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Gene-Chemical Interaction AnnotationsGene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 17beta-hydroxy-5alpha-androstan-3-one | increases expression | ISO | RGD:736792 | 6480464 | Dihydrotestosterone results in increased expression of ADCYAP1R1 mRNA | CTD | PMID:17254854 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of ADCYAP1R1 mRNA | CTD | PMID:21215274 | 4,4'-diaminodiphenylmethane | increases expression | ISO | RGD:10085 | 6480464 | 4,4'-diaminodiphenylmethane results in increased expression of ADCYAP1R1 mRNA | CTD | PMID:18648102 | benzo[a]pyrene | multiple interactions | ISO | RGD:10085 | 6480464 | [Benzo(a)pyrene co-treated with XPA gene mutant form co-treated with TRP53 gene mutant form] affects the expression of ADCYAP1R1 mRNA | CTD | PMID:21715664 | benzo[a]pyrene | increases expression | ISO | RGD:10085 | 6480464 | Benzo(a)pyrene results in increased expression of ADCYAP1R1 mRNA | CTD | PMID:22228805 | benzo[a]pyrene | multiple interactions | ISO | RGD:10085 | 6480464 | AHR protein affects the reaction [Benzo(a)pyrene affects the expression of ADCYAP1R1 mRNA] | CTD | PMID:22228805 | cyclophosphamide | affects expression | EXP | | 6480464 | Cyclophosphamide affects the expression of ADCYAP1R1 mRNA | CTD | PMID:18563302 | dibutyl phthalate | decreases expression | ISO | RGD:10085 | 6480464 | Dibutyl Phthalate results in decreased expression of ADCYAP1R1 mRNA | CTD | PMID:21266533 | ethanol | decreases expression | EXP | | 6480464 | Ethanol results in decreased expression of ADCYAP1R1 mRNA | CTD | PMID:20655511 | exemestane | increases expression | ISO | RGD:736792 | 6480464 | exemestane results in increased expression of ADCYAP1R1 mRNA | CTD | PMID:17254854 | pirinixic acid | multiple interactions | ISO | RGD:10085 | 6480464 | NCF1 protein promotes the reaction [pirinixic acid results in decreased expression of ADCYAP1R1 mRNA] | CTD | PMID:17950772 | pirinixic acid | decreases expression | ISO | RGD:10085 | 6480464 | pirinixic acid results in decreased expression of ADCYAP1R1 mRNA | CTD | PMID:17950772 | pirinixic acid | decreases expression | EXP | | 6480464 | pirinixic acid results in decreased expression of ADCYAP1R1 mRNA | CTD | PMID:19162173 | tacrine | increases expression | EXP | | 6480464 | Tacrine results in increased expression of ADCYAP1R1 mRNA | CTD | PMID:12832660 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology AnnotationsMolecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Circadian entrainment |
| Insulin secretion | |
| Neuroactive ligand-receptor interaction | |
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Circadian entrainment |
| Insulin secretion | |
| Neuroactive ligand-receptor interaction | |
References - curated| 1. |
Abu-Hamdan MD, etal., Neuroscience. 2006 Jun 19;140(1):147-61. Epub 2006 Apr 19. |
| 2. |
Apostolakis EM, etal., Mol Endocrinol. 2005 Nov;19(11):2798-811. Epub 2005 Jun 23. |
| 3. |
Chatterjee TK, etal., J Biol Chem. 1996 Dec 13;271(50):32226-32. |
| 4. |
Drescher MJ, etal., Neuroscience. 2006 Sep 29;142(1):139-64. Epub 2006 Jul 31. |
| 5. |
Girard BM, etal., J Mol Neurosci. 2008 Nov;36(1-3):310-20. Epub 2008 Jun 19. |
