Fbxw7 (F-box and WD repeat domain containing 7) - Rat Genome Database

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Gene: Fbxw7 (F-box and WD repeat domain containing 7) Rattus norvegicus
Analyze
Symbol: Fbxw7
Name: F-box and WD repeat domain containing 7
RGD ID: 2321145
Description: Predicted to enable several functions, including cyclin binding activity; phosphothreonine residue binding activity; and ubiquitin ligase-substrate adaptor activity. Predicted to be involved in several processes, including SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; positive regulation of intracellular signal transduction; and positive regulation of protein metabolic process. Predicted to act upstream of or within several processes, including Notch signaling pathway; protein destabilization; and vasculogenesis. Predicted to be located in several cellular components, including Golgi apparatus; nuclear lumen; and perinuclear region of cytoplasm. Predicted to be part of Parkin-FBXW7-Cul1 ubiquitin ligase complex and SCF ubiquitin ligase complex. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in developmental delay, hypotonia, and impaired language. Orthologous to human FBXW7 (F-box and WD repeat domain containing 7); PARTICIPATES IN Notch signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase; F-box and WD-40 domain protein 7; F-box/WD repeat-containing protein 7; Fbw7; LOC100360914; LOC102551266; uncharacterized LOC102551266
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82172,447,738 - 172,609,591 (+)NCBIGRCr8
mRatBN7.22170,149,706 - 170,311,536 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2170,149,694 - 170,309,941 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.02184,230,191 - 184,309,805 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2184,231,260 - 184,309,664 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02203,633,724 - 203,708,120 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42176,675,226 - 176,750,737 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2164,144,641 - 164,303,043 (+)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The Fbw7 tumor suppressor regulates nuclear factor E2-related factor 1 transcription factor turnover through proteasome-mediated proteolysis. Biswas M, etal., J Biol Chem. 2011 Nov 11;286(45):39282-9. doi: 10.1074/jbc.M111.253807. Epub 2011 Sep 27.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Loss of Fbxw7 expression is a predictor of recurrence in colorectal liver metastasis. Kawashita Y, etal., J Hepatobiliary Pancreat Sci. 2017 Oct;24(10):576-583. doi: 10.1002/jhbp.500. Epub 2017 Oct 12.
4. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11425854   PMID:11735228   PMID:12354302   PMID:12628165   PMID:15103331   PMID:15917200   PMID:17434132   PMID:17558397   PMID:17873522   PMID:18625840   PMID:19028597   PMID:20208556  
PMID:21503901   PMID:21620836   PMID:23507969   PMID:23791182   PMID:23823476   PMID:23858059   PMID:24912190   PMID:25897075   PMID:27238018   PMID:28007894   PMID:29149593   PMID:31257502  
PMID:32707070   PMID:34951343   PMID:36427396   PMID:36660176  


Genomics

Comparative Map Data
Fbxw7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82172,447,738 - 172,609,591 (+)NCBIGRCr8
mRatBN7.22170,149,706 - 170,311,536 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2170,149,694 - 170,309,941 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.02184,230,191 - 184,309,805 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2184,231,260 - 184,309,664 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02203,633,724 - 203,708,120 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42176,675,226 - 176,750,737 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2164,144,641 - 164,303,043 (+)NCBICelera
Cytogenetic Map2q34NCBI
FBXW7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384152,320,544 - 152,536,092 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4152,320,544 - 152,536,092 (-)EnsemblGRCh38hg38GRCh38
GRCh374153,241,696 - 153,457,244 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364153,461,860 - 153,675,622 (-)NCBINCBI36Build 36hg18NCBI36
Build 344153,601,099 - 153,690,635NCBI
Celera4150,566,189 - 150,779,958 (-)NCBICelera
Cytogenetic Map4q31.3NCBI
HuRef4148,968,491 - 149,182,492 (-)NCBIHuRef
CHM1_14153,220,162 - 153,434,185 (-)NCBICHM1_1
T2T-CHM13v2.04155,643,699 - 155,859,255 (-)NCBIT2T-CHM13v2.0
Fbxw7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39384,721,901 - 84,886,505 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl384,722,575 - 84,886,505 (+)EnsemblGRCm39 Ensembl
GRCm38384,814,990 - 84,979,198 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl384,815,268 - 84,979,198 (+)EnsemblGRCm38mm10GRCm38
MGSCv37384,619,499 - 84,783,120 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36385,038,138 - 85,063,561 (+)NCBIMGSCv36mm8
Celera384,827,347 - 84,997,996 (+)NCBICelera
Cytogenetic Map3F1NCBI
cM Map337.7NCBI
