Dlx5 (distal-less homeobox 5) - Rat Genome Database

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Gene: Dlx5 (distal-less homeobox 5) Rattus norvegicus
Analyze
Symbol: Dlx5
Name: distal-less homeobox 5
RGD ID: 2506
Description: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; HMG box domain binding activity; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in cellular response to zinc ion starvation and positive regulation of osteoblast differentiation. Predicted to be located in cytoplasm and nucleus. Predicted to be part of chromatin. Human ortholog(s) of this gene implicated in split hand-foot malformation 1 and split hand-foot malformation 1 with sensorineural hearing loss. Orthologous to human DLX5 (distal-less homeobox 5); INTERACTS WITH 1,2,4-trimethylbenzene; 17alpha-ethynylestradiol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Distal-less homeobox; DLX-3; homeobox protein DLX-3; homeobox protein DLX-5; RDLX
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8435,965,579 - 35,969,973 (-)NCBIGRCr8
mRatBN7.2434,999,139 - 35,003,504 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl434,999,139 - 35,003,407 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx439,958,038 - 39,962,304 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0435,884,208 - 35,888,474 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0434,304,193 - 34,308,455 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0432,387,741 - 32,392,085 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl432,387,741 - 32,392,007 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0432,255,323 - 32,259,589 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4431,778,500 - 31,782,767 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1431,897,039 - 31,901,307 (-)NCBI
Celera430,515,648 - 30,519,914 (-)NCBICelera
Cytogenetic Map4q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2,4-trimethylbenzene  (EXP)
1,2-dichloroethane  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetohydrazide  (ISO)
all-trans-retinoic acid  (EXP,ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
benzo[a]pyrene  (EXP,ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbonyl sulfide  (EXP)
CGP 52608  (ISO)
clofibrate  (ISO)
Cuprizon  (EXP)
cyproconazole  (ISO)
DDT  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (ISO)
dorsomorphin  (ISO)
fenvalerate  (EXP)
flusilazole  (EXP)
fonofos  (ISO)
genistein  (EXP)
gentamycin  (EXP)
hexaconazole  (ISO)
ketamine  (EXP)
mercury dibromide  (ISO)
methimazole  (EXP)
methylmercury chloride  (ISO)
monosodium L-glutamate  (EXP)
morphine  (ISO)
naphthalenes  (EXP)
ochratoxin A  (ISO)
oxaliplatin  (EXP)
p-chloromercuribenzoic acid  (ISO)
parathion  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
progesterone  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
tamoxifen  (ISO)
terbufos  (ISO)
Tetrachlorobisphenol A  (ISO)
tetrachloromethane  (EXP)
thapsigargin  (ISO)
topotecan  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromatin  (IEA,ISO)
cytoplasm  (IEA,ISO)
nucleus  (IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Zinc deficiency decreases osteoblasts and osteoclasts associated with the reduced expression of Runx2 and RANK. Hie M, etal., Bone. 2011 Dec;49(6):1152-9. doi: 10.1016/j.bone.2011.08.019. Epub 2011 Aug 26.
4. BMP-2-induced Runx2 expression is mediated by Dlx5, and TGF-beta 1 opposes the BMP-2-induced osteoblast differentiation by suppression of Dlx5 expression. Lee MH, etal., J Biol Chem 2003 Sep 5;278(36):34387-94. Epub 2003 Jun 18.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Molecular cloning and evolutional analysis of a mammalian homologue of the Distal-less 3 (Dlx-3) homeobox gene. Shirasawa T, etal., FEBS Lett 1994 Sep 12;351(3):380-4.
12. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
13. rDlx, a novel distal-less-like homeoprotein is expressed in developing cartilages and discrete neuronal tissues. Zhao GQ, etal., Dev Biol 1994 Jul;164(1):37-51.
Additional References at PubMed
PMID:9415433   PMID:10516593   PMID:12112878   PMID:12142028   PMID:12533617   PMID:15306564   PMID:15383550   PMID:15456894   PMID:16115867   PMID:16330189   PMID:16582099   PMID:16900517  
PMID:17420000   PMID:17804636   PMID:17878916   PMID:18326838   PMID:19497851   PMID:19956613   PMID:20843790   PMID:21503878   PMID:24042587   PMID:25937343   PMID:29901112  


