Cryge (crystallin, gamma E) - Rat Genome Database

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Gene: Cryge (crystallin, gamma E) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Cryge (Ensembl: Cryga)
Name: crystallin, gamma E (Ensembl:crystallin, gamma A)
RGD ID: 2423
Description: Predicted to be a structural constituent of eye lens. Involved in lens development in camera-type eye. Human ortholog(s) of this gene implicated in cataract 4 multiple types and cataract 7. Orthologous to human CRYGD (crystallin gamma D).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Cryg5; Crystallin, gamma polypeptide 5; gamma-2; gamma-crystallin 3-1; gamma-crystallin D-like; gamma-crystallin E; gamma-E-crystallin; Len; LOC100363730
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8973,923,661 - 73,926,258 (-)NCBIGRCr8
mRatBN7.2966,429,924 - 66,432,521 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl966,429,924 - 66,433,274 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx974,943,162 - 74,945,759 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0980,078,465 - 80,081,062 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0978,486,894 - 78,489,491 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0971,764,317 - 71,767,045 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
RGSC_v3.4963,698,609 - 63,701,230 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1963,845,590 - 63,848,212 (-)NCBI
Celera963,827,782 - 63,828,162 (-)NCBICelera
RH 3.4 Map9577.2RGD
Cytogenetic Map9q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Strict co-linearity of genetic and protein folding domains in an intragenically duplicated rat lens gamma-crystallin gene. Moormann RJ, etal., J Mol Biol 1983 Dec 25;171(4):353-68.
6. Extensive intragenic sequence homology in two distinct rat lens gamma-crystallin cDNAs suggests duplications of a primordial gene. Moormann RJ, etal., Proc Natl Acad Sci U S A 1982 Nov;79(22):6876-80.
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Differential synthesis of crystallins in the developing rat eye lens. Voorter CE, etal., Exp Eye Res. 1990 Apr;50(4):429-37.
Additional References at PubMed
PMID:2777080   PMID:3562235   PMID:9367641   PMID:26385181  


Genomics

Variants

.
Variants in Cryge
5 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92207116986369743Rat
631643Bp120Blood pressure QTL 12030.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)92207120067071200Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)92375414483851531Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)92526804479271759Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)92746863972468639Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)93253550577535505Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)93253550577535505Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)93696235977814038Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)93696235992058970Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
6903941Pur31Proteinuria QTL 310.036urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)94019418885194188Rat
11353949Bp393Blood pressure QTL 393arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94019418885194188Rat
61352Bp34Blood pressure QTL 345arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94249534379271511Rat
10058949Gmadr5Adrenal mass QTL 520.014adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)94279151387976209Rat
11353951Bp394Blood pressure QTL 394arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94464992189649921Rat
12879506Pur33Proteinuria QTL 33urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)94464992189649921Rat
11353957Bmd92Bone mineral density QTL 920.01tibia mineral mass (VT:1000283)volumetric bone mineral density (CMO:0001553)94611419991114199Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94859825193598251Rat
1598849Memor17Memory QTL 172.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)94996854671098346Rat
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)95584784177026453Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)95662771378595166Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)95662771378595166Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)95662771378595166Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)956771635101771635Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)958163035100929646Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)961381434104821652Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)96207227596470995Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)96207227596470995Rat
61385Edpm9Estrogen-dependent pituitary mass QTL 93.430.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)963869687108869687Rat
731171Glom6Glomerulus QTL 62.80.0003kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)964573531109573531Rat

