Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (+)-catechin | multiple interactions | ISO | DENND5B (Homo sapiens) | 6480464 | [Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of DENND5B mRNA | CTD | PMID:24763279 | (1->4)-beta-D-glucan | multiple interactions | ISO | Dennd5b (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of DENND5B mRNA | CTD | PMID:36331819 | 1,2-dimethylhydrazine | decreases expression | ISO | Dennd5b (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of DENND5B mRNA | CTD | PMID:22206623 | 17alpha-ethynylestradiol | increases expression | EXP | | 6480464 | Ethinyl Estradiol results in increased expression of DENND5B mRNA | CTD | PMID:29097150 | 2,3',4,4',5-Pentachlorobiphenyl | increases expression | ISO | Dennd5b (Mus musculus) | 6480464 | 2 more ... | CTD | PMID:31388691 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Dennd5b (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of DENND5B mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of DENND5B mRNA | CTD | PMID:32109520 | 3,4-methylenedioxymethamphetamine | decreases expression | ISO | Dennd5b (Mus musculus) | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in decreased expression of DENND5B mRNA | CTD | PMID:26251327 | 4,4'-sulfonyldiphenol | increases methylation | ISO | Dennd5b (Mus musculus) | 6480464 | bisphenol S results in increased methylation of DENND5B exon | CTD | PMID:33297965 | 4,4'-sulfonyldiphenol | decreases methylation | ISO | DENND5B (Homo sapiens) | 6480464 | bisphenol S results in decreased methylation of DENND5B gene | CTD | PMID:31601247 | 4-hydroxyphenyl retinamide | increases expression | ISO | Dennd5b (Mus musculus) | 6480464 | Fenretinide results in increased expression of DENND5B mRNA | CTD | PMID:28973697 | aflatoxin B1 | increases expression | ISO | Dennd5b (Mus musculus) | 6480464 | Aflatoxin B1 results in increased expression of DENND5B mRNA | CTD | PMID:19770486 | all-trans-retinoic acid | increases expression | ISO | DENND5B (Homo sapiens) | 6480464 | Tretinoin results in increased expression of DENND5B mRNA | CTD | PMID:21934132 | all-trans-retinoic acid | decreases expression | ISO | DENND5B (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of DENND5B mRNA | CTD | PMID:33167477 | amphetamine | decreases expression | EXP | | 6480464 | Amphetamine results in decreased expression of DENND5B mRNA | CTD | PMID:30779732 | antirheumatic drug | increases expression | ISO | DENND5B (Homo sapiens) | 6480464 | Antirheumatic Agents results in increased expression of DENND5B mRNA | CTD | PMID:24449571 | aristolochic acid A | decreases expression | ISO | DENND5B (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of DENND5B mRNA | CTD | PMID:33212167 | atrazine | decreases expression | ISO | DENND5B (Homo sapiens) | 6480464 | Atrazine results in decreased expression of DENND5B mRNA | CTD | PMID:22378314 | avobenzone | increases expression | ISO | DENND5B (Homo sapiens) | 6480464 | avobenzone results in increased expression of DENND5B mRNA | CTD | PMID:31016361 | benzo[a]pyrene | increases mutagenesis | ISO | DENND5B (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased mutagenesis of DENND5B gene | CTD | PMID:25435355 | benzo[a]pyrene | decreases expression | ISO | DENND5B (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of DENND5B mRNA | CTD | PMID:32234424 | benzo[a]pyrene | increases methylation | ISO | DENND5B (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of DENND5B promoter | CTD | PMID:27901495 | benzo[a]pyrene | multiple interactions | ISO | Dennd5b (Mus musculus) | 6480464 | AHR protein affects the reaction [Benzo(a)pyrene affects the expression of DENND5B mRNA] | CTD | PMID:22228805 | bisphenol A | decreases expression | ISO | Dennd5b (Mus musculus) | 6480464 | bisphenol A results in decreased expression of DENND5B mRNA | CTD | PMID:26063408 | bisphenol A | multiple interactions | ISO | DENND5B (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in increased methylation of DENND5B gene | CTD | PMID:31601247 | bisphenol A | decreases methylation | ISO | DENND5B (Homo sapiens) | 6480464 | bisphenol A results in decreased methylation of DENND5B gene | CTD | PMID:31601247 | caffeine | decreases phosphorylation | ISO | DENND5B (Homo sapiens) | 6480464 | Caffeine results in decreased phosphorylation of DENND5B protein | CTD | PMID:35688186 | carbon nanotube | decreases expression | ISO | Dennd5b (Mus musculus) | 6480464 | Nanotubes and Carbon analog results in decreased expression of DENND5B mRNA | CTD | PMID:25554681 | chlorpyrifos | decreases expression | ISO | Dennd5b (Mus musculus) | 6480464 | Chlorpyrifos results in decreased expression of DENND5B mRNA | CTD | PMID:37019170 | cisplatin | multiple interactions | ISO | DENND5B (Homo sapiens) | 6480464 | [Cisplatin co-treated with jinfukang] results in decreased expression of DENND5B mRNA | CTD | PMID:27392435 | cisplatin | decreases expression | ISO | DENND5B (Homo sapiens) | 6480464 | Cisplatin results in decreased expression of DENND5B mRNA | CTD | PMID:27392435 | cobalt dichloride | increases expression | EXP | | 6480464 | cobaltous chloride results in increased expression of DENND5B mRNA | CTD | PMID:24386269 | folic acid | increases expression | ISO | Dennd5b (Mus musculus) | 6480464 | Folic Acid results in increased expression of DENND5B mRNA | CTD | PMID:25629700 | FR900359 | increases phosphorylation | ISO | DENND5B (Homo sapiens) | 6480464 | FR900359 results in increased phosphorylation of DENND5B protein | CTD | PMID:37730182 | fulvestrant | multiple interactions | ISO | DENND5B (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in increased methylation of DENND5B gene | CTD | PMID:31601247 | genistein | increases expression | ISO | Dennd5b (Mus musculus) | 6480464 | Genistein results in increased expression of DENND5B mRNA | CTD | PMID:32186404 | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of DENND5B mRNA | CTD | PMID:33387578 | ozone | multiple interactions | ISO | Dennd5b (Mus musculus) | 6480464 | [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased expression of DENND5B mRNA | CTD | PMID:34911549 | paracetamol | decreases expression | ISO | DENND5B (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of DENND5B mRNA | CTD | PMID:21420995 | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of DENND5B mRNA | CTD | PMID:33387578 | parathion | increases expression | ISO | Dennd5b (Mus musculus) | 6480464 | Parathion results in increased expression of DENND5B mRNA | CTD | PMID:34813904 | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Dennd5b (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of DENND5B mRNA | CTD | PMID:36331819 | phenobarbital | affects expression | ISO | Dennd5b (Mus musculus) | 6480464 | Phenobarbital affects the expression of DENND5B mRNA | CTD | PMID:23091169 | potassium dichromate | decreases expression | ISO | DENND5B (Homo sapiens) | 6480464 | Potassium Dichromate results in decreased expression of DENND5B protein | CTD | PMID:23718831 | potassium dichromate | decreases expression | ISO | Dennd5b (Mus musculus) | 6480464 | Potassium Dichromate results in decreased expression of DENND5B mRNA | CTD | PMID:23608068 | sodium fluoride | increases expression | ISO | Dennd5b (Mus musculus) | 6480464 | Sodium Fluoride results in increased expression of DENND5B mRNA | CTD | PMID:27862939 | testosterone | decreases expression | ISO | DENND5B (Homo sapiens) | 6480464 | Testosterone results in decreased expression of DENND5B mRNA | CTD | PMID:33359661 | trichostatin A | increases expression | ISO | DENND5B (Homo sapiens) | 6480464 | trichostatin A results in increased expression of DENND5B mRNA | CTD | PMID:24935251 | troglitazone | decreases expression | ISO | Dennd5b (Mus musculus) | 6480464 | troglitazone results in decreased expression of DENND5B mRNA | CTD | PMID:28973697 | trovafloxacin | increases expression | ISO | Dennd5b (Mus musculus) | 6480464 | trovafloxacin results in increased expression of DENND5B mRNA | CTD | PMID:35537566 | tungsten | decreases expression | ISO | Dennd5b (Mus musculus) | 6480464 | Tungsten results in decreased expression of DENND5B mRNA | CTD | PMID:30912803 | valproic acid | decreases expression | ISO | DENND5B (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of DENND5B mRNA | CTD | PMID:23179753 | valproic acid | increases expression | ISO | DENND5B (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of DENND5B mRNA | CTD | PMID:23179753 more ... | zinc atom | increases expression | ISO | DENND5B (Homo sapiens) | 6480464 | Zinc deficiency results in increased expression of DENND5B mRNA | CTD | PMID:22171008 | zinc(0) | increases expression | ISO | DENND5B (Homo sapiens) | 6480464 | Zinc deficiency results in increased expression of DENND5B mRNA | CTD | PMID:22171008 | |