Dennd5b (DENN domain containing 5B) - Rat Genome Database

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Gene: Dennd5b (DENN domain containing 5B) Rattus norvegicus
Analyze
Symbol: Dennd5b
Name: DENN domain containing 5B
RGD ID: 2318606
Description: Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in positive regulation of triglyceride transport. Predicted to be located in membrane. Orthologous to human DENND5B (DENN domain containing 5B); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; amphetamine.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: DENN domain-containing protein 5B; DENN/MADD domain containing 5B; DENN/MADD domain containing 5B-like; LOC100365679
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84183,688,039 - 183,821,012 (-)NCBIGRCr8
mRatBN7.24181,959,597 - 182,089,661 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4181,961,386 - 182,089,362 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.04183,476,093 - 183,604,940 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4183,476,093 - 183,544,850 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04247,608,015 - 247,704,356 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera4170,433,402 - 170,556,221 (-)NCBICelera
Cytogenetic Map4q44NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
membrane  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:20937701   PMID:30837651  


Genomics

Comparative Map Data
Dennd5b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84183,688,039 - 183,821,012 (-)NCBIGRCr8
mRatBN7.24181,959,597 - 182,089,661 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4181,961,386 - 182,089,362 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.04183,476,093 - 183,604,940 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4183,476,093 - 183,544,850 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04247,608,015 - 247,704,356 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera4170,433,402 - 170,556,221 (-)NCBICelera
Cytogenetic Map4q44NCBI
DENND5B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381231,382,226 - 31,591,136 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1231,382,226 - 31,591,136 (-)EnsemblGRCh38hg38GRCh38
GRCh371231,535,160 - 31,744,070 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361231,426,424 - 31,635,219 (-)NCBINCBI36Build 36hg18NCBI36
Celera1211,356,369 - 11,566,294 (-)NCBICelera
Cytogenetic Map12p11.21NCBI
HuRef1231,287,816 - 31,496,409 (-)NCBIHuRef
CHM1_11231,500,166 - 31,708,943 (-)NCBICHM1_1
T2T-CHM13v2.01231,258,770 - 31,467,670 (-)NCBIT2T-CHM13v2.0
Dennd5b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396148,889,566 - 149,003,178 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6148,889,569 - 149,003,178 (-)EnsemblGRCm39 Ensembl
GRCm386148,988,069 - 149,101,680 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6148,988,071 - 149,101,680 (-)EnsemblGRCm38mm10GRCm38
MGSCv376148,936,591 - 149,050,202 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366148,971,158 - 149,058,708 (-)NCBIMGSCv36mm8
Celera6152,026,106 - 152,141,735 (-)NCBICelera
Cytogenetic Map6G3NCBI
cM Map678.71NCBI
Dennd5b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555054,208,320 - 4,295,112 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555054,134,686 - 4,295,112 (+)NCBIChiLan1.0ChiLan1.0
DENND5B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21065,179,861 - 65,390,784 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11265,176,281 - 65,387,177 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01254,650,609 - 54,858,862 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11257,236,855 - 57,444,819 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1257,236,973 - 57,444,819 (+)Ensemblpanpan1.1panPan2
DENND5B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12717,250,526 - 17,366,021 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2717,044,309 - 17,361,570 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2729,051,206 - 29,250,680 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02717,348,446 - 17,549,134 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2717,348,446 - 17,548,801 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12717,159,010 - 17,358,756 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02717,191,053 - 17,389,619 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02729,204,343 - 29,403,719 (-)NCBIUU_Cfam_GSD_1.0
Dennd5b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494577,825,694 - 77,945,439 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366074,663,703 - 4,775,956 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366074,598,370 - 4,777,241 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DENND5B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl542,643,115 - 42,879,729 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1542,642,676 - 42,870,980 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2545,983,366 - 46,005,315 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DENND5B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11130,858,764 - 31,060,928 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1130,859,822 - 31,060,633 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660693,926,033 - 4,127,804 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dennd5b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247784,680,389 - 4,873,418 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247784,680,320 - 4,870,818 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dennd5b
335 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:26
Count of miRNA genes:25
Interacting mature miRNAs:26
Transcripts:ENSRNOT00000071407
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4145568712182687754Rat
10053718Scort25Serum corticosterone level QTL 252.150.0097blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4155561574182687754Rat
1300109Rf13Renal function QTL 133.91renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)4157710145182687754Rat