Genomics

Comparative Map Data
Dlx5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8435,965,579 - 35,969,973 (-)NCBIGRCr8
mRatBN7.2434,999,139 - 35,003,504 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl434,999,139 - 35,003,407 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx439,958,038 - 39,962,304 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0435,884,208 - 35,888,474 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0434,304,193 - 34,308,455 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0432,387,741 - 32,392,085 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl432,387,741 - 32,392,007 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0432,255,323 - 32,259,589 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4431,778,500 - 31,782,767 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1431,897,039 - 31,901,307 (-)NCBI
Celera430,515,648 - 30,519,914 (-)NCBICelera
Cytogenetic Map4q21NCBI
DLX5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38797,020,396 - 97,024,831 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl797,020,396 - 97,024,950 (-)EnsemblGRCh38hg38GRCh38
GRCh37796,649,708 - 96,654,143 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36796,487,638 - 96,492,079 (-)NCBINCBI36Build 36hg18NCBI36
Build 34796,294,358 - 96,298,794NCBI
Celera791,343,634 - 91,348,072 (-)NCBICelera
Cytogenetic Map7q21.3NCBI
HuRef791,251,295 - 91,255,732 (-)NCBIHuRef
CHM1_1796,579,739 - 96,584,181 (-)NCBICHM1_1
T2T-CHM13v2.0798,250,072 - 98,254,502 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2795,972,198 - 95,976,639 (-)NCBI
Dlx5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3966,877,801 - 6,882,068 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl66,877,805 - 6,882,085 (-)EnsemblGRCm39 Ensembl
GRCm3866,877,801 - 6,882,068 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl66,877,805 - 6,882,085 (-)EnsemblGRCm38mm10GRCm38
MGSCv3766,827,805 - 6,832,068 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3666,827,805 - 6,832,068 (-)NCBIMGSCv36mm8
Celera67,023,868 - 7,028,132 (-)NCBICelera
Cytogenetic Map6A1NCBI
cM Map62.83NCBI
Dlx5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543213,429,415 - 13,434,258 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543213,429,832 - 13,434,160 (-)NCBIChiLan1.0ChiLan1.0
DLX5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26114,856,668 - 114,863,007 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17163,121,305 - 163,127,639 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0788,972,066 - 88,977,588 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17102,556,636 - 102,561,186 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7102,555,267 - 102,561,186 (-)Ensemblpanpan1.1panPan2
DLX5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11422,080,351 - 22,085,188 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1422,080,699 - 22,084,867 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1421,648,083 - 21,652,478 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01421,897,429 - 21,901,826 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1421,897,417 - 21,902,078 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11422,044,142 - 22,048,532 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01421,779,484 - 21,783,873 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01422,043,227 - 22,047,620 (-)NCBIUU_Cfam_GSD_1.0
Dlx5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511835,346,260 - 35,401,337 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365853,461,944 - 3,466,641 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365853,462,063 - 3,466,641 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DLX5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl976,639,561 - 76,643,884 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1976,639,915 - 76,643,689 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
LOC103226510
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12152,032,933 - 52,092,791 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2152,036,401 - 52,040,903 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604252,268,203 - 52,315,364 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dlx5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248133,760,661 - 3,765,517 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248133,760,890 - 3,765,309 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dlx5
21 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:56
Count of miRNA genes:48
Interacting mature miRNAs:56
Transcripts:ENSRNOT00000014946
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61415Eae11Experimental allergic encephalomyelitis QTL 112.9nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)4139505420Rat
634323Hc2Hypercalciuria QTL 22.15urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)421079645210796Rat
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4521460278882945Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
2302371Stl22Serum triglyceride level QTL 225.15blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829457114705Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829465958103Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521917856647776Rat
631209Bw2Body weight QTL24.2retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)4994088544463908Rat
1300141Bp178Blood pressure QTL 178arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)41002490139524530Rat
6478724Anxrr35Anxiety related response QTL 350.00449defecation behavior trait (VT:0010462)defecation measurement (CMO:0000997)41008408955084089Rat
6478766Anxrr47Anxiety related response QTL 470.09637locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)41008408955084089Rat
6478769Anxrr48Anxiety related response QTL 480.02514locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)41008408955084089Rat
8694374Bw155Body weight QTL 1553.390.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)41008408955084089Rat
9590304Scort17Serum corticosterone level QTL 174.960.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)41008408955084089Rat
8552906Pigfal3Plasma insulin-like growth factor 1 level QTL 3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)41008408955084089Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41081417091360527Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
2303585Bw86Body weight QTL 864body mass (VT:0001259)body weight (CMO:0000012)41467806559678065Rat
2313401Anxrr27Anxiety related response QTL 27aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)41793350862933508Rat
70222Eae2Experimental allergic encephalomyelitis QTL 24.3nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)42133334339505420Rat
1354665Stl10Serum triglyceride level QTL 103.57blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)42133334344463908Rat
61412Pia2Pristane induced arthritis QTL 23.9joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)42133334362278020Rat
6909122Insul22Insulin level QTL 224.63blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)42690728575585128Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)42690728575585128Rat
8655906Rf60Renal function QTL 603.8blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)42949419581006281Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)432583980114627242Rat
11530004Niddm71Non-insulin dependent diabetes mellitus QTL 710.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)43258419952754138Rat
8655949Rf62Renal function QTL 6222blood urea nitrogen amount (VT:0005265)plasma urea nitrogen level (CMO:0000586)43443011944463908Rat
8552782Vie1Viral induced encephalitis QTL 126.4brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43443048482490359Rat
8552801Bw143Body weight QTL 1437.3body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)43443048482490359Rat
8552809Vie5Viral induced encephalitis QTL 525.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43443048482490359Rat

