Krtap12-2 (keratin associated protein 12-2) - Rat Genome Database

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Gene: Krtap12-2 (keratin associated protein 12-2) Rattus norvegicus
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Symbol: Krtap12-2
Name: keratin associated protein 12-2
RGD ID: 2319746
Description: Orthologous to several human genes including KRTAP12-2 (keratin associated protein 12-2); INTERACTS WITH (+)-catechin (ortholog); aflatoxin B1 (ortholog); benzo[a]pyrene (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: keratin-associated protein 12-1; LOC100361626; rCG61034-like
RGD Orthologs
Human
Mouse
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82010,904,025 - 10,904,354 (-)NCBIGRCr8
mRatBN7.22010,904,422 - 10,904,751 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx2011,603,941 - 11,604,270 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02010,964,904 - 10,965,233 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02011,436,654 - 11,436,983 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02011,620,616 - 11,620,945 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2011,620,616 - 11,620,945 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02013,786,698 - 13,787,027 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42011,283,027 - 11,283,356 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2012,406,997 - 12,407,326 (-)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Krtap12-2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82010,904,025 - 10,904,354 (-)NCBIGRCr8
mRatBN7.22010,904,422 - 10,904,751 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx2011,603,941 - 11,604,270 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02010,964,904 - 10,965,233 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02011,436,654 - 11,436,983 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02011,620,616 - 11,620,945 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2011,620,616 - 11,620,945 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02013,786,698 - 13,787,027 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42011,283,027 - 11,283,356 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2012,406,997 - 12,407,326 (-)NCBICelera
Cytogenetic Map20p12NCBI
KRTAP12-2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382144,666,189 - 44,666,927 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2144,666,189 - 44,666,927 (-)EnsemblGRCh38hg38GRCh38
GRCh372146,086,106 - 46,086,844 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362144,910,534 - 44,911,272 (-)NCBINCBI36Build 36hg18NCBI36
Build 342144,910,534 - 44,911,272NCBI
Celera2131,193,740 - 31,194,478 (-)NCBICelera
Cytogenetic Map21q22.3NCBI
HuRef2131,460,249 - 31,460,987 (-)NCBIHuRef
CHM1_12145,646,942 - 45,647,680 (-)NCBICHM1_1
T2T-CHM13v2.02143,026,607 - 43,027,345 (-)NCBIT2T-CHM13v2.0
Krtap12-22
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391077,547,280 - 77,547,843 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1077,547,291 - 77,547,843 (+)EnsemblGRCm39 Ensembl
GRCm381077,711,446 - 77,712,009 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1077,711,457 - 77,712,009 (+)EnsemblGRCm38mm10GRCm38
MGSCv371077,174,202 - 77,174,754 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera1078,755,341 - 78,755,893 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
KRTAP12-2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1288,382,006 - 88,383,652 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605416,514,167 - 16,514,930 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124159021Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125159026Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20289259726381954Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20362165614101050Rat
4889857Pur27Proteinuria QTL 2712.20.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20460660717617956Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20460660717617956Rat
70154Insul2Insulin level QTL 23.75blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20669170617489458Rat
1581577Pur15Proteinuria QTL 154.380.0002urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)20804241017617956Rat
4889870Pur30Proteinuria QTL 30190.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20804241029322208Rat
631265Iresp1Immunoglobin response QTL18.3blood anti-double stranded DNA antibody amount (VT:0004762)serum anti-DNA antibody level (CMO:0001533)20903971913461775Rat

Markers in Region
BF387291  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22010,905,654 - 10,905,821 (+)MAPPERmRatBN7.2
Rnor_6.02011,621,849 - 11,622,015NCBIRnor6.0
Rnor_5.02013,787,931 - 13,788,097UniSTSRnor5.0
RGSC_v3.42011,284,260 - 11,284,426UniSTSRGSC3.4
Celera2012,408,230 - 12,408,396UniSTS
RH 3.4 Map20154.39UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system reproductive system
High
Medium
Low
Below cutoff 1 1 1

Sequence


RefSeq Acc Id: ENSRNOT00000079725   ⟹   ENSRNOP00000075306
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2011,620,616 - 11,620,945 (-)Ensembl
RefSeq Acc Id: NM_001402163   ⟹   NP_001389092
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82010,904,025 - 10,904,354 (-)NCBI
mRatBN7.22010,904,422 - 10,904,751 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001389092 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL97086 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: ENSRNOP00000075306   ⟸   ENSRNOT00000079725
RefSeq Acc Id: NP_001389092   ⟸   NM_001402163
- UniProtKB: A6JK70 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2KA89-F1-model_v2 AlphaFold A0A0G2KA89 1-109 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701499
Promoter ID:EPDNEW_R12020
Type:single initiation site
Name:Krtap12-2_1
Description:keratin associated protein 12-2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02011,620,983 - 11,621,043EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2319746 AgrOrtholog
BioCyc Gene G2FUF-4251 BioCyc
Ensembl Genes ENSRNOG00000057487 Ensembl
InterPro KAP UniProtKB/TrEMBL
KEGG Report rno:100361626 UniProtKB/TrEMBL
NCBI Gene 100361626 ENTREZGENE
Pfam Keratin_B2_2 UniProtKB/TrEMBL
PhenoGen Krtap12-2 PhenoGen
RatGTEx ENSRNOG00000057487 RatGTEx
UniProt A6JK70 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-09-25 Krtap12-2  keratin associated protein 12-2  LOC100361626  rCG61034-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-05 LOC100361626  rCG61034-like      Symbol and Name status set to provisional 70820 PROVISIONAL