Markers in Region
RH94588  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2966,429,637 - 66,429,737 (+)MAPPERmRatBN7.2
Rnor_6.0971,764,032 - 71,764,131NCBIRnor6.0
Rnor_5.0970,804,150 - 70,804,249UniSTSRnor5.0
RGSC_v3.4963,698,323 - 63,698,422UniSTSRGSC3.4
RH 3.4 Map9577.2UniSTS
Cytogenetic Map9q32UniSTS
Crygf  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2966,429,952 - 66,430,118 (+)MAPPERmRatBN7.2
Rnor_6.0971,764,347 - 71,764,512NCBIRnor6.0
Rnor_5.0970,803,769 - 70,803,934UniSTSRnor5.0
RGSC_v3.4963,698,638 - 63,698,803UniSTSRGSC3.4
Cytogenetic Map9q32UniSTS
UniSTS:463202  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2967,448,568 - 67,450,216 (+)MAPPERmRatBN7.2
Rnor_6.0972,933,608 - 72,935,255NCBIRnor6.0
Rnor_5.0974,363,661 - 74,365,308UniSTSRnor5.0
RGSC_v3.4964,679,915 - 64,681,562UniSTSRGSC3.4
Celera964,941,525 - 64,943,172UniSTS
Cytogenetic Map9q32UniSTS
Cryge  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2967,448,641 - 67,450,187 (+)MAPPERmRatBN7.2
Rnor_6.0972,933,681 - 72,935,226NCBIRnor6.0
Rnor_5.0974,363,690 - 74,365,235UniSTSRnor5.0
RGSC_v3.4964,679,988 - 64,681,533UniSTSRGSC3.4
Celera964,941,598 - 64,943,143UniSTS
Cytogenetic Map9q32UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000064562   ⟹   ENSRNOP00000060248
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl966,429,924 - 66,433,274 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000106108   ⟹   ENSRNOP00000093789
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl966,429,924 - 66,432,479 (-)Ensembl
RefSeq Acc Id: NM_173289   ⟹   NP_775411
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8973,923,661 - 73,926,258 (-)NCBI
mRatBN7.2966,429,924 - 66,432,521 (-)NCBI
RGSC_v3.4963,698,609 - 63,701,230 (-)RGD
Celera963,827,782 - 63,828,162 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_775411 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA40985 (Get FASTA)   NCBI Sequence Viewer  
  AAA40987 (Get FASTA)   NCBI Sequence Viewer  
  CAA25073 (Get FASTA)   NCBI Sequence Viewer  
  CAA25074 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000060248.4
  ENSRNOP00000093789.1
GenBank Protein P02528 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_775411   ⟸   NM_173289
- UniProtKB: P02528 (UniProtKB/Swiss-Prot),   D3ZR45 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000060248   ⟸   ENSRNOT00000064562
RefSeq Acc Id: ENSRNOP00000093789   ⟸   ENSRNOT00000106108
Protein Domains
Beta/gamma crystallin 'Greek key'

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P02528-F1-model_v2 AlphaFold P02528 1-174 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2423 AgrOrtholog
BioCyc Gene G2FUF-27308 BioCyc
Ensembl Genes ENSRNOG00000014790 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000064562.4 UniProtKB/TrEMBL
  ENSRNOT00000106108.1 UniProtKB/TrEMBL
Gene3D-CATH Crystallins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Beta/gamma_crystallin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_crystallin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24279 UniProtKB/Swiss-Prot
NCBI Gene 24279 ENTREZGENE
PANTHER BETA/GAMMA CRYSTALLIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GAMMA-CRYSTALLIN E-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Crystall UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cryge PhenoGen
PRINTS BGCRYSTALLIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CRYSTALLIN_BETA_GAMMA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000014790 RatGTEx
SMART XTALbg UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49695 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6AKQ5_RAT UniProtKB/TrEMBL
  CRGE_RAT UniProtKB/Swiss-Prot
  D3ZR45 ENTREZGENE, UniProtKB/TrEMBL
  P02528 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-03-29 Cryge  crystallin, gamma E  LOC100363730  gamma-crystallin D-like  Data merged from RGD:2322421 737654 PROVISIONAL
2010-05-06 LOC100363730  gamma-crystallin D-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-11-06 Cryge  crystallin, gamma E    Crystallin, gamma polypeptide 5  Name updated 625702 APPROVED
2002-06-10 Cryge  Crystallin, gamma polypeptide 5      Symbol and Name status set to approved 70586 APPROVED