Fbxw7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554716,848,101 - 6,955,881 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554716,852,459 - 7,026,590 (-)NCBIChiLan1.0ChiLan1.0
FBXW7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23150,206,219 - 150,420,227 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14150,563,293 - 150,777,771 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04144,660,676 - 144,874,404 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14156,312,274 - 156,527,649 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4156,312,274 - 156,402,351 (-)Ensemblpanpan1.1panPan2
FBXW7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11550,187,579 - 50,417,188 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1550,189,240 - 50,417,195 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1550,529,850 - 50,761,421 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01550,869,433 - 51,101,086 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1550,870,969 - 50,964,288 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11550,130,239 - 50,363,954 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01550,231,872 - 50,463,188 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01550,542,860 - 50,774,097 (-)NCBIUU_Cfam_GSD_1.0
Fbxw7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530140,081,138 - 40,271,734 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366892,259,477 - 2,344,764 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366892,261,163 - 2,449,951 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FBXW7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl876,482,844 - 76,699,348 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1876,482,027 - 76,699,354 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
FBXW7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1798,894,261 - 99,105,955 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl798,892,504 - 99,106,084 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603778,541,091 - 78,756,369 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fbxw7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248583,775,795 - 3,873,336 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248583,778,842 - 3,974,351 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fbxw7
603 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:92
Count of miRNA genes:56
Interacting mature miRNAs:65
Transcripts:ENSRNOT00000015279, ENSRNOT00000052051
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2114837527185876470Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527185876470Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
6907363Bp357Blood pressure QTL 3574.10.002arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2129540907174540907Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2133914684202447032Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2135552573202446871Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2136916935189599348Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2141596551202447032Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2143157029210020885Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2143657411190602963Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2143657411190602963Rat
6903312Bw112Body weight QTL 1123.20.0013body mass (VT:0001259)body weight (CMO:0000012)2143657569184114274Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2144599348189599348Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2147798556192798556Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150341585189039377Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150341684202446871Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150540301202447032Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2150540301202447032Rat
12879845Cm89Cardiac mass QTL 890.008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2152413072175950118Rat
12879846Cm90Cardiac mass QTL 900.011heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)2152413072175950118Rat
12879847Am4Aortic mass QTL 40.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2152413072175950118Rat
11565180Kidm56Kidney mass QTL 560.003kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2152413072175950118Rat
11565181Bw176Body weight QTL 1760.002body mass (VT:0001259)body weight (CMO:0000012)2152413072175950118Rat
2301415Cm67Cardiac mass QTL 670.003heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2152413072175950118Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2152413072185122374Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2152413072185122374Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2152413072185122374Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2152413072185122374Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2152413072185122374Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2157142078192625452Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2157142078211086598Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2157142209202446871Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2160564068205564068Rat