Markers in Region
D4Got145  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera4170,557,329 - 170,557,455UniSTS
RH 3.4 Map41123.61UniSTS
RH 3.4 Map41123.61RGD
D4Got244  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.04183,519,270 - 183,519,510NCBIRnor6.0
Rnor_5.04247,647,242 - 247,647,499UniSTSRnor5.0
Celera4170,472,849 - 170,473,107UniSTS
AI852444  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24181,956,754 - 181,956,868 (+)MAPPERmRatBN7.2
Rnor_6.04183,470,149 - 183,470,262NCBIRnor6.0
Rnor_5.04247,598,648 - 247,598,761UniSTSRnor5.0
Celera4170,424,501 - 170,424,614UniSTS
RH138972  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24182,085,815 - 182,085,939 (+)MAPPERmRatBN7.2
Rnor_6.04183,601,459 - 183,601,582NCBIRnor6.0
Rnor_5.04247,726,314 - 247,726,437UniSTSRnor5.0
Celera4170,552,283 - 170,552,406UniSTS
RH 3.4 Map10499.9UniSTS
RH141419  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24181,961,361 - 181,961,558 (+)MAPPERmRatBN7.2
Rnor_6.04183,474,755 - 183,474,951NCBIRnor6.0
Rnor_5.04247,603,254 - 247,603,450UniSTSRnor5.0
Celera4170,429,106 - 170,429,302UniSTS
RH 3.4 Map41122.2UniSTS
AI104522  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24181,956,766 - 181,956,997 (+)MAPPERmRatBN7.2
Rnor_6.04183,470,161 - 183,470,391NCBIRnor6.0
Rnor_5.04247,598,660 - 247,598,890UniSTSRnor5.0
Celera4170,424,513 - 170,424,743UniSTS
RH 3.4 Map41125.62UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 34 35 25 13 25 8 8 74 31 36 11 8
Low 1 9 22 16 6 16 3 4 5
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000071407   ⟹   ENSRNOP00000064573
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4181,961,386 - 182,029,466 (-)Ensembl
Rnor_6.0 Ensembl4183,476,093 - 183,544,850 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000101410   ⟹   ENSRNOP00000086881
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4181,961,386 - 182,089,362 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000105569   ⟹   ENSRNOP00000085174
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4181,961,386 - 182,089,362 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000107257   ⟹   ENSRNOP00000096895
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4181,961,386 - 182,089,362 (-)Ensembl
RefSeq Acc Id: XM_039108922   ⟹   XP_038964850
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84183,688,039 - 183,821,009 (-)NCBI
mRatBN7.24181,959,597 - 182,089,657 (-)NCBI
RefSeq Acc Id: XM_039108923   ⟹   XP_038964851
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84183,688,039 - 183,821,009 (-)NCBI
mRatBN7.24181,959,597 - 182,089,656 (-)NCBI
RefSeq Acc Id: XM_039108924   ⟹   XP_038964852
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84183,688,039 - 183,821,007 (-)NCBI
mRatBN7.24181,959,597 - 182,089,655 (-)NCBI
RefSeq Acc Id: XM_039108925   ⟹   XP_038964853
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84183,688,039 - 183,821,012 (-)NCBI
mRatBN7.24181,959,597 - 182,089,661 (-)NCBI
RefSeq Acc Id: XM_039108926   ⟹   XP_038964854
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84183,688,039 - 183,821,007 (-)NCBI
mRatBN7.24181,959,597 - 182,089,654 (-)NCBI
RefSeq Acc Id: XM_063286868   ⟹   XP_063142938
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84183,688,039 - 183,797,689 (-)NCBI
RefSeq Acc Id: ENSRNOP00000064573   ⟸   ENSRNOT00000071407
RefSeq Acc Id: XP_038964853   ⟸   XM_039108925
- Peptide Label: isoform X4
- UniProtKB: A0A8I6AR19 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038964850   ⟸   XM_039108922
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AR19 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038964851   ⟸   XM_039108923
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A6X2 (UniProtKB/TrEMBL),   A0A8I6AR19 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038964852   ⟸   XM_039108924
- Peptide Label: isoform X3
- UniProtKB: A0A8I5ZYN4 (UniProtKB/TrEMBL),   A0A8I6AR19 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038964854   ⟸   XM_039108926
- Peptide Label: isoform X5
- UniProtKB: A0A8I6AR19 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000085174   ⟸   ENSRNOT00000105569
RefSeq Acc Id: ENSRNOP00000086881   ⟸   ENSRNOT00000101410
RefSeq Acc Id: ENSRNOP00000096895   ⟸   ENSRNOT00000107257
RefSeq Acc Id: XP_063142938   ⟸   XM_063286868
- Peptide Label: isoform X6
Protein Domains
PLAT   RUN   uDENN

