Tmem276 (Transmembrane protein 276) - Rat Genome Database

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Gene: Tmem276 (Transmembrane protein 276) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Tmem276 (Ensembl: Zftraf1)
Name: Transmembrane protein 276 (Ensembl:zinc finger TRAF-type containing 1)
RGD ID: 2318728
Description: Predicted to be located in membrane. Predicted to be active in nucleus. Orthologous to human ZFTRAF1 (zinc finger TRAF-type containing 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Cyhr1; cysteine and histidine rich 1; cysteine and histidine rich 1-like; cysteine and histidine-rich protein 1; cysteine/histidine-rich 1; LOC100362155; MGC108816; MGC188650; RGD1561328
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87110,259,212 - 110,261,096 (-)NCBIGRCr8
mRatBN7.27108,378,569 - 108,380,453 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7108,364,381 - 108,380,021 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7110,120,401 - 110,121,851 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07112,343,977 - 112,345,427 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07112,304,813 - 112,306,263 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07117,720,909 - 117,722,734 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7117,706,727 - 117,722,723 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07117,694,694 - 117,707,842 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47114,692,798 - 114,705,940 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera7104,728,720 - 104,730,170 (-)NCBICelera
Cytogenetic Map7q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA)
nucleus  (IBA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10745073   PMID:12477932   PMID:15057822   PMID:15489334  


Genomics

Variants

.
Variants in Tmem276
3 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)743747012108555253Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)768938720113886318Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)768938720113886318Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)768938720113886318Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)769736226117455174Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)769736356112729554Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)773829340130221005Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)780221299109401111Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)780221299112308525Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)780221299124373579Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)780221299125221299Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)781737938126737938Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)783153392128153392Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)784257275129257275Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)784257275129257275Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)786983365131983365Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)791412594129807172Rat
2313102Bmd79Bone mineral density QTL 792.30.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)794811085116738842Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)794811326116294265Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7103146217116738842Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat

Markers in Region
RH134279  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27108,378,741 - 108,378,949 (+)MAPPERmRatBN7.2
Rnor_6.07117,721,082 - 117,721,289NCBIRnor6.0
Rnor_5.07117,709,168 - 117,709,375UniSTSRnor5.0
RGSC_v3.47114,707,272 - 114,707,479UniSTSRGSC3.4
Celera7104,728,893 - 104,729,100UniSTS
RH 3.4 Map7795.4UniSTS
Cytogenetic Map7q34UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 40 43 27 19 27 8 11 74 35 41 11 8
Low 3 14 14 14
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000019853   ⟹   ENSRNOP00000019852
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl7117,709,168 - 117,721,955 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000019876   ⟹   ENSRNOP00000019876
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7108,378,012 - 108,380,021 (-)Ensembl
Rnor_6.0 Ensembl7117,720,912 - 117,722,359 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000077172   ⟹   ENSRNOP00000068606
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7108,367,571 - 108,377,265 (-)Ensembl
Rnor_6.0 Ensembl7117,709,910 - 117,719,605 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000088696   ⟹   ENSRNOP00000071738
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7108,364,381 - 108,379,615 (-)Ensembl
Rnor_6.0 Ensembl7117,706,727 - 117,719,331 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000092789   ⟹   ENSRNOP00000075992
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl7117,721,206 - 117,722,723 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000092930   ⟹   ENSRNOP00000076014
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl7117,710,868 - 117,712,213 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000093083   ⟹   ENSRNOP00000076065
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl7117,708,755 - 117,722,703 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000111651   ⟹   ENSRNOP00000084336
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7108,364,381 - 108,377,265 (-)Ensembl
RefSeq Acc Id: NM_001025122   ⟹   NP_001020293
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87110,259,212 - 110,260,674 (-)NCBI
mRatBN7.27108,378,569 - 108,380,031 (-)NCBI
Rnor_6.07117,720,909 - 117,722,359 (-)NCBI
Celera7104,728,720 - 104,730,170 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001408118   ⟹   NP_001395047
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87110,259,212 - 110,261,096 (-)NCBI
mRatBN7.27108,378,569 - 108,380,453 (-)NCBI
RefSeq Acc Id: NM_001408119   ⟹   NP_001395048
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87110,259,212 - 110,260,674 (-)NCBI
mRatBN7.27108,378,569 - 108,380,031 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001020293 (Get FASTA)   NCBI Sequence Viewer  
  NP_001395047 (Get FASTA)   NCBI Sequence Viewer  
  NP_001395048 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH91178 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000019876
  ENSRNOP00000019876.3
  ENSRNOP00000068606.2
GenBank Protein P0DW88 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_001020293   ⟸   NM_001025122
- Peptide Label: isoform 1 precursor
- UniProtKB: P0DW88 (UniProtKB/Swiss-Prot),   Q5BK76 (UniProtKB/Swiss-Prot),   F1M4N0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000075992   ⟸   ENSRNOT00000092789
RefSeq Acc Id: ENSRNOP00000068606   ⟸   ENSRNOT00000077172
RefSeq Acc Id: ENSRNOP00000076014   ⟸   ENSRNOT00000092930
RefSeq Acc Id: ENSRNOP00000019876   ⟸   ENSRNOT00000019876
RefSeq Acc Id: ENSRNOP00000019852   ⟸   ENSRNOT00000019853
RefSeq Acc Id: ENSRNOP00000076065   ⟸   ENSRNOT00000093083
RefSeq Acc Id: ENSRNOP00000071738   ⟸   ENSRNOT00000088696
RefSeq Acc Id: ENSRNOP00000084336   ⟸   ENSRNOT00000111651
RefSeq Acc Id: NP_001395047   ⟸   NM_001408118
- Peptide Label: isoform 1 precursor
- UniProtKB: P0DW88 (UniProtKB/Swiss-Prot),   F1M4N0 (UniProtKB/Swiss-Prot),   Q5BK76 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: NP_001395048   ⟸   NM_001408119
- Peptide Label: isoform 2
Protein Domains
RING-type   TRAF-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5BK76-F1-model_v2 AlphaFold Q5BK76 1-311 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695432
Promoter ID:EPDNEW_R5956
Type:initiation region
Name:Cyhr1_1
Description:cysteine and histidine rich 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07117,722,371 - 117,722,431EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2318728 AgrOrtholog
BioCyc Gene G2FUF-32913 BioCyc
Ensembl Genes ENSRNOG00000014811 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000019876 ENTREZGENE
  ENSRNOT00000019876.7 UniProtKB/Swiss-Prot
  ENSRNOT00000077172.3 UniProtKB/TrEMBL
Gene3D-CATH Zinc/RING finger domain, C3HC4 (zinc finger) UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7325408 IMAGE-MGC_LOAD
InterPro Sina-like_RING UniProtKB/TrEMBL
  ZFTRAF1 UniProtKB/TrEMBL
  Znf_RING UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
  Znf_TRAF UniProtKB/TrEMBL
KEGG Report rno:100362155 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108816 IMAGE-MGC_LOAD
NCBI Gene 100362155 ENTREZGENE
PANTHER CYSTEINE AND HISTIDINE-RICH PROTEIN 1 UniProtKB/TrEMBL
  CYSTEINE AND HISTIDINE-RICH PROTEIN 1 UniProtKB/TrEMBL
Pfam Sina_RING UniProtKB/TrEMBL
PhenoGen Tmem276 PhenoGen
PROSITE ZF_RING_2 UniProtKB/TrEMBL
  ZF_TRAF UniProtKB/TrEMBL
RatGTEx ENSRNOG00000014811 RatGTEx
Superfamily-SCOP RING/U-box UniProtKB/TrEMBL
  TRAF domain-like UniProtKB/TrEMBL
UniProt A0A0G2JT83_RAT UniProtKB/TrEMBL
  F1M4N0 ENTREZGENE
  P0DW88 ENTREZGENE
  Q5BK76 ENTREZGENE
  TM276_RAT UniProtKB/Swiss-Prot
UniProt Secondary F1M4N0 UniProtKB/Swiss-Prot
  Q5BK76 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-02-14 Tmem276  Transmembrane protein 276  Zftraf1  zinc finger TRAF-type containing 1  Name and Symbol changed 629549 APPROVED
2022-05-27 Zftraf1  zinc finger TRAF-type containing 1  Cyhr1  cysteine and histidine rich 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-06-15 Cyhr1  cysteine and histidine rich 1  Cyhr1  cysteine/histidine-rich 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-03-02 Cyhr1  cysteine/histidine-rich 1  RGD1561328  cysteine and histidine rich 1-like  Data merged from RGD:1561328 737654 APPROVED
2012-08-27 RGD1561328  cysteine and histidine rich 1-like  Cyhr1  cysteine and histidine rich 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-08-27 Cyhr1  cysteine/histidine-rich 1  LOC100362155  cysteine and histidine rich 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-05 LOC100362155  cysteine and histidine rich 1      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-02-09 Cyhr1  cysteine and histidine rich 1      Symbol and Name status set to provisional 70820 PROVISIONAL