| 6. |
GOA data from the GO Consortium |
| 7. |
Hammack SE, etal., Psychoneuroendocrinology. 2009 Jul;34(6):833-43. Epub 2009 Jan 31. |
| 8. |
Koh PO and Won CK, J Vet Med Sci. 2006 Jun;68(6):537-41. |
| 9. |
Kojro E, etal., FASEB J. 2006 Mar;20(3):512-4. Epub 2006 Jan 9. |
| 10. |
McCaffrey G, etal., Traffic. 2009 Jul;10(7):938-50. Epub 2009 Mar 5. |
| 11. |
McCulloch DA, etal., Mol Pharmacol. 2001 Jun;59(6):1523-32. |
| 12. |
MGD data from the GO Consortium |
| 13. |
Miampamba M, etal., Regul Pept 2002 May 30;105(3):145-54. |
| 14. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 15. |
Nicot A, etal., J Neurosci 2002 Nov 1;22(21):9244-54. |
| 16. |
Oh DS, etal., J Mol Neurosci. 2005;26(1):85-97. |
| 17. |
Pilzer I and Gozes I, Peptides. 2006 Nov;27(11):2867-76. Epub 2006 Aug 14. |
| 18. |
Pisegna JR and Wank SA, Proc Natl Acad Sci U S A 1993 Jul 1;90(13):6345-9. |
| 19. |
Reichenstein M, etal., J Mol Neurosci. 2008 Nov;36(1-3):330-8. Epub 2008 Jul 1. |
| 20. |
RGD automated import pipeline for gene-chemical interactions |
| 21. |
Riek-Burchardt M, etal., Neuropharmacology. 2010 Jan;58(1):199-207. Epub 2009 Jul 30. |
| 22. |
Seki T, etal., Neurosci Lett. 1997 Dec 5;238(3):127-30. |
| 23. |
Spengler D, etal., Nature 1993 Sep 9;365(6442):170-5. |
| 24. |
Tominaga A, etal., J Mol Neurosci. 2008 Nov;36(1-3):73-8. Epub 2008 Jul 15. |
| 25. |
Vaccari S, etal., J Endocrinol. 2006 Oct;191(1):287-99. |
| 26. |
Zhang W, etal., J Neurochem. 2007 Nov;103(3):1157-67. Epub 2007 Aug 6. |
References - uncurated| PubMed | 11784714 |
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| 16888209 | |
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| 16888229 | |
| 17213203 | |
| 18337184 | |
| 18353507 | |
| 20093365 | |
| 20599818 | |
| 21539889 | |
| 21620115 | |
| 21693142 | |
| 22766684 | |
| 22886412 | |
| 23080176 | |
| 7687425 | |
| 8394723 | |
| 8394834 | |
| 8396930 | |
| 9115282 |
RGD Disease Portals| Adcyap1r1 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Adcyap1r1 (Rattus norvegicus) |
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| ADCYAP1R1 (Homo sapiens) |
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| Adcyap1r1 (Mus musculus) |
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Position Markers| AI846590 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_001270579 | (Get FASTA) | Search GEO for Microarray Profiles |
| NM_001270580 | (Get FASTA) | Search GEO for Microarray Profiles | |
| NM_001270581 | (Get FASTA) | Search GEO for Microarray Profiles | |
| NM_001270582 | (Get FASTA) | Search GEO for Microarray Profiles | |
| NM_001270583 | (Get FASTA) | Search GEO for Microarray Profiles | |
| NM_133511 | (Get FASTA) | Search GEO for Microarray Profiles | |
| GenBank Nucleotide | AABR06031052 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHX01030274 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AC091657 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH474011 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CR475040 | (Get FASTA) | Search GEO for Microarray Profiles | |
| D14908 | (Get FASTA) | Search GEO for Microarray Profiles | |
| D14909 | (Get FASTA) | Search GEO for Microarray Profiles | |