Markers in Region
AA998469  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0432,387,925 - 32,388,790NCBIRnor6.0
Rnor_5.0432,255,507 - 32,256,372UniSTSRnor5.0
RGSC_v3.4431,778,684 - 31,779,550UniSTSRGSC3.4
Celera430,515,832 - 30,516,697UniSTS
RH 3.4 Map4811.83UniSTS
Cytogenetic Map4q13UniSTS
AI385752  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2434,999,397 - 34,999,499 (+)MAPPERmRatBN7.2
Rnor_6.0432,388,000 - 32,388,101NCBIRnor6.0
Rnor_5.0432,255,582 - 32,255,683UniSTSRnor5.0
RGSC_v3.4431,778,759 - 31,778,860UniSTSRGSC3.4
Celera430,515,907 - 30,516,008UniSTS
Cytogenetic Map4q13UniSTS
MARC_9717-9718:996688547:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2435,002,916 - 35,003,225 (+)MAPPERmRatBN7.2
Rnor_6.0432,391,517 - 32,391,825NCBIRnor6.0
Rnor_5.0432,259,099 - 32,259,407UniSTSRnor5.0
RGSC_v3.4431,782,277 - 31,782,585UniSTSRGSC3.4
Celera430,519,424 - 30,519,732UniSTS
Cytogenetic Map4q13UniSTS
Dlx5  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2434,999,262 - 34,999,813 (+)MAPPERmRatBN7.2
Rnor_6.0432,387,865 - 32,388,415NCBIRnor6.0
Rnor_5.0432,255,447 - 32,255,997UniSTSRnor5.0
RGSC_v3.4431,778,624 - 31,779,174UniSTSRGSC3.4
Celera430,515,772 - 30,516,322UniSTS
Cytogenetic Map4q13UniSTS
DLX5_2316  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2434,999,093 - 34,999,786 (+)MAPPERmRatBN7.2
Rnor_6.0432,387,696 - 32,388,388NCBIRnor6.0
Rnor_5.0432,255,278 - 32,255,970UniSTSRnor5.0
RGSC_v3.4431,778,455 - 31,779,147UniSTSRGSC3.4
Celera430,515,603 - 30,516,295UniSTS
Cytogenetic Map4q13UniSTS
Dlx5  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2434,999,182 - 34,999,598 (+)MAPPERmRatBN7.2
Rnor_6.0432,387,785 - 32,388,200NCBIRnor6.0
Rnor_5.0432,255,367 - 32,255,782UniSTSRnor5.0
RGSC_v3.4431,778,544 - 31,778,959UniSTSRGSC3.4
Celera430,515,692 - 30,516,107UniSTS
Cytogenetic Map4q13UniSTS
Dlx5  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2435,003,163 - 35,003,228 (+)MAPPERmRatBN7.2
Rnor_6.0432,391,764 - 32,391,828NCBIRnor6.0
Rnor_5.0432,259,346 - 32,259,410UniSTSRnor5.0
RGSC_v3.4431,782,524 - 31,782,588UniSTSRGSC3.4
Celera430,519,671 - 30,519,735UniSTS
Cytogenetic Map4q13UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 32 2
Low 18 4 4 4 26 2 21
Below cutoff 1 22 11 2 5 2 3 3 12 15 9 6 3

