Lamtor1l1 (late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 like 1) - Rat Genome Database

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Gene: Lamtor1l1 (late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 like 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Lamtor1l1 (Ensembl: Lamtor1)
Name: late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 like 1 (Ensembl:late endosomal/lysosomal adaptor, MAPK and MTOR activator 1)
RGD ID: 2319924
Description: Predicted to enable protein-membrane adaptor activity. Predicted to contribute to guanyl-nucleotide exchange factor activity and molecular adaptor activity. Predicted to be involved in several processes, including cholesterol homeostasis; positive regulation of intracellular signal transduction; and regulation of cholesterol transport. Located in late endosome membrane and membrane raft. Orthologous to human LAMTOR1 (late endosomal/lysosomal adaptor, MAPK and MTOR activator 1).
Type: protein-coding
RefSeq Status: INFERRED
Previously known as: AABR07038019.1; LOC100361543; ragulator complex protein LAMTOR1; RhoA activator C11orf59-like
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X38,446,140 - 38,447,189 (+)NCBIGRCr8
mRatBN7.2X34,637,460 - 34,638,509 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX34,637,459 - 34,638,516 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0X37,261,428 - 37,262,470 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1166,991,474 - 166,997,045 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X37,574,256 - 37,575,298 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X55,835,013 - 55,836,076 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX35,310,104 - 35,311,146 (+)NCBICelera
Cytogenetic MapXq14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
late endosome membrane  (IDA,IEA)
lysosomal membrane  (IEA,ISS)
lysosome  (IBA,ISS)
membrane raft  (IDA,IEA)
Ragulator complex  (IBA,IEA,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. The novel lipid raft adaptor p18 controls endosome dynamics by anchoring the MEK-ERK pathway to late endosomes. Nada S, etal., EMBO J. 2009 Mar 4;28(5):477-89. doi: 10.1038/emboj.2008.308. Epub 2009 Jan 29.
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X143491017Rat
1298071Edpm12Estrogen-dependent pituitary mass QTL 123.2pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)X292789847927898Rat
10755455Coatc13Coat color QTL 130coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7440600049406000Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X449454949494549Rat
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
71116Niddm16Non-insulin dependent diabetes mellitus QTL 167.81blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X1529780260297802Rat
1598873Memor2Memory QTL 22.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)X2099094741052531Rat
2290375Gluco34Glucose level QTL 342.75blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X2099094741203591Rat

Markers in Region
RH140986  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21156,277,361 - 156,277,548 (+)MAPPERmRatBN7.2
mRatBN7.2X34,638,188 - 34,638,375 (+)MAPPERmRatBN7.2
Rnor_6.0X37,262,151 - 37,262,337NCBIRnor6.0
Rnor_6.01166,996,720 - 166,996,906NCBIRnor6.0
Rnor_5.01173,187,474 - 173,187,660UniSTSRnor5.0
Rnor_5.0X37,574,979 - 37,575,165UniSTSRnor5.0
RGSC_v3.4X55,835,736 - 55,835,922UniSTSRGSC3.4
RGSC_v3.41159,372,717 - 159,372,903UniSTSRGSC3.4
Celera1154,351,020 - 154,351,206UniSTS
CeleraX35,310,827 - 35,311,013UniSTS
Cytogenetic Map1q32UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000005702   ⟹   ENSRNOP00000089922
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX34,637,459 - 34,638,516 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000027150   ⟹   ENSRNOP00000027150
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1156,272,105 - 156,277,695 (+)Ensembl
Rnor_6.0 Ensembl1166,991,474 - 166,997,045 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000101397   ⟹   ENSRNOP00000076850
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1156,272,064 - 156,291,179 (+)Ensembl
RefSeq Acc Id: NM_001409102   ⟹   NP_001396031
RefSeq Status: INFERRED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X38,446,140 - 38,447,189 (+)NCBI
mRatBN7.2X34,637,460 - 34,638,509 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001396031 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000076850.1
  ENSRNOP00000089922
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000027150   ⟸   ENSRNOT00000027150
RefSeq Acc Id: ENSRNOP00000076850   ⟸   ENSRNOT00000101397
RefSeq Acc Id: ENSRNOP00000089922   ⟸   ENSRNOT00000005702
RefSeq Acc Id: NP_001396031   ⟸   NM_001409102
- UniProtKB: Q6P791 (UniProtKB/Swiss-Prot),   A6I6Y5 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6P791-F1-model_v2 AlphaFold Q6P791 1-161 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2319924 AgrOrtholog
BioCyc Gene G2FUF-2495 BioCyc
Ensembl Genes ENSRNOG00000004319 Ensembl, ENTREZGENE
  ENSRNOG00000020016 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000005702 ENTREZGENE
  ENSRNOT00000101397.1 UniProtKB/TrEMBL
InterPro LAMTOR1/MEH1 UniProtKB/TrEMBL
NCBI Gene 100361543 ENTREZGENE
PANTHER RAGULATOR COMPLEX PROTEIN LAMTOR1 UniProtKB/TrEMBL
  RAGULATOR COMPLEX PROTEIN LAMTOR1 UniProtKB/TrEMBL
Pfam LAMTOR UniProtKB/TrEMBL
PhenoGen Lamtor1l1 PhenoGen
RatGTEx ENSRNOG00000004319 RatGTEx
  ENSRNOG00000020016 RatGTEx
SMART LAMTOR UniProtKB/TrEMBL
UniProt A0A8I5Y5M8_RAT UniProtKB/TrEMBL
  A6I6Y5 ENTREZGENE
  Q6P791 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-09-19 Lamtor1l1  late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 like 1  LOC100361543  RhoA activator C11orf59-like  Symbol and Name Changed 1299863 APPROVED
2022-06-02 LOC100361543  RhoA activator C11orf59-like  AABR07038019.1    Data merged from RGD:15003277 737654 PROVISIONAL
2019-11-08 AABR07038019.1        Symbol and Name status set to provisional 45752 PROVISIONAL
2010-05-05 LOC100361543  RhoA activator C11orf59-like      Symbol and Name status set to provisional 70820 PROVISIONAL