| D16465 | (Get FASTA) | Search GEO for Microarray Profiles | |
| L16506 | (Get FASTA) | Search GEO for Microarray Profiles | |
| L16680 | (Get FASTA) | Search GEO for Microarray Profiles | |
| U82669 | (Get FASTA) | Search GEO for Microarray Profiles | |
| U84740 | (Get FASTA) | Search GEO for Microarray Profiles | |
| Z22735 | (Get FASTA) | Search GEO for Microarray Profiles | |
| Z23272 | (Get FASTA) | Search GEO for Microarray Profiles | |
| Z23273 | (Get FASTA) | Search GEO for Microarray Profiles | |
| Z23274 | (Get FASTA) | Search GEO for Microarray Profiles | |
| Z23275 | (Get FASTA) | Search GEO for Microarray Profiles | |
| Z23279 | (Get FASTA) | Search GEO for Microarray Profiles | |
| Z23282 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_133511 | ||||||||||||||||||||
| RefSeq Status: | VALIDATED | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_598195 | ||||||||||||||||||||
| Peptide Label: | precursor | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_001257508 | (Get FASTA) |
| NP_001257509 | (Get FASTA) | |
| NP_001257510 | (Get FASTA) | |
| NP_001257511 | (Get FASTA) | |
| NP_001257512 | (Get FASTA) | |
| NP_598195 | (Get FASTA) | |
| GenBank Protein | AAA02990 | (Get FASTA) |
| AAA41792 | (Get FASTA) | |
| AAG16771 | (Get FASTA) | |
| BAA03608 | (Get FASTA) | |
| BAA03609 | (Get FASTA) | |
| BAA03932 | (Get FASTA) | |
| CAA80429 | (Get FASTA) | |
| CAA80810 | (Get FASTA) | |
| CAA80811 | (Get FASTA) | |
| CAA80812 | (Get FASTA) | |
| CAA80813 | (Get FASTA) | |
| CAA80817 | (Get FASTA) | |
| CAA80820 | (Get FASTA) | |
| CAA80821 | (Get FASTA) | |
| EDL88073 | (Get FASTA) | |
| EDL88074 | (Get FASTA) | |
| EDL88075 | (Get FASTA) | |
| EDL88076 | (Get FASTA) | |
| EDL88077 | (Get FASTA) | |
| EDL88078 | (Get FASTA) | |
| EDL88079 | (Get FASTA) | |
| EDL88080 | (Get FASTA) | |
| EDL88081 | (Get FASTA) | |
| EDL88082 | (Get FASTA) | |
| EDL88083 | (Get FASTA) | |
| EDL88084 | (Get FASTA) | |
| P32215 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000012098 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Protein | ENSRNOP00000016175 | UniProtKB/Swiss-Prot |
| ENSRNOP00000030759 | ENTREZGENE, UniProtKB/Swiss-Prot | |
| ENSRNOP00000044267 | UniProtKB/Swiss-Prot | |
| ENSRNOP00000050048 | UniProtKB/Swiss-Prot | |
| Ensembl Transcript | ENSRNOT00000016175 | UniProtKB/Swiss-Prot |
| ENSRNOT00000035722 | ENTREZGENE, UniProtKB/Swiss-Prot | |
| ENSRNOT00000043851 | UniProtKB/Swiss-Prot | |
| ENSRNOT00000046192 | UniProtKB/Swiss-Prot | |
| Entrez Gene | 24167 | ENTREZGENE |
| Germonline | ENSRNOG00000012098 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 870 | ENTREZGENE |
| InterPro | GPCR_2-like | UniProtKB/Swiss-Prot |
| GPCR_2_extracellular_dom | UniProtKB/Swiss-Prot | |
| GPCR_2_PACAP_1_rcpt | UniProtKB/Swiss-Prot | |
| GPCR_2_secretin-like | UniProtKB/Swiss-Prot | |
| GPCR_2_secretin-like_CS | UniProtKB/Swiss-Prot | |
| IPI | IPI00214249 | UniProtKB/Swiss-Prot |
| IPI00231305 | UniProtKB/Swiss-Prot | |
| IPI00231306 | UniProtKB/Swiss-Prot | |
| IPI00231307 | UniProtKB/Swiss-Prot | |
| IPI00231308 | UniProtKB/Swiss-Prot | |
| KEGG Report | rno:24167 | ENTREZGENE, UniProtKB/Swiss-Prot |
