Krtap12-1 (keratin associated protein 12-1) - Rat Genome Database

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Gene: Krtap12-1 (keratin associated protein 12-1) Rattus norvegicus
Analyze
Symbol: Krtap12-1 (Ensembl: LOC100361793)
Name: keratin associated protein 12-1 (Ensembl:keratin associated protein 12-1-like)
RGD ID: 2319481
Description: Orthologous to several human genes including KRTAP12-2 (keratin associated protein 12-2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine (ortholog); 4,4'-diaminodiphenylmethane (ortholog); benzo[a]pyrene (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: keratin associated protein 12-1-like; Keratin-associated protein 12-1-like; LOC100361793; uncharacterized protein LOC100361793
RGD Orthologs
Human
Mouse
Bonobo
Dog
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82010,916,943 - 10,917,552 (-)NCBIGRCr8
mRatBN7.22010,917,340 - 10,917,949 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx2011,617,097 - 11,617,429 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02010,978,060 - 10,978,392 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02011,449,810 - 11,450,142 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02011,633,805 - 11,634,137 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2011,633,805 - 11,634,137 (-)EnsemblRnor6.0rn6Rnor6.0
RGSC_v3.42011,298,982 - 11,299,314 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2012,419,866 - 12,420,198 (-)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Krtap12-1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82010,916,943 - 10,917,552 (-)NCBIGRCr8
mRatBN7.22010,917,340 - 10,917,949 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx2011,617,097 - 11,617,429 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02010,978,060 - 10,978,392 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02011,449,810 - 11,450,142 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02011,633,805 - 11,634,137 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2011,633,805 - 11,634,137 (-)EnsemblRnor6.0rn6Rnor6.0
RGSC_v3.42011,298,982 - 11,299,314 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2012,419,866 - 12,420,198 (-)NCBICelera
Cytogenetic Map20p12NCBI
KRTAP12-1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382144,681,576 - 44,682,163 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2144,681,576 - 44,682,163 (-)EnsemblGRCh38hg38GRCh38
GRCh372146,101,491 - 46,102,078 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362144,925,919 - 44,926,506 (-)NCBINCBI36Build 36hg18NCBI36
Build 342144,925,920 - 44,926,506NCBI
Celera2131,209,126 - 31,209,713 (-)NCBICelera
Cytogenetic Map21q22.3NCBI
HuRef2131,475,564 - 31,476,151 (-)NCBIHuRef
CHM1_12145,662,332 - 45,662,919 (-)NCBICHM1_1
T2T-CHM13v2.02143,041,991 - 43,042,578 (-)NCBIT2T-CHM13v2.0
Krtap12-1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391077,556,420 - 77,557,090 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1077,556,433 - 77,557,088 (+)EnsemblGRCm39 Ensembl
GRCm381077,720,586 - 77,721,256 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1077,720,599 - 77,721,254 (+)EnsemblGRCm38mm10GRCm38
MGSCv371077,183,331 - 77,184,001 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361077,164,302 - 77,164,972 (+)NCBIMGSCv36mm8
Celera1078,764,470 - 78,765,140 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
LOC100990879
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22240,724,588 - 40,725,234 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12135,595,357 - 35,596,003 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02130,973,102 - 30,973,742 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12144,267,147 - 44,267,787 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2144,267,403 - 44,267,753 (-)Ensemblpanpan1.1panPan2
LOC610887
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13136,042,743 - 36,043,443 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3135,196,643 - 35,197,627 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03135,560,592 - 35,561,576 (+)NCBIROS_Cfam_1.0
UNSW_CanFamBas_1.03135,434,669 - 35,435,653 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03135,928,673 - 35,929,657 (+)NCBIUU_Cfam_GSD_1.0
KRTAP12-1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1288,397,074 - 88,398,186 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605416,528,929 - 16,529,773 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Krtap12-1
1 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124159021Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125159026Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20289259726381954Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20362165614101050Rat
4889857Pur27Proteinuria QTL 2712.20.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20460660717617956Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20460660717617956Rat
70154Insul2Insulin level QTL 23.75blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20669170617489458Rat
1581577Pur15Proteinuria QTL 154.380.0002urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)20804241017617956Rat
4889870Pur30Proteinuria QTL 30190.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20804241029322208Rat
631265Iresp1Immunoglobin response QTL18.3blood anti-double stranded DNA antibody amount (VT:0004762)serum anti-DNA antibody level (CMO:0001533)20903971913461775Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system appendage
High
Medium
Low 1
Below cutoff 1 1 1 1 1 1 1 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000083064   ⟹   ENSRNOP00000072410
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2011,633,805 - 11,634,137 (-)Ensembl
RefSeq Acc Id: NM_001271304   ⟹   NP_001258233
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82010,916,943 - 10,917,552 (-)NCBI
mRatBN7.22010,917,340 - 10,917,949 (-)NCBI
Rnor_6.02011,633,805 - 11,634,137 (-)NCBI
Celera2012,419,866 - 12,420,198 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001258233 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL97088 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_001258233   ⟸   NM_001271304
- UniProtKB: A6JK72 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000072410   ⟸   ENSRNOT00000083064

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K2X1-F1-model_v2 AlphaFold A0A0G2K2X1 1-110 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701498
Promoter ID:EPDNEW_R12022
Type:single initiation site
Name:LOC100361793_1
Description:keratin associated protein 12-1-like
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02011,634,172 - 11,634,232EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2319481 AgrOrtholog
BioCyc Gene G2FUF-4249 BioCyc
Ensembl Genes ENSRNOG00000058151 Ensembl
InterPro KAP UniProtKB/TrEMBL
KEGG Report rno:100361793 UniProtKB/TrEMBL
NCBI Gene 100361793 ENTREZGENE
Pfam Keratin_B2_2 UniProtKB/TrEMBL
PhenoGen Krtap12-1 PhenoGen
RatGTEx ENSRNOG00000058151 RatGTEx
UniProt A6JK72 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-07-11 Krtap12-1  keratin associated protein 12-1  LOC100361793  keratin associated protein 12-1-like  Name and Symbol changed 629549 APPROVED
2010-05-05 LOC100361793  keratin associated protein 12-1-like      Symbol and Name status set to provisional 70820 PROVISIONAL