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2162765032207765032Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
1598838Bp290Blood pressure QTL 2901.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166539266211539266Rat
1549833Bp257Blood pressure QTL 2570.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168354880185122374Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2168594495213594495Rat
61469Bp16Blood pressure QTL 165.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
70162Bp63Blood pressure QTL 635.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat

Markers in Region
D2Rat119  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.02203,274,410 - 203,274,569NCBIRnor5.0
Rnor_5.02203,274,411 - 203,274,569NCBIRnor5.0
RGSC_v3.42176,639,396 - 176,639,583UniSTSRGSC3.4
RGSC_v3.42176,639,397 - 176,639,583RGDRGSC3.4
RGSC_v3.12176,589,503 - 176,589,689RGD
Celera2164,199,696 - 164,199,869UniSTS
RH 3.4 Map21103.5RGD
RH 3.4 Map21103.5UniSTS
SHRSP x BN Map270.0898UniSTS
SHRSP x BN Map270.0898RGD
Fbxw7  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22170,283,174 - 170,283,548 (-)MAPPERmRatBN7.2
Rnor_6.02184,263,190 - 184,263,563NCBIRnor6.0
Rnor_5.02203,661,427 - 203,661,800UniSTSRnor5.0
RGSC_v3.42176,722,135 - 176,722,508UniSTSRGSC3.4
Celera2164,277,230 - 164,277,603UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 19 10 2 19 2 5 5 74 6 33 11 5
Low 2 24 47 39 39 3 6 29 8 3
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001419528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_002729089 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_003749311 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006232555 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596140 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596144 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596146 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596147 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596148 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596149 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039103738 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039103739 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039103741 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039103742 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039103743 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039103744 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281082 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide FQ231989 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000015279   ⟹   ENSRNOP00000015280
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2170,283,010 - 170,309,941 (+)Ensembl
Rnor_6.0 Ensembl2184,231,830 - 184,263,564 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000052051   ⟹   ENSRNOP00000050193
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2170,149,694 - 170,309,941 (+)Ensembl
Rnor_6.0 Ensembl2184,231,260 - 184,309,664 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000076609
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2184,309,277 - 184,309,663 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000081678   ⟹   ENSRNOP00000074892
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2170,256,686 - 170,309,941 (+)Ensembl
Rnor_6.0 Ensembl2184,231,785 - 184,289,126 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000116921   ⟹   ENSRNOP00000090758
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2170,149,712 - 170,309,941 (+)Ensembl
RefSeq Acc Id: NM_001419528   ⟹   NP_001406457
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82172,447,738 - 172,609,591 (+)NCBI
mRatBN7.22170,149,706 - 170,311,536 (+)NCBI
RefSeq Acc Id: XM_003749311   ⟹   XP_003749359
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82172,581,171 - 172,609,591 (+)NCBI
mRatBN7.22170,283,140 - 170,310,698 (+)NCBI
Rnor_6.02184,230,191 - 184,265,235 (-)NCBI
Rnor_5.02203,633,724 - 203,708,120 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006232555   ⟹   XP_006232617
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82172,543,852 - 172,609,591 (+)NCBI
mRatBN7.22170,257,098 - 170,310,698 (+)NCBI
Rnor_6.02184,230,191 - 184,291,736 (-)NCBI
Rnor_5.02203,633,724 - 203,708,120 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039103738   ⟹   XP_038959666
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82172,496,848 - 172,609,591 (+)NCBI
mRatBN7.22170,198,820 - 170,310,698 (+)NCBI
RefSeq Acc Id: XM_039103739   ⟹   XP_038959667
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82172,448,583 - 172,609,591 (+)NCBI
mRatBN7.22170,150,552 - 170,310,698 (+)NCBI
RefSeq Acc Id: XM_039103741   ⟹   XP_038959669
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82172,448,583 - 172,609,591 (+)NCBI
mRatBN7.22170,150,552 - 170,310,698 (+)NCBI
RefSeq Acc Id: XM_039103742   ⟹   XP_038959670
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82172,448,583 - 172,609,591 (+)NCBI