Sequence


RefSeq Acc Id: ENSRNOT00000014946   ⟹   ENSRNOP00000014946
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl434,999,139 - 35,003,407 (-)Ensembl
Rnor_6.0 Ensembl432,387,741 - 32,392,007 (-)Ensembl
RefSeq Acc Id: NM_012943   ⟹   NP_037075
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8435,965,579 - 35,969,845 (-)NCBI
mRatBN7.2434,999,139 - 35,003,407 (-)NCBI
Rnor_6.0432,387,741 - 32,392,007 (-)NCBI
Rnor_5.0432,255,323 - 32,259,589 (-)NCBI
RGSC_v3.4431,778,500 - 31,782,767 (-)RGD
Celera430,515,648 - 30,519,914 (-)RGD
Sequence:
RefSeq Acc Id: XM_017592486   ⟹   XP_017447975
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8435,966,225 - 35,969,973 (-)NCBI
mRatBN7.2434,999,675 - 35,003,504 (-)NCBI
Rnor_6.0432,389,485 - 32,392,085 (-)NCBI
Sequence:
RefSeq Acc Id: NP_037075   ⟸   NM_012943
- UniProtKB: A0A0G2JSK6 (UniProtKB/TrEMBL),   A6IDV1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017447975   ⟸   XM_017592486
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000014946   ⟸   ENSRNOT00000014946
Protein Domains
Homeobox

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P50575-F1-model_v2 AlphaFold P50575 1-289 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692867
Promoter ID:EPDNEW_R3391
Type:single initiation site
Name:Dlx5_1
Description:distal-less homeobox 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0432,392,025 - 32,392,085EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2506 AgrOrtholog
BioCyc Gene G2FUF-45680 BioCyc
Ensembl Genes ENSRNOG00000010905 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00065010746 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000014946 ENTREZGENE
  ENSRNOT00000014946.4 UniProtKB/TrEMBL
  ENSRNOT00065017408 UniProtKB/Swiss-Prot
Gene3D-CATH Homeodomain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Distal-less_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_metazoa UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HTH_motif UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25431 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 25431 ENTREZGENE
PANTHER HOMEOBOX PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HOMEOBOX PROTEIN DLX-5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DLL_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeodomain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Dlx5 PhenoGen
PRINTS HOMEOBOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HTHREPRESSR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE HOMEOBOX_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HOMEOBOX_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000010905 RatGTEx
  ENSRNOG00065010746 RatGTEx
SMART HOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF46689 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC219849
UniProt A0A0G2JSK6 ENTREZGENE, UniProtKB/TrEMBL
  A6IDV0_RAT UniProtKB/TrEMBL
  A6IDV1 ENTREZGENE, UniProtKB/TrEMBL
  DLX5_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q91WY7_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Dlx5  Distal-less homeobox      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed specifically in osteogenic cells 1298882
gene_expression expressed in developing skeletal and neuronal tissues 1298881
gene_expression expressed in fibroblasts 1298881
gene_process important mediator of BMP-2-induced Runx2 expression 1298882
gene_process induces BMP-2 mediated osetoeblast differentiation and blocks TGFB1-mediated inhibition of osteoblast differentiation 1298882
gene_transcript induced by bone morphogenic protein (BMP) 2 and 4 signaling 1298882
gene_transcript suppressed by TGFB1 1298882