Znf57l (zinc finger protein 57 like) - Rat Genome Database

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Gene: Znf57l (zinc finger protein 57 like) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Znf57l (Ensembl: LOC100125368)
Name: zinc finger protein 57 like (Ensembl:zinc finger protein LOC100125368)
RGD ID: 1642422
Description: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to several human genes including ZNF490 (zinc finger protein 490).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC100125368; LOC102551539; MGC156774; uncharacterized protein LOC100125368; zinc finger protein 431-like; zinc finger protein 709-like; zinc finger protein LOC100125368
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr878,688,422 - 8,712,170 (-)NCBIGRCr8
mRatBN7.278,037,649 - 8,060,640 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl78,037,652 - 8,060,035 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx710,924,214 - 10,946,485 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0712,799,878 - 12,822,149 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0710,662,089 - 10,689,359 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0710,893,763 - 10,916,685 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl710,498,064 - 10,500,392 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl710,894,119 - 10,896,447 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0711,063,248 - 11,086,179 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.479,510,066 - 9,532,434 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera76,228,621 - 6,251,007 (-)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleus  (IBA)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932  


Genomics

Variants

.
Variants in Znf57l
192 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7127829089Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)766427026029351Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat
10755440Coatc10Coat color QTL 100coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7749649952496499Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7757398552573985Rat

Markers in Region
RH137268  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.278,061,965 - 8,062,126 (+)MAPPERmRatBN7.2
Rnor_6.0710,917,374 - 10,917,534NCBIRnor6.0
Rnor_6.099,931,054 - 9,931,214NCBIRnor6.0
Rnor_5.0711,086,859 - 11,087,019UniSTSRnor5.0
Rnor_5.098,931,481 - 8,931,641UniSTSRnor5.0
RGSC_v3.479,534,379 - 9,534,539UniSTSRGSC3.4
Celera76,252,952 - 6,253,112UniSTS
Cytogenetic Map7q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system exocrine system hepatobiliary system nervous system reproductive system
High
Medium
Low
Below cutoff 1 1 1 2 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000031481   ⟹   ENSRNOP00000058056
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl78,037,652 - 8,060,035 (-)Ensembl
Rnor_6.0 Ensembl710,894,119 - 10,896,447 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000043099   ⟹   ENSRNOP00000045941
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl710,498,064 - 10,500,392 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000096798   ⟹   ENSRNOP00000094472
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl78,037,722 - 8,040,691 (-)Ensembl
RefSeq Acc Id: NM_001139487   ⟹   NP_001132959
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr878,688,422 - 8,710,790 (-)NCBI
mRatBN7.278,037,652 - 8,060,020 (-)NCBI
Rnor_6.0710,893,766 - 10,916,134 (-)NCBI
Rnor_5.0711,063,248 - 11,086,179 (-)NCBI
RGSC_v3.479,510,066 - 9,532,434 (-)RGD
Celera76,228,621 - 6,251,007 (-)RGD
Sequence:
RefSeq Acc Id: XM_006240835   ⟹   XP_006240897
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr878,688,422 - 8,712,170 (-)NCBI
mRatBN7.278,037,649 - 8,052,337 (-)NCBI
Rnor_6.0710,893,763 - 10,908,153 (-)NCBI
Rnor_5.0711,063,248 - 11,086,179 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008765080   ⟹   XP_008763302
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr878,688,422 - 8,712,170 (-)NCBI
mRatBN7.278,037,649 - 8,060,640 (-)NCBI
Rnor_6.0710,893,763 - 10,916,685 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063262827   ⟹   XP_063118897
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr878,688,422 - 8,712,170 (-)NCBI
RefSeq Acc Id: XM_063262828   ⟹   XP_063118898
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr878,688,422 - 8,712,170 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001132959   ⟸   NM_001139487
- UniProtKB: A1A5R0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006240897   ⟸   XM_006240835
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_008763302   ⟸   XM_008765080
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000058056   ⟸   ENSRNOT00000031481
RefSeq Acc Id: ENSRNOP00000045941   ⟸   ENSRNOT00000043099
RefSeq Acc Id: ENSRNOP00000094472   ⟸   ENSRNOT00000096798
RefSeq Acc Id: XP_063118898   ⟸   XM_063262828
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063118897   ⟸   XM_063262827
- Peptide Label: isoform X1
Protein Domains
C2H2-type   KRAB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M4D5-F1-model_v2 AlphaFold F1M4D5 1-500 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1642422 AgrOrtholog
BioCyc Gene G2FUF-35048 BioCyc
Ensembl Genes ENSRNOG00000043289 Ensembl
  ENSRNOG00000048864 Ensembl
  ENSRNOG00000068608 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000031481 ENTREZGENE
  ENSRNOT00000031481.4 UniProtKB/TrEMBL
  ENSRNOT00000096798.1 UniProtKB/TrEMBL
Gene3D-CATH 6.10.140.140 UniProtKB/TrEMBL
  Classic Zinc Finger UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7123097 IMAGE-MGC_LOAD
InterPro KRAB_dom_sf UniProtKB/TrEMBL
  Krueppel-associated_box UniProtKB/TrEMBL
  Znf_C2H2/integrase_DNA-bd UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
KEGG Report rno:100125368 UniProtKB/TrEMBL
MGC_CLONE MGC:156774 IMAGE-MGC_LOAD
NCBI Gene 100125368 ENTREZGENE
PANTHER KRAB DOMAIN C2H2 ZINC FINGER UniProtKB/TrEMBL
  SPERM MOTILITY KINASE X-LIKE UniProtKB/TrEMBL
  ZINC FINGER PROTEIN 142 UniProtKB/TrEMBL
  ZINC FINGER PROTEIN 747 UniProtKB/TrEMBL
Pfam KRAB UniProtKB/TrEMBL
  zf-C2H2 UniProtKB/TrEMBL
  zf-C2H2_6 UniProtKB/TrEMBL
PhenoGen Znf57l PhenoGen
PROSITE KRAB UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000043289 RatGTEx
  ENSRNOG00000048864 RatGTEx
  ENSRNOG00000068608 RatGTEx
SMART KRAB UniProtKB/TrEMBL
  ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP Krueppel-associated_box UniProtKB/TrEMBL
  SSF57667 UniProtKB/TrEMBL
UniProt A0A8I6AL20_RAT UniProtKB/TrEMBL
  A1A5R0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-09-19 Znf57l  zinc finger protein 57 like  LOC100125368  zinc finger protein LOC100125368  Symbol and Name Changed 1299863 APPROVED
2021-03-09 LOC100125368  zinc finger protein LOC100125368  LOC102551539  zinc finger protein 709-like  Data merged from RGD:7655688 737654 PROVISIONAL
2013-12-18 LOC102551539  zinc finger protein 709-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2007-09-15 LOC100125368  zinc finger protein LOC100125368      Symbol and Name status set to provisional 70820 PROVISIONAL