A8I5ZMH5 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63545-F1-model_v2 AlphaFold Q63545 1-239 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2516 AgrOrtholog
BioCyc Gene G2FUF-9452 BioCyc
Ensembl Genes ENSRNOG00000017048 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000022923 ENTREZGENE
  ENSRNOT00000022923.7 UniProtKB/TrEMBL
  ENSRNOT00000099321.1 UniProtKB/TrEMBL
  ENSRNOT00000106963.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7442457 IMAGE-MGC_LOAD
InterPro 4_helix_cytokine-like_core UniProtKB/TrEMBL
  Somatotropin UniProtKB/TrEMBL
KEGG Report rno:24315 UniProtKB/TrEMBL
MGC_CLONE MGC:114317 IMAGE-MGC_LOAD
NCBI Gene 24315 ENTREZGENE
PANTHER DECIDUAL PRL-RELATED PROTEIN-RELATED UniProtKB/TrEMBL
  Somatotropin UniProtKB/TrEMBL
Pfam Hormone_1 UniProtKB/TrEMBL
PhenoGen Prl8a2 PhenoGen
RatGTEx ENSRNOG00000017048 RatGTEx
Superfamily-SCOP 4_helix_cytokine UniProtKB/TrEMBL
UniProt A0A0M6L0N8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZMH5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A3J3_RAT UniProtKB/TrEMBL
  Q4QRA1 ENTREZGENE, UniProtKB/TrEMBL
  Q62903 ENTREZGENE
  Q63545 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q62903 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-04-07 Prl8a2  prolactin family 8, subfamily A, member 2  Prl8a2  prolactin family 8, subfamily a, member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-05-04 Prl8a2  prolactin family 8, subfamily a, member 2  Dtprp  decidual/trophoblast prolactin-related protein   Symbol and Name updated 1624237 APPROVED
2003-04-09 Dtprp  decidual/trophoblast prolactin-related protein   Dprp  decidual prolactin-related protein  Symbol and Name updated 629477 APPROVED
2002-06-10 Dprp  decidual prolactin-related protein      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in decidual tissue 1298892
gene_expression produced abundantly at midgestation 1298892
gene_process may function in the physiology of pregnancy 1298892
gene_process possesses luteotropic actions 1298892