| PANTHER | PAC_1_rcpt | UniProtKB/Swiss-Prot |
| Pfam | 7tm_2 | UniProtKB/Swiss-Prot |
| HRM | UniProtKB/Swiss-Prot | |
| PRINTS | GPCRSECRETIN | UniProtKB/Swiss-Prot |
| PACAPRECEPTR | UniProtKB/Swiss-Prot | |
| PROSITE | G_PROTEIN_RECEP_F2_1 | UniProtKB/Swiss-Prot |
| G_PROTEIN_RECEP_F2_2 | UniProtKB/Swiss-Prot | |
| G_PROTEIN_RECEP_F2_3 | UniProtKB/Swiss-Prot | |
| G_PROTEIN_RECEP_F2_4 | UniProtKB/Swiss-Prot | |
| SMART | HormR | UniProtKB/Swiss-Prot |
| UniGene | Rn.7552 | ENTREZGENE |
| UniProt | PACR_RAT | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2010-05-28 | Adcyap1r1 | adenylate cyclase activating polypeptide 1 receptor 1 | Adcyap1r1 | adenylate cyclase activating polypeptide 1 (pituitary) receptor type I | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2008-09-18 | Adcyap1r1 | adenylate cyclase activating polypeptide 1 (pituitary) receptor type I | Adcyap1r1 | adenylate cyclase activating polypeptide 1 receptor 1 | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2008-05-15 | Adcyap1r1 | adenylate cyclase activating polypeptide 1 receptor 1 | Adcyap1r-1 | adenylate cyclase activating polypeptide 1 type 1 receptor | Symbol and Name updated | 10779 | APPROVED |
| 2001-06-29 | Adcyap1r1 | adenylate cyclase activating polypeptide 1 receptor 1 | Name withdrawn | 461 | WITHDRAWN | ||
| 2001-06-29 | Adcyap1r1 | adenylate cyclase activating polypeptide 1 receptor 1 | Name updated to reflect Human and Mouse nomenclature | 461 | APPROVED | ||
| 2001-06-18 | Adcyap1r1 | adenylate cyclase activating polypeptide 1 receptor 1 | Name updated to reflect Human and Mouse nomenclature | 461 | APPROVED | ||
| 2001-06-18 | Adcyap1r1 | Rat pituitary adenylate cyclase activating polypeptide 1 receptor (1) | Name withdrawn | 461 | WITHDRAWN |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_disease | a therapeutic target in childhood medulloblastoma (a granule cell malignancy caused by abnormal Shh-signaling) | 628387 |
| gene_domains | contains seven transmembrane domains characteristic of G-protein coupled receptors | 631731 |
| gene_expression | expressed in the hypothalamus, brain stem, adrenal gland, testis, and pituitary | 631732 |
| gene_expression | mRNA expressed in the developing cerebellum | 628387 |
| gene_function | high-affinity receptor for pituitary adenylyl cyclase-activating polypeptide | 631731 |
| gene_process | involved in adenylyl cyclase and phospholipase C mediated signaling | 631732 |
| gene_process | regulates neuropeptide signaling | 631731 |
| gene_process | regulates neural precursor proliferation | 628387 |
| gene_process | participates in inhibitory signaling for Shh-induced proliferation in the developing cerebellum | 628387 |
| gene_transcript | has four splice variants with insertions within the third intracellular loop | 631732 |
| More on Adcyap1r1 | |
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Entrez Gene |
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Ensembl Gene |
| Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 2038 |
| Created: | 2000-05-25 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-23 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.