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0R5A9-F1-model_v2 AlphaFold M0R5A9 1-977 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2318606 AgrOrtholog
BioCyc Gene G2FUF-42368 BioCyc
Ensembl Genes ENSRNOG00000049378 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000071407.3 UniProtKB/TrEMBL
  ENSRNOT00000101410.1 UniProtKB/TrEMBL
  ENSRNOT00000105569.1 UniProtKB/TrEMBL
  ENSRNOT00000107257.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.58.900 UniProtKB/TrEMBL
  3.30.450.200 UniProtKB/TrEMBL
  3.40.50.11500 UniProtKB/TrEMBL
  PLAT/LH2 domain UniProtKB/TrEMBL
InterPro cDENN_dom UniProtKB/TrEMBL
  dDENN_dom UniProtKB/TrEMBL
  DEN5A/B UniProtKB/TrEMBL
  DENN_C UniProtKB/TrEMBL
  PLAT/LH2_dom UniProtKB/TrEMBL
  PLAT/LH2_dom_sf UniProtKB/TrEMBL
  PLAT_RAB6IP1 UniProtKB/TrEMBL
  RUN1_DENND5B UniProtKB/TrEMBL
  RUN2_DENND5B UniProtKB/TrEMBL
  Run_dom UniProtKB/TrEMBL
  Run_dom_sf UniProtKB/TrEMBL
  Tripartite_DENN UniProtKB/TrEMBL
  uDENN_dom UniProtKB/TrEMBL
NCBI Gene 100365679 ENTREZGENE
PANTHER DENN DOMAIN-CONTAINING PROTEIN 5B UniProtKB/TrEMBL
  PINSTRIPE, ISOFORM A UniProtKB/TrEMBL
Pfam dDENN UniProtKB/TrEMBL
  DENN UniProtKB/TrEMBL
  PLAT UniProtKB/TrEMBL
  RUN UniProtKB/TrEMBL
  uDENN UniProtKB/TrEMBL
PhenoGen Dennd5b PhenoGen
PROSITE DENN UniProtKB/TrEMBL
  PLAT UniProtKB/TrEMBL
  RUN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000049378 RatGTEx
SMART dDENN UniProtKB/TrEMBL
  DENN UniProtKB/TrEMBL
  RUN UniProtKB/TrEMBL
  uDENN UniProtKB/TrEMBL
Superfamily-SCOP SSF140741 UniProtKB/TrEMBL
  SSF49723 UniProtKB/TrEMBL
UniProt A0A8I5ZYN4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A6X2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AR19 ENTREZGENE, UniProtKB/TrEMBL
  M0R5A9_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-17 Dennd5b  DENN domain containing 5B  Dennd5b  DENN/MADD domain containing 5B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-08-08 Dennd5b  DENN/MADD domain containing 5B  LOC100365679  DENN/MADD domain containing 5B-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-05 LOC100365679  DENN/MADD domain containing 5B-like      Symbol and Name status set to provisional 70820 PROVISIONAL