Ppial4d (peptidylprolyl isomerase A (cyclophilin A)-like 4D) - Rat Genome Database

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Gene: Ppial4d (peptidylprolyl isomerase A (cyclophilin A)-like 4D) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Ppial4d
Name: peptidylprolyl isomerase A (cyclophilin A)-like 4D
RGD ID: 2321083
Description: Predicted to enable heparan sulfate binding activity; integrin binding activity; and peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in several processes, including cell adhesion molecule production; regulation of intracellular signal transduction; and regulation of protein modification process. Predicted to be located in cytosol; extracellular region; and nucleus. Human ortholog(s) of this gene implicated in cholangiocarcinoma and human immunodeficiency virus infectious disease. Orthologous to human PPIA (peptidylprolyl isomerase A); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC100360977; peptidyl-prolyl cis-trans isomerase A; TRIMCyp-like
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81421,361,379 - 21,362,147 (+)NCBIGRCr8
mRatBN7.21421,006,522 - 21,007,284 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1421,006,538 - 21,007,310 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01422,706,906 - 22,707,648 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1422,706,901 - 22,707,668 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01422,609,711 - 22,610,447 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41422,612,891 - 22,613,385 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Cytogenetic Map14p21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,ISS)
cytosol  (ISS)
extracellular region  (ISS)
nucleus  (ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Ppial4d
20 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300159Bmd61Bone mineral density QTL 615.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
2300183Bmd60Bone mineral density QTL 605.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
619619Rf4Renal disease susceptibility QTL 44.10.002urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)14132754612Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141131407Rat
1300114Srn2Serum renin concentration QTL 23.27blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)14381307421217635Rat
70195Mcs8Mammary carcinoma susceptibility QTL 84.28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)14381307424531477Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14381307430767156Rat
1581500Renag1Renal agenesis QTL 1kidney development trait (VT:0000527)percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)14817066868298175Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14826709053267090Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14826709053267090Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)14908897839057237Rat
2302277Gluco38Glucose level QTL 385.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062228035204Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
631212Bw5Body weight QTL55.43retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)141103081230320092Rat
1300140Srn3Serum renin concentration QTL 33.19blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)141487516830883947Rat
71117Niddm17Non-insulin dependent diabetes mellitus QTL 172.35blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)141759376142336881Rat
631262Tcas4Tongue tumor susceptibility QTL 47.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)141762256142337007Rat
2313397Coatc1Coat color QTL1coat/hair pigmentation trait (VT:0010463)coat/hair color measurement (CMO:0001808)141854133263541332Rat
61420Pia6Pristane induced arthritis QTL 64.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)141863134542337007Rat
10755459Coatc15Coat color QTL 150.01681coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)141983694464836944Rat

Markers in Region
UniSTS:265677  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21421,006,765 - 21,007,058 (+)MAPPERmRatBN7.2
mRatBN7.2441,829,100 - 41,829,392 (+)MAPPERmRatBN7.2
Rnor_6.01422,707,130 - 22,707,422NCBIRnor6.0
Rnor_5.01422,609,939 - 22,610,231UniSTSRnor5.0
RGSC_v3.41422,613,076 - 22,613,368UniSTSRGSC3.4
Cytogenetic Map14q21UniSTS
Ppia  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21421,006,634 - 21,006,784 (+)MAPPERmRatBN7.2
Rnor_6.01422,706,999 - 22,707,148NCBIRnor6.0
Rnor_5.01422,609,808 - 22,609,957UniSTSRnor5.0
Cytogenetic Map14q21UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000088798   ⟹   ENSRNOP00000071404
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1422,706,901 - 22,707,668 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000106407   ⟹   ENSRNOP00000089529
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1421,006,538 - 21,007,310 (+)Ensembl
RefSeq Acc Id: XM_006250801   ⟹   XP_006250863
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81421,361,379 - 21,362,147 (+)NCBI
mRatBN7.21421,006,522 - 21,007,284 (+)NCBI
Rnor_6.01422,706,906 - 22,707,648 (+)NCBI
Rnor_5.01422,609,711 - 22,610,447 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_006250863 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000089529
  ENSRNOP00000089529.1
Reference Protein Sequences
RefSeq Acc Id: XP_006250863   ⟸   XM_006250801
- UniProtKB: P18303 (UniProtKB/Swiss-Prot),   Q5BK98 (UniProtKB/Swiss-Prot),   P10111 (UniProtKB/Swiss-Prot),   A6IKU0 (UniProtKB/TrEMBL),   A6IKT9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000071404   ⟸   ENSRNOT00000088798
RefSeq Acc Id: ENSRNOP00000089529   ⟸   ENSRNOT00000106407
Protein Domains
PPIase cyclophilin-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P10111-F1-model_v2 AlphaFold P10111 1-164 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699264
Promoter ID:EPDNEW_R9781
Type:single initiation site
Name:Ppial4d_1
Description:peptidylprolyl isomerase A -like 4D
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01422,706,901 - 22,706,961EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2321083 AgrOrtholog
BioCyc Gene G2FUF-16096 BioCyc
Ensembl Genes ENSRNOG00000055068 Ensembl
  ENSRNOG00000068764 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000106407.1 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.100.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cyclophilin-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyclophilin-type_PPIase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyclophilin-type_PPIase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyclophilin-type_PPIase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:100360977 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  rno:25518 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 100360977 ENTREZGENE
PANTHER PEPTIDYL-PROLYL CIS-TRANS ISOMERASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Pro_isomerase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ppial4d PhenoGen
PIRSF Peptidylpro_ismrse UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS CSAPPISMRASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CSA_PPIASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CSA_PPIASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000055068 RatGTEx
  ENSRNOG00000068764 RatGTEx
Superfamily-SCOP Cyclophilin-like UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt A6IKT9 ENTREZGENE, UniProtKB/TrEMBL
  A6IKU0 ENTREZGENE, UniProtKB/TrEMBL
  P10111 ENTREZGENE
  P18303 ENTREZGENE
  PPIA_RAT UniProtKB/Swiss-Prot
  Q5BK98 ENTREZGENE
UniProt Secondary P18303 UniProtKB/Swiss-Prot
  Q5BK98 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Ppial4d  peptidylprolyl isomerase A (cyclophilin A)-like 4D  Ppial4d  peptidylprolyl isomerase A (cyclophilin A)-like 4D  Data merged from RGD:149736382 737654 PROVISIONAL
2021-08-09 Ppial4d  peptidylprolyl isomerase A (cyclophilin A)-like 4D      Symbol and Name status set to provisional 45752 PROVISIONAL
2015-06-09 Ppial4d  peptidylprolyl isomerase A (cyclophilin A)-like 4D  LOC100360977  TRIMCyp-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-05 LOC100360977  TRIMCyp-like      Symbol and Name status set to provisional 70820 PROVISIONAL