LOC100359876 (multifunctional protein ADE2-like) - Rat Genome Database

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Gene: LOC100359876 (multifunctional protein ADE2-like) Rattus norvegicus
Analyze
No known orthologs.
Symbol: LOC100359876
Name: multifunctional protein ADE2-like
RGD ID: 2323267
Description: Predicted to enable 5-amino-4-imidazole carboxylate lyase activity; ATP binding activity; and phosphoribosylaminoimidazole carboxylase activity. Predicted to be involved in 'de novo' IMP biosynthetic process. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human PAICS (phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase).
Type: protein-coding
RefSeq Status: MODEL
Previously known as: AABR07036855.1; bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase-like
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X6,635,011 - 6,636,484 (+)NCBIGRCr8
mRatBN7.2X4,032,827 - 4,034,310 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX4,032,895 - 4,033,896 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0X4,285,780 - 4,287,222 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX4,285,857 - 4,287,160 (+)NCBIRnor6.0rn6Rnor6.0
Rnor_5.0X5,076,182 - 5,077,624 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X15,624,831 - 15,626,639 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX4,574,113 - 4,575,569 (+)NCBICelera
Cytogenetic MapXq11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IEA)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in LOC100359876
6 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X143491017Rat
70166Bp65Blood pressure QTL 655.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X144797211374346Rat
634325Bw13Body weight QTL 130body mass (VT:0001259)body weight (CMO:0000012)X144797220991088Rat
70165Bp64Blood pressure QTL 645.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X144812931706553Rat
631204Gluco15Glucose level QTL 150.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X162371522646544Rat
1298071Edpm12Estrogen-dependent pituitary mass QTL 123.2pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)X292789847927898Rat

Markers in Region
RH143742  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01433,360,622 - 33,360,963NCBIRnor5.0
Rnor_5.01433,758,508 - 33,758,849NCBIRnor5.0
Rnor_5.0X5,076,828 - 5,076,944NCBIRnor5.0
RGSC_v3.4X15,625,492 - 15,625,607UniSTSRGSC3.4
RGSC_v3.41433,498,533 - 33,498,873UniSTSRGSC3.4
CeleraX4,574,774 - 4,574,889UniSTS
Celera1430,517,945 - 30,518,285UniSTS
RH 3.4 Map14423.4UniSTS
Cytogenetic Map14p11UniSTS


Expression


Sequence


RefSeq Acc Id: ENSRNOT00000082159   ⟹   ENSRNOP00000073540
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX4,032,895 - 4,033,896 (+)Ensembl
RefSeq Acc Id: XM_039100238   ⟹   XP_038956166
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X6,635,011 - 6,636,484 (+)NCBI
mRatBN7.2X4,032,827 - 4,034,310 (+)NCBI
Protein Sequences
Protein RefSeqs XP_038956166 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000073540
  ENSRNOP00000073540.2
RefSeq Acc Id: XP_038956166   ⟸   XM_039100238
- UniProtKB: A0A0G2K5S4 (UniProtKB/TrEMBL),   A6JZV0 (UniProtKB/TrEMBL),   A6JCW6 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000073540   ⟸   ENSRNOT00000082159
Protein Domains
PurE

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K5S4-F1-model_v2 AlphaFold A0A0G2K5S4 1-371 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2323267 AgrOrtholog
BioCyc Gene G2FUF-3137 BioCyc
Ensembl Genes ENSRNOG00000056398 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000082159.2 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1970 UniProtKB/TrEMBL
  ATP-grasp fold, B domain UniProtKB/TrEMBL
InterPro PurE_classII UniProtKB/TrEMBL
  PurE_dom UniProtKB/TrEMBL
  SAICAR_synt/ADE2_N UniProtKB/TrEMBL
  SAICAR_synthetase_CS UniProtKB/TrEMBL
NCBI Gene 100359876 ENTREZGENE
PANTHER MULTIFUNCTIONAL PROTEIN ADE2 UniProtKB/TrEMBL
  MULTIFUNCTIONAL PROTEIN ADE2 UniProtKB/TrEMBL
Pfam AIRC UniProtKB/TrEMBL
  SAICAR_synt UniProtKB/TrEMBL
PhenoGen LOC100359876 PhenoGen
PROSITE SAICAR_SYNTHETASE_1 UniProtKB/TrEMBL
  SAICAR_SYNTHETASE_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000056398 RatGTEx
SMART AIRC UniProtKB/TrEMBL
Superfamily-SCOP N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) UniProtKB/TrEMBL
  SAICAR synthase-like UniProtKB/TrEMBL
UniProt A0A0G2K5S4 ENTREZGENE, UniProtKB/TrEMBL
  A6JCW6 ENTREZGENE, UniProtKB/TrEMBL
  A6JZV0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 LOC100359876  multifunctional protein ADE2-like  AABR07036855.1    Data merged from RGD:15010212 737654 PROVISIONAL
2019-11-08 AABR07036855.1        Symbol and Name status set to provisional 45752 PROVISIONAL
2010-05-06 LOC100359876  multifunctional protein ADE2-like      Symbol and Name status set to provisional 70820 PROVISIONAL