mRatBN7.22170,150,552 - 170,310,698 (+)NCBI
RefSeq Acc Id: XM_039103743   ⟹   XP_038959671
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82172,448,583 - 172,609,591 (+)NCBI
mRatBN7.22170,150,552 - 170,310,698 (+)NCBI
RefSeq Acc Id: XM_039103744   ⟹   XP_038959672
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82172,448,583 - 172,609,591 (+)NCBI
mRatBN7.22170,150,552 - 170,310,698 (+)NCBI
RefSeq Acc Id: XM_063281082   ⟹   XP_063137152
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82172,448,583 - 172,609,591 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_003749359   ⟸   XM_003749311
- Peptide Label: isoform X3
- UniProtKB: D3ZQU4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006232617   ⟸   XM_006232555
- Peptide Label: isoform X4
- UniProtKB: A0A0G2K979 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000074892   ⟸   ENSRNOT00000081678
RefSeq Acc Id: ENSRNOP00000015280   ⟸   ENSRNOT00000015279
RefSeq Acc Id: ENSRNOP00000050193   ⟸   ENSRNOT00000052051
RefSeq Acc Id: XP_038959669   ⟸   XM_039103741
- Peptide Label: isoform X2
- UniProtKB: D3Z902 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038959671   ⟸   XM_039103743
- Peptide Label: isoform X2
- UniProtKB: D3Z902 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038959667   ⟸   XM_039103739
- Peptide Label: isoform X2
- UniProtKB: D3Z902 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038959670   ⟸   XM_039103742
- Peptide Label: isoform X2
- UniProtKB: D3Z902 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038959672   ⟸   XM_039103744
- Peptide Label: isoform X2
- UniProtKB: D3Z902 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038959666   ⟸   XM_039103738
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AED9 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000090758   ⟸   ENSRNOT00000116921
RefSeq Acc Id: NP_001406457   ⟸   NM_001419528
- UniProtKB: D3Z902 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063137152   ⟸   XM_063281082
- Peptide Label: isoform X2
Protein Domains
F-box

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3Z902-F1-model_v2 AlphaFold D3Z902 1-713 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2321145 AgrOrtholog
BioCyc Gene G2FUF-52625 BioCyc
Ensembl Genes ENSRNOG00000010889 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055023861 UniProtKB/Swiss-Prot
  ENSRNOG00060031911 UniProtKB/Swiss-Prot
  ENSRNOG00065027460 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000015279.6 UniProtKB/TrEMBL
  ENSRNOT00000052051.7 UniProtKB/Swiss-Prot
  ENSRNOT00000081678.2 UniProtKB/TrEMBL
  ENSRNOT00000116921.1 UniProtKB/TrEMBL
  ENSRNOT00055040942 UniProtKB/Swiss-Prot
  ENSRNOT00060055349 UniProtKB/Swiss-Prot
  ENSRNOT00065047356 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1280.50 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.130.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro F-box-like_dom_sf UniProtKB/TrEMBL
  F-box_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  F-box_dom_like UniProtKB/Swiss-Prot
  G-protein_beta_WD-40_rep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40_repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40_repeat_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:100360914 UniProtKB/TrEMBL
NCBI Gene 100360914 ENTREZGENE
PANTHER F-BOX/WD REPEAT-CONTAINING PROTEIN 7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PHOSPHOLIPASE A-2-ACTIVATING PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam F-box-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Fbxw7 PhenoGen
PRINTS GPROTEINBRPT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE FBOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD_REPEATS_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD_REPEATS_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD_REPEATS_REGION UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000010889 RatGTEx
  ENSRNOG00055023861 RatGTEx
  ENSRNOG00060031911 RatGTEx
  ENSRNOG00065027460 RatGTEx
SMART FBOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50978 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF81383 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K979 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AED9 ENTREZGENE, UniProtKB/TrEMBL
  D3Z902 ENTREZGENE
  D3ZQU4 ENTREZGENE, UniProtKB/TrEMBL
  FBXW7_RAT UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Fbxw7  F-box and WD repeat domain containing 7  LOC102551266  uncharacterized LOC102551266  Data merged from RGD:7728029 737654 PROVISIONAL
2015-11-25 Fbxw7  F-box and WD repeat domain containing 7  Fbxw7  F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-12-18 LOC102551266  uncharacterized LOC102551266      Symbol and Name status set to provisional 70820 PROVISIONAL
2012-08-09 Fbxw7  F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase  LOC100360914  F-box and WD-40 domain protein 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-05 LOC100360914  F-box and WD-40 domain protein 7      Symbol and Name status set to provisional 70820 PROVISIONAL